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人事管理制度 改善에 관한 硏究 : 性格檢査制度의 導入 및 適用을 中心으로 on the Base of Personality Testing System
金奉珪 단국대학교 대학원 1980 學術論叢 Vol.4 No.-
To achieve effectively goal of organization, the effective personal management system is required. This problem that we face will require personality testing system (PTS). First, we must scientifically test military personels personality with their personal affairs in order to know their personal affairs. Second, because defects of one's personality results in accidents and inefficiency, these defects of their personality ought to be reflected personel system such as promotion, transfer, suspension from office, and disciplinary action, etc. Third, by means of teaching and training military personels who have defects of personality, they can understand themselves and their morale can be promoted. Forth, Personality Testing System (PTS) can be applyed recruitment for conscription. Fifth, PTS will be required in order to teach and train prisoners. Finally, the problem that we face will be solved by means of effective leadership and personel management on the base of PTS. Summary, we can effectively manage and lead military organization by means of PTS. Therefore, we me required military personel management system on the base of PTS.
김종배,박효상,최봉주,이용규,남동석,박관수 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.2
Benign cementoblastoma is uncommon odontogenic tumor of the jaw of mesenchymal origin. It is common in male below 25 years of age, commonly occurs in mandibular molar and premolar area. Principal symptom is painless swelling. Radiologically, radiopaque mass is fused with a root or roots of teeth, surrounded, and limited peripherally by a radiolucent halo. Histologically, the tumor is composed of sheets of an osteocementum like material with basophilic reversal line. Because of unlimited growth potential, the usual treatment is complete surgical excision with extraction of the associated teeth. The patient, 16-year old male, was admitted to our hospital with chief complaint of painless swelling on right mandible body area. Surgical excision of lesion and extraction of associated tooth was performed. On follow up check, we obtained good result without any signs of recurrence of the lesion.
김종배,박효상,김창환,이용규,최봉주,장학원 啓明大學校 醫科大學 1997 계명의대학술지 Vol.16 No.2
Cyclosporin is a relatively new immunosuppressive agent which has been used to prevent organ transplant rejection, to treat type-I diabetes mellitus and several other autoimmune disorders. It is anticipated that the therapeutic use of cyclosporin will increase progressively in the future to treat numerous other disorders. As its clinical use broadens, it will needed for health professionals to be familiar with the beneficial effects as well as some of the undesirable side effects of cyclosporin therapy. A side effect of this drug in dentistry appears to be pronounced gingival hyperplasia. Cyclosporin induced gingival hyperplasia is indistinguishable from gingival hyperplasia induced by phenytoin and nifedipine in clinical and histopathologic finding. We experienced two cases of gingival hyperplasia secondary to cyclosporin therapy in patients, 48-year old & 28-year old females who received a kidney allograft transplant. Clinical examinations revealed a severely overgrown and inflammed gingiva. Surgical excision of the excess tissue was accomplished under local anesthesia. On follow-up check, gingival hyperplasia in a 48-year old patient whose oral hygiene was very poor showed successive recurrence after three times surgical excision, another patient who could control oral hygiene thoroughly showed good healing. Conclusively, it seems to be very important to control oral hygiene thoroughly to decrease occurrence and recurrence of cyclosporin-induced gingival hyperplasia.
Bong-Wook Park,June-Ho Byun,Young-Sool Hah,Deok-Ryong Kim,In-Kyo Chung,Jong-Ryoul Kim,Uk-Kyu Kim,Bong-Soo Park,Gyoo-Cheon Kim 대한구강악안면외과학회 2007 대한구강악안면외과학회지 Vol.33 No.1
This study was to evaluate the expression of vascular endothelial growth factor receptors (VEGFRs) in tumor and stromal cells of tougue squamous cell carcinoma (SCC). We also wanted to characterize the differences, from the angiogenic aspect, between cancer-associated stromal cells and non-malignant stromal cells. Paraffin-embedded tumor specimens from eleven patients with tongue SCCs were studied. Immunohistochemical staining for VEGFR-1,-2, and -3 was performed on the tumor cells, stromal fibroblasts and tumor-associated macrophages of the specimens. The expression of all 3 receptors was detected in the tumor cells themselves of the biopsy specimens. All 3 receptors were also expressed on stromal cells, except that VEGFR-2 was not expressed in stromal fibroblasts. In radical excision specimens, the staining intensity for VEGFR-1, -2 in the tumor cells and VEGFR-1,-3 in the tumor-associated macrophages was significantly lower than that in the biopsy specimens (P < 0.05). By using the general marker of fibroblast and macrophage, 5B5 and CD68, respectively, we performed double immunofluorescence staining for 5B5 and each VEGFR in the stromal fibroblasts and for CD68 and each VEGFR in the tumor-associated macrophages of the radical excision specimens. We used 4 cases of fibroma and 4 cases of chronic inflammation tissue as the controls. It was found that only each marker was expressed in the control group, however, 5B5/VEGFR-1 and 5B5/VEGFR-3 in the stromal fibroblasts, and CD68/VEGFR-1 and CD68/VEGFR-3 in the tumor-associated macrophages were double stained in the radical excision specimens. Although our study used small number of specimens, the results of our study showed that in tongue SCC, in association with the angiogenesis, the stromal cells showed the activated phenotype and this was different from the nonmalignant stromal cells.
설암에서 신부가화학요법후 미세혈관밀도에 대한 종양관련 대식세포의 역할
박봉욱(Bong-Wook Park),정인교(In-Kyo Chung),김종렬(Jong-Ryoul Kim),김욱규(Uk-Kyu Kim),박봉수(Bong-Soo Park),김규천(Gyoo-Cheon Kim),변준호(June-Ho Byun) 대한구강악안면외과학회 2006 대한구강악안면외과학회지 Vol.32 No.3
Preoperative neoadjuvant chemotherapy using cisplatin and 5-FU is generally given in oral and maxillofacial cancer. At tissue level both inflammation and fibrosis occur after chemotherapy. The cellular changes mimic those of a granulating wound, with activated macrophages and fibroblasts replacing the malignant cells as they are erradicated. Stromal cells, together with extracellular matrix components, provide the microenvironment that is pivotal for tumor cell growth, invasion, and metastatic progression. Vascular endothelial growth factor(VEGF), an important regulator of angiogenesis in cancer, induces mitogenesis of vascular endothelial cells, and vascular permeabilization and microvessel formation in a tumor are associated with tumor nutrition and oxygenation. Also, they are associated with chemotherapeutic drug delivery. Oxygen delivery to tumor appears to rely on a network of microvessels, On the other hand, the tumor microvessel is clearly an important factor in chemotherapeutic drug delivery to cancer cells, and the efficacy of drug delivery can be high in richly vascularized tumors. So, this study was conducted to evaluate the effect of neoadjuvant chemotherapy on microvessel density from 11 patients with tongue cancers. Our results showed that neoadjuvant chemotherapy was seemed to decrease VEGF expression in tumor cells, however, it did not significantly alter VEGF expression in tumor-associated macrophages. Also, Neoadjuvant chemotherapy had little effect on the microvessel density using CD34, and tumor-associated macrophage level using CD68. Thus, tumorassociated macrophages seem to be the key factor associated with the maintenance of microvessel density after neoadjuvant chemotherapy in tongue cancer.