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Carlo Scognamiglio Renner Araujo,Luciana Parente Costa Seguro,Paulo Schiavom Duarte,Carlos Alberto Buchpiguel,Rosa Maria Rodrigues Pereira 대한핵의학회 2019 핵의학 분자영상 Vol.53 No.6
68Ga-DOTATATE uptake in mesenchymal tumors causing hypophosphatemic osteomalacia has been recently described. Herein, we present a case of 68Ga-DOTATATE uptake in an intramastoid phosphaturic mesenchymal tumor that had not been depicted in previous 99mTc-Sestamibi and 18F-FDG scans. The lesion was surgically removed and the phosphorus level increased to the normal range.
Ueda Cristina Emiko,Duarte Paulo Schiavom,Castroneves Luciana Audi,Coura-Filho George Barbério,Sado Heitor Naoki,Sapienza Marcelo Tatit,Ana Oliveira Hoff,Buchpiguel Carlos Alberto 대한핵의학회 2020 핵의학 분자영상 Vol.54 No.6
Purpose To compare the 18F-NaF PET/CT studies (18F-NaF) with other imaging methods in the detection of skeletal metastases (SM) in patients with medullary thyroid cancer (MTC). Methods We retrospectively analyzed 31 patients with MTC who performed 18F-NaF to assess SM. The results of the 18F-NaF were compared with other imaging methods performed for metastasis detection: 99Tc-MDP bone scan (BS), magnetic resonance imaging (MRI), contrast-enhanced CT (CT), and 68Ga-Dotatate and 18F-FDG PET/CT studies. A qualitative analysis comparing the 18F-NaF findings with the ones of the other methods was performed, and the results were classified as superior (>), equal (=), and inferior (<). Results Eleven patients had no bone metastases detected on any of the imaging methods used. Twenty patients presented SM depicted on 18F-NaF. Of these 20 patients, 12 performed bone scan (in 9 18F-NaF > BS and in 3 18F-NaF = BS), 1 performed 18F-FDG (18F-NaF > 18F-FDG), 4 performed 68Ga-Dotatate (in 2 18F-NaF > 68Ga-Dotatate and in 2 18F-NaF = 68Ga-Dotatate), 20 performed CT of at least one body segment (in 15 18F-NaF = CT and in 5 18F-NaF > CT), and 16 performed MRI of at least one body segment, and in all of them, the 18F-NaF was equal to the MRI. Beside this, the 18F-NaF detected SMin body segments not routinely scanned in MRI and CT. Conclusion In patients with MTC, the 18F-NaF seems to be equal or superior to other imaging modalities in the detection of SM and allows the analysis of the whole skeletal in a single study.
Paulo Schiavom Duarte,Luciana Audi de Castroneves,Heitor Naoki Sado,Marcelo Tatit Sapienza,Ana Amélia Fialho de Oliveira Hoff,Carlos Alberto Buchpiguel 대한핵의학회 2018 핵의학 분자영상 Vol.52 No.4
Herein, we report a case of a 19-year-old man with multiple endocrine neoplasia type 2B (MEN2B) and medullary thyroidcarcinoma (MTC) diagnosed when he was 12 years of age. The patient had previously undergone total thyroidectomy, cervicalradiotherapy, and chemotherapy. He progressed with known bone, pulmonary, and lymph node metastases and was scanned with18F-fluoride (18F-NaF) and 68Ga-dotatate whole-body positron emission tomography/computed tomography (PET/CT) for metastaticdisease monitoring.We found that the MTC bone metastases and soft tissue calcified metastases were better characterizedon 18F-NaF PET/CT than on 68Ga-dotatate PET/CT. This case illustrates that the 18F-NaF PET/CT could be helpful not only tothe detection of bone metastases but also to the detection of calcified soft tissue metastases in patients with MTC.