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New Cytotoxic Benzopyrans from the Leaves of Mallotus apelta
Kiem Phan Van,Dang Nguyen Hai,Bao Ha Viet,Huong Hoang Thanh,Minh Chau Van,Huong Le Mai,Lee Jung Joon,Kim Young Ho The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.10
Two new benzopyrans 6-[1'-oxo-3'(R)-hydroxy-butyl]-5,7 -dimethoxy-2,2-dimethyl-2H-1-ben-zopyran (1) and 6-[1'-oxo-3'(R)-methoxy-butyl]-5,7 -dimethoxy-2,2-dimethyl-2H-1-benzopyran (2) were isolated from the leaves of Mallotus apelta Muell.-Arg., (Euphorbiaceae). Their chemical structures were elucidated by spectroscopic analyses, especially by 1D-, 2D-NMR and MS spectra. Compound 1 was found to have strong cytotoxic effect against two human cancer cell lines as human hepatocellular carcinoma (Hep-2, $IC_{50}\;:\;0.49\;{\mu}g/mL$) and rhabdosarcoma (RD, $IC_{50}\;:\;0.54\;{\mu}g/mL$), while compound 2 showed moderate activity against Hep-2 cell line ($IC_{50}\;:\;4.22\;{\mu}g/mL$) by in vitro assay.
New Cytotoxic Benzopyrans from the Leaves of Mallotus apelta
Phan Van Kiem,Nguyen Hai Dang,Ha Viet Bao,Hoang Thanh Huong,Chau Van Minh,Le Mai Huong,이정준,김영호 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.10
Two new benzopyrans 6-[1'-oxo-3'(R)-hydroxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (1) and 6-[1'-oxo-3'(R)-methoxy-butyl]-5,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran (2) were isolated from the leaves of Mallotus apelta Muell.-Arg., (Euphorbiaceae). Their chemical structures were elucidated by spectroscopic analyses, especially by 1D-, 2D-NMR and MS spectra. Compound 1 was found to have strong cytotoxic effect against two human cancer cell lines as human hepatocellular carcinoma (Hep-2, IC50: 0.49 µg/mL) and rhabdosarcoma (RD, IC50: 0.54 µg/mL), while compound 2 showed moderate activity against Hep-2 cell line (IC50, 4.22 µg/mL) by in vitro assay.