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      • 牧丹皮가 Collagen 誘發 關節炎에 미치는 影響

        金東赫,宋峰根,金炯均 한국전통의학연구소 1997 한국전통의학지 Vol.7 No.2

        류마티스관절염은 활막관절 부위의 만성 염증을 특징으로하며 병이 진행될에 따라 이환된 관절의 연골 및 골과 관절주위 연체조직의 파괴를 초래하는 전신성 자가면역질환이다. 전세계에 걸쳐서 주로 젊은층에서 발병하며 전 인구의 약 2-4%가 이환되는 것으로 알려진 류마티스관절염의 병인에 대하여는 아직도 완전히 규명되지 못하고 있으며,이 질병을 완치 시키거나 질병의 질행을 막을 수 있은 치료법이 정리되지 않은 실정이다. 牧丹皮는 淸熱凉血 活血祛瘀의 효능이 있어 임상적으로 발열,도한,월경불순등 이나 급성충수염 또는 跌打瘀血 등에 응용되어 왔으며 최근에는 진정,최면,진통작용과 항염 및 항알레르기 작용 등이 보고되고 있고 adjuvant 관절염에서 염증반응을 억제하는 것으로 보고되고 있다. 목단피가 콜라겐유발관절염(CIA)에 미치는 영향을 알아보기 위하여 bovine type II collagen을 랫트의 꼬리에 주사하고 목단피를 투여하여 CIA의 유발과정중의 면역학적 변화에 미치는 영향에 대하여 관찰하였다. 그 결과 목단피는 생체내와 생체외에서 담식세포에 의한 탐식능을 증가시켰으며 활막세포에 의한 반응산소중간물질 생성능을 감소시켰다. 또한 목단피는 림프구의 증식을 억제하였고,CD4+세포의 비율을 증가시키고 CD8+세포의 비율을 감소시켰다. 아울러 목단피는 요증 미tric oxide(NO)의 분비를 억제시켰고, 활막세포에서의 NO생성을 약간 증가시키는 효과를 보였으나 고농도의 목단피를 투여할 경우 다시 감소하는 결과를 보였다. 이상의 결과로 볼 때 collagen에 의한 관절염의 진행시 목단피의 투여는 면역반응을 조절하여 ROI와 NO의 생성을 억제하고 탐식능을 증가시켜 외부 항원에 대한 탐식을 효과적으로 하여 관절염의 진행을 완화시킨 것으로 생각되며,따라서 목단피는 류마티스관절염의 치료에 임상적으로 활용할 수 있을 것으로 사료된다. Rheumatoid arthritis(RA) is an autoimmune disorder characterized by a chronic inflammatory, proliferative polyarthritis with joint destruction. The disease occurs throughout the world. Most cases are common in young adult age, and 2-4% of the population are affected with female predominance. However the curative therapy of RA is not yet available, so the development of successful management is required. Moutan Cortex is an herb drug applied for such disease as fever, sweating, menstrual irregularity, acute appendicitis and trauma. Recently it is reported that Moutan Cortex has the antiinflammatory, antimicrobial and antihypertensive actions. It also has analgesic, sedative, and anticonvulsant effects. And it is reported to inhibil swelling of rat's paw and reduce arthritic joint swelling. So as to investigate the effects of Moutan Cortex on collagen-induced arthritis, its water extract was administered in the rat immunized by collagen and the immune responses were measured. The phagocytosis was increased in vivo and in vitro after administration of Moutan Cortex, which was strikingly increased after secondary immunization in vivo. Moutan Cortex decreased lhe reactive oxygen intermediate(ROI) formation and nitric oxide(NO) secretion in urine. While formation of reactive nitrogen intermediate was slightly increased after administration, it showed tendency of decrement in high dose. Moutan Cortex also inhibit lymphocytes proliferation. The ratio of CD4+ T cell was decreased and CD8+ T cell was increased. These results suggest that Moutan Cortex might inhibit arthritic changes by regulating immune response, inhibiting ROI and NO formation and increasing phagocytosis. So Moutan Cortex could be applied for the treatment of RA.

      • 우리나라 行政區劃線의 不合理要因과 그 改善方向에 관한 硏究

        金裕赫,琴東信,梁在乾,李鳳三 단국대학교 법정대학 지역개발학과 1980 地域開發論叢 Vol.2 No.-

        1. This thesis aims at analyzing the characteristics of the demarcation line of the administration areas in Korea by reviewing the history and background of how it was drawn and at the same time at exploring ways of correcting factors contributing to problems and ineffectiveness of administration. In order to collect data of opinions on this matter from officials actually assigned to the counties and their sub-level administration areas where administration is bifurcated in two separated blocks of areas, irrespective of the administrative efficiency and convenience of the populace in the areas, we selected eight kuns of this nature and sent questionaires to 488 chiefs and leading officials of kuns, myuns and villages. A total of 237 persons, 48.6% out of 488 responded. This data proved to be very expedient and instrumental in carrying out this study. 2. One of the characteristics of the demarcation line of administration areas is that it is drawn on the basis of natural conditions such as the extention of mountains, meandering lines of rivers, the formation of the community, traditional reasons, and so forth rather than on the theoretical as well practical backgrounds imbued with administrative philosophy, which seeks for rational and balanced development of a whole community with two factors in mind: the principle of spatial division as an administrative skill and the principle of spatial harmony for balanced division of administration zones. However, it is true that a large number of local inhabitants have felt inconveniences due to the boundary lines being zigzag or meandering. When we surveyed on the frequency of going to market as an indicator of economic activities of the people living along the boundary lines, it is found that almost 77.6% of the people questioned answered that they were going to markets located in the neighboring kun rather than those in their own administration zones. The factors that lead to choosing markets are usually two: one is spatial distance and the other is the peoples norm of life. Although the nature of the responses may vary according to where people live within the divided block of the administration area, a total of 86.6% of the questioned expressed their hope that the boundary lines would be straightened. This reflects their wishes of improving the efficiency of local administration and convenience of living for effectiveness of the administration cantrol. For example, state boundary lines of the U.S and Australia belong to the theoretical type is whereas sung boundary lines of China and kun(county) demarcation lines of Korea belong to the natural condition (or setting) type. Especially, some of administration demarcation lines of Korea have been zigzay so that one kun is divided into two or more separate blocks of areas as the result of city administration areas within the kun becoming enlarged. There are eight cases of this nature in Korea. 3. Our survey which was conducted to discover in part the extent of awareness of such bifurcation or division by the inhabitants living in the divided zones, showed that only 83.4% of those who responded said that they had knows the fact and the remaining 15.5% were quite unaware of the fact until they came to realize it upon reading our questionaire. This extent of unawareness means that local ranking administration leaders did not pay much attention to the effect of the local administration with respect to the boundary lines. 4. Speaking from the above finding, we are to propose that irrational factors related to the present administration demareation lines be corrected and improved for the following reasons: 1) To enhence the efficiency of administration, 2) To reestablish the system of utilization of resources 3) And finally to enlarge the integrated potentials of various social dynamics. We hope that efforts will be made to straighten administration demarcation lines as far as possible, taking into consideration the opinions and wishes of the people living in the affected areas and zones so that directions of development and improvement on this matter may be effectively explored. At the same time we propose the establishment of long range policies with a view of eliminating disparity in the development between the regions, by implementing necessary measures for development of local cities.

      • 충주 지역에서 10년간 급성심근경색의 임상관찰에 대한 연구

        박봉안,류하근,이종혁,김인숙,류주성,유재등,이용구,문언수,김형수 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

        Background: The current treatments of acute myocardial infarct(AMI) Include noninvasive method using thrombolytics and invasive methods such as primary percutaneous transluminal coronary angioplasty(PTCA) and coronary artery bypass graft(CABG)surgery. Although there are many studies comparing the effectiveness of noninvasive and invasive methods, when large clinical centers, 20% of totar hospitals, were excluded, most middle-sized hospitals lacked personnels and facilities for the invasive methods. Thus they opted for the noninvasive methods. Therefore, in this study, the clinical characteristics of AMI patients and the results of thrombolytic & conservative treatment were observed. Method: 137 patients with acute myocardial infarct, who visited KonKuk University Medical Center, ChoongJu Hospital during Sept. 1990 to Sept. 1999 were analysed retrospectively using medical records. Result: The sexual compositions of patients were 63.5% male, and 36.5% female. The mean age for male patients were 56±12.9, and for female patients 68.7±9.6 (p<0.05). The mean age for female patients was significantly older than male patients. The patients in the thrombolytic treatment group had mortality rate of 6.25% which is lower than that of the conservative treatment group at 12% (p>0.05). Conclusion: Although in our study, small number of acute myocardial infarct patients caused the statistical insignificance, rapid revascularization by thrombolytic therapy within 6 hours of onset of symptoms improved mortality rate and early ambulation. And we had good results on AMI with thrombolytic agent in ChungJu including near rural area as primary emergency hospital. Therefore a prospective research with greater number of subjects is needed to develop better treatments for AMI.

      • KCI등재

        쇼핑호스트에 대한 의사인간관계가 홈쇼핑 TV에 대한 태도 및 구매의도에 미치는 영향 : 지각된 위험과 지각된 혜택의 매개효과를 중심으로

        주지혁,최명일,김봉철 한국방송광고공사 2008 광고연구 Vol.0 No.80

        Home-shopping in cable TV is considered as one of the important channels by innovative changes for the shopping. In this process, shopping hosts take a great portion, but they are not weighted in other studies. This study explores various emotions for the shopping hosts in the field of parasocial interaction and examines how those emotions affect to purchase intention. Also, the study can see over how perceived risk, perceived benefit, and attitude for the CATV home-shopping have an impact on the purchase intention. In the result, as parasocial interaction with shopping-hosts would grow, perceived risk for home-shopping is reduced, meanwhile perceived benefit is grown. Perceived risk can mediate purchase intention, and perceived benefit also can moderate attitude for homeshopping and purchase intention. It could mean that consumers can have positive image for CATV home-shopping under the conditions that parasocial interaction with shopping-hosts would be grown. The result can show that CATV home-shopping should attempt to establish parasocial interaction in order to take upper hands against open markets and internet shopping malls.

      • 사각튜브의 동적 압괴 특성 연구

        安大植,朴鳳賢,李鎭赫,韓庚基 弘益大學校 科學技術硏究所 1995 科學技術硏究論文集 Vol.6 No.-

        Sixty six dynamic tests on thin-walled square aluminum tubes having cross-sections with t/b=0.333 and various speeds were crushed axially on a rail type equipment. Approximate theoretical predictions were modified for the axial progressive crushing of square box columns using N. Johns`s kinematically admissible method of analysis. This theoretical study predicts two deformation modes. New diagonal symmetric deformation mode were predicted theoretically and confirmed in the experimental tests. These diagonal symmetric mode cause an inclination of a column. The effective crushing distance is considered in the approximate theoretical analysis together with the influence of material strain rate sensitivity, which is important for steel but which is not important for aluminum. The simple equations presented herein for the design of axially crushed square box columns give reasonable agreement with the corresponding experimental results.

      • KCI등재

        자동차용 컨트롤 링크 업셋 용접부의 용접성 및 피로강도 향상에 관한 유한요소 해석

        조해용,권혁홍,이봉규 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.6

        This study is concerned with Finite Element Analysis on welded part of control link for automobile. For analysis, control link was modeled into two parts, ring and rod. Heating condition, temperature distributions and fatigue fracture strength were analyzed using "HEAT Ⅲ" and "ENDURE" module of NISA Ⅱ. Metal flow in the process of welding was simulated by DEFORM^TM 2D. The analyzed results were compared with experimental inspection. Quality of welded part was able to be improved by controlling metal flow in the process of welding by increase the friction constant of ring part. Heat transfer analysis and flow simulations were in good agreement with welding experiments.

      • KCI등재

        저열팽창성 Fe-29Ni-17Co 코바 합금의 고온균열 발생과 고온연성에 미치는 S 및 Mn의 영향

        이기안,박종혁,조봉현,남궁정,김문철 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.12

        The effect of S & Mn on the hot ductility of Fe-29Ni-17Co Kovar alloy and the mechanism of high temperature cracking occurrence were investigated. It has been found that the brittle intergranular fracture at high temperature cracking is closely associated with the sulfide along grain boundary. Experimental results showed, especially when the S content was high and the Mn content was free, that small cavities could be nucleated easily on FeS particles along grain boundary and propagated fast at high temperature. The hot ductility of Kovar alloy was drastically increased with the addition of Mn and it was also increased with decreasing S content. SEM and FE-SEM analyses showed that the Mn addition in this alloy could cause ductile intergranular fracture appearance below 1150℃ by the precipitation of MnS. It was proposed from the results that the addition of Mn and optimum S content (below 30 ppm) in Kovar alloy was necessary in order to reduce the hot cracking susceptibility.

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