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- 저자 : Benlin (검색결과 4 건)
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Clinical Grading System, Surgical Outcomes and Prognostic Analysis of Cranial Base Chordomas
Wang, Benlin,Tian, Fengxuan,Tong, Xiaoguang The Korean Neurosurgical Society 2022 Journal of Korean neurosurgical society Vol.65 No.3
Objective : Cranial base chordomas are rare, but their treatment is challenging. Tumor recurrence is still common despite improvements in microsurgical techniques and postoperative radiotherapy. We retrospectively analyzed the course of treatment, overall survival, and recurrence/progression of chordomas over the past 10 years. Methods : We retrospectively reviewed 50 patients who underwent surgery at Tianjin Huanhu Hospital between 2010 and 2020 and were pathologically diagnosed with chordomas. Tumor resection was performed within the maximum safe range in all patients; the extent of resection was evaluated by imaging; and the incidence of complications, recurrence or progression, and overall survival were assessed. Results : Fifty patients were divided into the low-risk group (LRG) and high-risk group (HRG) based on the cranial chordoma grading system (CCGS). The Karnofsky Performance Scale scores and gross total resection rate of the LRG were significantly higher than those of the HRG (p<0.05). The incidence of complications and mortality in the LRG were lower than those of HRG. The analysis of cumulative survival and cumulative recurrence free survival/progression free survival (RFS/PFS) showed no statistical differences in the extent of resection for survival, recurrence, or progression. Univariate and multivariate analyses showed that Ki-67 was significantly associated with tumor recurrence and was an independent hazard factor (p=0.02). Conclusion : The CCGS can help neurosurgeons anticipate surgical outcomes. Pathological results are important in evaluating the possibility of tumor recurrence, and postoperative radiotherapy improves overall survival and RFS/PFS.
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Wang, Benlin,Li, Qi,Sun, Yang,Tong, Xiaoguang The Korean Neurosurgical Society 2022 Journal of Korean neurosurgical society Vol.65 No.3
Objective : The clinical management paradigm of skull base chordomas is still challenging. Surgical resection plays an important role of affecting the prognosis. Endonasal endoscopic approach (EEA) has gradually become the preferred surgical approach in most cases, but traditional transcranial surgery cannot be completely replaced. This study presents a comparison of the results of the two surgical strategies and a summary of the treatment algorithms for skull base chordomas. Methods : We retrospectively analyzed the surgical outcomes and follow-up data of 48 patients with skull base chordomas diagnosed pathologically who received transnasal midline approaches (TMA) and transcranial lateral approaches (TLA) from 2010 to 2020. Results : Among the 48 patients, 36 cases were adopted TMA and 12 cases were performed with TLA. In terms of gross total resection (GTR) rate, 27.8% in TMA and 16.7% in TLA and with EEA alone it was increased to 38.9%, while 29.7% in primary surgery. In TMA, the cerebrospinal fluid (CSF) leak remains the most common complication (13 cases, 36.1%), other main complications included death, cranial nerve palsy, hypopituitarism, all the comparisons were no statistical significance. The Karnofsky Performance Scale scores in TMA were all better than those in TLA at different time, and the overall survival (OS) and recurrence free survival/progression free survival was just the reverse. Conclusion : The EEA for skull base chordomas resection has improved the GTR rate, but transcranial approach is still an alternative approach. It is necessary to select an appropriate surgical approach based on the location and the pattern of tumor growth in order to obtain the best surgical outcomes.
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Adsorption and separation of lignin-based aromatic aldehydes using macroporous resins
Zhen Wu,Lei Hu,Ning Xu,Benlin Dai,Jiaxing Xu 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.7
Lignin-based aromatic aldehydes (p-hydroxybenzaldehyde, vanillaldehyde and syringaldehyde) have wide applications in flavoring. However, their separation using chromatographic methods has not been explored. We studied the adsorption and desorption behaviors of aromatic aldehydes on macroporous resins and four macroporous resins X-5, CAD-40, AB-8 and D101 were screened for separation of aromatic aldehydes. The results demonstrated that X-5 showed the highest adsorption and desorption capacities. The adsorption capacities for p-hydroxybenzaldehyde, vanillaldehyde and syringaldehyde on X-5 were 33.5mg/g, 46.6mg/g and 47.0mg/g at 20 oC, respectively, higher than that of CAD-40, AB-8 and D101. Adsorption isotherms of aromatic aldehydes on X-5 were confirmed to fit to Freundlich equation which was calculated by lnQe=0.6933lnCe+6.788, lnQe=0.7031lnCe+7.7358 and lnQe=0.7107lnCe+ 8.2412 for p-hydroxybenzaldehyde, vanillaldehyde and syringaldehyde, respectively. The results of dynamic adsorption and desorption experiments demonstrated that 50% (v/v) ethanol solution was an effective elution solvent for aromatic aldehydes. The maximum concentration of the three kinds of aromatic aldehydes in eluent reached 3.74 g/L, 5.44 g/L and 7.03 g/L, which indicated that the elution process was also an effective enrichment process for sorbate.
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Xiaoyan Liu,Jinshun Lv,Jiaxing Xu,Jun Xia,Benlin Dai,Xiangqian Xu,Jiming Xu 한국식품과학회 2017 Food Science and Biotechnology Vol.26 No.4
Mutants of Yarrowia lipolytica with high erythritol production were generated through an atmospheric and room temperature plasma (ARTP) mutation system. Among these mutants, Y. lipolytica M53 exhibited the highest erythritol yield. In a batch culture, M53 produced 64.8 g/L erythritol from 100 g/L glycerol. The yields of byproducts (e.g. mannitol, arabitol, and a-ketoglutaric acid) were low, and the mechanisms underlying these changes were examined by measuring enzyme activities in the pentose phosphate pathway. Up to 145.2 g/L erythritol was produced by M53 from 200 g/L of glycerol, and erythritol accumulation was promoted by 3.7 mg/L of Cu2?, 10.15 mg/L of Mn2?, and 30.37 g/L of NaCl. Fed-batch cultivation of M53 in a 5-L fermentor produced 169.3 g/L erythritol with low levels of byproducts within 168 h. This finding confirmed the potential of M53 as an erythritol producer on a commercial scale.
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