Teratogenicity of Antiepileptic Drugs

Betül Tekin Güveli,Rasim Özgür Rosti,Alper Güzeltaş,Elif Bahar Tuna,Dilek Ataklı,Serra Sencer,Ensar Yekeler,Hülya Kayserili,Ahmet Dirican,Nerses Bebek,Betül Baykan,Ayşen Gökyiğit,Candan Gürses 대한정신약물학회 2017 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.15 No.1

Objective: Antiepileptic drugs (AED) have chronic teratogenic effects, the most common of which are congenital heart disease, cleft lip/palate, urogenital and neural tube defects. The aim of our study is to examine teratogenic effects of AED and the correlation between these malformations and AED in single or multiple pregnancies. Methods: This is a retrospective study of malformations in children born to mothers currently followed up by our outpatient clinics who used or discontinued AED during their pregnancy. Their children were then investigated using echocardiography, urinary ultrasound, cranial magnetic resonance image, and examined by geneticists and pediatric dentists. Results: One hundred and seventeen children were included in the study. Ninety one of these children were exposed to AED during pregnancy. The most commonly used AED were valproic acid and carbamazepine in monotherapy. The percentage of major anomaly was 6.8% in all children. Dysmorphic features and dental anomalies were observed more in children exposed especially to valproic acid. There were 26 mothers with two and four mothers with three pregnancies from the same fathers. No correlation was found between the distribution of malformations in recurring pregnancies and AED usage. Conclusion: Our study has the highest number of dysmorphism examined in literature, found in all the children exposed to valproic acid, which may account for the higher rate of facial dysmorphism and dental anomalies. On lower doses of valproic acid, major malformations are not seen, although the risk increases with polytherapy. Our data also indicate possible effects of genetic and environmental factors on malformations.

Electron beam treatment for eliminating the antimicrobial activity of piperacillin in wastewater matrix

László Szabó,Orsolya Gyenes,Júlia Szabó,Krisztina Kovács,András Kovács,Gabriella Kiskó,Ágnes Belák,Csilla Mohácsi-Farkas,Erzsébet Takács,László Wojnárovits 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.58 No.-

Effluents of wastewater treatment plants represent critical control points for antibiotic resistancemanagement. To meet strict regulations coming into effect in the future advanced technologies need tobe implemented that can remove the factors contributing to the development of resistance in receivingnatural environments. By performing microbiological assays we show that electron beam treatment of acomplex synthetic effluent wastewater matrix is able to eliminate one of these factors, the antimicrobialactivity of the b-lactam antibiotic piperacillin present at environmentally relevant concentration. SinceOH governs the antibacterial inactivation the technology needs to be designed to the stoichiometricpresence of OH.

Construction of The Culture in Turkish Television Advertisements

Betül Çanakpınar 고려대학교 응용문화연구소 2023 에피스테메 Vol.- No.29

Communication provides an understanding of the culture of a society and the symbols, values, and norms within that culture. It is aimed to persuade the target audience by making use of cultural signs in advertisements, which are one of the communication methods. Therefore, the cultural codes of the society in which individuals live are placed in advertisements. While advertisements are influenced by culture, they also influence culture. Advertisements can reflect the cultural characteristics of the society as well as their power to influence and direct societies. In this sense, as advertisements are mirrors of society, they should reflect the culture accurately in order to be successful. Based on the idea that advertising is a cultural sign, in this study, the way culture is presented in advertisements is examined. For this purpose, how the cultural values and norms of Turkish society are presented in advertisements and how they are placed in advertisement texts are emphasized. In this context, ‘Kent Advertisement of Bairam’, which emphasizes the values of Turkish society, was selected and examined. It was emphasized which cultural elements were included in this commercial, and how these elements and characters were positioned. In the advertisement, which was analyzed with the method of cultural semiotics, it was seen that the cultural elements were presented successfully and the characters in the advertisement were positioned in accordance with Turkish culture.

Turkish Version of Kolcaba's Immobilization Comfort Questionnaire: A Validity and Reliability Study

Betül Tosun,Ozlem Aslan,Servet Tunay,Aygül Akyüz,Hüseyin Ozkan,Dogan Bek,Semra Açıksoz 한국간호과학회 2015 Asian Nursing Research Vol.9 No.4

Purpose: The purpose of this study was to determine the validity and reliability of the Turkish version of the Immobilization Comfort Questionnaire (ICQ). Methods: The sample used in this methodological study consisted of 121 patients undergoing lower extremity arthroscopy in a training and research hospital. The validity study of the questionnaire assessed language validity, structural validity and criterion validity. Structural validity was evaluated via exploratory factor analysis. Criterion validity was evaluated by assessing the correlation between the visual analog scale (VAS) scores (i.e., the comfort and pain VAS scores) and the ICQ scores using Spearman's correlation test. The Kaiser-Meyer-Olkin coefficient and Bartlett's test of sphericity were used to determine the suitability of the data for factor analysis. Internal consistency was evaluated to determine reliability. The data were analyzed with SPSS version 15.00 for Windows. Descriptive statistics were presented as frequencies, percentages, means and standard deviations. A p value .05 was considered statistically significant. Results: A moderate positive correlation was found between the ICQ scores and the VAS comfort scores; a moderate negative correlation was found between the ICQ and the VAS pain measures in the criterion validity analysis. Cronbach a values of .75 and .82 were found for the first and second measurements, respectively. Conclusions: The findings of this study reveal that the ICQ is a valid and reliable tool for assessing the comfort of patients in Turkey who are immobilized because of lower extremity orthopedic problems.

Diagnostic difficulties by the unusual presentations in children and adolescents with Hashimoto thyroiditis

Betül Ersoy,Kiremitçi Yılmaz Seniha,Deniz Kızılay,Münevver Yılmaz,Şenol Coşkun 대한소아내분비학회 2016 Annals of Pediatirc Endocrinology & Metabolism Vol.21 No.3

Complex clinical presentation with diverse timing of particular symptoms may cause diagnostic difficulties, especially in children and adolescents. This paper presents diagnostic difficulties and pitfalls in 3 children with acquired primary hypothyroidism due to Hashimoto’s thyroiditis (HT) presenting with unusual manifestations. We described 3 children with acquired primary hypothyroidism due to HT. One of our patients had musculoskeletal pain and was diagnosed and treated as having connective tissue disease. Another patient presented with chest pain, dyspnea, and swelling in the abdomen. She had a massive pericardial effusion (PE). Two patients had severe growth failure. A third patient with Down syndrome had a small PE. Her complaint was dyspnea during sleep. All patients improved with thyroxin therapy. Patients with hypothyroidism due to HT who have complicated clinical manifestations were misdiagnosed and mismanaged at childhood and adolescence. Growth failure is an important sign in children and adolescents. In the presence of complicated manifestations in children and adolescents, thyroid dysfunction must be considered in differential diagnosis.

Lipolytic Changes in Fermented Sausages Produced with Turkey Meat: Effects of Starter Culture and Heat Treatment

Betül Karsloğlu,Ümran Ensoy Çiçek,Nuray Kolsar,Kezban Candoğan 한국축산식품학회 2014 한국축산식품학회지 Vol.34 No.1

In this study, the effects of two different commercial starter culture mixes and processing methodologies (traditional andheat process) on the lipolytic changes of fermented sausages manufactured with turkey meat were evaluated during process-ing stages and storage. Free fatty acid (FFA) value increased with fermentation and during storage over 120 d in all fer-mented sausage groups produced with both processing methodologies (p<0.05). After drying stage, free fatty acid values oftraditional style and heat processed fermented sausages were between 10.54-13.01% and 6.56-8.49%, respectively. Thiobar-bituric acid (TBA) values of traditionally processed fermented sausages were between 0.220-0.450 mg·kg-1, and TBA val-ues of heat processed fermented sausages were in a range of 0.405-0.795 mg·kg-1. Oleic and linoleic acids were predominantfatty acids in all fermented sausages. It was seen that fermented sausage groups produced with starter culture had lowerTBA and FFA values in comparison with the control groups, and heat application inhibited the lipase enzyme activity andhad an improving effect on lipid oxidation. As a result of these effects, heat processed fermented sausages had lower FFAand higher TBA values than the traditionally processed groups.

Effects of raster angle on tensile and surface roughness properties of various FDM filaments

Betül Gülçimen Çakan 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.8

Parts produced by FDM (fused deposition modelling) technique, where polymer filaments are used, are anisotropic and their properties vary depending on the printing parameters, one of which is raster angle. In this study, the effects of this parameter on the tensile and the surface roughness properties were investigated. It was determined that the ultimate tensile strength (UTS) decreased with increasing raster angle; hence, 0° raster angle where tensile loading direction is parallel to the raster yielded the highest strength. Besides ±45° raster angle resulted the most ductile behaviour with the highest fracture strains. Fracture occurred due to raster failure for 0° raster angle but for 90° raster angle, it was due to the failure of the interlayer raster bonds. In the case of ±45°, both of the failure mechanisms were effective. Surface roughness values increased up to 7 µm when measurement was perpendicular to the raster and dropped below 1 µm when it was parallel to the raster.

Physico-chemical Properties and In vitro Cellular Response of Electrospun Polyurethane Nanofibers Enriched with Copper Chloride and Natural Fish Head Powder

Betül Çelebi-Saltik,Zeynep Haciomeroglu,Didem Kart,Hasan Hüseyin Ünal,Mustafa Özgür Öteyaka 한국섬유공학회 2022 Fibers and polymers Vol.23 No.11

Tissue engineering strategies include successful management of bone injuries with biomaterials to develop bonelikestructures. The production of natural biomaterials for this purpose helps both to ensure tissue integrity and to presentalternative products for clinical purposes. However, natural materials are mostly used together with synthetic or metallicmaterials due to their low stability and mechanical properties for bone tissue regeneration. There is a clinical need formaterial combinations that have both antimicrobial properties and the ability to increase osteogenic induction. This workaims to fabricate a nanofiber scaffold using polyurethane (PU) loaded with natural fish head powder (FHP) fromArgyrosomus regius species and copper (II) chloride (CuCl2) using the electrospinning technique in order to respond to thisclinical need. There has not been any material combination in the literature that contains these compounds, supports bonedifferentiation of stem cells, and prevents bacterial adhesion. To evaluate our composite materials morphology, chemicalstructure, wettability, and thermal analysis were studied with different techniques. Anti-adhesive properties of theStreptococcus mitis (S. mitis) on composite materials were tested with bacterial colonization, and osteogenic inductiveproperties by human bone marrow mesenchymal stem cells (hBMSCs) with and without osteogenic differentiation mediumwere performed with cell viability assay, Alizarin Red staining, Ca deposition and SEM analysis. According to FESEM-EDSand ATR_FTIR data, the additives were highly incorporated into the PU nanofibers. The produced materials had randomlyoriented nanofiber with a porosity of ~72 %. The FHP loaded nanofiber had an average diameter of ~185 nm. The swellingbehavior of FHP-loaded PU roughly decreased for 3, 5, and 7 days due to the hydrophobic character of the sample. Anincreasing percentage of FHP decreased the bacterial colonization of S. mitis. PUn-CuCl2-FHP nanofibers did not exhibit anycytotoxic effect on the hBMSCs. According to Alizarin Red Staining and Ca deposition analysis, stimulation with both thematerial and the osteogenic medium triggered the bone differentiation of the hBMSCs in a combined manner at days-14. Based on the results, it can be deduced that natural fish head is a promising additive material for fabricating bone-likebiomaterials.

Structure Optimization with Metaheuristic Algorithms and Analysis by Finite Element Method

Betül Üstüner,Erkan Doğan 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.1

In engineering, design is made by considering functionality, reliability, manufacturability, usability, and total cost. There are a wide variety of methods for design optimization. Metaheuristic methods inspired by nature are one of them. In this study, the Refinement firefly algorithm is proposed as a new method. Grey Wolf, Particle Swarm, and Firefly algorithms are compared with the proposed Refinement Firefly Algorithm. Mathematical benchmark problems are used to examine the performance of algorithms. Also, welded beam, cellular beam, and frame system designs are considered sample problems. These design examples are solved by algorithms and the sections are determined. The sections determined by optimization were analyzed using the ABAQUS CAE program and its reliability was examined. Numerical analysis with the finite element method is very useful as it provides realistic solutions. ABAQUS CAE is used to detect and show deformations in the structure. Finite element solution with ABAQUS solves the problems analytically and it is seen that the sections determined by the optimum design algorithm remain within the limits. The proposed Refinement Firefly algorithm demonstrates superior performance compared to the Firefly algorithm. However, it yields inferior results when compared to the Grey Wolf and Particle Swarm algorithms.

Erratum: Correction for the second author’s name Diagnostic difficulties by the unusual presentations in children and adolescents with Hashimoto thyroiditis

Betül Ersoy,Seniha Kiremitch Yilmaz,Deniz Kızılay,Münevver Yılmaz,Şenol Coşkun 대한소아내분비학회 2016 Annals of Pediatirc Endocrinology & Metabolism Vol.21 No.4