Feasibility online survey to estimate physical activity level among the students studying professional courses : a cross-sectional online survey

Bhumika Sudha,Asir John Samuel,Kanimozhi Narkeesh 한국운동재활학회 2018 JER Vol.14 No.1

The aim of the study was to estimate the physical activity (PA) level among the professional college students in North India. One hundred three professional college students in the age group of 18–25 years were recruited by simple random sampling for this cross-sectional online survey. The survey was advertised on the social networking sites (Facebook, WhatsApp) through a link www.surveymonkey.com/r/MG- 588BY. A Short Form of International Physical Activity Questionnaire was used for this survey study. The questionnaire included total 8 questions on the basis of previous 7 days. The questionnaire consists of 3 main categories which were vigorous, moderate and high PA. Time spent in each activity level was multiplied with the metabolic equivalent of task (MET), which has previously set to 8.0 for vigorous activity, 4.0 for moderate activity, 3.3 for walking, and 1.5 for sitting. By multiplying MET with number of days and minutes performed weekly, amount of each activity level was calculated and measured as MET-min/wk. Further by adding MET minutes for each activity level, total MET-min/wk was calculated. Total number of 100 students participated in this study, and it was shown that all professional course students show different levels in PA. The total PA level among professional college students, which includes, physiotherapy, dental, medical, nursing, lab technician, pharmacy, management, law, engineering, were 434.4 (0–7,866), 170.3 (0–1,129), 87.7 (0–445), 102.8 (0–180), 469 (0–1,164), 0 (0–0), 645 (0–1,836), 337 (0–1,890), 396 (0–968) MET-min/wk respectively. PA levels among professional college students in North India have been established.

Antibody drug conjugates as targeted cancer therapy: past development, present challenges and future opportunities

Ritwik Maiti,Bhumika Patel,Nrupesh Patel,Mehul Patel,Alkesh Patel,Nirav Dhanesha 대한약학회 2023 Archives of Pharmacal Research Vol.46 No.5

Antibody drug conjugates (ADCs) are promising cancer therapeutics with minimal toxicity as compared to small cytotoxic molecules alone and have shown the evidence to overcome resistance against tumor and prevent relapse of cancer. The ADC has a potential to change the paradigm of cancer chemotherapeutic treatment. At present, 13 ADCs have been approved by USFDA for the treatment of various types of solid tumor and haematological malignancies. This review covers the three structural components of an ADC—antibody, linker, and cytotoxic payload—along with their respective structure, chemistry, mechanism of action, and influence on the activity of ADCs. It covers comprehensive insight on structural role of linker towards efficacy, stability & toxicity of ADCs, different types of linkers & various conjugation techniques. A brief overview of various analytical techniques used for the qualitative and quantitative analysis of ADC is summarized. The current challenges of ADCs, such as heterogeneity, bystander effect, protein aggregation, inefficient internalization or poor penetration into tumor cells, narrow therapeutic index, emergence of resistance, etc., are outlined along with recent advances and future opportunities for the development of more promising next-generation ADCs.

GENERATING FUNCTIONS FOR THE EXTENDED WRIGHT TYPE HYPERGEOMETRIC FUNCTION

Jana, Ranjan Kumar,Maheshwari, Bhumika,Shukla, Ajay Kumar Korean Mathematical Society 2017 대한수학회논문집 Vol.32 No.1

In recent years, several interesting families of generating functions for various classes of hypergeometric functions were investigated systematically. In the present paper, we introduce a new family of extended Wright type hypergeometric function and obtain several classes of generating relations for this extended Wright type hypergeometric function.

Densitometric quantification for the validation of decolorization of Disperse Orange ERL by lichen <i>Parmelia</i> sp.

Kulkarni, Ashwini N.,Bhalkar, Bhumika N.,Khandare, Rahul V.,Kurade, Mayur B.,Jeon, Byong-Hun,Govindwar, Sanjay P. Society for Bioscience and Bioengineering, Japan 2019 Journal of bioscience and bioengineering Vol. No.

<P>Densitometric high performance thin layer chromatography (HPTLC) quantification method was developed to validate the decolorization/biotransformation of Disperse Orange ERL and dye mixture by lichen <I>Parmelia</I> sp. which release several colored compounds during decolorization process, hence unable to use colorimetric estimation. Percent decolorization of Disperse Orange ERL and dye mixture by lichen <I>Parmelia</I> sp. was observed when estimated using developed HPTLC method. Limit of detection and limit of quantification for both dyes in mixture were obtained as 0.3 and 1 μg/μl, respectively. Area of peak of control Disperse Orange ERL was reduced by 43% after 12 h, 71% after 48 h and upto 82% after 72 h of incubation. Precision and repeatability of data elucidated the % relative standard deviation less than 3 for all the values thus indicating statistically acceptable. Biodegradation of dye and mixture was confirmed with Fourier transform infrared spectroscopy analysis, i.e., altered fingerprinting spectral pattern.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Densitometric quantification of textile dyes biotransformation products. </LI> <LI> Quantification of dye in presence of released colored compounds. </LI> <LI> Reported for the first time in dye decolorization studies. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

SOME PROPERTIES OF EXTENDED τ-HYPERGEOMETRIC FUNCTION

Jana, Ranjan Kumar,Maheshwari, Bhumika,Shukla, Ajay Kumar Korean Mathematical Society 2018 대한수학회논문집 Vol.33 No.4

Recently, Parmar [5] introduced a new extension of the ${\tau}$-Gauss hypergeometric function $_2R^{\tau}_1(z)$. The main object of this paper is to study this extended ${\tau}$-Gauss hypergeometric function and obtain its properties including connection with modified Bessel function of third kind and extended generalized hypergeometric function, several contiguous relations, differential relations, integral transforms and elementary integrals. Various special cases of our results are also discussed.

Assessing the Impact of Microfinance Services on the Economic Transformation of Women in Nepal

Bharatram Dhungana,Laxmi Kanta Sharma,Bhumika Adhikari 전남대학교 지역개발연구소 2022 지역개발연구 Vol.54 No.3

Microfinance is an essential strategy for promoting financial independence and inclusion for people living in poverty by helping them improve their household income, acquire assets, and reduce their vulnerability through accessible financial services. This study aims to assess the impact of microfinance services on the economic transformation of women living in the Kaski district of Nepal. The study was confined to NESDO microfinance clients who have been involved for at least five years. The survey is based on primary sources and includes 215 randomly selected clients. The study finds a significant impact of microfinance services on household income, employment development, asset formation, saving behaviors, and consumer spending of clients. Although microfinance institutions are powerful tools for socio-economic change, they do not reach the most disadvantaged. So, the regulatory authority needs to devise a good plan to help more poor and unbanked people get microfinance services. The government should establish a supportive environment that can aid microfinance institutions in providing microcredit and using it in beneficial ways.

Adaptive filtering method for EMG signal using bounded range artificial bee colony algorithm

Agya Ram Verma,Yashvir Singh,Bhumika Gupta 대한의용생체공학회 2018 Biomedical Engineering Letters (BMEL) Vol.8 No.2

In this paper, an adaptive artefact canceller is designed using the bounded range artificial bee colony (BR-ABC) optimizationtechnique. The results of proposed method are compared with recursive least square and other evolutionaryalgorithms. The performance of these algorithms is evaluated in terms of signal-to-noise ratio (SNR), mean square error(MSE), maximum error (ME) mean, standard deviation (SD) and correlation factor (r). The noise attenuation capability istested on EMG signal contaminated with power line and ECG noise at different SNR levels. A comparative study ofvarious techniques reveals that the performance of BR-ABC algorithm is better in noisy environment. Our simulationresults show that the ANC filter using BR-ABC technique provides 15 dB improvement in output average SNR, 63 and83% reduction in MSE and ME, respectively as compared to ANC filter based on PSO technique. Further, the ANC filterdesigned using BR-ABC technique enhances the correlation between output and pure EMG signal.

Understanding the Role of Heat Shock Protein Isoforms in Male Fertility, Aging and Apoptosis

Kaveri Purandhar,Prasant Kumar Jena,Bhumika Prajapati,Parth Rajput,Sriram Seshadri 대한남성과학회 2014 The World Journal of Men's Health Vol.32 No.3

Heat shock proteins (HSPs) play a role in the homeostasis, apoptosis regulation and the maintenance of the various other physiological processes. Aging is accompanied by a decrease in the resistance to environmental stress, while mitochondria are primary targets in the process of aging, their expression decreasing with age. Mitochondrion also plays a significant role in the process of spermatogenesis. HSPs have been shown to be involved in apoptosis with some of acting as apoptotic inhibitors and are involved in cytoprotection. In this review we discuss the roles of Hsp 27, 60, 70, and 90 in aging and male infertility and have concluded that these particular HSPs can be used as a molecular markers for mitochondrially- mediated apoptosis, aging and male infertility.