DIAZEPAM 과 β-CCM 의 장기투여가 조건행동동결에 미치는 효과

정봉교,장현갑,강성군 한국심리학회 한국심리학회지 생물 및 생리 Vol.5 No.1

본 연구의 목적은 benzodiazepine 수용기에 대해 효능제로 작용하는 diazepam(DZP)과 역전 효능제로 작용하는 β-CCM의 장기투여가 조건 공포반응의 지표인 행동동결에 미치는 효과를 검토하고자 하는 것이다. 실험 1에서 DZP의 훈련전 단기투여는 조건 행동동결을 감소시켰으나, 훈련전 장기투여는, 조건 행동동결을 감소시키지 못하였으므로, 내성효과를 나타내었다. 실험 2에서 β-CCM의 투여는 조건 행동동결을 증가시켰고, 단기투여와 장기투여의 효과차이는 없었다. 효능제와 역전 효능제의 효과가 반대라는 결과는 흰쥐의 종특유의 방어반응인 조건행동동결이 benzodiazepine 수용기를 중개로 하여 학습되는 반응임을 입증해 주는 것이다. 아울러 효능제의 경우에는 장기투여에 의해 내성효과를 일으킴을 시사해 준다. This study investigated the effects of chronic injection of benzodiazepine agonist, diazepam(2㎎/㎏) and inverse agonist, β-CCM(1㎎/㎏) on the conditioned freezing in Sparague-Dawley male rats, using 2-trial conditioned fear test. Each animal in chronic treatment groups was injected twice a day for 5 days. Each animal in acute treatment groups was injected only once before training. On the first training day, each rat was placed in the observation chamber, and 3 min later it recieved three shock (0.75s, 1㎃) at a 20-s intershock interval. During the second testing day, the animal's behavior was observed according to a time-sampling procedure in the same preshocked chamber. Results showed that the conditioned freezing was significantly reduced in animals treated with single injection of diazepam, administered before the 1st training trial, but not in those treated with repeated injections of diazepam(exp 1). In constrast, both single and repeated injections of β-CCM caused an increasing in the conditioned freezing response(exp 2). The finding that the acute treatment of diazepam given before training attenuate the conditioned freezing was consistent with our previous study. It was also founded that the repeated administrations of diazepam induced tolerance effect and the effects of agonist and inverse agonist ligands of benzodiazepine receptor on conditioned freezing were contrary to each other. It is suggested that benzodiazepine receptors are involved in the control of the rat's species-specific defensive response.

Instrumental Variable 법을 이용한 시스템 매개변수의 직접추정

이건명,신봉인,이한희 경상대학교 생산기술연구소 2001 工學硏究院論文集 Vol.1 No.-

The direct parameter estimation method can estimate system parameter matrices from measured time data of excitation force and acceleration. The acceleration data are integrated numerically to obtain the velocities and displacements, and the system parameters are estimated from these data by solving equations of motion. The parameter estimation method has some advantages over other estimation methods. But the method is very sensitive to measurement noise and cannot estimate accurate parameters from noise corrupted measurements. To solve this problem, the instrumental variable method is applied to direct parameter estimation. Simulation results show that the accuracy of the estimated parameters is much improved by the application of the instrumental variable method.

梁山法基里出土遺物

沈奉謹 東亞大學校 博物館 1985 考古歷史學志 Vol.1 No.-

活性슬러지工法에서 微生物濃度에 따른 基礎設計要素의 比較硏究

林鳳洙,李充根 大田大學校 1989 論文集 Vol.8 No.1

해당정보 없음

내시경역행성담췌관조영술 후 발생한 종격동기종, 피하공기증, 긴장성 기흉 1예

조용건,이현승,권균홍,김자영,김봉진,김지연,배용목,박선자 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.4

However, Endoscopic retrograde cholangiopancreatography (ERCP) is still helpful procedure for the diagonosis of the pancreatobiliary disease and treatment through endoscopic sphinterectomy (EST) is relatively safe, these have possiblity of complications such as hemorrhage, infection, panceatitis, and perforation. ERCP related perforation was rarely reported in 0.3 to 1.1% of previous study, but most serious complication. A report of Pneumomediastinum, Tension Pneumothorax complicating perforation after ERCP and EST is very uncommon. In our hospital, we experienced case of pneumomediastinum, subcutaneous emphysema, and tension pneumothorax after ERCP and EST, and the patient (a 58 years old female with suspicious common bile duct stone) was treated successfully with conservative treatment.

Al 용탕 중의 수소함량이 주물의 미세기공에 미치는 영향

최봉근,박순 울산대학교 2002 공학연구논문집 Vol.33 No.1

Al 주물의 기공발생 원인을 이론적으로 규명하고, Al 용탕 중의 수소함량을 직접 측정하여 탈가스의 효과와 주물품의 미세조직변화를 관찰하였다. 그 결과, 다이캐스팅용 합금으로 많이 사용되는 Al-7.5%Si-0.4%Mg 합금에서 기공이 전혀 발생하지 않을 용탕 중의 최소수소농도는 0.1㎤/100g이며, 용탕 중의 수소는 장입물 속의 수분에 의해서라기 보다는 주로 용해 중의 분위기로부터 침투한다는 사실을 알았다. 또한 탈가스 효과는 초기 수소농도가 높을수록, 용탕의 온도가 낮을수록 더 좋다는 결론을 얻었다. We studied theoretically the formation of porosities in Al castings, and observered by experimentally the hydrogen contents in Al melts and the changes of microstructures in Al castings. As results, we know that the minimun hydrogen content which will not generate the porosity in Al-7.5%Si-0.4%Mg diecasting alloy is 0.1㎤/100g and, the hydrogen penetrates into the Al melts by the melting atmospheres rather than by the moistures in Al scrap. Also, we know the facts that the initial hydrogen contents are higher and the temperature of melts are lower, the effect of degassing is supenor.

心電圖 信號의 雜音 除去와 R-점 檢出을 爲한 웨이브렛 解析의 適用

李建基,張斗泰 慶尙大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.13 No.-

One of the main techniques for diagnosing heart disease is by examining the electrocardiogram(ECG). Many studies on detecting the QRS complex, P, and T waves have been performed because meaningful information is contained in these parameters. However, the earlier detecting techniques can not effectively extract those parameters from the ECG that is severely contaminated by noise source such as 60Hz power-line interference, muscle artifact and baseline drift. In this paper, we performed the extracting of parameters from the ECG signal and recovering using wavelet transform that recently been applying to various fields.

경복궁 복원에 관한 고찰

김봉건 서울시립대학교 부설 서울학연구소 2007 서울학연구 Vol.- No.29

Gyeongbok palace is a main palace of the Joseon period which contains abundant cultural essences of the late Joseon period. The Reconstruction of Gyeongbok palace is an important national project which requires more than 20years duration. About 40% of the buildings are expected to be layout compared to the late Joseon period. The aim of the project is to recover the national identity by utilizing education center for history. The main purpose of the project is to recover the basic layout of Joseon palace. Throughout the process some problems are revealed. The demolition of government building of the Japanese colonial period was to be in the center of dispute. The problem of limited reconstruction of the stream and corridor were also appeared. The reconstruction should be based on evidences. But propound research results are not accumulated before the beginning of the project. The exact analysis on the different evidences are required. Basic materials should be collected in systematic way. The selection of proper materials and skillful craftsman are another important issues. The utilizations must be considered from the planning stage.

銅 表面의 화학 腐蝕에 의한 蝕刻 패턴 연구

김민건,서봉원 강원대학교 산업기술연구소 2000 産業技術硏究 Vol.20 No.B

In order to observe the pattern forming of copper plate and chemical corrosion reaction, a study on the effect of the process parameters on the formation of micro-pattern by a photochemical etching of copper plate was carried out. The results are as follows : 1) Etching rate increases as the concentration of etchant increases under the regular condition of the temperature by the increasing of diffusion rate to surface. 2) Etching rate increases as the temperature of etchant increases by the fast acting of the material delivery of diffusion to surface under the regular condition of concentration. 3) It was found that etching speed increases as the material delivery of convection rising increased when the aeration speed of etchant increases. This result was from the fact acted by the material delivery of convection rising rather than material delivery of diffusion to the surface.

국내에서 분리된 Esherichia Coli 와 Klebsiella pneumoniae의 CTX-M형 Extended-Spectrum β-Lactamase 생성 현황

배일권,우건조,정석훈,박광옥,조병규,김둘만,권수봉,김현주,강현경 대한임상미샐물학회 2004 Annals of clinical microbiology Vol.7 No.1