Increased 11β-hydroxysteroid dehydrogenase type 1 contributes to barrier dysfunction in aged skin

( Beom Jun Kim ),( Noo Ri Lee ),( Chung Hyeok Lee ),( Young Bin Lee ),( Solam Lee ),( Hyun Jee Hwang ),( Eunjung Kim ),( Eung Ho Choi ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts inactive cortisone into cortisol, an active form, and is expressed by several tissues including the skin. Excessive active glucocorticoid (GC) deteriorates skin barrier function. Objectives: To find out if 11β-HSD1 affects on the barrier function in aged skin. Methods: We have performed human and in vivo studies. We measured cortisol in stratum corneum (SC) and oral epithelium of the elderly and young. Hairless mice were used for 11β-HSD1 immunohistochemistry staining of skin and measuring skin barrier function and serum cytokines. 11β-HSD1 knock-out (KO) mice and its wild-type were used for measuring lipid synthesis related enzyme. Results: Cortisol levels were elevated in SC and oral epithelium of the elderly rather than young. The 11β -HSD1 expression was increased in immunohistochemistry stain of aged mice skin. Aged mice showed decreased transepidermal water loss (TEWL) and SC hydration, and increased SC integrity than young. Serum inflammatory cytokines including interleukin-1α, -4, -10, -31 and tumor necrosis factor-α were increased in aged mice than young. The expressions of lipid synthesis related enzymes in epidermis were elevated in KO mice and topical 11β -HSD1 inhibitor applied mice. Conclusion: 11β-HSD1 expression is elevated in aged skin. It increases active GC and then deteriorates skin barrier function.

Insulation Coating of Fe–Si–Cr Soft Magnetic Powder by Selective Oxidation

Jae‑Young Park,Kwangsuk Park,Bosung Seo,Julien O. Fadonougbo,Tae‑Wook Na,Ki Beom Park,Hyeon‑Tae Im,Nong‑Moon Hwang,Hyung‑Ki Park 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7

This study examines the insulation coating technology of Fe–Si–Cr powder via selective oxidation annealing, which oxidizeselements selectively by controlling the oxidation potential. The study calculated the oxidation driving force of Fe, Si, andCr, and conducted a thermodynamic analysis of oxidation and reduction conditions according to temperature and oxidationpotential. Based on the results, a selective oxidation annealing was performed in an atmosphere in which Fe is reduced andonly Si and Cr are selectively oxidized. The oxidation potential was controlled through the partial pressure ratio of hydrogenand water vapor. The XPS analysis results confirmed that a Si and Cr complex oxide layer formed on the powder surfaceafter the selective oxidation annealing. Afterward, withstanding voltages were analyzed to evaluate the insulation property. Then, the withstanding voltage of the powder applying the selective oxidation annealing increased significantly comparedto that of the initial powder. Further analysis showed that the powder annealed in an air atmosphere had a significantly lowersaturation magnetic flux density than the initial powder, while the powder applying the selective oxidation annealing hadonly a slightly reduced saturation magnetic flux density.

왕우렁이(apple snails)의 생리ㆍ생태적 특성에 관한 연구

이상범,고문환,나영은,김진호 한국환경농학회 2002 한국환경농학회지 Vol.21 No.1

왕우렁이가 자연상태에 전파되어 서식되는 경로는 양식장의 배수시, 홍수로 인한 노지 양식장 붕괴 및 제초용 왕우렁이 입식에 의하여 이루어지고 있다. 왕우렁이의 생리적 특성을 보면 알 크기는 2.47 ㎜, 난괴크기는 1.8×4.3×0.94 ㎝, 알무게 12.78 ㎎, 산란수 157∼784개/1마리(평균 321개/마리) 유체크기 1.69×2.15㎜, 유체 무게 3.32㎎ 최저 산란 왕우렁이 크기 2.40×2.26 ㎝ 이상, 1개알 산란소요시간 22.4초 였다. 알의 색변화는 산란직후 우유빛의 연분홍에서 중기에는 선홍색, 부화직전에는 흐린 연보라색으로 변화하면서 부화된다. 왕우렁이 섭식 대상은 벼, 논잡초, 미나리, 토마토, (양)배추, 무, 호박, 콩잎 등 대부분의 농작물을 포함한 식물체 및 동족의 왕우렁이 등 수중동물이었다. 왕우렁이 월동지역은 장항, 장성 및 해남지역으로 양지녘의 식물체 줄기나 벼 그루터기에 산란된 알과 성체 상태로 저수지나 논의 물웅덩이에서 월동고, 5월 중순이후 수로의 벽이나 식물체 줄기에 산란하며 6월과 9월에 번식이 가장 왕성하였다. 서식지 수질특성은 변이 폭이 컸으나 pH가 7.07∼9.50 범위로 알칼리성에서 주로 번성하였다. 왕우렁이에 의한 벼 가해 양상중 바 발아초기에는 왕우렁이 크기에 관계없이 모두 벼싹을 가해하였고, 벼품종과 생육시기에 따라 차이가 있으며 어린묘 일수록 가해율이 높았으며, 이앙후 45일 벼(초장 약 73 ㎝)도 각고 3.3∼3.5 ㎝ 이상의 중형 왕우렁이는 가해하였다. This experiment was carried out to obtain some information about overwintering, physiological and ecological characteristics of apple snails. Another purpose of this experiment was to characterize an appetite for rice plants by apple snails and to elucidate their choice of fresh green ones (vegetables, some other crops, weeds in rice fields). The freshwater snails were found with higher population at sites abundant organic compounds such as plant debris and at regions with high temperature. They also prefer calcium-rich water. This is a naturally occurring process. Apple snails were exceptionally well-adapted to the south regions of Korea, especially Janghang, Jangseong and Haenam, even if the temperature of winter season is cold below 0℃. Apple snails were not very selective in their food choice and eat almost everything available in their environment. A snail have something called a radula in its mouth for grinding up its food. A apple snail also chews on fruits and young succulent plant barks. In case of reproduction, apple snails deposit about 157~784 (average of 321 eggs) milky white to pale orange colored eggs above the waterline. In approximately every 22.4 seconds a new egg appears. The total time needed to deposit a egg mass varies from 58 minutes~4 hours 13 minutes. Apple snails reproduct actively from May to June and from September to October. An appetite of apple snails for rice plants was the different depending on their size and growing stage for rice plants. Apple snails had a great appetite of rice plants as well as dropwort, tomato, cabbage, radish, aquatic plants etc. They preferred to eat young rice plants and drastically quit eating rice plants of over 40 cm in height. Thus considering the food preference of apple snail for various plants including rice, they were thought to be a potentially strong predator in fields, especially, at regions with warmer winter.

서울의 PPNG 발생 빈도(1991-1992)

김재홍,윤기범,박평원,김영진,전경민,김영태,김중환,곽호,구상완,송민석,유옥,지혜구,김동원,문상은,박영립,정승호,성범진,성순제,엄주용,황정열,이기홍,이주협,전태진 대한화학요법학회 1994 대한화학요법학회지 Vol.12 No.1

The prevalence of PPNG among pretreated gonorrhea cases isolated at the STD clinic of Choong-Ku Public Health Center in Seoul has been studied and reported annually since 1981. In 1991, 123 strains of N.gonorrhoeae were isolated, among which 58(47.1%) were PPNG. In 1992, 98 starains of N.gonorrhoeae were isolated, among which 51(52.0%) were PPNG. In all, 109(49.3%) strains were found to be PPNG among 221 strains isolated between 1991-1992. The prevalence of PPNG in Seoul showed increased tendency till 1989, thereafter, it has been stationary or slightly decreasing.

토당귀 종자의 형태적 특성과 발아와 입모율에 대한 저장방법,생장조절제 및 프라이밍 처리 효과

안희정,안복주,·김도현,·안영섭,·김영국,박춘근,이상원,·박충범·차선우,·송범헌, 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.1

This study was conducted to have basic and applied informations to establish the cultivation method and to improve the cultivation techniques of Angelica gigas Nakai through investigating the rates of germination and seedling establishment with treatment of plant growth regulator and seed priming. The germination rates of round shape seed were about 0.3~12% higher than those of parallel shape. The germination rates with different storage durations were increased at the level of 25oC and 4oC with the storage days, while they were clearly higher at -20oC compared to those at 4oC and 25oC without the storage durations. With the results of germination rates with treating of plant growth regulator and seed priming, their rates with the round shape seeds were comparatively higher about 6% than those with parallel shape seed and they were increased with increasing of the storage durations. The germination rates were generally appeared higher with GA3 than did those with seed priming. The highest germination rate was appeared at 50 ppm GA3 of plant growth regulator and at -0.5 MPa PEG6000 of seed priming. The germination rates?ㅤ ?ㅤ of Angelica gigas were different with different temperature, storage durations and the treatments of plant growth regulator and seed priming. These results could be used according to different cultivating conditions.

흰쥐의 원위콩팥단위내 칼슘결합단백질 (calbindin-D28k)에 관한 면역세포화학적 연구

김영희,김완영,김인범,한승호,오수자,차정호,김진 대한해부학회 1997 Anatomy & Cell Biology Vol.30 No.6

Chitosan 濾過 System을 利用한 새로운 中水道 工程의 開發과 溫泉水 淨化에 관한 硏究

김용범,백광욱,안병제,조영주,심재용 서울産業大學校 1994 논문집 Vol.39 No.1

각종 금속이나 중금속을 비롯하여 각종 오염물(SS, COD, BOD, CI 등)을 강력히 흡착제거하는 성능을 가진 chitosan(Cs)응집제와 여과사(SF) 및 활성탄 column(ACC)을 병용하여 hotel잡수와 온천사용수등의 정화실험을 행하여 생물학적 처리과정을 생략할 수 있는 사용수의 재활용 process(Fig. 1)를 개발하였다. 이 process에서 hotel 잡수의 경우 20ppm의 chitosan 투입으로 1차응집 처리하여 약 60%이상의 오염물을 제거한 후 여과사와 활성탄 column을 이용하여 최종적으로는 80~99%의 오염물을 제거할 수 있었다. 또한 온천수의 경우 20ppm의 chitosan 투입으로 1차응집 처리하여 약 50%이상의 COD와 BOD의 제거율을 달성할 수 있었다. 따라서 이러한 process를 산업현장에 적용할 경우 종전의 생물학적 공정을 생략하거나 소규모화하여 보다 간편하며 처리공간이나 경비등을 절감하면서도 사용수를 방류수 또는 재활용수 기준이내로 처리할 수 있음을 확인하였다. 본 연구는 수자원 보호나 수자원 재활용면에서 크게 기여 되리라 믿는다. A simplifid and economic process for recycling the used water discharged from a large scale residence(e. g. hotel and apartment etc.) was developed. The used water was purified through adsorption and flocculation of contaminants by chitosan at the first stage where the average removal rates of COD and BOD of the used water were found more than 60%. The previously treated water through flocculation by chitosan was subjected to filtration systems of a sand filter and an activated carbon column, and the average removal rates of COD and BOD were found more than 80%. The experimental results suggest that the biological process which is very popular in the treatment of the used water for the removal of COD and BOD can be omitted and expected to reduce a spacial and running expenditure. On the other hand, testing the used water discharged from hot springs with chitosan proves a possibility of development of a simple and economical process for the treatment of the used water to the criteria of recycled water quality without any addition of more complicated equipments and facilities.

객체지향 기법을 이용한 다중 스레드 프로그램 기법에 관한 연구

송기범,박영옥,이준 조선대학교 동력자원연구소 1995 動力資源硏究所誌 Vol.17 No.2

The Software which uses object-oriented method has the advantage of extensibility, independence and easy maintenance, but has the disadvantage of decrease of system performance. Object-oriented software provides parallel process of objects, and then to improve of system performance we categorize objects into active and passive ones and then use active one. Therefore we implement active and passive objects with object-oriented language, propose multi threaded programming method using thread library for real time process.

IS 인적자원 혁신의 영향 요인에 관한 사례 연구

이재범,고영호 서강대학교 경영학연구원 2002 서강경영논총 Vol.13 No.1

정보기술의 발전은 기업이 혁신적으로 비용을 감축하거나, 고객에게 전혀 다른 차원의 서비스를 제공할 수 있는 과거에 갖지 못했던 새로운 능력을 제공하고 있다. 이러한 기업에게 요구되는 정보 시스템(Information System : IS)의 새로운 능력들이 성공적으로 확보하기 위해서는 기업 IS 혁신 및 IS를 통한 경쟁적 우위의 확보를 위해서 IS 인적자원 혁신의 중요성이 강조되고 있다. 그러나 IS 연구는 전무한 실정이다. 따라서 본 연구는 조직 혁신, IS 혁신, 인적자원 혁신에 대한 문헌 연구를 통하여 IS 인적자원 혁신의 영향 요인을 도출하고, 이들 영향 요인들이 IS 인적자원 혁신과정에 어떠한 메커니즘을 통해 영향을 미치는지 나타낸다.

품질경영에 있어서의 다꾸지 방법과 VTA 방법에 관한 연구

金容範 忠州大學校 1998 한국교통대학교 논문집 Vol.33 No.1

As new methods for off-line quality control, Taguchi and VTA methods are presented. Taguchi methods using experimental design and VTA methods using regression analysis are studied and compared with each other in terms of parameter design and tolerance design. Also, an example of calculating tolerance interval for the given defect rate in ppm are introduced in this study.