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염산 메트폴민을 함유하는 경구방출제어형 제제의 제조 및 용출특성
구본철,김정수,이계원,지웅길 忠南大學校 生命科學硏究院 醫藥品開發硏究所 2006 藥學論文集 Vol.21 No.-
Metformin is an antihyperglycemic agent of the biguanide class used in the treatment of non-in-sulin-dependent diabetes mellitus. Metformin hydrochloride has intrinsically poor permeability in the lower portion of the GI-tract leading to absorption almost exclusively in the upper part of the GI-tract. Its oral bioavailability is in the range of 50 to 60%. It also has a very high water solubility. In this study, we prepared sustained release matrix system containing metformin hydrochloride using various characteristics of polyethylene oxide (PEO). The metformin hydrochloride matrix tablets were prepared by direct compressed method and wet granulation compressed method with various molecular weight of PEO. Even though the molecular weights of PEOs used were 900K, 2,000K, and 5,000K. Moreover, three types of matrix tablets were formulated compositions were same, the hardness was different. The release kinetics were studied for 9 hours in pH 1.2 simulated gastric fluid and pH 6.8 simulated intestinal fluid, using a dissolution tester at 37.5℃, 50 rpm. As the molecular weight of PEO increased, the release rate decreased due to the slower swelling and dissolution of PEO. For the effect of hardness of matrix tablets, the rate of drug release was decreased with increasing hardness.
부유대역 용융응고법으로 제조된 YBa_2Cu_3O_x 산화물초전도체의 미세구조와 전기적 특성
노태형,송정환,장규철,한이섭,김소정,구본급,김호기 대전산업대학교 반도체기술연구소 2000 半導體技術硏究所報 Vol.2 No.-
The YBa_2Cu_3O_x-20 wt% Y_2BaCuO_5 composition designed in YBCO system was synthesized by solid state reaction method. The optimum condition of hot zone temperature and growth rate in floating-zone melt were 1080 ℃ and 2.5 mm/hour, respectively. In samples growth as these condition, the low angel boundaries in grain direction and small amount of amorphous phase known as decreasing characteristics of superconducting materials between grain boundaries in microstructure are investigated by polarized light microscopy on the whole. The critical current density(Jc) at 77k of sample using powder fabricated with no CeO_2 and doped 5 wt%CeO_2 were 8,000 A/㎠(Jc : 561A) and 12,000 A/㎠(Jc: 826A) at 0 T by direct current transport method, respectively.
Bon-Cheol Ku,Young-Chul Han,Jung-Eun Lee,이재근,Sang-Ho Park,Yu-Jin Hwang 한국정밀공학회 2010 International Journal of Precision Engineering and Vol.11 No.4
In this study, the tribological behaviors of fullerene nanoparticles-added mineral oil were investigated as a function of viscosities (e.g., 12, 30, 55, 96 and 145 mm2/s). Extreme pressure and anti-wear properties were evaluated using a four-ball tester, respectively. The lubrication tests were performed with a disk-on-disk tester for different normal loads. Tribological properties were evaluated by measuring friction surface temperature and the friction coefficient, and interpreted in terms of the Stribeck curve. We note that the weld points of the raw- and nano-oil increased as the oil viscosity increased and weld points for all nano-oil were higher than those of raw oil. Also the wear scar diameters of the raw- and nano-oil decreased as the oil viscosity increased and wear scar diameters for all nano-oil were less than those of raw oil. Also, we have found that the difference of friction coefficient between raw oil and nano-oil was outstanding when the viscosity of raw oil was low and the normal load is high. Our results indicate that the addition of fullerene additives in lubricant was more effective when the viscosity of raw oil was low under the higher normal load conditions.
Bon Cheol, Koo,M., Kucharska The Korean Society of Crop Science 1997 Korean journal of crop science Vol.42 No.2
세 유형의 화학 돌연변이제 처리(1.5mol Na$N_2$ +0.75mol MNH, 0.75mo1 MNH+0.75mo1 M-NH 및 0.5mol MNH+0.5mol MNH)를 한 M$_2$ 유묘를 이용, Est 1, 2, 4, 5, GOT 1, 2, 3, LAP 1, 2 등의 isozyme band pattern에 대한 돌연변이율을 조사하였다. 1. 세 가지 돌연변이제로 처리된 M$_2$식물체에 대한 돌연변이율 조사를 실시하였는데 엽록체에 대한 돌연변이율은 폴랜드 품종인 Dema에서는 3.3%였고 사천006에서는 1.8%로 나타났다. 2. Esterase유전자좌에 대한 돌연변이율은 Dema에서 3.5%로 사천 006의 0%보다 높았으며 GOT와 LAP에서는 두 품종간 차이가 없었다. 3. 세 가지 isozyme중 대개의 돌연번이체가 Es-terase에 관계된 유전자좌에서 발생하였으며 (75% 차지) 나머지에서의 돌연변이율은 극히 미미하였다. Mutation rate of M$_2$ plants that were treated with three types of double treatments of chemical mutagens(1.5mol Na$N_2$ + 0.75mol MNH, 0.75mol MNH + 0.75mol MNH and 0.5mol MNH + 0.5mol MNH) were estimated on the rate of chlorophyll mutant, changes of isozyme loci ; esterase (Est), glutamate oxaloacetate transaminase(GOT ; AAT) and leucyl aminopeptydase(LAP ; AMP). Rate of chlorophyll mutants (3.3% =no. of seedling carrying mutant / all number of M$_2$ seedlings $\times$ 100) and rate of esterase isozyme loci mutants(3.5% =no. of plant carrying mutant / all number of M$_2$ plant) in Dema were higher than one of Sacheon 6, but no significant differences in GOT, LAP. Among isozymes, most of mutants in M$_2$ plant of two varieties were found in esterase (73% of total mutants were occurred in esterase loci). Although many of null bands were found in GOT 3, these were not repeatable and no real mutants. It might be due to qualities of starch, amount of extract buffer and degradation of isozyme during electrophoresis and staining.