근위부 후하소뇌동맥의 자연박리성 동맥류 1예

구본대,이종호,김상범,이계훈,허경,이병희 대한신경과학회 1999 대한신경과학회지 Vol.17 No.5

상악 4전치 후방 견인시 치근 주위 응력 분포에 대한 광탄성법적 분석 : High Pull J-hook Headgear의 효과 The Effects of the High Pull J-hook Headgear

구본준,성재현 慶北大學校 齒科大學 1990 慶北齒大論文集 Vol.8 No.1

The purpose of this study was to investigate the effects of the High Pull J-hook Headgear in retraction the maxillary 4 incisors. The maxillary part of a dry skull that had Angle's Class Ⅱ malocclusion and axes of the central incisors were 60 degrees to the occlusal plane was duplicated with epoxy resin. In this epoxy resin model, the maxillary 4 incisors were retracted by the 1㎜ activated vertical closing loop, High Pull J-hook Headgear with a directional force of 34 degrees to the occlusal plane and 600g in total force, and both of them. The obtained stress distributions around the roots were analysed by three dimensional photoelastic method. The results were as follows; 1. When the maxillary 4 incisors were retracted by the 1㎜ activated vertical closing loop, simple lingual tipping movement patterns were shown. 2. When the maxillary 4 incisors were retracted by the High Pull J-hook Headgear with a directional force of 34 degrees to the occlusal plane and 600g in total force, intrusive bodily movement patterns were shown. 3. When the maxillary 4 incisors were retracted by the 1㎜ activated vertical closing loop and the High Pull J-hook headgear with a directional force of 34 degrees to the occlusal plane and 600g in total force, simple lingual tipping movement patterns and intrusive bodily movement patterns were shown in the same time. J. Kyungpook. Nat. Univ. Sch. Dent. Vol.8, No.1, 91∼103, 1991.

주의력결핍 과잉행동장애 아동에 있어서 연속수행검사의 진단적 유용성

구본훈,박형배,이희정,송창진,김진성,이광헌 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

서 론: 본 연구는 주의력결핍 과잉행동장애(이하 ADHD) 아동과 정상대조군의 연속수행검사(이하CPT) 결과 양상을 비교하여 CPT의 진단적 유용성을 알아보고자 하였다. 그리고, ADHD 아동의 연령과 성별, 지능, 그리고, 장애의 유형 등과 같은 변수에 따른 CPT의 결과양상을 비교하여, CPT가 ADHD의 어떤 특성을 잘 반영해주는가를 알아보고자 하였다. 대상 및 방법: DSM-Ⅳ의 진단기준에 의하여 진단이 내려진 ADHD 실험군 68명과 정상대조군 30명을 선정하였으며, 두 군간의 연령과 성별을 통제하였다. 실험군과 정상대조군 모두 환아의 부모가 ADHD 평가척도(ADDES-HV)를 작성하였으며, 환아에게 직접 CPT를 실시하였고 지적 능력을 평가하기 위해 K-ABC를 시행하였다. 결 과: 실험군과 정상대조군에서의 CPT 결과 양상을 비교하였을 때, 실험군과 정상대조군 사이에 민감도가 유의한 차이를 나타내었고, 반응 기준도 유의한 차이를 나타내었다(p<0.05). ADHD 아동을 대상으로 연령과 지능의 변화에 따른 CPT의 결과 양상을 비교하였을 때, 연령과 지능이 증가함에 따라 CPT각각의 결과들도 대체로 수행력이 호전되는 경향을 나타내었다. 주의력결핍 과잉행동 장애의 유형을 과잉행동을 동반한 군과 과잉행동을 동반하지 않은 군으로 나누어 비교분석을 한 결과, CPT 각각의 결과에서 유의한 차이는 나타나지 않았다. CPT 결과 양상에 있어서 남녀간 차이점을 비교하였을 때, 오경보오류와 정반응시간의 표준편차, 표준편차의 다양성, 그리고, 민감도가 유의한 차이를 나타내었다(p<0.05). CPT 각각의 8가지 결과 변수들에 대해 판별분석을 실시한 결과, 각각의 결과 변수들에 있어서 진단에 대한 전체 판별력이 모두 50%이상을 나타내었다. 그 중, 정반응시간의 표준편차와 표준편차의 다양성, 그리고, 민감도는 진단에 대한 전체 판별력이 모두 60%이상을 나타내었다. 결론 및 고찰: 이러한 결과들은 CPT가 ADHD의 진단에 있어서 어느 정도의 유용성을 가지고 있다는 점을 보여준다 하겠다. 즉, ADHD에 있어서 CPT는 비교적 선별검사와 같은 목적으로는 유용할 것으로 생각되며, 이는 또한 CPT가 장애의 진단에 있어서 보조적인 검사도구임을 나타낸다 하겠다. Objectives: The purpose of this study was to examine to diagnostic availability of CPT in children with ADHD, and what factors are affected to CPT results in the diagnosis of ADHD. Method: CPT, ADHD scales(ADDES-HV), K-ABC were administered to 68 ADHD patients and 30 normal elementary school students as the control group. Also, ages and sex are controlled between two groups. Results: In the differences of the results of CPT between ADHD patients and normal subjects, attentiveness and risk taking are significantly different(p<0.05). In the differences of the results of CPT between ages in ADHD patients, usually as more aged children are better performances in CPT. Also, in the differences of the results of CPT between intelligence in ADHD patients, usually as higher intelligent children are better performances in CPT. There are no differences of the results of CPT between types of ADHD in ADHD patients. In the differences of the results of CPT between sex in ADHD patients, commission error, hit reaction time standard error, variability of standard error, and attentiveness are significantly different between male and female patients(p<0.05). The correlations between ADHD scales and the results of CPT show that inattention subscale is significantly related to hit, omission error, hit reaction time standard error, and variability of standard error. In the discriminant ability between ADHD patients and normal children by the results of CPT, accuracy rates are more than 50% in all results of CPT. Especially, the accuracy rate of hit reaction time standard error, and the accuracy rate of variability of standard error, and also, the accuracy rate attentiveness are more than 60%. Conclusion: In this point of view, this study suggest that CPT is relatively valuable method in the diagnosis of ADHD. For instances, CPT is more likely to screen the ADHD from normal children, or to use as assisted method of diagnosis of ADHD in clinical settings.

후복막강내 발생한 Castleman병 1례

남성진,이동욱,박찬규,정시욱,김추성,조성래,구본천,양사규,이일웅,박정자 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.2

Castleman' s disease is a rare, reactive lymphoid proliferation of unknown cause and pathogenesis. Depending on histololgic findings, it has been divided into two distinct histologic subtypes that include hyaline-vascular type(90%) and plasmacell type(10%). This disease occurs most commonly in mediastinal lymph nodes and cervical lymph nodes, inguinal lymph nodes respectively. But occurs rarely in retroperitoneum. We report a case of hyaline-vascular type asymptomatic Castleman' s disease of the retroperitoneum in a 47-year-old man.

三黃瀉心湯이 自發性高血壓 흰쥐의 血壓 및 血淸에 미치는 影響

李星斗,具本泓 慶熙大學校 1983 論文集 Vol.12 No.-

In order to study the effectiveness of Samhwangsasimtang on the Blood Pressure and Serum, the amount of total cholesterol, phospholipid and triglyceride in Serum and Blood Pressure of Spontaneously hypertensive rats were measured. The results were obtained as follows: 1. The Blood Pressure of S.H.R. were significantly lowered than the control group; in the case of sample B group, the effectiveness was recognized from three to four hours after administration, and of sample D group, proved effective around four hours. 2. The effects of administrative medicines on the amount of S-total cholesterol were significant in sample B·D groups, and in sample B group, recognized more effective than sample D group. 3. The effects of administrative medicines on the amount of S-phospholipid were decline to lower in sample B·D groups, but not effective. 4. The effects of administrative medicines on the amount S-triglyceride were recognized in

알코올 의존 환자의 Tryptophan Hydroxylase 유전자 다형성

홍주봉,이상익,신철진,김헌,지경환,정인원 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 알코올 의존 환자에서 세로토닌 합성 조절 효소인 tryptophan hydroxylase(TPH) 유전자 다형성 빈도를 정상 대조군과 비교함으로써 알코올 의존의 유전적 요인을 추적하고, 임상변인과 이 유전자 다형성과의 관련성을 알아보고자 하였다. 방 법 : DSM-IV진단기준에 부합되는 알코올 의존 환자 100명과 정상 대조군 100명을 대상으로 TPH유전자 다형성을 증합효소 연쇄반응과 제한효소 처리법을 이용하여 동정하였다. 여기서 분리된 대립 유전자와 유전자형에 따른 빈도의 차이를 서로 비교하였으며, 알코올 의존 환자군의 여러 임상 변인에 따른 차이를 비교하였다. 결 과 : 알코올 의존 환자군과 대조군 간에 TPH의 A216C 유전자형 및 대립유전자 빈도에서의 통계적으로 유의한 차이는 관찰되지 않았으나, 조기 발병한 환자의 경우는 유전자형의 빈도가 AA,AC,CC형이 0.57, 0.39, 0.04, 후기 발병한 환자의 경우 0.34, 0.45, -.21로, 조기 발병한 환자군에서 대조군과 비교하여 통계적으로 유의하게 A 대립 유전자의 빈도가 높은 것이 관찰되었다.(by chi-square test, p<0.05). 결 론 : 이는 조기 발병형 알코올 의존의 경우 TPH유전자 다형성과 관련이 있으며, 일부 알코올 의존 환자에서 유전적으로 세로토닌계의 이상이 있다는 사실을 시사한다. Objectives : This study was performed to explore the association of tryptophan hydroxylase (TPH) gene with diagnosis of alcohol dependence and/or clinical characteristics such as age of onset, family history, and severity of symptoms in Korean alcoholics. Methods : The genotype and allele frequencies of TPH in 100 male hospitalized patients who met DSM-IV criteria for alcohol dependence were investigated using polymerase chain reaction and restriction fragment length plymorphism and were compared with 100 age-matched healthy male control subjects. And the associations between gene polymorphisms and clinical characteristics in alcoholic patients were explored. Results : The distributions of TPH genotype and allele in alcohol dependent patients were not different from control subjects. However, the frequencies of TPH genotype in early-onset alcoholic patients, which were 0.57, 0.39, and 0.04(AA, AC and CC, respectively), were significantly different from those of late-onset alcoholics(0.34, 0.45, and 0.21, respectively). "A" allele was found more frequent in early-onset alcoholics. Conclusion : The result suggests that TPH gene polymorphism is associated with early-onset alcioholic patients possibly related with inherited abnormalities of serotonin system.

아데노이드 및 구개편도 절제술이 비저항과 비강 내 Geometry에 미치는 영향

나기상,박찬희,구본석,김영덕,김관호,박용호 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

수술 전 최소단면적이나 비강 부피는 아데노이드나 구개편도의 비대 정도와 상관관계를 보이지 않았으나 비저항은 아데노이드 비대 정도와 유의한 상관관계를 보였다. 구개편도 및 아데노이드 절제술 후 코막힘과 구호흡 증상의 유의한 호전을 보였다. 수술 후 비강의 최소단면적과 부피 등 nasal geometry는 통계적으로 유의한 변화가 없었으나 비저항은 수술 후 유의한 감소를 보였으며 수술 후 비저항의 감소 정도는 아데노이드 비대 정도와 유의한 상관 관계를 보였다 . 이상의 결과로 아데노이드와 구개편도의 비대를 보이는 소아에서 코막힘 증상을 일으키는 데는 아데노이드 비대가 주요 원인이 되며 주로 비강의 후방에 위치한 아데노이드의 mass effect에 의할 것으로 생각한다. The aim of this study was to determine whether adenoid or tonsillar hypertrophy and subsequent adenoidectomy and tonsillectomy affect pediatric nasal airway resistance and nasal geometry and to evaluate the relationships between the degree of hypertrophy and nasal airway resistance or nasal geometry. Thirty-two children, aged 3 to 15 years, selected for adenoidectomy and tonsillectomy due to chronic nasal obstruction and mouth breathing were enrolled. The size of adenoid was evaluated by cephalometric radiograph. The degree of tonsillar hypertrophy was graded clinically. Nasal airway resistance and nasal geometry was evaluated by active anterior rhinomanometry and acoustic rhinometry respectively. These measurements were repeated one month and three months post-operatively. The size of adenoid was found well correlated to preoperative nasal airway resistance. However, there were no correlations between the degree of tonsillar hypertrophy and preoperative nasal airway resistance or nasal geometry. Nasal geometry was not changed after operation. However, nasal airway resistance was reduced significantly at 3 months after operation and the size of adenoid was found well correlated to postoperative changes of nasal airway resistance.

RuO₂-Glass 복합계의 임피던스특성에 미치는 Glass 조성의 영향

박상보,구본급 大田工業大學 1991 한밭대학교 논문집 Vol.8 No.2

As funtion of the glass composition and reaction temperature, the complex impedance properties and the electrical conduction mechanisms were investigated in the RuO_2-glass composites. The amount of Ru impurity in glass matrix increased with decreasing the glass softening point and incresing the reaction temperature. For the RuO_2-high softening point (530˚C ) glass composite, the complex impedance shows a vertical line on the R`axis, which indicates that the ionic conduction. In the case of the RuO_2-medium softening point (445˚C) glass composites, the complex impedance spectra changed from a vertical line on the R axis to a semicircle arc corresponding to the hopping conduction with increasing the reaction temperature. However, in the RuO_2-low softening point glass composites, the complex imprdance spectra changed from a semicircle are to nearly one point on the R axis corresponding to metallic like conduction.

Trichoclerma sp가 生産하는 Cellulase에 關한 硏究

具本聖,金敎昌,南相烈 충북대학교 농업과학기술연구소 1987 農業科學硏究 Vol.5 No.1

This experiment was conducted to investigate the composition of the medium for the cellulase production by Trichoclerma sp. and the characteristics of the cellulase. The results obtained were as follows; 1.The optimum composition of the medium for cellulase production consists of 1% substrate, 0.5% KH2PO4, 0.3% (NH2)2CO, 0.3% NaNO3 0.05% MaSO4·7H2O, 0.01% Fe SO4·7H2O, respectively. 2.The optimum pH of cellulase was 5.0 and pH range of its stability was 4-6. 3.The optimum temperature of cellulase was 50℃ and heat stability was below 50℃. 4.In the concentration of substrate for enzyme, the activities of cellulase were respectively increased to the concentration of 1% substrate, but above the concentration of 3% stbstrate the activities of cellulase were slowly increased. 5.In general the activities of cellulase were proportionally increased by adding the amount of enzyme solution up to 1 ml, but those of cellulase were slowly increased up to 3ml. 6.The cellulase was inhibited by Hg.++

몰리브뎀(Ⅴ)의 아닐린, 톨루이딘 및 트리에틸아민 착물의 합성과 그 성질

오상오,구본권 慶北大學校 1982 論文集 Vol.33 No.-

[MoO(NCS)_5]^2-의 아닐린늄, 톨루이딘늄 및 트리에틸암모늄염을 합성하고 원소분석, 전기전도도, 흡수스펙트라, 자화율 측정으로부터 분자식과 그 성질을 조사하였다. 이들 염에서 아닐린, 톨루이딘 그리고 트리에틸아민은 배위자가 아닌 양이온으로 존재하며 착물의 음이온은 티오시아나토의 질소가 몰리브덴에 결합되어 있음을 알 수 있었다. 이들 착물은 상자성체이며 가시 및 자외선 영역에서 d-d 전이와 전하이동전이에 해당하는 3개의 흡수띠가 관찰되었다. Anilinium, toluidinium and triethylammonium salts containing [MoO(NCS)_5]^2- have been synthesized. The complexes have been characterized by elemental analysis, electrical conductivity, absorption spectra, and magnetic susceptibility measurement. In these salts, aniline, toluidine and triethylamine are not ligand but counter ion for [MoO(NCS)_5]^2-. The complex anions are mononuclear containing N-bonded NCS^- ligand. These salts are paramagnetism and three absorption peaks corresponding to d-d and charge transfer transition in the UV-visible region were observed.