천추 갈색종양(Brown tumor)으로 발현된 부갑상선 기능항진증 1예

홍우정,구본정,이재민,한상우,이효진,나소영,노흥규,김영건,송민호 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

부갑상선 기능항진증에 의한 골병변으로 갈색종양이 있다. 갈색종양은 주로 장골을 침범하고 척추골에서의 발생은 매우 드물다. 국내의 보고에서 갈색종양의 장골 침범은 있었으나, 척추골에서의 발생은 보고된바 없다 .저자들은 부갑상선 기능항진증으로 인하여 척추골의 천추에 발생된 갈색종양 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. The bony involvement in primary hyperparathyroidism present as browm tumor or osteitis fibrosa cystica and lead to pathologic fracture. Brown tumor commonly involve long bone such as femur, tibia, fibula, humerus, and radius. Brown tumor of axial skeleton is a rare entity. Previously reported case that involve axial skeleton still not present. We report a 47-year-old male patient that he has a hyperparathyroidism presenting as brown tumor involving sacrum.

牙山湖에서 大湖湖 沿岸의 淡水湖 連結에 의한 效率的인 水資源 利用方案

구본수,최한규,이성홍 江原大學校 産業技術硏究所 1998 産業技術硏究 Vol.18 No.-

The Asan Bay area Korea is situated in an unbalance or water supply and demand relating to the Ansung, Sapkyo, Dangjin and Youmwha rivers and their estuary reservoirs. The multi-reservoir operation was studied by the Hierarchical Operation Model for Multi-reservoir System(HOMMS) assuming that these four estuary reservoirs were linked to each other in order. The result of this study shows that storage capacity deficiency in 2011 was estimated as 8 MCM in the Sapkyo and 31 MCMin Dae Ho estuary reservoir, respectively. In case of linking four reservoirs, the water deficiency will not occurs in all the reservoirs even if additional agricultural water of 78 MCM/yr was supplied. Total additional water demand for agricultural, municipal and industrial uses was estimated as 321.9 MCM /yr while additional supply by linking the reservoirs was estimated as 160.4 MCM/yr, 50% of additional demand. The remaining 161.5 MCM/yr would be supplied transferring other watershed.

갑상선 세포에서 전사보조활성인자인 CBP와 CIITA의 인터페론-감마 활성 부위에 대한 조절 : CBP and CIITA on GAS(Interferon- γ Activated Site)-Mediated Transcription in Thyroid Cells

채수흥,홍우정,김군순,조영석,김도희,김현진,구본정,송민호,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Background : In the previous stuides, we identified that the interferon-r activated sequence (GAS) in the 5-flanking region of rat ICAM-1 gene is major element for interferon-r-inducible expression of the gene in rat thyroid cells, FRTL-5. We here, investigated the role of transcriptional coactivators, CBP(CREB binding protein) and CⅡTA (class Ⅱ transactivator) in the modulation of the activity of GAS which could interacts with signal transducers and activators of transcription-1 and 3 (STAT1 and STAT3). Methods : The expression of CBP RNA and protein were quantitated in FRTL-5 after stimulation with interferon-r (IFN-r), thyroid stimulating hormone (TSH), forskolin and methimazole. Direct association of CBP with STAT were analyzed by immunoprecipitation. The transcriptional roles of CBP and CⅡTA in the regulation of GAS were assessed by the cotransfection with their expression vectors with reporters; 5-deletion constructs of rat ICAM-1 promoter or 8xGAS-luc constructs, into FRTL-5 thyroid cells. Results : The level of CBP RNA and protein were not changed by the treatment with TSH, IFN-r, forskolin and methimazole in FRTL-5, FRT and BRL liver cells. The CBP could be directly associated with STAT1. Furthermore, the overexpression of CBP significantly increases the both promoter activities; rat ICAM-1 gene promoter which has GAS element and 8xGAS-luc cassette constructs. However, the cotransfection of CⅡTA decreased the constitutive and CBP-mediated transactivation of rat ICAM-1 promoter and 8xGAS-luc cassette constructs. Conclusion : We identified that the two tanscriptional coactivators; CBP and CⅡTA has differential roles in the regulation of transcriptional activity of GAS drived promoter. CBP increases the GAS activity through the direct binding with STAT1, but CⅡTA inhibited the CBP-mediated transactivation of GAS activity.

三黃瀉心湯이 自發性高血壓 흰쥐의 血壓 및 血淸에 미치는 影響

李星斗,具本泓 慶熙大學校 1983 論文集 Vol.12 No.-

In order to study the effectiveness of Samhwangsasimtang on the Blood Pressure and Serum, the amount of total cholesterol, phospholipid and triglyceride in Serum and Blood Pressure of Spontaneously hypertensive rats were measured. The results were obtained as follows: 1. The Blood Pressure of S.H.R. were significantly lowered than the control group; in the case of sample B group, the effectiveness was recognized from three to four hours after administration, and of sample D group, proved effective around four hours. 2. The effects of administrative medicines on the amount of S-total cholesterol were significant in sample B·D groups, and in sample B group, recognized more effective than sample D group. 3. The effects of administrative medicines on the amount of S-phospholipid were decline to lower in sample B·D groups, but not effective. 4. The effects of administrative medicines on the amount S-triglyceride were recognized in

高血壓性 腦卒中(中風)에 對한 東西醫學的 疫學硏究

鄭在赫,具本泓,張仁圭,崔栖영,柳東俊 中央醫學社 1983 中央醫學 Vol.45 No.3

Epidemiological studies were done on the 162 hypertensive cerebrovascular accid-ents cases admitted in the affiliated Oriental Medicine School Hospital Kyung Hee University in 1983 and the following results were obtained. 1. The male to female ratio of the patients was 1. 3 : 1 and the age distribution frequency was as follows; fifties, forties, seventies and thirties(Table 2). 2. In the C.T.A., there were 119 cases of cerebral thrombosis(73.5%) and 45 cases of intracerebral hemorrhage (26.5%). The ratio was 2.8 : 1. In the former the male to female ratio was 1.3 : 1, in the latter it was 1.2 : 1(Table 3). 3. There were considerable numbers of recurrent cases as shown in Table 4. The first attack was noted in 125 cases(77.2%), the 2nd attack 30 cases(18.5%), the 3rd attack 6 cases(3.1%), 4th attack 1 case(0.6%). The male to female ratio was as follows. In the first attack it was 1. 3 : 1, in the 2nd attack 1.1 : 1, the 3rd attack 5.0: 1, the 4th attack was noted only in one male case. 4. The occupational frequency order was as follows(Table 5). Unemployed initi-ated with 45 cases(27.8%), home care 21 cases, Unspecified 19 cases, office worker, business men, farmers and public official etc. 5. The regional distribution was as follows(Table 6). Seoul city led with 102 cases (63. 0%) then it was followed by Kyung-Gi, Chung-Cheong, Kyung-Sang, Kang-Won and Jon-Ra province. 6. The systolic pressures at admission were disclosed as follows(Table 7). There were 42 cases(male 20 cases-12.3%, female 22 cases-13.6%) of systolic hypertens-ive over the WHO standard of 160mmHg, the mean value of systolic pressure was 145mmHg. The diastolic pressures at admission were shown as follows(Table 8). There were 92 cases(56.8 %) (male 48 cases-29.6%' female 44 cases-27.2%) of diastolic hypertension over the WHO standard of 95mmHg, the mean value of diastolic pressure was 98mmHg. 7. The patient's favors to salty food, animal fatty food, cigarettes and alcoholic beverage were examined (Table 9). Salty' foods were favored by 78 cases(48.2%), animal fatty foods by 78 cases(48.2%), cigarettes by 64 cases(39.5%) and alcohol imbibers were noted in 77 cases(47.5%) as shown in table 9. 8. The family history of C. V.A and hypertension was studied (Table 10). In C. V.A there were 28 cases (17.3%) with parental history, 12 cases (7.4%) with siblings history and 7 cases (4.3%) with other relatives, and in hypertension there appeared 14 cases(8.6%) with parental history, 9 cases(5.6%) with sibling history and 6 cases(3.7%) with other relatives. 9. In the past history, hypertension led with 124 case s(76.5°%), then C.V.A 37 cases(22.9%) and diabetes mellitus 33 cases(20.4%)(Table 11). 10) In treatment the frequently used herbal recipes were Gamichungshimtang(), BoSimgunbitang( ), Kyuntongdudamtang( ) in 15% of the cerebral hemorrhage cases, respectively; Camichungshimtang( ) in 20% Yangkyeuksan(), Chowishungchumtang(), Yukmichihwangt-ang() in 6%, respectively, in cerebral thrombosis. The most frequently used acupuncture points in C. V. A were shown in Table 12. Taechung(), Habgok ( ), Joksamri(), Oekwan(), Chungjue( ), Jokimueb.(), Kokji(), Taebak() were frequency order used in C.V.A of both cerebral thrombosis and hemorrhage. 11. In admitted C.V.A patient care, it was stressed that the Oriental Medical Hospital plays important roles and, accordingly, the propriety of East-West medical cooperation was addressed. 12. Through classified disease distribution of admitted patients in the Oriental Medicine Hospital the epidemiological epitome of cerebrovascular accidents and other diseases was presented. * East-West medicine denotes a methodology of approaching a creative medicine through cooperation between East-West medicines.

高血壓性 腦卒中(中風)에 對한 東西醫學的 疫學硏究

鄭在赫,具本泓,張仁圭,崔栖瀅,柳洞俊 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 1983 東西醫學硏究所 論文集 Vol.2 No.1

Epidemiological studies were done on the 162 hypertensive cerebrovascular accidents cases admitted in the affiliated Oriental Medicine School Hospital Kyung Hee University in 1983 and the following results were obtained. 1. The male to female ratio of the patients was 1.3:1 and the age distribution frequency was as follows; fifties, forties, seventies and thirties(Table 2.) 2. In the C.V.A., there were 119 cases of cerebral thrombosis(73.5%) and 45 cases of intracerebral hemorrhage(26.5%). The ratio was 2.8:1. In the former the male to female ratio was 1.3:1, in the latter it was 1.2:1(Table 3). 3. There were considerable numbers of recurrent cases as shown in Table 4. The first attack was noted in 125 cases(77.2%), the 2nd attack 30 cases(18.5%), the 3rd attack 6 cases(3.1%) , 4th attack 1 case(0.6%). The male to female ratio was as follows. In the first attack it was 1.3:1, in the 2nd attack 1.1:1, the 3rd attack 5.0:1, the 4th attack was noted only in one male case. 4. The occupational frequency order was as follows(Table 5). Unemployed initiated with 45 cases(27.8%), home care 21 cases, Unspecified 19 cases, office worker, business men, farmers and public official etc. 5. The regional distribution was as follows(Table 6). Seoul city led with 102 cases (63.0%) then it was followed by Kyung-Gi, Chung-Cheong, Kyung-Sang, Kang-Won and Jon-Ra province. 6. The systolic pressures at admission were disclosed as follows(Table 7). There were 42 cases(male 20 cases-12.3%, female 22 cases-13.6%) of systolic hypertensive over the WHO standard of 160mmHg, the mean value of systolic pressure was 145mmHg. The diastolic pressures at admission were shown as follows(Table 8). There were 92 cases(56.8%)(male 48 cases-29.6%, female 44 cases-27.2%) of diastolic hypertension over the WHO standard of 95mmHg, the mean value of diastolic pressure was 98mmHg. 7. The patient's favors to salty food, animal fatty food, cigarettes and alcoholic beverage were examined(Table 9). Salty foods were favored by 78 cases(48.2%), animal fatty foods by 78 cases(48.2%), cigarettes by 64 cases(39.5%) and alcohol imbibers were noted in 77 cases(47.5) as shown in table 9. 8. The family history of C.V.A and hypertension was studied (Table 10). In C.V.A there were 28 cases(17.3%) with parental history, 12 cases(7.4%) with siblings history and 7 cases(4.3%) with other relatives, and in hypertension there appeared 14 cases(8.6%) with parental history, 9 cases(5.6%) with sibling history and 6 cases(3.7%) with other relatives. 9. In the past history, hypertension led with 124 cases(76.5%), then C.V.A 37 cases(22.9%) and diabetes mellitus 33 cases(20.4%)(Table 11). 10. In treatment the frequently used herbal recipes were Gamichungshimtang(加味淸心湯), Bosimgunbitang(補心健脾湯), Kyuntongdodamtang(腱痛導痰湯) in 15% of the cerebral hemorrhage cases, respectively, Gamichungshimtang(加味淸心湯) in 20%, Yangkyeuksan(凉膈散), Chowisungchongtang(調胃升淸湯), Yukmichihwangtang(六味地黃湯) in 6%, respectively, in cerebral thrombosis. The most frequently used acupuncture points in C.V.A were shown in Table 12. Taechung(太衡) , Habgok(合谷), Joksamri(足三里), Oekwan(外關), Chungjue(中渚), Jokimeub(足姙泣), Kokji(曲池), Taebak(太白) were frequency order used in C.V.A of both cerebral thrombosis and hemorrhage. 11. In admitted C.V.A patient care, it was stressed that the Oriental Medical Hospital plays important roles and, accordingly, the propriety of East-West medical cooperation was addressed. 12. Through classified disease distribution of admitted patients in the Oriental Medicine Hospital the epidemiological epitome of cerebrovascular accidents and other diseases was presented.

HMG-CoA 환원효소 억제제에 의한 ICAM-1 유전자의 발현조절

김현진,정효균,홍우정,김군순,조영석,김도희,채수흥,구본정,송민호,노흥규,김영건 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Background : ICAM-1 act as one of major adhesion molecules in the atherosclerotic lesion. ICAM-1 expression is mainly regulated at the level of transcription and depend on IFN-γ signal transduction pathway in which the STAT1 transcrption factor is a critical intermediate. IFN-γreceptor not only initiates tyrosine 701 phosphorylation of STAT1 by Jak1 and Jak2, but also phosphorylates serine 727 through the activation of Raf-1/MAP kinases. HMG-CoA reductase inhibitors have anti-atherosclertic effects, beyond normalization of hypercholesterolemia, by directly acting on endothelial cells, macrophages and vascular smooth muscle cells. HMG-CoA reductase inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibition posttranslational farnesylation and geranyl-geranylation processing of small GTP-binding preoteins and inhibition of normal signaling activities. Method : We made several 5'-deletion constructs of rat ICAM-1 promoter and analyzed the promoter activities by measuring the luciferase activity after transfection into ECV304 cells and smooth muscle cells. We checked the level of total and phosphorylated STAT1 protein by immunoblot analysis using specific antibodies. Results : Lovastatin inhibits IFN-γ-induced ICAM-1 gene expression in the ECV304cell. The cells pretreated with PD98059, MEKK inhibitor showed significantly low ICAM-1 RNA induction with IFN-γ stimulatio. IFN-γ induced phosphorylation of tyrosine 701 was not significantly changed by the pretreatment of lovastatin. But lovastatin suppresses IFN-γ-induced phosphorylation of ERK1/ERK2 which are responsible for the seine 727 phosphorylation in STAT1. Conclusion : We showed that HMG-CoA reductase inhibitors, lovastatin, suppresses IFN-γ mediated ICAM-1 gene expression through the inhibition of transcription. HMG-CoA reductase inhibitor suppresses IFN-γ-induced phosphorylation of serine 727 in STAT1 through the modulation of MAP kinases.

부신 결핵에 의한 Addison씨병 1예

송치운,구본정,안봉수,전준식,안미애,이진홍,송민호,김영건,노흥규 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

Addison's disease is a rare primary adrenal insufficient disorder resulting from chronic deficiency of adrenal cortical hormones. Clinical manefestations are generalized weakenss, weight loss, hyperpigmentation (especially sun exposed area and mucous membrane), hypotension, hyponatremia, hyperkalemia, gastrointestinal symptoms (involving anorexia, nausea, vomiting, abdominal pain). A 34-year-old woman has experienced slowly progressive generalized weakenss and skin pigmentation, anorexia, nausea, vomiting with ascites and diffuse abdominal pain. On the time of admission, her main clinical manifestations were anorexia, nausea, vomiting, fatigue, generalized weakness, amenorrhea, hair loss, diffuse abdominal pain revealed as Addison's disease due to bilateral adrenal tuberculosis. Her adrenal insufficient symptoms were recovered with the replacement of adrenocortical hormones and antituberculous medications. After treatment, Her skin pigmentation was decreased and menstruation was reappeared. Here we experienced one cases of Addison's disease with tuberculous peritonitis.

山査子의 效能에 關한 硏究

韓圭彦,具本泓 慶熙大學校 1985 論文集 Vol.14 No.-

In order to study on the effects of Crataegi Fructus(Crataegus pinnatifida Bunge var. major N.E. Br), I obtained the following conclusion as a result of the experiments used animals on the action in G - I tract and uterus. 1. Crataegi Fructus suppressed the spontanceous motility of isolated mice - lieum, and showed ileums of mice and guineapigs direct relaxation of intestinal smooth muscle. 2, Crataegi Fructus suppressed the spontaneous motility of rat-intestine, and inhibited the contractions induced by acetylcholine chloride and BaCl_2 in proportion to the concentration by the pretreatment of the sample. 3. Crataegi Fructus suppressed the contractile motility of isolated rat-uterus, and had anti-oxytocin and anti-prostaglanding actions. 4. Crataegi Fructus suppressed the motility of the small intestine in rabbits. 5. Crataegi Fructus accelerated the transport ratio in the small intestine of mice, and inhibited the stimulent peristalsis induced by FeSO_4 in the small intestine of mice. 6. Crataegi Fructus had the anticathartic action of mice induced by castor oil. 7. Crataegi Fructus showed the inhibitory effects of gastric secretion. By reviewing the above result, it seems that there are thing that have antagonistic interactions in Crataegi Fructus, and I understood that the experimental result were consistent with the effects, namely, digesting the amassed food, digesting the chronic indigestion, circulation the stayed air based on the oriental medical references. In recognition of being applied to gastrointestinal diseases, it is suggested that continuous studies on the heart system in future being applied to are also needed.

보리 춘파재배 적응성 품종의 특성 및 선발

이춘우,구본철,백성범,손영구,김홍식 한국국제농업개발학회 2002 韓國國際農業開發學會誌 Vol.14 No.1

보리 품종 중 춘파에 적응하는 품종을 선발하기 위하여 올보리 등 16품종을 시험한 결과를 요약하면 다음과 같다. 가. 천립중과 설립량과는 상관관계가 있어 천립중이 무거울수록 10a당 설립이 적고 수량은 많아지는 경향이었다. 춘파 재배는 생육기간이 짧고 고온하에 등숙이 이루어지므로 천립중이 가벼워지는데 대립종이 소립중에 비하여 설립이 적었다. 나. 수량은 맥종간에는 쌀보리가 겉보리나 맥주보리에 비하여 적었고, 또한 년차나 품종간 변이도 컸다. 다. 쌀보리 품종들은 겉보리에 비하여 간장이 짧고, 설립이 많아 수량이 적었다. 라. 춘파재배용으로는 천립중, 설립량, 간장, 성숙기, 수량 등을 고려할 때 올보리와 사천6호가 가장 안정성이 있는 품종으로 판단되었다. This study was conducted to select varieties for spring sowing in barley. The accumulated and the average temperatures affected the 1,000-grain weight and unmatured grain yield. There was a negative correlation between 1,000-grain weight and the yield of unmatured grain. The 1,000-grain weight became lighter because of short growth period and maturing in high temperature under spring sowing condition. Compare with the covered and two-row barley, the grain was lower than naked barley. Among 16 barley varieties. "Olbori", "Sacheon6" were well adapted to spring sowing condition.