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Anti-stress Effect of Scutellaria baicalensis in SD Rats and ICR Mice
( Jong Hoon Ryu ),( Blendyl Saguan Tan Lee ),( Ji Wook Jung ),( Nam Yoon Ahn ),( Seung Joo Lee ),( Gu Young Yu ),( Shin Ha Han ),( Jeong Hoon Lee ),( Geum Seon Lee ),( Jae Hoon Cheong ) 한국응용약물학회 2004 Biomolecules & Therapeutics(구 응용약물학회지) Vol.12 No.1
N/A Pyroligneous liquid(PL) is produced by carbonizing Oak in 350∼400℃. It is traditionally used for treating stress-related disorder, hepatic disease, immune disorder, G-I disorder and inflammatory disease. The aim of this study is to investigate anti-stress effects of PL. The experiments were performed with the use of young(9 weeks of age) male rats of SD strain and the male ICR mice (20-25g). Animals of the normal group were not exposed to any stress and the control group were exposed to stress. The rats of the Ginseng, diazepam(BZ) and PL supplementary group were orally administered once a day 100g of Ginseng extract-kg body weight, 5 mg of BZ/kg body weight and 1 ml of PL/100 g body weight and then exposed to stress. The mice of the Ginseng, BZ and PL supplementary group were given water containing 100 g of Ginseng extract/100 ml potable water, 5 mg of BZ/kg 100 ml of drinking water and 10 ml of PL/100 ml of drinking water and exposed to stress. Animals were given materials for 7 days after stabilizing them, and then were given supplementary materials for 5 days with stress. They were stressed by immobilization for 30 minutes and then the animals were exposed to electroshocks for 5 minutes. We recorded stress-related behavioral changes of experimental animals by stressing them using the Etho-vision system and measured the levels of corticosterone in blood While stress suppressed locomotor activity of animals, PL-supplementation partially blocked the stress effect of locomotion in rats and mice, and also partially blocked stress-induced behavioral changes such as freezing, burrowing, smelling and rearing activity in rats and in closed area it increased relatively in elevated plus maze test. However, these changes also partially were blocked by PL-supplementation. PL-supplementation decreased levels of blood corticosterone increased by stress in rats. These results suggest that PL protects partially the living organism from stress attack in some cases.
Stress related activities of Sun-ginseng in SD Rats and ICR Mice
( Geum Seon Lee ),( Blendyl Saguan Tan Lee ),( Mi Kang Kim ),( Kyung Uoo Dong ),( Joo Yun Kim ),( Gu Young Yu ),( Jeong Sup Han ),( Hong Sook Ko ),( Il Ho Park ),( Jae Hoon Cheong ) 한국응용약물학회 2004 Biomolecules & Therapeutics(구 응용약물학회지) Vol.12 No.4
Anti-stress Effect of Pyroligneous Liquid in SD Rats and ICR Mice
( Mi Kang Kim ),( Gu Yong Yu ),( Blendyl Saguan Tan Lee ),( Hyun Jin Oh ),( Kyung Woo Dong ),( Seung Hwa Jeong ),( Seong Wook Han ),( Jae Hoon Cheong ) 한국응용약물학회 2003 Biomolecules & Therapeutics(구 응용약물학회지) Vol.11 No.4
N/A Pyroligneous liquid(PL) is produced by carbonizing Oak in 350∼400℃. It is traditionally used for treating stress-related disorder, hepatic disease, immune disorder, G-I disorder and inflammatory disease. The aim of this study is to investigate anti-stress effects of PL. The experiments were performed with the use of young(9 weeks of age) male rats of SD strain and the male ICR mice (20-25g). Animals of the normal group were not exposed to any stress and the control group were exposed to stress. The rats of the Ginseng, diazepam(BZ) and PL supplementary group were orally administered once a day 100g of Ginseng extract-kg body weight, 5 mg of BZ/kg body weight and 1 ml of PL/100 g body weight and then exposed to stress. The mice of the Ginseng, BZ and PL supplementary group were given water containing 100 g of Ginseng extract/100 ml potable water, 5 mg of BZ/kg 100 ml of drinking water and 10 ml of PL/100 ml of drinking water and exposed to stress. Animals were given materials for 7 days after stabilizing them, and then were given supplementary materials for 5 days with stress. They were stressed by immobilization for 30 minutes and then the animals were exposed to electroshocks for 5 minutes. We recorded stress-related behavioral changes of experimental animals by stressing them using the Etho-vision system and measured the levels of corticosterone in blood While stress suppressed locomotor activity of animals, PL-supplementation partially blocked the stress effect of locomotion in rats and mice, and also partially blocked stress-induced behavioral changes such as freezing, burrowing, smelling and rearing activity in rats and in closed area it increased relatively in elevated plus maze test. However, these changes also partially were blocked by PL-supplementation. PL-supplementation decreased levels of blood corticosterone increased by stress in rats. These results suggest that PL protects partially the living organism from stress attack in some cases.
고홍숙(Hong Sook Ko),이금선(Geum Seon Lee),블랜딜(Blendyl Saguan Tan Lee),박형근(Hyun Geun Park),유구용(Gu Young Yoo),임동술(Dong Sool Yim),정인경(In Kyung Jung),오세관(Sei Kwan Oh),정재훈(Jae Hoon Cheong) 대한약학회 2005 약학회지 Vol.49 No.4
Gardenia Jasminoides (GJ) is traditionally used for treatment of hepatic disease, insomnia, anxiety? and inflammatory disease. The aim of this study is to examine effects of GJ extract in response to stress. Animals of the normal group were not exposed to any stress and the control group were exposed to stress. The rats of the Ginseng and GJ supplementary group were orally administered once a day with 100 mg of red ginseng extract, 100 mg of GJ extract/kg body weight. The mice were given water containing 200 mg of red ginseng extract, 200 mg of GJ extract/100 ㎖ potable water. Animals were given supplements for 7 days without stress, and then were given supplements for 5 days with restraint and electroshock stress. After loading final stress, we examined stress related behavioral changes of experimental animals and measured the levels of blood corticosterone. GJ-supplementation partially blocked the stress effect on locomotion and elevated plus maze test in rats, and also partially blocked stress-induced behavioral changes such as freezing, burrowing, face-washing, smelling and rearing behavior in rats. The effect was almost equipotent to Ginseng's effect. GJ-supplementation didn't influence on fatigue related behavior or physical stress resistance. GJ-supplementation decreased the levels of blood corticosterone which is increased by stress in rats. These results suggest that GJ protects partially the living organism from stress attack and it has the potential to be used as a functional material to alleviate stress response.