Association of triclosan and human infertility: A systematic review

Belen Daza-Rodriguez,Dilia Aparicio-Marenco,Johana Marquez-Lazaro 환경독성보건학회 2023 환경독성보건학회지 Vol.38 No.2

Poster Session : PS 0124 ; Cardiology : Riser Blood Pressure Pattern and Sleep Apnea-Hypopnea Syndrome: Prevalence and Comorbidity

( Belen Roig Espert ),( Juan Jose Tamarit Garcia ),( Carmen Ricart Olmo ),( Pedro Rollan Garcia ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

Objective: Determine the prevalence and morbidity of sleep apnea-hypopnea syndrome (SAHS) in hypertensive patients with riser pattern. Methods: Were selected the fi rst 100 consecutive patients valued, from January 1 2013, into the hypertension doctor`s offi ce of two hospitals. Inclusion criteria: Being hypertensive with a riser pattern at the ambulatory blood pressure monitoring. The diagnosis of SAHS was performed by polysomnography in patients with riser pattern. As an comorbidity we considered: obesity, hypercholesterolemia, smoking, heart failure, ischemic heart disease, ischemic cerebrovascular disease, peripheral artery disease and renal disease. Results: We reviewed 897 hypertensive patients until arrived to the fi rst 100 patients with a riser pattern. Of them: - SAHS: 83 - Mean age: 71 ± 16.7 - Men: 75 - Years of evolution of hypertension: 8.4 - Body mass index: 29.04 (CI 27.62-31.02) - Total cholesterol: 236 (95% CI 213-254) - Smokers: 32% - Comorbidity 72%: dyslipidemia 60%, type 2 diabetes mellitus 32%, benign prostatic hyperplasia 24%, left ventricular hypertrophy 16%, microalbuminuria 13%, ischemic heart disease 12%, transient ischemic attack 9% - Risk by SCORE: normal 8%, light20%, moderate 16%, high 48%, very high 8% - Erectile dysfunction: 36% Conclusions: We detected a prevalence of SAHS fi ve times higher among hypertensive patients than in the general population and especially in patients with riser pattern. Those patients have been associated higher incidence of cardiovascular effects. We can say that maintaining a high suspicion of SAHS, will lead to an early diagnosis and therefore better treatment of hypertension. The existence of SAHS entails greater comorbidity, SAHS is considered as an independent vascular factor risk for angina and peripheral artery disease. Therefore maintaining a high suspicion of this disease would lead to early treatment to prevent the onset of these cardiovascular events.

Therapeutic effect of the immunomodulatory drug lenalidomide, but not pomalidomide, in experimental models of rheumatoid arthritis and inflammatory bowel disease

Belen Lopez-Millan,Rafael Diaz de la Guardia,Heleia Roca-Ho,Carmen M García-Herrero,Jessie R Lavoie,Michael Rosu-Myles,Elena Gonzalez-Rey,Francisco O’Valle,Gabriel Criado,Mario Delgado,Pablo Menendez 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

Thalidomide is an immunomodulatory drug (IMiD) with proven therapeutic action in several autoimmune/inflammatory diseases; however, its inherent high toxicity has led to the development of more powerful and safer thalidomide analogs, including lenalidomide and pomalidomide. These are new generation IMiDs that exhibit direct antitumor activity as well as anti-inflammatory/immunomodulatory properties, and are FDA-approved for the treatment of several hematological malignances. Here we investigated the potential therapeutic effects of lenalidomide and pomalidomide in several experimental murine models of autoimmune/inflammatory diseases: 2,4,6-trinitrobenzene sulfonic acid- and dextran sulfate sodium-induced inflammatory bowel disease and type II collagen-induced arthritis. Lenalidomide displayed a strong therapeutic effect in all these models of autoimmune/inflammatory diseases, while the effect of pomalidomide was less pronounced. In vitro experiments confirmed the immunosuppressive effect of both IMiDs on the proliferative response of stimulated human lymphocytes and on the balance of secreted cytokines toward an anti-inflammatory profile. We conclude that lenalidomide may offer a therapeutic opportunity against autoimmune/inflammatory diseases.

Recent Developments in the EU Investment Policy : Towards an Investment World Court?

Belen Olmos Giupponi 한국중재학회 2016 중재연구 Vol.26 No.3

The controversies that have surrounded the negotiation of both the Comprehensive Economic and Trade Agreement (CETA) and the Transatlantic Trade and Investment Partnership (TTIP) have underlined the difficulties arising out from the adoption of a truly common EU investment policy. Non‐governmental organizations have called into question transparency and legitimacy of international investment arbitration during the negotiations. The article presents a reflection about current developments of the EU investment policy addressing, in particular, the criticisms towards the whole investor‐to‐State system and the EU’s efforts in developing a “tailor‐made” investment agreement and Investor‐to‐State Dispute resolution system. Along these lines, the article critically assesses the recently announced proposal for the establishment of an ‘Investment Court System’ put forward by the EU during the TTIP negotiations.

STATISTICAL A-SUMMABILITY OF DOUBLE SEQUENCES AND A KOROVKIN TYPE APPROXIMATION THEOREM

Belen, Cemal,Mursaleen, Mohammad,Yildirim, Mustafa Korean Mathematical Society 2012 대한수학회보 Vol.49 No.4

In this paper, we define the notion of statistical A-summability for double sequences and find its relation with A-statistical convergence. We apply our new method of summability to prove a Korovkin-type approximation theorem for a function of two variables. Furthermore, through an example, it is shown that our theorem is stronger than classical and statistical cases.

Removal of iron from an electrolytic solution rich in copper using selective hydrometallurgy

( Ana Belen Cueva-sola ),( Jungshin Kang ),( Jin-young Lee ),( Rajesh Kumar Jyothi ) 한국폐기물자원순환학회 2022 ISSE 초록집 Vol.2022 No.-

Current technological development towards a cleaner, greener energy sources and an increased consumption of electronic and electric devices are driving the continuous increase in the demand of metals such as copper and iron. Even though, in the foreseeable future there is no predicted shortage of copper, it is imperative to improve and optimize the recovery of copper from secondary sources in pro of the environment protection and the achievement of circular economy. Currently, non-ferrous metals such as copper obtained from secondary sources are meeting the demand of around 30% of the worldwide requirement. However, copper usually comes associated with iron. By using hydrometallurgical processes, these metals are recovered and separated as a part of a continuous effort to reduce the environmental burden of wastewater and recover valuable metals from waste. During this experimental study, an electrolytic solution rich in Cu²⁺ (~ 50 g/L) with a small concentration of Fe²⁺ (~ 2 g/L) was processed using liquid- liquid extraction. Various phosphorous (P) based commercial extractants D2EHPA, Cyanex 272 and PC 88A were evaluated to remove iron. The optimum conditions for extraction and stripping were derived and removal of iron with minimal copper loss (< 3%) was proposed in a variety of hydrometallurgical routes.

Leverage, Corporate Governance and Real Earnings Management: Evidence from Korean Market

Ana Belen Tulcanaza Prieto,이용환,구정호 사람과세계경영학회 2020 Global Business and Finance Review Vol.25 No.4

Purpose: This study examines how corporate governance (CG) and leverage simultaneously influence real earnings management (REM). Methodology: We employed CG score (CGS), total, short-term, and long-term debt ratios as independent variables, and REM metrics as dependent variables. We include ordinary least-squares (OLS) panel data regressions, residual test, and interaction analysis in our study. Findings: While a significant positive relationship existed between leverage and REM, CG had a negative effect on real manipulations. Our results from the interaction analysis and residual test show that CG is a key player in explaining the relationship between leverage and REM. We also find that firms with a low-level of CG were more likely to conduct REM activities than those with a high-level CG. Research limitations/implications: These results imply that the reduction in opportunistic behavior of managers in the presence of strong CG could decrease the leverage of firms and REM activities and improve the quality of their earnings. Moreover, shareholder rights and audit organizations were the prominent CG characteristics influencing REM activities, as they enforce additional monitoring of financial reporting quality and increase audit standards. CG strategies mitigate the corporate corruption scandals through the adoption of high-quality accounting and financial norms in reporting and management. Thus, executives decrease their incentives to conduct REM activities and leverage cannot be used freely as a mechanism to manipulate earnings, given firms’ leverage position is audited and reviewed by the financial committee in firms with strong CG. For future research, the authors suggest including the degree of leverage as a disaggregation sample and adding the degree of cost stickiness. Originality/value: Several s tudies have investigated e ither the relationship between ( 1) REM and leverage, or ( 2) REM and CG, including leverage as a control variable. Our study, extends this bilateral relationship to simultaneous relationship between leverage, CG, and REM. Moreover, we investigate the predominant CG characteristics that influence the association among leverage and REM. We conduct interaction analysis and residual effect to investigate if CG should be considered as a determinant variable in the recurrence of REM activities of managers. We include firms with high- and low- levels of CG to show which firms are leveraged.

STATISTICAL A-SUMMABILITY OF DOUBLE SEQUENCES AND A KOROVKIN TYPE APPROXIMATION THEOREM

Cemal Belen,Mohammad Mursaleen,Mustafa Yildirim 대한수학회 2012 대한수학회보 Vol.49 No.4

In this paper, we dene the notion of statistical A-summabil-ity for double sequences and nd its relation with A-statistical conver-gence. We apply our new method of summability to prove a Korovkin-type approximation theorem for a function of two variables. Furthermore,through an example, it is shown

Determinants of Stock Market Performance: VAR and VECM Designs in Korea and Japan

Ana Belen Tulcanaza Prieto,Younghwan Lee 사람과세계경영학회 2019 Global Business and Finance Review Vol.24 No.4

We examine commodities and macroeconomic factors of the Korean’ and Japanese’ stock market performance during the period of 1993-2017. Using both Kospi and Nikkei 225 as proxy for stock market performance, we designed a Vector Error Correction Model (VECM) which integrates the econometric model in the short- and long-run. We found that the Korean and Japanese stock market reflects both macroeconomic variables and commodity prices on stock price indices. Our results reveal that each stock market index, GDP growth, inflation rate, interest rate, exchange rate, crude oil WTI price, and gold price perform a cointegration in the long-term, suggesting that Kospi and Nikkei 225 are corrected in -19.6% and -39.6% in each quarter, respectively. In addition, GDP growth, interest rate, exchange rate, oil price, and gold price affect the Kospi short-run performance, while GDP growth, interest rate, and gold price affect Nikkei 225 in the short-term. Using impulse-response function and the variance decomposition, we identified that the most significant impulse on each stock market index is its own shock, and its magnitude declines from the short- to the long-run. Our results are mostly consistent with the experience of other countries, especially Turkey and India, meaning the stock market index has been particularly affected by its own past prices. Our paper complements the literature of corporate finance by comparing the determinants of stock market performance of two Asian countries, including different robustness tests to explain the effect on Kospi and Nikkei 225 of each independent variable. For future research, the authors suggest to include a dummy variable for structural changes to increase the power of the model.

Internal and External Determinants of Capital Structure in Large Korean Firms

Ana Belen Tulcanaza Prieto,이용환 사람과세계경영학회 2019 Global Business and Finance Review Vol.24 No.3

We examine the internal and external determinants of the capital structure of large Korean companies during the 2010-2017 period. Using total, short-term, and long-term debt ratios as proxies for capital structure, we found that both profitability and liquidity affect leverage negatively and significantly. These results are consistent with the experience of other nations, such as Malaysia, Pakistan, and Vietnam. We also show that both asset tangibility and firm size have a positive effect on long-term borrowings but a negative effect on short-term borrowings. These findings are aligned with observations from Pakistani and Vietnamese firms. The external determinants, however, show little statistical significance. Using an empirical approach simultaneously including both firm-specific and external determinants that influence the debt-equity choice for large companies listed on the Korea Exchange, our study complements the literature on corporate finance. For future research, we suggest including a dummy variable for structural changes (e.g. the world financial crisis) and measures of leverage dispersion and industry concentration to increase the power of the statistical models.