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Polydopamine-Based Simple and Versatile Surface Modification of Polymeric Nano Drug Carriers
Park, Joonyoung,Brust, Tarsis F.,Lee, Hong Jae,Lee, Sang Cheon,Watts, Val J.,Yeo, Yoon American Chemical Society 2014 ACS NANO Vol.8 No.4
<P>The surface of a polymeric nanoparticle (NP) is often functionalized with cell-interactive ligands and/or additional polymeric layers to control NP interaction with cells and proteins. However, such modification is not always straightforward when the surface is not chemically reactive. For this reason, most NP functionalization processes employ reactive linkers or coupling agents or involve prefunctionalization of the polymer, which are complicated and inefficient. Moreover, prefunctionalized polymers can lose the ability to encapsulate and retain a drug if the added ligands change the chemical properties of the polymer. To overcome this challenge, we use dopamine polymerization as a way of functionalizing NP surfaces. This method includes brief incubation of the preformed NPs in a weak alkaline solution of dopamine, followed by secondary incubation with desired ligands. Using this method, we have functionalized poly(lactic-<I>co</I>-glycolic acid) (PLGA) NPs with three representative surface modifiers: a small molecule (folate), a peptide (Arg-Gly-Asp), and a polymer [poly(carboxybetaine methacrylate)]. We confirmed that the modified NPs showed the expected cellular interactions with no cytotoxicity or residual bioactivity of dopamine. The dopamine polymerization method is a simple and versatile surface modification method, applicable to a variety of NP drug carriers irrespective of their chemical reactivity and the types of ligands.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2014/ancac3.2014.8.issue-4/nn405809c/production/images/medium/nn-2013-05809c_0008.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn405809c'>ACS Electronic Supporting Info</A></P>
Aesthetic and functional bra attributes as emotional triggers
Mônica Greggianin,Leandro Miletto Tonetto,Priscila Brust‑Renck 한국의류학회 2018 Fashion and Textiles Vol.5 No.1
This paper aims to evaluate how bra design can trigger positive emotional experiences among users through aesthetic and functional attributes. To achieve this aim, the relationships between women and their favorite bras were investigated, since the users’ preferred products tend to evoke positive experiences. Emotional experiences while using the chosen bras were accessed through five measures: Arousal (intensity of an emotional response); Valence (degree of pleasantness); Dominance (degree of control experienced by the person facing a stimulus); how attractive the chosen bra is; and agreement levels with sentences stating that each design attribute from a list (aesthetic and functional) was determinant for the choice of a certain bra as favorite. The research instrument was a printed questionnaire, which was answered by 182 women. The results indicate that pleasantness (Valence) was related to relaxation (low Arousal), but the feeling of being in control (Dominance), when wearing the chosen bra, was not connected to pleasantness. Attractiveness of the bra, relaxation and pleasantness were related to both aesthetic and functional attributes. The feeling of being in control when using the chosen bra was mostly related to functional attributes. Results are discussed to foster bra design with potential to evoke positive experiences among users.
Wavelength and solvent independent photochemistry: the electrocyclic ring-closure of indolylfulgides
Cordes, Thorben,Herzog, Teja T.,Malkmus, Stephan,Draxler, Simone,Brust, Thomas,Digirolamo, Jessica A.,Lees, Watson J.,Braun, Markus Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.4
A wavelength and solvent dependent study of a photochromic indolylfulgide is presented. The ring-closure reaction is characterized using stationary and time-resolved spectroscopy with femtosecond time resolution. After excitation into the first excited singlet state ($S_1$) the photoprocesses proceed on ultrafast timescales (0.3-0.45 ps) in both polar and non-polar solvents. Excitation into higher electronic states results in similar reaction kinetics as found for $S_1$ excitation. A simple kinetic scheme can be established for the photoprocesses under all different experimental conditions: as expected from organic textbooks neither the solvent surroundings nor the excitation wavelength strongly alter the reaction scheme. The experimental study demonstrates that the ring-closure reaction of photochromic indolylfulgides can be considered as a very robust photoprocess: this fact may lead to a great variety of different applications where the reaction dynamics of the molecular switch are not disturbed by any surrounding effects.
Novel Indole Derivatives as Potential Imaging Agents for Alzheimer's Disease
Yu, Lihai,Scheunemann, Matthias,Deuther-Conrad, Winnie,Hiller, Achim,Fischer, Steffen,Sorger, Dietlind,Sabri, Osama,Jia, Hongmei,Steinbach, Jorg,Brust, Peter,Liu, Boli Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.1