정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

골전이를 보인 혈관외피세포성 수막종

양기화,김병기,김선무 대한병리학회 1991 Journal of Pathology and Translational Medicine Vol.25 No.1

전신성 홍반성 낭창이 속발된 헐괄 면역아구성 임프선종 1예

양기화,김병기,심상인,김원일,김선무 大韓血液學會 1984 大韓血液學會誌 Vol.19 No.2

목탄분말 시용량이 양파 생육 및 토양 이화학성에 미치는 영향

윤봉기,박인진,유용권,허원녕,김병운,김용웅 한국국제농업개발학회 2004 韓國國際農業開發學會誌 Vol.16 No.2

양파재배 토양에서 목탄의 적정 사용량 및 토양개량 효과를 구명하기 위하여 참나무 목탄분말을 10a당 0(무처리), 300, 500, 1,000, 1,500, 2,000㎏ 수준의 6처리로 2000년에 시험한 결과는 다음과 같다. 1. 목탄 시용으로 양파생육이 좋아지는 경향이었으며 10a당 300㎏시용에서 초장, 엽수, 줄기직경 등 생육이 좋았다. 2. 목탄 시용에 따른 순량 구성요소는 10a당 300㎏ 시용에서 가장 좋았으며 수량도 300, 500㎏ 시용에서 각각 7%, 2% 증수되었고 1,000㎏ 이상 시용에서는 감수되는 경향 이었다. 3. 목탄 시용으로 토양 pH가 중성 가까이 변화되고 토양 유기물 함량과 양이온 치환용량 이 증가하여 토양 화학성이 개선되었다. 4. 목탄 시용으로 토양의 용적밀도와 고상율이 감소하고 토양 공극율이 증가하여 토양 물 리성이 개선되었다. This experiment was conducted to find out an application amount of wood charcoal pow-der and soil improvement effect of wood charcoal in 2000 year. The wood charcoal was made of a black oak. An application amount of used wood charcoal was 0, 3, 5, 10, 15, 20 Mg/㏊. Effect of soil improvement and application amount of wood charcoal was summerized as follows; Onion growth of plot applied wood charcoal was better than that of plot not applied wood charcoal. The plant height, the number of leaf and diameter of stem of plot applied wood charcoal 3 Mg/㏊ were better than any other that of plot. Yield components of plot applied wood charcoal 3Mg/Bμ were the best. Yied of plot applied wood charcoal 3 and 5 Mg/ha was increased 7% and 2% than that of control. But that of plot applied wood charcoal 10 Mg/㏊ over was trend to decrease.

양이온 교한 크로마토그라피에 의한 Fe(Ⅲ), V(Ⅳ), Cu(Ⅱ), Ni(Ⅱ), Co(Ⅱ), Mn(Ⅱ), Cr(Ⅲ) 의 분리정량

이병조,김영기 건국대학교 1971 學術誌 Vol.12 No.1

The quantitative separation of a mixture containing 1ml of 0.1M each V (IV), Cu (II), Ni(II), Co(II), Mn(II) Cr(III) and 1ml of 0.2M Fe(III) is obtaind by elution, through a 35cmx3.14cm2 column of the resein Dowex50W×12(50∼100mesh), using 0.6M NaCl+0.1M Na-tartrate solution and 0.7M NaCl + 0.05M Na2C2O4 solution as eluents.

시각장애인 점자블록의 실용성 분석에 관한 연구

성기창,강병근,김인순 대한건축학회 2005 대한건축학회논문집 Vol.21 No.1

A raised block for blind and visually imparted person is a very useful facility for a orientation For this reason, the raised block has been Installed obligatorily in the building and on the sidewalk In recent years the Installation has been increasing at a rapid rate in the whole country but It is required to Improve upon the method of installation Tim, study tries to provide useful and alternative models of the raised block To accomplish this purpose, the existing models m Korea (Japan), Germany and Austria have been analyzed and tested by the 110 visually Impaired persons As the result, this study shows how the models of reused block can apply practically to different conditions and environment.

1996년과 1999년 경기지역 초등학교 학생들에서 유행성이하선염에 대한 면역도 조사

나병국,이주영,고운영,이진수,신구철,이주연,최보율,기모란,양병국,강춘,김우주,김지희 대한감염학회 2001 감염 Vol.33 No.3

Background : Although massive use of live attenuated mumps virus vaccines successfully reduced the incidence of mumps virus infection worldwide, mumps outbreaks have not been completely eliminated, even in vaccinated populations. In recent years, the incidence of mumps has been remarkably increased in Korea. This study was designed to evaluate the recent seroprevalence rate of mumps IgG among children in Kyonggi province at 1996 and 1999. Methods : Study population included students from 8 elementary schools in Kyonggi province. Serum samples were collected twice at 1996 and 1999 and tested for mumps-specific antibody by enzyme-linked immunosorbent assay (ELISA). We also conducted a questionnaire survey on the parents and collected the records including history of vaccination and mumps infection. Results : The seropositive rates against mumps were 89.47% and 89.74% at 1996 and 1999, respectively, and they were not significantly different when compared to age, sex, and region. Although the first vaccination rates were 92.17% and 92.25% at 1996 and 1999, respectively, the second vaccination rates were only 37.89% and 38.03% at 1996 and 1999, respectively. Infection rate showed no significant difference between vaccinated groups and nonvaccinated gropus. Seropositive rate of infected group was higher than that of noninfected group but it was not significantly different between the vaccinated and the nonvaccinated. Conclusions : This study showed the seropositive rate and vaccination against mumps in children. There were no significant relationships between vaccination and infection. Therefore, it seems likely that the vaccination is not fully protective against mumps infection. This study will be helpful for the establishment of guideline for prevention and treatment of mumps in Korea. (Korean J Infect Dis 33: 157∼164, 2001)

고온 접촉식 탐상용 초음파 탐촉자 개발 및 평가

김기복,김병극,이승석,윤남원,윤동진,안윤국 한국비파괴검사학회 2003 한국비파괴검사학회지 Vol.23 No.1

고온(500℃) 환경에서 접촉식 탐상이 가능한 초음파 탐촉자를 개발하고 평가하였다. 고온용 탐촉자는 Curie 온도가 600 ℃ 이상인 bismuth titanate 계열의 압전세라믹 소자, 텅스텐 분말과 inorganic binder를 혼합한 후면재, 알루미나 튜브, 전면재, 하우징 등으로 구성되었다. 기본 공진주파수가 각각 1.04 및 2.08 ㎒의 2 종류 탐촉자를 제작하였으며 각종 고온용 커플런트의 온도특성을 시험하였다. 개발된 고온용 탐촉자를 이용하여 강재 시편을 대상으로 시편에서의 초음파 반사신호를 측정한 결과 시편의 온도가 증가함에 따라 반사신호의 크기는 감소하였다. 고온에서 반복측정 실험결과 500℃에서 연속적인 접촉식 초음파 탐상이 가능한 것으로 나타났다. Piezoelectric ultrasonic transducers for high temperature contact measurement were developed. These high temperature ultrasonic transducers (HTUT) consisted of bismuth titanate piezoceramic element whose Curie temperature is higher than 600℃, a backing material of the mixture of tungsten powder and inorganic binder, an inner alumina tube, a wear plate and a housing. The operational frequencies of the HTUT were 1.04 and 2.08 ㎒, respectively. Various commercially available couplant for high temperature were evaluated and compared. As a couplant for high temperature ultrasonic testing between HTUT and test specimen, gold epoxy was selected. The peak amplitude of pulse-echo signals from steel test specimen decreased with increasing temperature. The operational temperature of the HTUT reached up to 500℃ at which the continuous contact measurement was possible.

목탄분말의 입자크기가 양파 생육과 토양 이화학성에 미치는 영향

윤봉기,박인진,유영권,허원영,김병운,김용웅 한국국제농업개발학회 2004 韓國國際農業開發學會誌 Vol.16 No.3

토양개량용으로 적합한 목탄의 입자크기를 구명하기 위하여 양파 재배 토양에서 참나무 목탄분말과 소나무 목탄분말의 입자크기를 각각 1 ㎜이하, 1~5㎜, 5~10㎜의 3처리로 하여 목탄분말을 500㎏/10a 수준으로 사용하고 2001년에 시험 한 결과는 다음과 같다. 1) 시험에 사용된 목탄의 화학적 특성은 참나무 목탄은 pH10.1, T-N 0.04%, P₂O_(5) 1.63%, K₂O 0.34%이었으며 소나무 목탄은 pH 9.3, T-N 0.24%, P₂O_(5) 2.18%, K₂O 0.33%이었다. 2) 수확기의 양파 생육은 초장 50.0~62.6㎝, 엽수 6.0~6.5매, 줄기직경 11.2~16.4㎜이었으며 1 ㎜이하 크기의 목탄 시용구에서 초장. 염수, 줄기직경 등 생육이 좋았다. 3) 목탄 입자크기에 따른 수량 구성요소는 1 ㎜이하 시용 구에서 구고. 구 직경, 구중 등이 좋았으며 수량도 목탄 입자크기 1 ㎜이하 시용구에서 많았다. 4) 시험후 토양 화학성은 토양 pH 5.9~6.3, OM 14.7~15.5 g ㎏^(-1), CEC 15.6~16.8 c㏖^(+)㎏^(-1), Avail. P₂O_(5) 147~186㎎ ㎏^(-1), Exch. K 0.35~0.41c㏖^(+) ㎏^(-1)으로 시험전 토양에 비하여 OM, CEC가 증가하고 Avail. P₂O_(5), Exch. K의 축적이 경감되었다. 5) 시험후 토양의 물리성은 용적밀도 1.20~l.24g ㎝^(-3), 고상 45.1~46.6%, 공극율 53.4~54.9% 이었으며 목탄 입자크기 1 ㎜이하 시용구에서 좋아지는 경향이었다. 6) 시험후 토양의 미생물상은 세균 64.3~200.4(×10^(5))cfu g^(-1),방선균 26.4~70.3(×10^(5)), 사상균 16.9~186.2(×10³))이었으며 <1㎜, 1~5㎜ 크기의 목탄 시용구에서 세균, 방선균, 사상균이 많은 경향이었다. This experiment was conduct to find out moderating particle size of wood charcoal powder for soil improvement in 2001 year. The wood charcoal material was a black oak and pine. The particle size of wood charcoal was 1㎜ below, 1~5 ㎜ and 5~10 ㎜. An amount of wood charcoal application was 500 ㎏ l0a^(-1), Chemical properties of a black oak charcoal used experiment was pH 10.1, T-N 0.04%, P₂O_5 1.63% and K₂O 0.34%. That of pine charcoal was pH 93, T-N 0.24%, P₂O_(5) 2.18%, K₂O 033%. At harvest stage of onion, plant height was 50.5~62.6㎝. The number of leaf was 6.0~6.5ea. Stem diameter was 11.2~16.4 ㎜. Plant height, the number of leaf and stem diameter of plot treated 1 ㎜ below wood char-coal were be longer, more or bigger than those of any other particle size. Onion height, diameter and weight of plot treated 1 ㎜ below wood charcoal was higher or bigger than that of any other particle size. Yield was similar to yield component. Soil chemical properties of after experiment was pH 5.9~63, OM 14.7~15.5 g ㎏^(-1), CEC 15.6~16.8 c㏖^+ ㎏^(-1), Avail. P₂O_(5) 147~486 mg ㎏^(-1) and Exch. K 035~0.41 c㏖+ ㎏^(-1). OM and CEC was increased than that of before experiment. Avail. P₂O_5 and Exch. K was decreased than that of before experiment. Soil texture after experiment was bulk density 1.20~4.24 g ㎝^(-1), solid phase 45.1~46.6%, porosity 53.4~54.9%. Soil texture was trend to be improved by l㎜ wood charcoal. Soil microflora after experiment bacteria 64.3~200.4(×10^(5))cfu g^(-1) actinomycete 26.4~70.3(×l0^(5))cfu g^(-1) and fungi 16.9~186.2(×10³)cfu g^(-1) Bacteria, actinomycete and fungi was much at plot treated with <1 ㎜, 1~5 ㎜ wood charcoal with out relation to wood charcoal material.

목탄분말의 원료수종이 양파 생육과 토양 이화학성에 미치는 영향

윤봉기,박인진,유영권,허원영,김병운,김용웅 한국국제농업개발학회 2004 韓國國際農業開發學會誌 Vol.16 No.3

양파재배 토양에서 토양개량용으로 적합한 목탄의 원료 수종을 선발하기 위해서 관행(무처리)과 코코넛피트, 대나무, 참나무, 활엽수 수피, 소나무로 만든 목탄분말의 6처리로 시용량 500㎏· 10a^(-1)으로 하여 2002년에 시험한 결과는 다음과 같다. 1. 시험에 사용한 5종 목탄의 pH는 5.1~10.1, T-N 0.15~0.71%, P₂O_(5) 2.06~2.65%, K₂O 0.20~0.86% 범위였으며 1 ㎜이하 입자의 분포는 9.0~84.8%이었다. 2. 양파의 생육은 목탄시용으로 줄기직경이 크고 주당 엽수가 많은 경향이었으며 참나무, 활엽수 수피, 대나무 목탄처리 구에서 생육이 좋았다. 양파의 수량은 4,631~5,114㎏ 10a^(-1)으로 무처리(4,638㎏)에 비하여 구고가 크고 구중이 무거운 참나무목탄과 활엽수 수피 목탄처리구에서 각각 10%, 소나무 목탄구에서 3% 증수되었으며 유의성이 인정되었다. 3. 시험 후 토양의 물리성은 목탄 시용으로 용적밀도와 토양의 고상비율이 줄어들 고 액상과 기상, 공극율이 증가하는 경향을 보였다. 화학성은 코코넛 피트처리구 를 제외한 처리구에서 토양 pH가 개선되었고, OM, CEC 는 모든 처리구에서 증가하는 경향을 보였다. This experiment was conducted to find out moderating tree kinds of wood charcoal pow-der for soil improvement and onion growth in 2002 year. The wood charcoal materials were coconut peat, bamboo, black oak, pine, and broadleaf tree bark. Wood charcoal application rate was 500 ㎏ 10a^(-1). Results were summerized as follows; Chemical properties of wood charcoal used experiment were pH 5.11~10.1, T-N 0.15~0.71%, P₂O_(5) 2.06~2.65% and K₂O 0.20~0.86%. The particle size of <0.1 ㎜ was 9.0~84.8%. Onion growth of plot applied wood charcoal was better than that of plot not applied wood charcoal. The number of leaf and diameter of stem at plot applied wood charcoal was better than that of plot not applied wood charcoal. Growth of plot applied black oak charcoal, broadleaf tree bark char-coal, and bamboo charcoal was better than that of any other plot. Yield of plot applied wood charcoal was 4,631~5,114 ㎏ 10a^(-1). The yield of plot applied black oak charcoal, broadleaf tree bark charcoal and pine charcoal was increased 10, 10, 3% than that of control(4,638 ㎏ 10a^(-l)), respectively. It was significant at 5% level. Soil physical properties of after experiment was decreased bulk density and solid phase, but liquid phase, air phase and porosity were increased than that of control. Soil chemical properties of after experiment trend to be improved pH. Soil OM and CEC was increased than that of control.