흰쥐에서 말초신경 손상후 뒤뿌리신경절세포의 신경영양인자와 그 수용체의 발현 양상

백선용,양만석,문총석,김봉선,김재봉,김진정 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.2

두경부 편평세포암에서 형질전환 성장인자-알파(TGF-α)의 발현에 관한 연구

도남용,이승학,김완수,김경일,이동용,김용기,최봉남 조선의대 1996 The Medical Journal of Chosun University Vol.21 No.2

光中斷 處里가 促成 딸기의 生育 및 體內 成分含量에 미치는 影響

金龍贊,朴庸奉,金榮龍 濟州大學校 亞熱帶農業硏究所 1993 亞熱帶農業硏究 Vol.10 No.-

本 硏究는 最近 딸기의 需要가 계절에 관계없이 계속됨에 따라 光周性을 利用한 각각 다른 光中斷 處理를 施行함으로서 生育狀態 및 體內 成分含量을 比較하고 周年 栽培의 可能性을 타진함과 아울러 醫學的 으로 證明되어있으며 近來에 관심의 대상이 되고 있는 抗癌物質인 ellagic acid를 定量分析하여 딸기를 健康食品으로 認識 定着시킴은 물론 栽培農家의 收入增大에 기여함을 目的으로 遂行하였는데 그 結果를 要約하면 다음과 같다. 1. 葉柄長, 葉數 等의 生育 狀態에서 光中斷處理區가 對照區보다 良好하였으며 處理時間이 길어질수록 높아지는 傾向을 보였다. 2. 收?? 開始期는 光中斷 處理區가 對照區보다 빨랐고, 時間이 길수록 效果는 上昇하였다. 3. 株當 果數는 女峰의 3時間 光中斷區에서 가장 많았으며 두 品種 공히 2時間과 3時間 光中斷 處理間에는 차이가 없었고 平均果實 무게에도 有意性은 인정되지 않았다. 4. 糖度와 酸度를 比較하면 初冬에 比하여 女峰의 糖과 酸 含量이 높았으며 두 品種 공히 處理時間이 길수록 糖ㆍ酸含量이 增加하였으나 初冬은 處理間에 糖度의 차이가 없었다. 5. Soluble sugar 含量은 還元糖인 果糖과 葡萄糖이 많았으며 非還元糖인 蔗糖은 적었고 處理時間이 길어질수록 增加하였다. 6. Organic acid 含量은 品種, 處理間에 관계없이 citric acid含量이 비교적 많았으며 fumaric acid, tartaric acid順이었다. 7. Ascorbic acid 含量은 女峰의 3時間處理區에서 가장 많았으며 初冬인 경우는 對照區에서 가장 적은 數値를 보였다. 8. 抗癌物質 Ellagic acid含量은 과실에 比하여 잎이 約 4배가 많았으며 分離形이 結合形에 比하여 約 2배가 높았고 處理間에는 初冬인 경우는 差異가 있었으나 女峰에서는 유의성이 없었다. This study was conducted by various lihgt break treatments using physiological characteristics, photoperiodism, to know possibility of year round culture of strawberry, the status of growth and development, comparison of component in vivo because demand of strawberry fruit is getting increase all the year round. In addition, as acting quantitative analysis of ellagic acid which is getting a target of concern recently and verifying medically, it was to fix recognition "strawberry fruit as a healthy food" and to contribute increase of income in farm house. Results were summerized as follows: 1. In the growth status of petiole length, leaf number, light break plots were bigger than that of control and showed getting bigger as time goes by. 2. In the harvest time, light break plots were earlier than that of control and the more the time of light break was the earlier the effect was. 3. Fruit numbers a plant were the most in light break plot for three hours of cv. Yeobong. But, there were't significant between 2 and 3 hour light break plot. There was also same trend in mean fruit weight. 4. Sugar and acid contents of cv. Yebong were higher than those of cv. Chodong and in both of two cultivars the more the time of light break was the higher the sugar and acid contents were. But ˚Brix wasn't significant in cv. Chodong. 5. Fructose and glucose contents were high but sucrose was a little and as time goes by titratable sugar contents were more and more increase in both of two cultivars. 6. Citric acid contents was the highest and in order of fumaric acid, tartaric acid 7. Ascorbic acid contents was the highest in 3 hour light break plot of cv. Yeobong and was the least in control plot of cv. chodong. 8. Ellagic acid contents in leaf was 4 time as much as that of fruit and that of free form was 2 time as much as that of conjugation form. As increase the elapsed time, ellagic acid contents was more increase remarkably in cv. Chodong but weren't significant among treatments except control in cv. Yeobong.

龍潭댐 建設에 따른 水質豫測

金煥起,梁奉龍,李正元 全北大學校 附設 都市및環境硏究所 1990 都市 및 環境硏究 Vol.5 No.-

This paper was the study on the change of the water quality an water quality management of reservior when Yong-dam dam constructed. The results obtained are as follows, water quality of river in surroundings area was BOD 1-2 ㎎/ℓ, TKN 1 ㎎/ℓ, T-P 0.03-0.013 ㎎/ℓ. Results from calculatin of the pollution loading of conteminations according to environmental factor, water quality was calculated to BOD 0.87 ㎎/ℓ, T-N 0.07 ㎎/ℓ. Because of increased of inlet nutrient, nutrient conditions in Yong-dam reservior will generated to eutrophication. Therefore, methods for control and management nutrition conditions are must be intercept and control to inflow of nutrient that included to water and wastewater.

흰쥐중심편도체핵에서 Neurotensin 면역양성세포의 다리옆핵으로의 투사

박인식,최정화,박봉수,백선용,김봉선,김재봉,김진정 대한해부학회 1996 Anatomy & Cell Biology Vol.29 No.2

만성중이염의 골도청력변화

박선홍,노용훈,이도용,나한조,김용기,최봉남,도남용 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1

We have usually experienced bone conduction impairment in chronic otitis media, but it is unclear that raised bone conduction threshold is due to the reflection of cochlear dam- age and / or Carhart effect ( an artificial elevation of bone conduction threshold due to conductive defect ) or both. The purpose of this study is to verify the influence of the artificial elevation of the bone conduction threshold in chronic otitis media and to estimate Carhart effect. A total of 336 cases of tympanoplasty with unilateral chronic otitis media without any other causes of sensorineural hearing loss was studied. The average threshold levels of the bone conduction in diseased ears ranged from 18.5dB at 4kHz to 12.1dB at 250Hz The longer duration of the disease, the larger perforation size, the more severe damage of the middle ear structure and the presence of the cholesteatoma made bone conduction threshold increased. The postoperative thresholds of bone conduction were Improved in 36 cases (40.4%) of the 89 cases that underwent operation with type I tympanoplasty technique without electrie drilling. The degree of the maximal improvement was 14.3dB at 2000Hz and the minimum was 8.8dB at 250Hz. but these result did differ from a statistically significant degree. The result suggest that the bone conduction threshold in chronic otitis media is elevated artificially by conductive defect and improved by successful reconstructive surgery.

진균성 부비동염의 임상적 양상과 내시경수술의 치료 결과

이봉재,김혁,김재호,김용재 대한이비인후과학회 1998 대한이비인후과학회지 두경부외과학 Vol.41 No.3

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.

프레탈정 (실로스타졸 100mg)에 대한 실로스탄정 (한국유나이티드 제약)의 생물학적 동등성

용철순,이경희,최진석,박병주,정세현,김용일,박상만,유봉규,이종달,최한곤 한국병원약사회 2003 병원약사회지 Vol.20 No.2

Bioequivalence of one cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and Cilostan^(R)(Korea united Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Sixteen normal male volunteers(age 20~30 years old)were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 100㎎ of cilostazol were orally administered, blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameter. The results showed that the differences in C_(max), T_(max) and AUC_(t) between one tablet were 16.08%, 18.88% and 17.57%, respectively. The powers (1-β) for C_(max), T_(max) and AUC_(t) were 85.03%, 83.92% and 80.12%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilostan^(R) tablet is bioequivalent to Pletaal^(R) tablet.

유소년영재의 창의적 성향·창의적사고력·다중지능·도덕성에 관한 탐색

류봉선,이경은,홍성용 韓國英才學會 2011 영재교육연구 Vol.21 No.4

Gifted children cultivate their many talents through experience. For the purpose of revealing the talents or abilities of gifted children, it is necessary to provide them with various types of environment for their exploration from the early stage of their school age. In addition, knowing their concern, aptitude and interest from the early stage of their school age will be much helpful for them to grow, advance and search for their future career path. Accordingly, the purpose of this study is to examine the definitional and cognitive characteristics of gifted children through tests on the creative disposition, creative thinking power, multiple intelligences and morality of gifted children at the early stage of their school age in order to provide basic information on the gifted children studies. Accordingly, 90 gifted children were selected as the participants of this study through observation and recommendation. The result showed much difference between the second grade and the third grade in their creative disposition, creative thinking power, multiple intelligences and morality according to school year. As for the difference according to gender, the second grade female students showed meaningful differences in the sub-domain of creative disposition, multiple intelligences and morality and the third grade showed no differences. Such study result shows that students in upper school year clearly have their own sense of purpose. 영재들은 경험을 통해 많은 재능을 발달시켜나간다. 영재들의 재능 혹은 능력을 최대한 발현시키기 위해서 학령기 초기부터 다양한 환경을 제공하고 탐색할 수 있도록 해야 한다. 또한 영재들이 가진 그들의 관심과 적성 및 흥미를 학령기 초기부터 알 수 있다면 성장하고 발달하며 진로를 탐색하는데 많은 도움이 될 것이다. 따라서 본 연구에서는 학령기 초기에 해당하는 유소년 영재의 창의적 성향·창의적사고력·다중지능·도덕성의 검사를 통해 유소년 영재의 정의적·인지적 특성을 탐색하여 유소년 영재연구의 기초자료로 제공하고자 하는데 목적이 있다. 이를 위해 관찰추천을 통해 선발된 유소년 영재 90명을 대상으로 하였다. 그 결과 창의적 성향·창의적사고력·다중지능·도덕성의 학년에 따른 결과는 2학년과 3학년의 차이가많음을 알 수 있었다. 성별에 따른 차이는 창의적 성향·다중지능·도덕성의 하위영역에서 여학생이 2학년에서 높았으며 3학년은 차이가 없는 결과를 보였다. 이러한 연구결과는 유소년 영재들은 남녀 구분 보다 발달적 이해와 영재의 특성을 고려한 질 높은 적절한 학습 환경의 초기노출이 유능한 인재로의 성장에 도움을 주며, 학년이 높을수록 앞으로 자기 목표의식을 분명히 가지고 있음을 보여주는 결과이다.