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Bhagwan, Jai,Nagaraju, Goli,Ramulu, Bhimanaboina,Yu, Jae Su Electrochemical Society 2019 Journal of the Electrochemical Society Vol.166 No.2
<P>ZnCo<SUB>2</SUB>O<SUB>4</SUB> (ZCO) hexagonal nanoplates were synthesized by a facile, robust and cost-effective co-precipitation method. The as-synthesized nanoplates were utilized as an electrode material and their electrochemical properties were investigated in three-electrode and two-electrode configurations with aqueous electrolyte of 1 M KOH. The fabricated ZCO electrode materials exhibited a specific capacity of 37 mAh g<SUP>−1</SUP> at 1 A g<SUP>−1</SUP>. The capacity of the pristine ZCO nanoplates was further improved by incorporating multiwall carbon nanotubes (MWCNTs). The MWCNT@ZCO showed a specific capacity of 64 mAh g<SUP>−1</SUP> at 1 A g<SUP>−1</SUP>. To examine practical performances, asymmetric supercapacitor (ASC) was also fabricated using MWCNT@ZCO as a positive electrode and activated carbon as a negative electrode. The specific capacity of the ASC was found to be 17 mAh g<SUP>−1</SUP> at 0.38 A g<SUP>−1</SUP>. ASC could store sufficient energy to power a parallel combination of two red color light-emitting diodes. These findings may open new opportunities for the design of effective, stable, and easily recyclable ZCO electrode material for energy storage devices.</P>
Flavonoid-induced apoptotic cell death in human cancer cells and itsmechanisms
Pritam Bhagwan Bhosale,하상은,Preethi Vetrivel,김훈환,김진아,박광일,김성민,김곤섭 충북대학교 동물의학연구소 2020 Journal of Biomedical and Translational Research Vol.21 No.2
Cancer is the second leading cause of death worldwide and currently there are many approaches developing towards cancer treatment. Cancer treatments like chemotherapy and radiation therapy are often painful and have adverse effects. The mechanism of apoptosis is a complex process and it involves different pathways in its mechanism of action. Apoptosis can be caused by signals within the cell such as stress, or by extrinsic signals such as ligands binding to cell surface death receptors. The programmed cell death plays a important role in the several physiological and pathological processes. It plays important role in homeostasis. Flavonoids have gained importance as anticancer agents promoting cytotoxicity and apoptosis in cancer cells. Flavonoids are present in many medicinal plants which are a kind of ubiquitous natural products and essential active ingredients. They have strong biological activities with high efficiency and low toxicity, possessing good preventive and cure effects on different tumor forms. Flavonoids such as Scutellarein, Pectolinarigenin and Naringin have reported to possess significant anti-cancer effects on different cancer cell lines till date. In this review, we provide a summary about the anti-cancer effect of the three flavonoids and its mechanisms of action that can be used in future for understanding their potent anti-tumor properties.
Colorimetric Detection of Norovirus in Oyster Samples through DNAzyme as a Signaling Probe
Batule, Bhagwan S.,Kim, Seong U,Mun, Hyoyoung,Choi, Changsun,Shim, Won-Bo,Kim, Min-Gon American Chemical Society 2018 Journal of agricultural and food chemistry Vol.66 No.11
<P>Worldwide, norovirus is one of the most associated causes of acute gastroenteritis, which leads to nearly 50 000 child deaths every year in developing countries. Therefore, there is great demand to develop a rapid, low-cost, and accurate detection assay for the foodborne norovirus infection to reduce mortality caused by norovirus. Considering the importance of norovirus, we have demonstrated a highly sensitive and specific colorimetric detection method for analysis of human norovirus genogroups I and II (HuNoV GI and GII) in oyster samples. This is the first report to employ colorimetric HRPzyme-integrated polymerase chain reaction (PCR) for direct norovirus detection from the real shellfish samples. We found that the HRPzyme-integrated PCR method is more sensitive than the gel electrophoresis approach and could detect the HuNoV GI and GII genome up to 1 copy/mL. The specificity of the proposed method was successfully demonstrated for HuNoV GI and GII. Further, we performed testing HuNoVs in the spiked oyster samples, and the HRPzyme-integrated PCR method proved to be an ultrasensitive and selective method for detecting HuNoVs in the real samples. By integration of the proposed method with the portable PCR machine, it would be more reliable to improve food safety by detecting HuNoVs in the different types of shellfish, such as oyster and mussel, at the production field.</P> [FIG OMISSION]</BR>