Aflatoxin류의 발암활성 영역 결정과 그들의 상대적 활성

朴柄珏,孫觀銖,宋寧大 嶺南大學校 基礎科學硏究所 1992 基礎科學硏究 Vol.12 No.-

The most stable stuructures of aflatoxins known as toxins cauing Turkey X disease(1962) were determined by molecular mechanics method. The carcinogenic region of aflatoxins were determined and calculated their indices by means of Extended Hukel method. The 1,2,3,and 4 position forming trans butadiene frame in the aflatoxins reconfirmed to be carcinogenic region, previous tentatively trans 1,2,and 4 region. The LUMO π-eletron densities of the trans-1,2,3,and 4 positions were calculated and found to be over critical value 1.0. It was found that carcinogenic activity is in other of M₁> ?? >P₁>B₁>M₂>G₁> ?? >GM₁>G₂>B₂.

異常氣象이 벼의 生育과 收量에 미치는 影響

鄭炳官,金容在,金東觀 全南大學校 農業科學技術硏究所 1997 農業科學技術硏究 Vol.32 No.-

1980年度 벼 減數分裂期의 異常低溫과 寡照現象 등 異常氣候條件에서 標高別에 따른 品種別 및 移秧期別로 全羅南道 求禮郡 山間地域의 一般 農家畓에서 生育의 進展度와 이에따른 主要 形質들의 變化를 調査分析한 結果를 要約하면 다음과 같다. 1. 出穗 遲延現象은 日本型에 비하여 統一系型이 그리고 早植에 比하여 晩植이 顯著하였고, 이 現象은 標高가 높아짐에 따라 더욱 심하였으며, 標高 100m씩 높아짐에 따라 平均 5日이 遲延되었다. 2. 生育의 進展抑制에 따라 主要 形質들의 變化는 品種 및 移秧期에 따라 差가 있었으나, 標高가 100m씩 높아짐에 따라 平均 4.5㎝가 짧아졌으나, 穗長은 增減變化가 없었다. 3. ㎡當 穗數는 標高 200m 以下에서는 增減變化가 없었으나, 200m 以上에서는 14∼16%가 減少하였고, 4. 穗當粒數 및 登熟率은 標高 100m씩 높아짐에 따라 각각 15粒 및 6.7%가 平均的으로 減少 하였으며, 5. 玄米種은 早植의 경우 400m 以上의 高標高에서 78%, 200∼400m에서 41∼67%가 減 收하였으나 晩植의 경우 300m 以上의 高標高에서 78%가 減收하였다. This study was carried out to improved the rice cultivation method under unusual weather condition such as low temperature and deficiency of sunshine hours of meiosis stage of rice in 1980. Investigation was taken with different varieties, transplanting time and altitude in farm land. Investigation region was mountainous area in Ku-Rae, Chonnam Province, Heading time was remarkable delay in the Tong-il pedigree. It was 5 days delay average according to raise of 100m altitude and culm length was observed 4.5㎝ shortage too but panicle length did not any change. The decreasing of panicle number(14∼16%), ripened grain(6.7%) was observed according to the raise of 100m altitude and brown rice yield was decreased of 41% in the 150∼200m, of 57% in the 200∼300m, of 67% in 300∼400m and 78% over the 400m altitude in early planting because of the decreasing of yield components when compared with those of plain land. But decreasing degree of yield was observed 78% over the 300m altitude when was planted late.

播種期差가 綠豆品種의 主要 特性變異에 關한 硏究

鄭炳官 순천대학 새마을연구소 1987 새마을硏究論文集 Vol.3 No.-

This experiment was conducted to investigate the variation of main characteristics of mung bean varieties according to plant time. 9 va-rieties with different biological characteristics were planted at 25 days interval from May 21th, and changes of various character was investigated. Results are summarized as follows. 1. Seeding later reduced flowering time, but period of fruitage was the shortest in planting on June 15th. 2. Stem length was the lowest in planting on Jun 15th and ea―rly variety. 3. Capsule numbers per plant were abundant in planting on June 15th among various planting time and in early variety, Seonhwa-Nokdu and Kyunggi-Jaerae 5#, among various varieties. 4. 1000 grains weight made no difference among planting time but varied from 4.1 to 6.1g among various varieties, and reduced in later harvesting time. 5. Yield per 10a was abundant in planting on June 15th, and in yi-eld with various varieties, Seohwan-Nokdu, Kyunggi-Jaerae 5# and Suweon 5# were increased in planting on May 21th and June 15th, but Seonhwa-Nokdu was also increased in plating on June 10th.

참깨 播種期에 따른 栽植密度가 生育 및 收量에 미치는 影響에 關한 硏究

鄭炳官 조선대학교 농업연구소 1984 農業硏究 Vol.1984 No.1

가. 試驗期間이 氣象은 平均氣溫 22.7℃에 比하여 地中5cm 10時溫度는 1.9℃가 더 높았고 13時溫度는 5℃가 더 높았으나 降水量은 平年(‘76~’80)보다 本年이 131.9mm가 많았고 降水日數도 4.6日 더 많았는데 잦은 降雨로 日照時數도 46.4時間이적어 참깨生育에 나쁜 영향을 미쳤다. 나. 播種期別 出芽率은 早播할수록 低調하였고 播種期別 溫度와 出芽率과의 相關은 高度의 有意性을 보였다. 다. 播種期別 ?數는 播種期가 빠를수록 各播種期間(15日 間隔)에 ?數가 約10個씩 增加하는 傾向을 보였으며 栽植密度別 ?數는 ??植할수록 增加하였으나 單位面積當(1m^2當) ?數는 密植區에서 增加하였다. 라. 播種期別 收量은 5月 15日區 播種區(72kg/10α)에 比하여 4月30日 播種이 8%增收를 보였으나 麥後作播種(6月 15日)은 25% 收量減少를 가져왔다. 마. 栽植密度別 收量은 50×10cm 1本에 比하여 密植한 40×10cm 1本處理와 40×20cm 2本處理에서 18~25%의 增收로 高度의 有意性이 認定되었다. 바. 以上 참깨 安全增收栽培는 低溫에 依한 發芽率向上을 爲하여 播種量을 늘려 早播하고 密植하여 (40×20cm 2本植) 비닐被覆하는 것이 좋다고 思料된다. Sesame is lower in an annual price variation than any other crops, but its prodution is very changeable according to weather conditions and cultivated methods. Especially, requring a high temperature, the southern place in a right one for Sesame. And it should be, if possible, ear1y sowed to get a high yield, causing the total growth period to be prolonged. However, under the same weather conditions, the range of quantity is broad according to the cultivated methods. Taking account of this, the study was carried out to control planting space that can lead to high-yielding with different sowing dates. Moreover, to maintain the temperature and humidity in the experiment, it was done in vinyl mulching. The results are as follows.

Nitric Oxide가 골개조에 미치는 영향

방병관,강정숙,채한정,김형룡 원광대학교 생체재료·매식연구소 1998 원광생체재료·매식 Vol.7 No.1

Nitric oxide(NO) is known to be implicated in bone metabolism, especially as a mediator of cytokine effects for remodeling of bone tissue. In this study we examine whether NO affects osteoblast activation of osteoblast or osteoclastic differentiation in primary mouse osteblast-like and osteosarcoma ROS 17/2.8 cells. Primary osteoblast and ROS 17/2.8 cells release NO upon stimulation of interleukin-1β, tumour necrosis factor-α, and interferon-γ. Sodium nitroprusside, a donor of NO, increases the activity of alkaline phosphatase in ROS 17/2.8 cells as well as the number of calcified nodule formations in primary mouse osteoblast-like cells. Sodium nitroprusside also completely also completely inhibites 1 α,25-(OH)_2D_3-induced osteoclast genration in a high concentration (100 μM). However, low concentrations of sodium nitroprusside (3∼30 μM) significantly increase the generation of osteoclasts. These results that NO appears to be an important regulatory molecule in the processes of bone formation and resorption. Hence, NO may be involved in the pathogenesis of bone loss in diseases associated with cytokine activation such as periodontal disease and rheumatoid arthritis.

TiN 박막 형성에 미치는 ion beam 조사 효과

안병건,추관식,문두수,안정식,김영대,김형자,이규용 釜慶大學校 2002 釜慶大學校 論文集 Vol.7 No.-

Low energy high current N_2 ion beam was used to modify the morphology and chemical composition of cemented carbide WC-Co(Co:10 wt%, TiC + TaC:15 wt%, WC:bal) hard material surface for the fabrication of the TiN thin film by sol-gel method. The effects of ion beam treatment on preparation of the TiN thin film by sol-gel mothod were investigated by XPS, SEM, AFM and GXRD. According to the N_2 ion beam bombardment, the surface roughness was increased and TiC binders in WC were dissolved. The dissolved Ti was recombind with nitrogen ion to form the TiN nucleuses which were acted as seeds for the forming of the TiN thin film on the cemented WC-Co surface. Besides, the sputter deposited Ti interlayer prevented the diffusion of TiO_2 sol into the porous WC-Co during the formation of TiN thin film.

구강 연조직 병소의 Nd:YAG laser를 이용한 치료 : 임상 증례보고 CLINICAL CASE REPORTS

김수관,조세인,권병곤,이상호 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.4

The neodymium:yttrium-aluminum-garnet (Nd:YAG) laser is most widely used for treatment of lesions affecting the oral mucosa. A pulsed Nd:YAG laser (SDL-300EN, Samsung Electronics, Korea) with a wavelength of 1.32㎛ was used. In all cases, contact mode was used. Four cases of soft tissue oral lesions are presented to document the clinical aspects. Surgery proceeded without complication and healing was uneventful. This study indicate that the Nd:YAG laser can be used successfully for intraoral soft tissue applications are well tolerated and minimal bleeding.

PEM을 이용한 連續基礎의 支持力에 대한 信賴度 解析

吳秉炫,羅德寬,朱宰佑 순천대학교 공업기술연구소 1994 工業技術硏究所論文集 Vol.8 No.-

The reliability analysis are performed for the bearing capacity of strip foundation using the point estimate method. The measure of the safety of structure is expressed in terms of the probability of failure instead of the conventional factor of safety. The analysis of the uncertainties around input parameter which is involved soil, site and loading condition introduce a measurable uncertainty on the prediction of bearing capacity of strip foundation. Both the soil properties and loads are assumed to be probability variables, and considered correlations of each variated. And as expected, the difference in the probability of failure of bearing between beta and normal distribution seems to be insignificant for practical use but the probability of failure by the given value of the correlation of each variable is more sensitive than that of not to be considered case. If probabilistic analysis techniques are to be adopted, it will be necessary to develop probability based tolerable bearing capacity criteria.

유지 투석중인 만성 신부전환자에서 허혈성 심질환의진단 지표로서의 심장트로닌-I의 유용성

신병철,강대웅,정지용,류봉관,서영욱,김정인,김범윤,김현리,정종훈 朝鮮大學校 附設 醫學硏究所 2004 The Medical Journal of Chosun University Vol.29 No.1

Background : Coronary disease is highly prevalent in patient with end stage renal disease (ESRD) and account for much of their observed morbidity and mortality. Troponin-I consistently maintains a high sensitivity and specificity and is most sensitive marker for ischemic heart disease (IHD). Method : We examed 49 hernodialyzed patients (22 male, 27 female) without evidence of acute coronary syndrome (ACS) for 6 months. Biochemical markers were measured in serial predialysis blood samples. For analysis, we used two cardio-specific assays for troponin-T (cTnT) as well as for troponin-I (cTnI) and compared the results with CK-MB (reference value ≤ 4.0 ng/mL) concentration. Results : Myocardial ischemia was observed in 47% (23/49) of patients. cTnT level above 0.1 ng/mL. and cTnI level above 0.5 ng/mL, were observed in 22% (11/49) and 20% (10/49) of patients respectively. cTnI revealed significantly higher positive rate in patients with myocardial ischemia than the patients without myocardial ischemia (43 % vs 30%) (p<0.05). cTnT and CK-MB revealed no difference in positive rate between the patients with and without myocardial ischemia (cTnT : 30% vs 15% and CK-MB : 30% vs 19%). The sensitivity and specificity of cTnI to myocardial ischemia were higher than those of cTnT and CK-MB (sensitivity 43% vs 30% and 30%. specificity 100% vs 85% and 81%). Conclusion: Both cTnT and cTnI are useful in ruling out myocardial injury in chronic renal failure patients. But. cTnI is a more sensitivity and excellent specificity of ischemic heart disease than cTnT and CK-MB in hemodialyzed patients. In patients with ischemic heart disease, the presences of DM and advanced age were higher than those in patients without ischemic heart disease (p<0.05). Among the baseline characteristics old age, elevated LDH and diabeties were significant more frequent in the patients with elevation of cardiac troponin-I (p>0.5 ng/mL) than those with cardiac troponin-I (p<0.5 ng/mL), p=0.038, p=0.049, and p=0.045, respectively. Our results suggest that these cTnI is the potential diagnostic marker for the prediction of IHD in ESRD patients.

구강 악안면 연조직 결손 재건을 위한 진피 지방 이식의 이용 : 증례보고

김수관,박노승,이병준,황경곤,여환호,김영균 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.3

Soft tissue defects in oral & maxillofacial region caused by tumor resection, trauma, congenital deformities have been treated in autogenous soft tissue flap, allogenic material, free dermal graft, fascia graft. Of these methods, autogenous dermis graft had initially been applied in hernia treatment at the beginning of nineteenth century and have been applied in soft tissue augmentation coverage of vital structure, dead space removal and reconstruction of fascia. A fat graft is used in reconstruction of orbit at the enucleation, restoration of facial contours, etc. In this case, patient with chin soft tissue defect in traffic accident was treated in autogenous dermis-fat graft from patient's abdominal and gluteal region. Chin defect was recons ructed favorably. There was no severe atrophy of grafted area 12 months postoperatively. We will report the result that is favorable esthetically with literature review.