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Di, Bao-Shan,Wei, Kong-Ping,Tian, Jin-Hui,Xiao, Xiao-Juan,Li, Yan,Zhang, Xu-Hui,Yu, Qin,Yang, Ke-Hu,Ge, Long,Huang, Wen-Hui,Zhang, Fang-Wa Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
Background: Our aim was to conduct a meta-analysis to compare the efficacy and safety of pemetrexed and docetaxel for non-small cell lung cancer (NSCLC). Materials and Methods: We systematically searched the Cochrane Library, PubMed, Embase, China Biology Medicine Database for randomized controlled trials (RCTs) comparing the efficacy and toxicities of pemetrexed versus docetaxel as a treatment for advanced NSCLC. We limited the languages to English and Chinese. Two reviewers independently screened articles to identify eligible trials according to the inclusion and exclusion criteria and assessed the methodological quality of included trials, and then extracted data. The meta-analysis was performed using STATA12.0. Results: Six RCTs involving 1,414 patients were identified. We found that there was no statistically significant differences in overall response rate, survival time, progression-free survival, disease control rate, and 1-2yr survival rate (p>0.050) but it is worthy of mention that patients in the pemetrexed arms had significantly higher 3-yr survival rate (P=0.002). With regard to the grade 3 or 4 hematological toxicity, compared with docetaxel, pemetrexed led to lower rate of grade 3-4 febrile neutropenia, neutropenia, and leukocyts toxicity (p<0.001). There was no significant difference in anemia between the two arms (p=0.08). In addition, pemetrexed led to higher rate of grade 3-4 thrombocytopenia toxicity (p=0.03). As for the non-hematological toxicities, compared with docetaxel, pemetrexed group had lower rate of grade 3-4 diarrhea and alopecia. Conclusions: Pemetrexed was almost as effective as docetaxel in patients with advanced NSCLC. At the same time, pemetrexed might increase the 3-yr survival rate. As for safety, pemetrexed led to lower rate of grade 3-4 febrile neutropenia, neutropenia, leukocytes, diarrhea and alopecia toxicity. However, it was associated with a higher rate of grade 3-4 thrombocytopenia.
Di Chong,Bao Xiaohua,Jiang Wei,Xie Bao 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.1
Skewing techniques have been widely used in the feld of the design of diferent types of electrical machines, because it can help to reduce the torque ripple, mitigate the electromagnetic noise and vibration, etc. To model the skewing efects in the electrical machine design accurately, the fnite element method is appreciated in both the academia and industry. To achieve a fast modelling of skewing efects, a novel 2D based approach to estimate the electromagnetic performances in the whole speed range for variable-speed electrical machines has been proposed in this paper, which is further improved from the traditional multi-slice method. Firstly, a series of simulations at diferent loads will be run to get the electromagnetic performances for the variable-speed machines. Secondly, based on the multi-slice method, the performance on diferent slices can be predicted from the results obtained from the existing simulations by coordinate transform and interpolation directly and no more extra simulations are needed. Thirdly, taking a ferrite magnet assisted synchronous reluctance machine (FMaSynRM) with skewing as an example, the electromagnetic performances including electromagnetic torque, stator current and voltage, efciency map are compared in detail by both the proposed method and experiments.
Zhuang Bao-Jun,Xu Su-Yun,Dong Liang,Zhang Pei-Hai,Zhuang Bao-Lin,Huang Xiao-Peng,Li Guang-Sen,You Yao-Dong,Chen Di'Ang,Yu Xu-Jun,Chang De-Gui 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.4
The protein encoded by dynein axonemal heavy chain 1 (DNAH1) is a part of dynein, which regulates the function of cilia and sperm flagella. The mutant of DNAH1 causes the deletion of inner dynein arm 3 in the flagellum, leading to multiple morphological abnormalities of the sperm flagella (MMAF) and severe asthenozoospermia. However, instead of asthenozoospermia and MMAF, the result caused by the mutation of DNAH1 remains unknown. Here we report a male infertility patient with severe asthenozoospermia and teratozoospermia. We found two heterozygous mutations in DNAH1 (c.6912C>A and c.7076G>T) and which were reported to be associated with MMAF for the first time. We next collected and analyzed 65 cases of DNAH1 mutation and found that the proportion of short flagella is the largest, while the bent flagella account for the smallest, and the incidence of head deformity is not high in the sperm of these patients. Finally, we also analyzed 31 DNAH1 mutation patients who were treated with intracytoplasmic sperm injection (ICSI) and achieved beneficial outcomes. We hope our research will be helpful in the diagnosis and treatment of male infertility caused by DNAH1 mutation.
Bao, Xiaohua,Di, Chong,Fang, Yong The Korean Institute of Electrical Engineers 2016 Journal of Electrical Engineering & Technology Vol.11 No.1
Generally, closed slots are adopted to reduce the water friction loss in both the stator and the rotor of water filling submersible motor due to the special environment of operation. One of the obvious differences between the traditional induction motors and water filling submersible motors is that the submersible motors only need relatively smaller starting torque. This paper aims to analyze the slot leakage reactance of water filling submersible motor during starting transient operation. An improved analytical method which considered the magnetic saturation of the slot bridge and the skin effect of rotor bars is proposed. The slot permeance factor which has a direct impact on the slot leakage reactance is calculated. Then finite element models with different stator slot types are constructed and search coils are introduced to measure the slot flux linkage. Moreover, the starting performances of the models with two typical stator slots are compared and the flux leakage characteristics are obtained. Finally, the results obtained by finite element method are very close to the results obtained by analytical method.
Di Tang,Shiyi Bao,Binbin Lv,Hao Cui,Lijia Luo,Min Xu 대한기계학회 2019 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.33 No.6
Shedding vortices in cross flow are of much practical importance in the analysis of flow induced vibrations of a steam generator. However, studies of shedding vortex are still few in present, especially in shedding patterns and its influences on lift performances. In this paper, five basic shedding patterns were investigated by numerical simulations of a 2D unsteady flow around a bundle with 253 cylinders. The numerical results clearly demonstrated that flow in line is the most common pattern. On the hand, the other four shedding patterns, cross in line, cross near line near, cross near line far and cross far line near, appear randomly. Influences of shedding vortices on lift performances were concluded as lift enhancement, lift pit and lift lag. These numerical results can provide a basic knowledge of shedding vortices for cylinders and can precisely quantify their influences on unsteady lift performances.
Calculation of Electromagnetic Excitation Forces in Double Skewed Motors
Bao, Xiaohua,Di, Chong,Zhou, Yang The Korean Institute of Electrical Engineers 2018 Journal of Electrical Engineering & Technology Vol.13 No.2
An electromagnetic excitation force is caused by the air-gap flux density, which greatly influences the noise and vibration of the motor. In many real projects, skewed slot technology is widely used to reduce the harmonic components of the air-gap flux density to reduce the noise and vibration of the motor. However, a skewed slot has several side effects such as a transverse current and axial drifting. Thus, a double skewed slot rotor is selected with the aim of eliminating these side effects. This paper presents the exact structure of the double skewed slot rotor and the mechanism whereby the electromagnetic excitation force can be reduced. A multi-slice method is adopted to model the special structure. Finite element simulation is used to verify the theory.
Sihang Bao,Junzhen Di,Jianguo Yang,Donglin Wang,Juan Sun,Yanrong Dong 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.3
In view of the high content of Cu<SUP>2+</SUP> and Zn<SUP>2+</SUP> in acid mine drainage (AMD), the adsorption properties of lignite for Cu<SUP>2+</SUP> and Zn<SUP>2+</SUP> were studied. The adsorption performance of lignite for Cu<SUP>2+</SUP> and Zn<SUP>2+</SUP> was revealed by combining with FT-IR, XPS and EDS. The results showed that the adsorption kinetic model of lignite for Cu<SUP>2+</SUP> and Zn<SUP>2+</SUP> conformed to the quasi-first-order kinetic model. The isothermal adsorption line fitting models of lignite for Cu<SUP>2+</SUP> and Zn<SUP>2+</SUP> were in accordance with the Langmuir model and the Freundlich model, respectively. The maximum equilibrium adsorption capacities of lignite for Cu and Zn were 67.84 mg/g and 55.5 mg/g. The adsorption process of Cu<SUP>2+</SUP> and Zn<SUP>2+</SUP> by lignite involved electrostatic, coordination and ion exchange. Under the condition of coexistence of two kinds of ion, the adsorption site of lignite had stronger binding ability to copper ions.