임신과 수유기간동안 약물사용

閔富基 대한의사협회 1998 대한의사협회지 Vol.41 No.5

韓國女性의 閉經에 關한 硏究

閔富基,丘秉參,李壽鍾 고려대학교 의과대학 1983 고려대 의대 잡지 Vol.20 No.3

The climacteric that is sometimes associated with symptomatology, is the phase in the aging process of women marking the transition from the reproductive stage of life to the nonreproductive stage. During this climacteric phase, physiologic and sexual function is decreased of lost. The menopause is defined the cessation of menstruation for consecutive 12 months. The age of onset of menopause may make a difference by the individual women, and moreover it does appear to depend on various factors; socioeconomic status, cultural background, genetic, and health status. In the same country, the age of menopause does not appear significant difference for generation as being shown in that of menarchal age initiating menstruation. But it is influenced by racial, geographic, climate, and natural factors. In the advanced country, it has been studied about information of closely static results for people’s health status. The study is attempted for understanding of physiology of women, in sexual & maturated phase and menopausal status. Furthermore, it is indicated for the clinlcal diagnosis, family planning, and health status of the people. The author noted the following results about the age of onset of menopause, indicating the reproductive physiology of women, 3378 cases living on various area in Korea. 1. With observation of menopausal age of 6 areas in Korea, the mean age is 48.8 yrs. In Seoul (range 38-59 yrs. Frequent occurring age 46-49 yrs.), 48.2 yrs. In Kyungki area, (range 41-55 yrs., frequency 47-49 yrs.), 49.1 yrs. At Kangwon (range 38-57 yrs., frequency 47-51 yrs.), 8.2 yrs. In Choongchung(range 38-56 yrs., frequency 48-51 yrs.), 47.4 yrs. At Kyongsang (38-55 yrs. 45-50 yrs.), and 48.2 yrs. In Junla area (38-59 yrs., frequency 47-50 yrs.). 2. With persentile distribution of menopausal age according to distinction of age, onset of menopause is occurred in 5% at age 45, 80% at age 50 and 98.4% at ge 55. The mean age of menopause is noted 47.6 yrs. 3. By the observation of menopausal age according to distinction of parity, the mean age of menopauses 47.8 yrs. (range 38-57 yrs., frequency 45-57 yrs.) at multiparity, 47.9 yrs. at primiparity (range 38-54 yrs., frequent 45-49 yrs.), 48.2 yrs. at para 2 (range 38-60 yrs., frequency 48-56 yrs.), 47.7 yrs. and 47.9 yrs. at para 3 and para 4 or more group (range 38-60 yrs., frequency 46-50 yrs. at both group). And therefore, there is tend to lowering of menopausal age at para 4 or more groups than other groups. 4. In relation with the menopausal age and cohabitation with a family, the mean age is noted 46.8 yrs. at single group, 47.5 yrs. at group of living with a husband, and 48.5 yrs. at group of living with children. And therefore, menopause is occurred earlier in the single group than the other groups. And there is a significant difference in menopausal age between the single group and the other groups. 5. in relation with the education and the menopausal age, the mean age was noted 47.4 yrs. at no-educational group, 47.6 yrs. at primary educational group, 46.8 yrs. at middle school. There is tend to rising of mean menopausal age at primary educational group than middle school. 6. There is no significant difference for onset of menopausal age among the 6th decades, 7th decades and 8th decades at the postmenopausal women. The mean ages of the 6th decades 7th decades and 8th decades of the postmenopausal women were noted at 48.2 yrs., 48.1 yrs., and 48.0yrs., respectively.

난소의 성숙 낭성 기형종에서 발생한 원발성 유암종 : 1예 보고 A case Report

조향정,민부기,문형배 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.1

저자들은 우측 난소의 성숙 낭성 기형종에서 발생한 원발성 유암종 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 본 예는 수술 후 상부 소화기 내시경검사, 대장 내시경 검사 및 복부와 골반에 대한 전산단층촬영을 시행하였으나 특이 소견은 없었고 현재 6개월정도 추적 관찰중이다. The most common malignant change in cystic teratoma is squamous cell carcinoma, followed by carcinoid tumor and adenocarcinoma. Ovarian carcinoid tumor can be seen in the ovary as a metastasis of a tumor located in the gastrointestinal tract or elsewhere, as a component of adult cystic teratoma, or as a primary pure neoplasm of the ovary. The prognosis in primary carcinoid tumors (whether pure or as a component of cystic teratoma) is very good, whereas metastatic carcinoids have a poor outcome. We report a case of a primary carcinoid tumor arising in a mature cystic teratoma of the ovary that developed in a 38-year-old woman with a brief review of literature.

Influence of Nuclear DNA Ploidy of Cells on Survival in Ovarian Cancer

( Bu Kie Min ),( Kie Suck Kim ),( Young Won Choi ) 대한산부인과학회 1988 대한산부인과학회 학술대회 Vol.62 No.-

Estradiol과 Medroxyprogesterone Acetate가 골아세포의 성장에 미치는 영향

김기석 ( Kie Suk Kim ),민부기 ( Bu Kie Min ),홍기연 ( Gi Youn Hong ),박승택 ( Seung Taek Park ),이승필 ( Seung Phil Lee ),김인숙 ( In Suk Kim ) 대한폐경학회 2001 대한폐경학회지 Vol.7 No.1

N/A This study was designed to clarify the hormonal effect on the growth of osteoblast. And the osteoblasts from neonatal mouse were cultured in the medium at various concentrations of 17β-estradiol(EST), medroxyprogesterone acetate(MPA) in addition 10nM of dexamethasone(DMS) and alcohol for 48 hours. And in order to detect the response of osteoblast on the those hormones, the alkaline phosphatase(ALP) activity also was measured. 1. At 48 hours after culture of osteoblasts in media at various concentrations of hormones, EST has an effect on increasing of the cell number in fashion of dose dependent, whereas MPA did not increase the cell number. 2. Dexametasone significantly promoted differentiation of osteoblasts does dependently with increasing of ALP activity. 3. In osteoblasts culture in media supplemented with alcohol in the absence of 10nM DMS, EST increased significantly ALP activity, while decreased ALP activity of osteoblast in the presence of DMS, 4. In culture of osteoblasts treated with alcohol in the absence of 10nM DMS, MPA did not show any change of ALP activity. But in the presence of DMS, MPA decreased ALP activity of osteoblast. 5. EST plus MPA stimulated the ALP activity in osteoblasts treated with alcohol in the absence of DMS. While, in the cells treated with DMS, they synergistically decreased ALP activity.

호르몬 보충용법이 단구세포의 조직인자 활동에 미치는 영향

민부기,김홍곤,김기석,홍기연,이희섭 대한폐경학회 1998 대한폐경학회지 Vol.4 No.1

"Our purpose was to investigate the effects of hormone replacement therapy on the reactivity of monocyte in whole blood, mesured by tissue factor activity. Thirty-eight women were randomized into oral combind homone replacement therapy and underwent blood sampling before and 3 and 12 months of treament,The tissue factor activity in monocytes was measured both in unstimulated whole blood and after a weak lipopolisaccaide stimulation. After 12months of hormone replacement therapy there were significant reduction of tissue factor activity in both unstimulated and lipopolisaccaride stimulated monocyte (p<0.001). Twelve months of hormone replacement therapy reduces cellular activation of blood monocytes; these changes may account for some of the beneficial effects in reducing the risk of cardiovascular disease. "

폐경기 골다공증 여성에 있어서 Alendronate 치료에 대한 골교체의 생화학적 표지자의 평가

김기석(Kie Suck Kim),민부기(Bu Kie Min),이승필(Seung Fil Lee),김인숙(In Suk Kim),김훈영(Hun Young Kim),심재량(Jae Ryang Sim) 대한폐경학회 2000 대한폐경학회지 Vol.6 No.1

N/A Objectives: To evaluate the clinical utility of recently developed biochemical markers of bone turnover to monitor the response of osteoporotic patients to antiresorptive therapy, we compared the results of two advanced assays for markars of bone resorption and two of bone formation. Subjects and Methods: The rate of bone turnover in 37 women (mean±SD age, 58.2±4.5yr) with low boe mass and all postmenopausal women (mean±SD yr PMP, 8.3±5.2) was compared to that in 16 Premenopausal women(mean+SD age, 40.2±5.3yr) randomly selected from out-patient in our hospital and all have a normal spine bone mineral density(BMD). Perodically during the 12-month study,the level of several markers of bone turnover wen, measured. Serum osteocalcin, bone specific alkaline phosphatase mesured by RIA were used to assess bone formation. To assess bone resorption, we measured urinary excretion of Dedxypyridinoline, type l collagen cross-linked N- telopeptide, Result: All bone formation markers and all bone resorption marker were significantly increased in PMP Osteoporotic women. Under treatment with alendronate, resorption markers decreased earlier than marker of bone formation, Conclusion: This study, using biochemical markers of bone turnover, demonstrates that bone turnover is increased in PMP osteoporotic women. Alendronate treatment decreased bone turnover to the normal premenopausal range, with a steady state level reached after 1 month of therapy with 10mg for resorption markers and after 3-6 months of therapy for markers of bone formation.

자궁내막증 치료 전후 환자의 혈청이 생쥐 난자의 수정률에 미치는 영향

김기석,민부기,이희섭,홍기연,이선영,박현진,김흥곤,Kim, Kie-Suck,Min, Bu-Kie,Rhee, Hee-Sub,Hong, Kie-Youn,Lee, Sun-Young,Park, Heon-Jin,Kim, Heung-Gon 대한생식의학회 1999 Clinical and Experimental Reproductive Medicine Vol.26 No.3

Objective: To evaluate the effect of serum obtained before and after treatment for endometriosis on in vitro fertilization and development of two cell mouse embryo. Design: Pretreatment and posttreatment comparoson of fertilization of mouse oocyte and embryo development in serum supplement from patients with endometriosis; result were compared using Stuent T-test analysis. Method: Infertility Clinic, Department of Obstetrics and Gynecology, Collage of Medicine, Won kwang university, Korea. Patients was chosed eleven consecutive women with endometriosis. Interventions was all patient underwent laparoscopic or conservative surgery. This was followed by a 6-month course of burserelin acetate $900{\mu}g/d$. Main outcome was measured total number of fertilization and embryo that was fertilization after 24 hours and reached blastocyst stage after 72 hours of incubation were compared before and after treatment. Result: Before treatment, 47% of the oocyte were fertilized and 31% of the embryo reached blastocyst stage. After treatment, Significantly more fertilized and Significantly more embryo developed to blastocyst on the stage I and II of endometriosis. Conclusion: The fertilization and embryo toxicity of serum samples from patients with endometriosis is lost after treatment.

인간 난관세포와의 체외 공동배양과정에서 혈소판 활성요소가 생쥐배의 발달에 미치는영향

민부기,김기석,이희섭,홍기연,김흥곤,신무철,이찬근,최은하,Min, Bu-Kie,Kim, Kie-Seok,Lee, Hee-Sup,Hong, Kie-Youn,Kim, Heung-Gon,Shin, Mu-Cheol,Lee, Chan-Kun,Choi, Eun-Ha 대한생식의학회 1996 Clinical and Experimental Reproductive Medicine Vol.23 No.1

There are a number of problems during the process of culture in vitro on fertilization and embryo development compared to those on in vivo counterparts. And the platelet activating factor (PAF), which is found not only in mammalian spermatozoa but also preembryos, is implicated on reproductive process. To improve the environment of culture on in vitro fertilization and embryo development, coculture using salpingeal epithelial cells has been considered to accept the better result on pregnancy rate. This study was designed to determine if two different culture systems, coculture alone and PAF treated coculture, are positive or negative influence on process of in vitro fertilization and embryo culture in mouse. The cell cleavage rate reached to 2-4 cell stage at 24 hours of culture is 56.81% (50/88) and 48.21%(54/112) respectively, in PAF treated group which is added PAF on coculture and in coculture group. But the rate of cells cleavage was similar in both group after 48 hours of culture. The rate of unfertilization after insemination of oocytes was higher in coculture group(55..53%) than in PAF treated group(42.37%). And in assessment of undeveped embryos, the rate of equalized cell block was similar on both, coculture alone (35.3%)and PAF treated coculture(35.5%). while unequalized cell block was higher rate in PAF treated coculture(19.4%) than coculture alone (11.8%). But the rate of cytoplasmic degeneration of undeveloped embryos was significantly higher in PAF treated coculture than coculture alone. In conclusion, we have observed that PAF treated coculture is superior in the rates of in vitro fertilization and early embryo cell cleavage compared to those in coculture alone, but there is no difference on the rates of embryo develpments, cell degeneration, cell quality in both PAF treated coculture and coculture alone when the embryo cells were continuosly cultured for 48 hours or more.

자궁경관 무력증에 관한 임상적 고찰

민부기,송정,국승무,최영원,김기석 圓光大學校 醫科學硏究所 1985 圓光醫科學 Vol.1 No.2

This is the report of a retrospective study of 42 cases in cervical incompetence, identified clinically by the department of Obstetrics and Gynecology at won Kwang University Hospital during the period of 4 years from March, 1981 through march, 1985. All 42 cases were divided as variety of operative techniques such as Mc Donald’s, 33 cases, Shirodkar’s, 5 cases, and Lash’s, 4 cases. The 38 cases of cervical incompetence on pregnant state were divided again by group 1, 30 cases of which cervical os were closed or opened as 1.5cm, by group 2, 8 cases of which cervix is effaced as 50 % or more dilated as 3 cm or more. In the age distribution of cervical incompetence, the range from 30 years to 34 years is most common as 21 cases among the 42 cases of I.I.O.C. On analysing by past history in 42 cases of cervical incompetence, the 25 cases, 59 % had one or more of artificial abortion, in 6 cases, birth trauma, in 6 cases, repeat cervical cerclage respectively. And the others are cervical conization, cervical cauterization, and previous C-section. On comparisons between methods of operation and success rate of fetal salvage, the success rate following the Me Donald’s operation is 84% in series of the 28 cases among the 33 cases, and the success rate of 100% following the Shirodkar’s in series of the 5 cases among the 5 cases, 75 % following the Lash and Lash’s. In the hospital days following the cervical cerclage, 19 cases remained in hospital for 5 days, for 5 days more to 7 days in 11 cases, and for 8 days more 10 days in 6 cases. All the period of the hospital days is considerably longer in group 2 than in group 1. The comparison between operative time and success rate, when cervical cerclage is performed before 17 weeks of pregnancy, is seen 100% of success rate, but in cases of cervical cerclage after 18 weeks of pregnancy is 66.7% as 14 cases of 21 cases. The complication rate following cervical cerclage is 13.2% as 5 cases of all 38 cases.