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Bing Xia,Jian Shang,Xiaobing Wang,Wei Wang,Huaqin Pan,Shi Liu,Lixia Li,Liping Chen 연세대학교의과대학 2016 Yonsei medical journal Vol.57 No.1
Purpose: The -1237T/C polymorphism of the Toll-like receptor 9 (TLR9) gene has been implicated in the susceptibility of inflammatorybowel diseases (IBDs), but the results remain conflicting. We further investigated this association via meta-analysis. Materials and Methods: Multiple electronic databases were extensively searched until February, 2015. The strength of associationwas evaluated by calculating the pooled odds ratios (ORs) and 95% confidence intervals (CIs). Results: A total of 2987 cases and 2388 controls from eight studies were analyzed. Overall, association was found between TLR9 -1237T/C polymorphism and the risk of IBDs when all the studies were pooled (recessive model, OR: 1.59, 95% CI: 1.02–2.47, p=0.04; homozygote comparison, OR: 1.62, 95% CI: 1.04–2.52, p=0.03; allele model, OR: 1.13, 95% CI: 1.00–1.27, p=0.05). Stratificationby ethnicity indicated an association between TLR9 -1237T/C polymorphism and IBDs risk in Caucasians (recessive model,OR: 1.59, 95% CI: 1.02–2.47, p=0.04; homozygote comparison, OR: 1.62, 95% CI: 1.04–2.52, p=0.03; allele model, OR: 1.12, 95% CI: 1.00–1.27, p=0.05). When stratified by disease type, significant correlation were only found in the Crohn’s disease subgroup (recessive model, OR: 1.69, 95% CI: 1.05–2.73, p=0.03; homozygote model, OR: 1.74, 95% CI: 1.07–2.82, p=0.02; allele model, OR: 1.15, 95% CI: 1.01–1.32, p=0.04). Conclusion: The present study suggested that the TLR9 -1237T/C polymorphism might act as a risk factor in the development of IBDs, particularly in Caucasians.
Hongbo Qiu,Wenfei Yu,Bingxia Tang,Cunxiang Yang,Haiyang Zhao 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.4
When the inter-turn short circuit (ITSC) fault occurs, the distortion of the magnetic field is serious. The motor loss variations of each part are obvious, and the motor temperature field is also affected. In order to obtain the influence of the ITSC fault on the motor temperature distribution, firstly, the normal and the fault finite element models of the permanent magnet synchronous motor (PMSM) were established. The magnetic density distribution and the eddy current density distribution were analyzed, and the mechanism of loss change was revealed. The effects of different forms and degrees of the fault on the loss were obtained. Based on the loss analysis, the motor temperature field calculation model was established, and the motor temperature change considering the loop current was analyzed. The influence of the fault on the motor temperature distribution was revealed. The sensitivity factors that limit the motor continuous operation were obtained. Finally, the correctness of the simulation was verified by experiments. The conclusions obtained are of great significance for the fault and high temperature demagnetization of the permanent magnet analysis.
Increase in Hypotonic Stress-Induced Endocytic Activity in Macrophages via ClC-3
Yutao Yan,Yu Ding,Bingxia Ming,Wenjiao Du,Xiaoling Kong,Li Tian,Fang Zheng,Min Fang,Zheng Tan,Feili Gong 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.5
Extracellular hypotonic stress can affect cellular function. Whether and how hypotonicity affects immune cell function remains to be elucidated. Macrophages are immune cells that play key roles in adaptive and innate in immune reactions. The purpose of this study was to investigate the role and underlying mechanism of hypotonic stress in the function of bone marrow-derived macrophages (BMDMs). Hypotonic stress increased endocytic activity in BMDMs, but there was no significant change in the expression of CD80, CD86, and MHC class II molecules, nor in the secretion of TNF- or IL-10 by BMDMs. Furthermore, the enhanced endocytic activity of BMDMs triggered by hypotonic stress was significantly inhibited by chloride channel-3 (ClC-3) siRNA. Our findings suggest that hypotonic stress can induce endocytosis in BMDMs and that ClC-3 plays a central role in the endocytic process.
Hongbo Qiu,Yuedong Guo,Wenfei Yu,Bingxia Tang,Cunxiang Yang 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.3
With the development of electric electron technology and controlling technology, controller for driving permanent magnet synchronous motors is used widely. The using of a controller can expand the motor speed range and improve motor runtime performances. However, the output current of a controller contains lots of time harmonics that will have bad infl uences on motor torque and losses. In order to analyze the infl uences of the time harmonics on the motor performances, diff erent time harmonic currents were injected into the motor armature. Taking a 750 W, 250 r/min permanent magnet synchronous motor with hybrid magnet poles (HPPMSM) as an example, the 2-D fi nite model was established. On this basis, the torque ripple and eddy current losses of permanent magnets with diff erent time harmonics were obtained. The infl uences of time harmonics on motor torque ripple and eddy current losses were determined, and the impacting mechanism was revealed. The analyses may be helpful for the optimal design of HPPMSM.
Influence of Frequency on Electromagnetic Field of Super High-Speed Permanent Magnet Generator
Hongbo Qiu,Yanqi Wei,Wei Wang,Bingxia Tang,Xifang Zhao,Cunxiang Yang 전력전자학회 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.4
When compared with traditional power frequency generators, the frequency of a super high-speed permanent magnet generator(SHSPMG) is a lot higher. In order to study the influence of frequency on the electromagnetic field of SHSPMGs, a 60000rpm,117kW SHSPMG was taken as a research object. The two-dimensional finite element model of the generator was established,and the two-dimensional transient field of the generator was simulated. In addition, a test platform of the generator was set upand tested. The reliability of the simulation was verified by comparing the experiment data with that of the simulation. Then thegenerator electromagnetic field under different frequencies was studied, and the influence mechanism of frequency on thegenerator electromagnetic field was revealed. The generator loss, voltage regulation rate, torque and torque ripple were analyzedunder the rated active power load and different frequencies. The influences of frequency on the eddy current density, loss, voltageregulation rate and torque ripple of the generator were obtained. These conclusions can provide some reference for the designand optimization of SHSPMGs.
Qiu, Hongbo,Yu, Wenfei,Tang, Bingxia,Yang, Cunxiang,Zhao, Haiyang The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.8 No.1
When the inter-turn short circuit (ITSC) fault occurs, the distortion of the magnetic field is serious. The motor loss variations of each part are obvious, and the motor temperature field is also affected. In order to obtain the influence of the ITSC fault on the motor temperature distribution, firstly, the normal and the fault finite element models of the permanent magnet synchronous motor (PMSM) were established. The magnetic density distribution and the eddy current density distribution were analyzed, and the mechanism of loss change was revealed. The effects of different forms and degrees of the fault on the loss were obtained. Based on the loss analysis, the motor temperature field calculation model was established, and the motor temperature change considering the loop current was analyzed. The influence of the fault on the motor temperature distribution was revealed. The sensitivity factors that limit the motor continuous operation were obtained. Finally, the correctness of the simulation was verified by experiments. The conclusions obtained are of great significance for the fault and high temperature demagnetization of the permanent magnet analysis.
Increase in Hypotonic Stress-Induced Endocytic Activity in Macrophages via ClC-3
Yan, Yutao,Ding, Yu,Ming, Bingxia,Du, Wenjiao,Kong, Xiaoling,Tian, Li,Zheng, Fang,Fang, Min,Tan, Zheng,Gong, Feili Korean Society for Molecular and Cellular Biology 2014 Molecules and cells Vol.37 No.5
Extracellular hypotonic stress can affect cellular function. Whether and how hypotonicity affects immune cell function remains to be elucidated. Macrophages are immune cells that play key roles in adaptive and innate in immune reactions. The purpose of this study was to investigate the role and underlying mechanism of hypotonic stress in the function of bone marrow-derived macrophages (BMDMs). Hypotonic stress increased endocytic activity in BMDMs, but there was no significant change in the expression of CD80, CD86, and MHC class II molecules, nor in the secretion of TNF-${\alpha}$ or IL-10 by BMDMs. Furthermore, the enhanced endocytic activity of BMDMs triggered by hypotonic stress was significantly inhibited by chloride channel-3 (ClC-3) siRNA. Our findings suggest that hypotonic stress can induce endocytosis in BMDMs and that ClC-3 plays a central role in the endocytic process.
Influence of Frequency on Electromagnetic Field of Super High-Speed Permanent Magnet Generator
Qiu, Hongbo,Wei, Yanqi,Wang, Wei,Tang, Bingxia,Zhao, Xifang,Yang, Cunxiang The Korean Institute of Power Electronics 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.4
When compared with traditional power frequency generators, the frequency of a super high-speed permanent magnet generator (SHSPMG) is a lot higher. In order to study the influence of frequency on the electromagnetic field of SHSPMGs, a 60000rpm, 117kW SHSPMG was taken as a research object. The two-dimensional finite element model of the generator was established, and the two-dimensional transient field of the generator was simulated. In addition, a test platform of the generator was set up and tested. The reliability of the simulation was verified by comparing the experiment data with that of the simulation. Then the generator electromagnetic field under different frequencies was studied, and the influence mechanism of frequency on the generator electromagnetic field was revealed. The generator loss, voltage regulation rate, torque and torque ripple were analyzed under the rated active power load and different frequencies. The influences of frequency on the eddy current density, loss, voltage regulation rate and torque ripple of the generator were obtained. These conclusions can provide some reference for the design and optimization of SHSPMGs.