益胃升陽湯 및 加減方이 家兎의 摘出腸管 運動에 미치는 影響

李學宰,盧永範,柳道坤,韓宗鉉,康舜洙 圓光大學校 韓醫學硏究所 1992 원광한의학 Vol.2 No.1

In order to investigate the action of Radix Bupleuri and Radix Cimicifugae in Yikwiserugyangtang(益胃升陽湯), Yikwiseungyangtang was divided into six samples : Sample Ⅰ : Yikwiseungyangtang Sample Ⅱ : Water extract of Yikwiseungyangtang excluded R.Bupleuri and R.Cimicifugae. Sample Ⅲ : Water extract of Yikwiseungyangtang excluded R.Cimicifugae. Sample Ⅳ : Water extract of Yikwiseungyangtang excluded R.Bupleuri. Sample Ⅴ : Water extract of Yikwiseungyangtang increased R.Bupleuri and R.Cimicifugae to 3.75g Sample Ⅵ : Water extract of R.Bupleuri and R.Cimicifuage. Effects of Yikwiseungyangtang and its variants on the contractile force of isolated rabbit ileums are as follows : 1. Yikwiseungyangtang was significantly increased the contractile force of isolated rabbits ileum. 2. The contractile of Yikwiseungyangtang was significantly inhibited by atropine. 3. The contractile force of Yikwiseungyangtang was not inhibited by cyproheptadine. 4. In the contraction of Norepinephrine(10^-3M), Sample Ⅱ, Sample Ⅵ and Sample Ⅴ were increased the contractile force than that of Sample Ⅰ. 5. In the contraction of acetylcholine (10^-3M), no change observed in contractile force than that of Sample Ⅰ.

치과병원 진료실 내에서 메티실린 또는 반코마이신 저항성 Staphylococcus aureus의 검출

민정희,박순낭,황호길,민정범,김화숙,국중기 대한치과보존학회 2007 Restorative Dentistry & Endodontics Vol.32 No.2

본 연구는 조선대학교 치과병원의 진료환경 및 진료요원으로부터 기회감염성 병원체로 알려진 methicillin 또는 vancomycin 저항성 황색포도상 구균 (methicillin- or vancomycin-resistant Staphylococcus aureus: MRSA or VRSA)의 존재 여부를 조사하여, 이를 광주지역 개원치과와 비교분석을 통해 현재 조선대학교 치과병원의 MRSA와 VRSA의 오염정도를 파악하고자 하였다. 이를 위해 진료실 환경 및 진료요원으로부터 분리한 S. aureus 균주들의 8종 항생제에 대한 감수성 조사를 시행하고, 기존에 알려진 항생제 내성 유전자 존재 여부를 PCR법을 이용하여 확인하였다. 그 결과, 조선대학교 치과병원의 진료요원에서 채취한 샘플 중 1개 (2.3%), 개원 치과에서는 2명 (10%)의 진료요원의 샘플에서 S. aureus가 분리되었으며, 진료환경에서는 두 곳 모두에서 S. aureus가 검출되지 않았다. 조선대학교 치과병원과 개원치과에서 분리된 S. aureus는 amoxicillin, penicillin G, ciprofloxacin, clindamycin, vancomycin에 내성을 보이며, oxacillin, cefuroxime에는 균주에 따라 감수성 또는 내성을 보였다. 조선대학교 치과병원에서 분리 된 S. aureus는 erythromycin과 clindamycin에 내성 유전자인 ermA가 존재 하였으며, 개원치과에서 분리된 3개의 S. aureus 중 2개에서 penicillin과 oxacillin에 내성 유전자 mecA가 존재하는 것으로 나타났다. Vancomycin 내성 유전자인 vanA, vanB는 어떠한 샘플에서도 검출되지 않았다. 이상의 결과를 종합할 때, 본 연구는 조선대학교 치과병원과 개원치과의 S. aurues 분포 및 MRSA 또는 VRSA의 존재여부를 조사하여 MRSA와 VRSA의 확산예방을 위한 치과진료 환경의 개선과 적절한 항생제 사용에 대한 기초 자료를 제공할 것으로 사료된다. The purpose of this study was to obtain the basic information for the improvement of dental environment by investigating the presence of methicillin- or vancomycin-resistant Staphylococcus aureus (MRSA or VRSA) isolated from dental health care workers (DHCWs) and environment of the Chosun University Dental Hospital (CUDH) and a private dental clinic (control group). Staphylococcus aureus (S. aureus) was isolated from anterior nares of 42 DHCWs and 38 sites, unit chairs, x-ray devices, computers, etc., at 10 departments of the CUDH and 20 DHCWs and 11 sites at the private dental clinic. S. aureus was isolated on mannitol salt agar plate and confirmed by PCR with S. aureus species-specific primer. Antimicrobial susceptibility test of clinical isolates of S. aureus against several antibiotics including methicillin (oxacillin) was performed by investigating minimum inhibitory concentration (MIC) using broth microdilution assay. In addition, PCR was performed to detect the methicillin- or vancomycin-resistant gene. The data showed that one strain of S. aureus was isolated from DHCWs of the CUDH and three strains of S. aureus was isolated from 3 samples of the private dental clinic, respectively. All of the isolates from the CUDH and the private dental clinic had resistance to penicillin G, amoxicillin and vancomycin and susceptibility to oxacillin and ciprofloxacin. The S. aureus strains were already obtained the resistance to penicillin G and amoxicillin. These results suggest that two dental clinics were under relatively safe environment.

Information Communication Information System Policy Analysis - Centered around Regulations in Mobile Communication Terminal Support -

Shin, Beum-Soon 한국컴퓨터게임학회 2007 한국컴퓨터게임학회논문지 Vol.10 No.-

The Effect of Internet Use on Political Participation

신범순(Shin Beum Soon,申範淳) 한국컴퓨터게임학회 2007 한국컴퓨터게임학회논문지 Vol.10 No.-

This thesis analyzes the connection between internet use trend of the netizen and political participation. An analysis was made to assess the influence of the political and social tendencies of the netizen and the successful political experience trends on the political efficacy. The result of the analysis shows higher political efficacy and internet political activities for netizens with liberal and revolutionary disposition, Roh Mu Hyun voters and anticipators. This analysis result supports the hypothesis that social and political tendencies and successful political experiences of the netizens affect the political efficacy. In other words, the political use of internet indirectly influences the political participation through the parameter of the netizen's political efficacy. Accordingly, the internet use trend of the netizen influenced their voting participation during the 16th presidential election.

모바일 환경에서의 삶의 질 측정모형에 관한 연구

신범순(Shin Beum Soon) 한국컴퓨터게임학회 2006 한국컴퓨터게임학회논문지 Vol.8 No.-

본 연구는 정보사회의 모바일환경(Mobile-environment)에서의 삶의 질의 개념을 정의하고 구성요소를 파악하여 측정모형(measurement model)의 타당성을 검증하였다. 본 연구에서의 삶의 질의 개념은 삶의 주체인 인간이 환경과의 상호작용을 통해 삶을 영위하는 과정에서 느끼는 '주관적 삶의 질(Subjective quality of life)'로 정의하였으며, 이를 '개인과 환경과의 적합성(Person-environment fit)'을 통해 측정하였다. 본 연구는 모바일 환경에서의 삶의 질 측정척도를 개발하기 위해 2차례의 예비조사를 거쳐서 최종적으로 본조사를 실시하였으며, 이를 통해 개발된 8개의 삶의 질 차원과 차원별로 최종선정된 측정항목 38개를 가지고 각 차원별로 측정항목들간에 존재하는 명확한 단일차원성(unidimentionality)을 확인하고 구성개념 타당성(construct validity)를 평가하기 위해 AMOS 5.0을 활용하여 확인적 요인분석(confirmatory factor analysis)을 실시하였다. 한편 지표구성 항목에 대해 타당도를 확인하고 구성항목 간의 내적일관성을 파악하기 위해 알파신뢰도계수(Cronbach α-reliability coefficient)를 산출하였다. 또한 부가적으로 성별과 이동통신이용 만족도에 따른 삶의 질 수준의 차이를 검증하기 위해 이원분산분석(two-way ANOVA)을 하였다. 분석결과를 요약하면 다음과 같다. 첫째, 모바일환경에서 삶의 질의 구성요소는 7가지, 즉 사회성, 여가문화, 기능성, 안전성, 경제성, 건강성, 자율성으로 밝혀졌다. 둘째, 구성요소의 개념에 따른 각 측정항목을 이용하여 확인적 요인분석을 하여 얻은 측정모형의 전반적 적합지수는 ×2, RMR, GFI, AGFI, NFI의 기준에 비추어 볼 때 대체로 평가기준을 충족시키는 것으로 나타나 모바일환경에서의 삶의 질의 측정모형으로 적합한 것으로 판단되었다. 부가적으로 이동통신이용 만족집단이 불만족 집단보다 여가문화, 기능성과 관련한 삶의 질 수준이 더 높다는 것과 남자가 여자보다 이동통신이용 만족도와 기능성측면에 있어서의 삶의 질에 더 관계있음을 보여주었다. 이와 같은 연구결과는 모바일환경에서 삶의 질의 구성요소와 측정모형을 체계적으로 분석하고 잠재변수(구성개념construct)들을 측정하기 위한 새로운 척도들을 개발했다는 점에서 의의가 있다. 향후 개발된 측정모형을 기반으로 다양한 평가와 적용이 수행될 필요성이 있다. 본 연구는 모바일환경에서 주관적 삶의 질을 과학적이고 경험적으로 측정한 척도를 제공함으로써 정보화의 궁극적인 목표인 기술적 진보와 삶의 질 향상 간의 균형이 유지되도록 삶의 질 수준이나 가치를 지속적으로 파악하는데 유의미한 시사점을 주고 있다. The article defines a concept of life quality and tests a validity of measurement method in a mobile-environment. The concept of life quality is defined as a subjective quality of life, which is measured in terms of the person-environment fit. The scale of measurement consists of 8 dimensions of life quality and 38 measurement items. The assessment of construct validity is performed through the confirmatory factor analysis which utilizes AMOS 5.0. I produce the Cronbach a-reliability coefficient in order to comprehend a validity and a consistence between indexes. I use the two-way ANOVA to test differences of life quality between sex and a fulfillment of mobile user. I can summarize results as followings. First, the elements of life quality in the mobile-environment consist of sociality, leasureㆍculture, function, security, economy, health and autonomy. Second, the total fit index satisfies the assessment standard. In addition, the satisfactory group is higher in the quality of life related to the leasureㆍculture and the function than the unsatisfactory group, and men's group is higher in the quality of life related to the fulfillment and the function than women's. This article finds out new scales and constructing elements of life quality. The developed measurement model can be applied to assessments to general relations between a quality of life and a mobile environment. The thesis has an important significance in that it seeks for a balance between a technological progress of informationization and an improvement of life quality as providing the scales to measure scientifically and empirically the subjective quality of life in the moble.

수술 후 암 재발 판정에 있어서 전신 F - 18 FDG - PET의 유용성

고창순(Chang Soon Koh),이명철(Myung Chul Lee),정준기(June Key Chung),이동수(Dong Soo Lee),강원준(Won Jun Kang),정재민(Jae Min Jeong),소영(Young So),곽철은(Cheol Eun Kwark),강순범(Soon Beum Kang),정희원(Hee Won Jung),김광현(Kwang Hyu 대한핵의학회 1997 핵의학 분자영상 Vol.31 No.3

N/A he purpose of this study was to evaluate the usefulness of whole body F-18 FDG PET scan for deceting postoperative recurrence of cancer. One hundred four cancer patients after operation were enrolled(l4 brain tumor, 15 head and neck cancer, 23 gynecologic cancer). Besides conventional images(CI) including CT and MRI, F-18 FDG PET scan was obtained on ECAT EXACT 47 scanner(Siemens-CTI), beginning 60 minutes after injection of 370MBq(10mCi) of F-18 FDG. Regional scan was also obtained with emission image. Transmission images using Ge-68 were carried out for attenuation correction in both whole body and regional images. Findings of PET and CI were confirmed by pathology or clinical follow up. The sensitivity and specificity of PET for detecting recurrence were 94% and 92%, respectively. Contrarily, the sensitivity and specific it of CI were 78% and 68% CI results were negative and PET results were positive in 11 cases. The biopsy or clinical follow-up of those cases confirmed recurrence of tumor. False negative cases of CI were frequent in patients with gynecologic cancers. Also we measured the Serum concentration of tumor markers in patients with gynecologic cancer(CA125), thyroid cancer(thyroglobulin), and colorectal cancer(CEA). The sensitivity and specificity of tumor markers were 71% and 84%, respectively. We conclude that F-18 FDG PET can be used valuably in detecting recurrent foci of a wide variety of malignancy compared to conventional diagnositic methods.

패혈증 환자에서 Ranitidine의 투여가 T-림프구 및 그 아형에 미치는 영향

조영현(Young Hyun Cho),하우송(Woo Song Ha),박순태(Soon Tae Park),홍순찬(Soon Chan Hong),한호성(Ho Seong Han),제정인(Jung In Je),김상범(Sang Beum Kim),김상범(Sang Beum Kim),이옥재(Ok Jae Lee) 대한외과학회 1993 Annals of Surgical Treatment and Research(ASRT) Vol.45 No.5

Feitility Evaluation of Upland Fields by Combination of Landscape and Soil Survey Data with Chemical Properties in Soil

( Soon Dal Hong ),( Jai Joung Kim ),( Kyong Beum Min ),( Bo Goo Kang ),( Hyun Ju Kim ) 한국토양비료학회 2001 한국토양비료학회 학술발표회 Vol.2001 No.-

山楂가 흰쥐의 식이성 高脂血症에 미치는 영향

권순혁(Soon Hyuk Kwon),김정범(Jeung Beum Kim) 한의병리학회 2010 동의생리병리학회지 Vol.24 No.1

Aqueous extract of Lycii fructus suppresses inflammation through the inhibition of nuclear factor kappa B signal pathway in murine raw 264.7 macrophages

Kim, Beum-Seuk,Lim, Hyung-Ho,Song, Yun-Kyung,Sung, Yun-Hee,Kim, Sung-Eun,Chang, Hyun-Kyung,Shin, Mal-Soon,Kim, Chang-Ju,Lee, Hye-Jung,Kim, Dong-Hee Kyung Hee Oriental Medicine Research Center 2010 Oriental pharmacy and experimental medicine Vol.10 No.3

Lycii fructus is the fruit of Lycium chinense Miller and is part of the Solanaceae family. Lycii fructus produces various effects such as hypotensive, hypoglycemic, anti-pyretic, and anti-stress activities. Lycii fructus is known to contain betaine, carotene, nicotinic acid, zeaxanthin, and cerebroside. In the present study, the effects of Lycii fructus aqueous extract on lipopolysaccharide (LPS)-induced inflammation in murine raw 264.7 macrophage cells were investigated. In this study we utilized the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, reverse transcriptionpolymerase chain reaction (RT-PCR), Western blotting, and nitric oxide (NO) detection. Lycii fructus aqueous extract suppressed NO production by inhibiting the LPS-induced expressions of inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-$\alpha$) mRNA and iNOS protein in murine raw 264.7 macrophage cells. Also, Lycii fructus aqueous extract suppressed the activation of nuclear factor-kappa B (NF-${\kappa}B$) in the nucleus. These results demonstrated that Lycii fructus aqueous extract causes an anti-inflammatory effect that was likely produced by the suppression of iNOS expression through the down-regulation of NF-$\hat{e}B$ binding activity.