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Bhavesh S. Barot,Punit B. Parejiya,Pragna K. Shelat,Gaurang B. Shah,Dharmik M. Mehta,Trupti V. Pathak 한국약제학회 2015 Journal of Pharmaceutical Investigation Vol.45 No.1
Intravenous iron formulations comprising ofiron/iron–oxyhydroxide–carbohydrate complex are anestablished therapy for the treatment of iron deficiency anemia. These preparations should be subjected to exhaustive physicochemical and toxicological studies in order to establish their safety and efficacy. Following VenoferⓇ (innovator iron–sucrose formulation), variousiron sucrose similar have entered into the market with equivalent physicochemical and toxicological profile. This report describes the physicochemical and toxicological studies of a novel iron sucrose injection (IS-Claris). IS-Claris and VenoferⓇ were subjected to various physicochemical studies such as elemental and chemical analysis;X-ray diffraction; particle size and distribution; labile iron detection, Mo¨ssbauer and Raman spectroscopy. The presenceof iron oxides in IS-Claris and VenoferⓇ could be confirmed by the major peaks at 24.65˚ (2θ) and 38.2˚ (2θ). The iron sucrose samples demonstrated similar reduction peaks of Fe(III) to Fe in their respective polarograms. The average diameter of the core of IS-Claris and VenoferⓇ was estimated to be 2.92 ± 0.01 and 2.77 ± 0.63 nm, respectively. The Mo¨ssbauer spectra of IS-Claris and VenoferⓇ showed a doublet with an isomer shift δ = 0.43 ± 0.01 mm/s. Moreover, the other physicochemical specifications of IS-Claris were comparable to VenoferⓇ. The toxicological studies demonstrated that IS-Claris safety profile is equivalent to VenoferⓇ. It could be concluded that IS-Claris could be used as a potential alternative to VenoferⓇ with similar clinical implications.
Kamble, Archana,Sinha, Bhavesh,Agawane, Ganesh,Vanalakar, Sharad,Kim, In young,Kim, Jin Young,Kale, Sampat S.,Patil, Pramod,Kim, Jin Hyeok The Royal Society of Chemistry 2016 Physical chemistry chemical physics Vol.18 No.40
<P>The sulfur ion concentration dependent morphological evolution and its subsequent effect on photo-electrochemical properties of chemically synthesized CdS thin films have been systematically investigated. The plausible growth mechanism for the morphological evolution of CdS thin films due to a change in sulfur ion concentration has been proposed. Scanning electron micrographs (SEMs) reveal that the morphology of CdS thin films has been changed from spherical grains to vertically aligned nanoflakes by systematic control of sulfur ion concentration. This article elucidates the astute relationships between precursor concentrations, reaction rate and morphological evolution. The X-ray diffraction (XRD) patterns reveal the formation of hexagonal wurtzite CdS thin films with the preferred (002) orientation for CdS nanoflakes, which is further supported by the analysis of the high resolution transmission electron micrographs (HRTEMs). Optical absorption studies show a red shift in the absorption edge with an increase in sulfur concentration. The beneficial role of nanoflake formation is easily reflected in the photo-electrochemical performance. Improved solar cell performances are observed for CdS nanoflakes grown with a sulfur to cadmium ion concentration ratio of 4 (S : Cd = 4).</P>
Punit B. Parejiya,Bhavesh S. Barot,Hetal K. Patel,Dharmik M. Mehta,Pragna K. Shelat,Arunkumar Shukla 한국약제학회 2014 Journal of Pharmaceutical Investigation Vol.44 No.3
In present day, availability of various carriers,innovative techniques of production and plenty of solventssupport the growth of solid dispersion (SD) technology inpharmaceutical industries to overcome many issues. Thepresent study was aimed to develop SD based sustainedrelease system of Milnacipran HCl (MH). The SD containingethyl cellulose, Eudragit RLPO and Eudragit RSPOat drug–polymer ratios of 1:1, 1:2, and 1:3 were developedusing solvent evaporation technique and different waxes atratio of 1:1, 1:1.25, 1:1.5 and 1:1.75 with drug weredeveloped by melting method. The physicochemicalproperties of SD were evaluated using Fourier transforminfrared spectroscopy (FTIR), differential scanning calorimetry(DSC) and X-ray diffraction (XRD). The desiredSD batch was further compressed into tablet unit to achievepredetermined once a day drug release. Tablets preparedwere evaluated for physicochemical parameters, in vitrodrug release, drug release kinetics and scanning electronmicroscopy. Out of selected carriers, bees wax had shownmaximum release retardation. The results of FTIR, DSCand XRD studies exhibited poor interaction amongst MH–bees wax and retention of crystalline state of MH in SDsystem. The presence of Benecel (HPMC K 200 M;75 mg) in tablets comprising SD (1:1.25, MH:bees wax)revealed remarkable drug release extension and it wasconsidered an optimal. The later was submitted to shortterm stability study and its results indicated the stablecharacteristic of system. Drug release from optimizedformulation fitted well into Higuchi model with anomalousdiffusion. The compressed unit of SD system of highlywater soluble drug can be successful single day regimen.
Kiran P. Shinde,오상수,백승규,김호섭,Bhavesh B. Sinha,정국채 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.61 No.12
A facile and rapid Glycine-assisted combustion method was developed to synthesize polycrystalline La<SUB>0.8</SUB>Ca<SUB>0.2</SUB>MnO<SUB>3</SUB> (LCMO) powder using dissolution of lanthanum nitrate, calcium nitrate, manganese nitrate (oxidant) and Glycine (fuel) as the starting materials and water as solvent, then heating the resulting solution on a heating plate. The x-ray diffraction and FTIR analysis confirms the orthorhombic crystal structure and morphological study shows the polycrystalline form of LCMO powder. The calculated lattice constant a = 5.46, b = 7.73 and c = 5.49 Å are well in agreement with standard values. The magnetic measurements show the paramagnetic behavior of LCMO at room temperature. The maximum change in entropy observed for the LCMO sample is -1.95 J/kgK at an applied magnetic field 2T at Curie temperature of 165 K.
Kumar, Nitish,Singh, Amritpal S.,Modi, Arpan R.,Patel, Armi R.,Gajera, Bhavesh B.,Subhash, Narayanan Institute of Forest Science 2010 Journal of Forest Science Vol.26 No.1
Sixteen microsatellite markers (simple sequence repeat (SSR) markers) were employed to examine the genetic stability of 27 randomly chosen date palm (Phoenix dactylifera L.) plants produced through somatic embryogenesis with upto forty two in vitro subcultures. No microsatellite DNA variation was observed among all micropropagated plants. Our results indicate that the micropropagation protocol used for rapid in vitro multiplication is appropriate and suitable for clonal propagation of date palm and corroborated that somatic embryogenesis can also be used as one of the safe modes for production of true-to-type plants of date palm. This is the first report on the use of microsatellite DNA markers to establish the genetic stability in micropropagated date palm plants.
Punit B. Parejiya,Rakshit C. Patel,Dharmik M. Mehta,Pragna K. Shelat,Bhavesh S. Barot 한국약제학회 2013 Journal of Pharmaceutical Investigation Vol.43 No.4
Present study aims at formulation and development of quick dissolving film of nebivolol hydrochloride applying simple lattice experimental design using three hetero polymers hydroxypropyl methylcellulose, pullulan and polyvinyl pyrrolidone. Films were prepared using solvent casting technique and optimized formulation was derived by desirability function. Regression equations and contour plots were executed to narrate dependent variables,i.e. percentage drug release in 30 s (Y30), tensile strength,elastic modulus, percentage elongation and load at yield, to independent variables. Results of the experimental design revealed that the independent factors hydroxypropyl methylcellulose and pullulan significantly influenced the mechanical properties and percentage drug release from the film which was ultimately reflect in the formulation of optimized batch. The high % drug release of the film in simulated saliva and simulated gastric fluid indicated that it can be successfully used in drug delivery systems for drugs with high first-pass metabolism.