http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Serum Resistance in Riemerella anatipestifer is Associated with Systemic Disease in Ducks
Bai Wei,Hye-Suk Seo,Ke Shang,Jong-Yeol Park,Yea-Jin Lee,Yu-ri Choi,Sang-Won Kim,Se-Yeoun Cha,Hyung-Kwan Jang,Min Kang 한국가금학회 2021 韓國家禽學會誌 Vol.48 No.4
리메렐라 아나티페스티퍼 감염증은 오리와 거위에서 섬유소성 심막염, 간주위염증, 기낭염, 건락성난관염, 뇌막염을 특징으로 하는 급성 또는 만성 패혈증이다. 이 균은 혈청형 또는 분리주별로 병원성에 큰 차이가 나타나는 것으로 알려져 있다. 그럼에도 불구하고 지금까지 이러한 다양한 병원성과 그 이유에 대한 연구는 거의 이루어지지 않았다. 본 연구에서는 리메렐라 아나티페스티퍼의 병원성과 serum resistance 상관성을 구명하였다. 우리는 다양한 분리원으로부터 확보한 130주의 균주를 대상으로 serum resistance 특성을 분석하였다. 건강한 오리 인후두에서 분리된 균주들은 혈청에 대한 감수성이 높은 반면에 전신감염을 일으킨 균주들은 강한 serum resistance를 보였다. 또한 우리는 이러한 혈청의 살균효과가 혈청내 보체 성분에 의해 유도됨을 확인하였다. 강한 serum resistance를 유발하는 세균의 표면 유전자와의 관련성을 조사한 결과, 외막 단백질의 AS87_09335, AS87_00480, AS87_05195 유전자가 serum resistance와 관련 있음을 알 수 있었다. 본 연구 결과로 serum resistance 특성이 리메렐라 아나티페스티퍼의 병원성 결정 요소 중 하나라는 것을 확인하였다. Riemerella anatipestifer (RA) can cause septicemia, polyserositis, and ataxia in ducks. It can also colonize the upper respiratory tract of healthy ducks. These differences in pathogenicity are probably the result of diverse mechanisms of virulence in different strains. Since serum resistance is a feature frequently found in systemic pathogens, 130 RA strains having different clinical origins were tested. A variety of serum susceptibility levels were detected. Pharynx strains from healthy ducks were mainly susceptible to the bactericidal effect of the serum, while systemic strains were serum resistant. Heat-treatment of the sera abolished the bactericidal activity, indicating that complement is a key factor in this effect. In an attempt to associate serum-resistance to surface determinant genes of the bacteria, we screened for six genes involved in lipopolysaccharide synthesis and membrane proteins in RA. Of these, three genes (AS87_09335, AS87_00480, and AS87_05195) encoding outer membrane proteins might be implicated in serum resistance statistically. The results indicate that serum resistance is a virulence mechanism in RA.
기후변화 바탕으로 한 다중수원 Water Blending 및 수처리 플랜트 최적화
박한배 ( Han Bai Park ),임성일 ( Sung Il Lim ),이유리 ( Yu Ri Lee ),이종만 ( Jong Man Lee ),이학수,우달식 ( Dal Sik Woo ) 한국수처리학회 2015 한국수처리학회지 Vol.23 No.2
Rapid climate change by global warming effects has frequently affected intake water qualities in water treatment process. This study evaluated a coagulant reduction method using multiple water resource blending. In normal conditions defined by turbidity 0-25NTU, TOC 0-8mg/L, and NO3-N 1-8mg/L, PASC dose of 15mg/L was determined based on the jar test and the pilot test. While insufficient water quantity or degradation of water quality was measured, ground water was blended a front or back of sandfilter to satisfy water quality and quantity. In emergency condition defined by turbidity 25-400NTU, TOC over 8mg/L, NO3-N over 8mg/L, pH 6.5-8.0, and TDS over 100 mg/L, the coagulant dose was determined 17.4mg/L at turbidity 100NTU, 23.2mg/L at 130NTU and 29mg/L at 150NTU. From over 400NTU, coagulant dose did not degrade water quality enough for sandfiltration. By that point, ground water was blended in the blending tank in order to reduce water contaminant levels. All results were satisfied with quality purpose of drinking water production.
최누리,주병현,변형배,김동석,이병채,Choi, Noo-Ri,Ju, Byeong-Hyeon,Byun, Hyung-Bai,Kim, Dong-Seok,Lee, Byung-Chai 한국자동차공학회 2007 한국 자동차공학회논문집 Vol.15 No.2
We suggest a design method for reducing the number of spot welds in the vehicle body in terms of durability. To reduce the number of spot welds, we use the DOE(Design of Experiments) analysis with two influence indices for the durability and the fatigue life of a spot weld itself. Through the suggested design method, we select spot welds that could be removed without serious reduction of durability of the whole model. We apply this new methodology to the BIW(Body In White) model of a vehicle by choosing some practical parts where durability-related point of view must be considered importantly by experience.
임신중절에 대한 사회적 여건 변화에 따른 임신 중기 양수검사의 감소
전혜원 ( Hye Won Jeon ),이택상 ( Taek Sang Lee ),배광범 ( Kwang Bum Bai ),황규리 ( Kyu Ri Hwang ),김병재 ( Byung Jae Kim ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.12
목적: 임신중절에 대한 사회적 여건변화가 임신 중기 양수검사 수용에 미치는 영향을 알아보고자 하였다. 연구 방법: 2009년 2월 1일부터 2010년 8월 31일까지 외래에 방문한 임신 20주 미만의 단태임신 산모를 대상으로 의무기록을 후향적으로 조사하였다. 2009년 11월까지(2009년 군)와 그 이후 기간(2010년 군)의 양상을 비교하였고, 개인병원에서 의뢰된 산모와도 비교하였다. 결과: 임신중절이 엄격하게 제한되기 시작한 2009년 12월 이후 임신중기 양수검사 빈도가 이전의 19% (19/101)에서 11% (10/93)로 감소하였으나 통계적 차이는 없었다(P=0.16). 35세 이상인 산모에서는 2010년 군(5/30, 25%)이 2009년 군(15/30, 50%)보다 유의하게 양수검사 수용도가 낮았고(P=0.01), 선별검사에서 고위험군으로 양수검사를 권유 받은 경우를 포함하여 분석하였을 때에도 유의하게 낮았다(9/35, 26% vs 19/34, 56%; P=0.02). 개인병원에서 이상소견이 있었거나, 고령으로 양수검사를 권유 받아 의뢰된 35명의 산모에서는 2009년 군(15/21, 71%)에 비해 2010년 군(13/14, 93%)에서 양수검사를 시행하는 빈도가 오히려 증가하는 양상이었지만, 유의한 차이는 없었다(P=0.20). 결론: 임신중절에 대한 사회적인 여건의 변화로 염색체 이상 및 신경관결손증의 고위험군에서 양수검사를 수용하는 빈도가 유의하게 감소하였는데, 외부병원에서 의뢰된 경우에는 변화가 없었다. Objective: To investigate the effect of alteration of social conditions towards pregnancy termination on the acceptance of genetic amniocentesis. Methods: Retrospective review of medical records was conducted for women (<20 weeks` gestation, singleton pregnancy) who visited our outpatient department between February 1, 2009 and August 31, 2010. Acceptance of genetic amniocentesis was compared between two groups of women: one from February 1, 2009 to November 30, 2009 (2009 group) and the other from December 1, 2009 to August 31, 2010 (2010 group) after strict regulation of pregnancy termination. The acceptance rate of those who were referred to our center for genetic amniocentesis in same time period was also evaluated. Results: Overall, 19 of 101 (19%) women in the 2009 group and 10 of 93 (11%) in the 2010 group, opted for invasive diagnostic methods (P=0.16). Women > 35 years in the 2010 group (5/30, 17%) were less likely to accept genetic amniocentesis than 2009 group (15/30, 50%; P=0.01). Similar results were observed in those who were indicated for genetic amniocentesis. (9/35, 26% vs 19/34, 56%; P=0.02). Acceptance rate of genetic amniocentesis was increased for those who were referred from private clinic, but without statistical significance (15/21, 71% vs 13/14, 93%; P=0.20). Conclusion: After strict regulation of pregnancy termination, acceptance rate of genetic amniocentesis was significantly decreased among women who had increased risk for chromosomal abnormalities or neural tube defect at our center. Whereas, there were no significant change in acceptance rate for those who were referred for amniocentesis from private clinic.
권숙희,김영자,문길남,김인순,박금자,박춘화,배정이,송애리,여정희,정은순,정향미 동의대학교 기초과학연구소 1997 基礎科學硏究論文集 Vol.7 No.1
This study was done for the purpose of analyzing the relationship between menopausal symptoms and depression. Data was collected by a questionaire from November 28 to December 30, 1995. The subjects were 134 women between 40-61 years of age. The instruments used for this study were The Menopausal symptom scale by Neugartom and Depression scale by Zung. The results of the study were as follows. 1. Mean score of menopausal symptoms was 1.59. Mean score orders of experienced symptoms were $quot;$quot;Back pain and joint pain$quot;$quot;(2.02), $quot;$quot;General weakness$quot;$quot; (1.98), $quot;$quot;Nervousness$quot;$quot;(1.96). The most serious menopausal symptom was psycho-somatic symptom.(1.88). Total score orders of experienced symptoms was 27.9 and over 90.3% of women complained menopausal symptom, 2. Mean score orders of depression was 39.13. It was normal range of depression. 85.1% of the women was normal range of depression and 14.2% of women mild depression. 3. The relationship between menopausal symptoms and depression was statistically significant(r=0.5307, P=0.000). When the relationship among three demensions of menopausal symptoms were explored the psycho-somatic symptom(r=0.4090, P=0.000), Physical symptom(r=0.319, P=0.000) were statistically significant. 4. General characteristic variable were significantly related to the level of menopausal symptoms as follows : enviroment of living (F=2.89, p=0.038). religion (F=4.18 p=0.007), times of birth(F=2.66, p=0.043). The analysis of this study have implication for management of middle aged women's health, to solve the nursing problems, and to prevent and relieve climacteric symptoms.
김영자,권숙희,박춘화,김인순,정은순,송애리,정향미,박금자,문길남,배정이,여정희 여성건강간호학회 1996 여성건강간호학회지 Vol.2 No.2
This study was done for the purpose of analyzing the relationship between menopausal symptoms and depression. Data were collected by a questionnaire from November 28 to December 30, 1995. The subjects were 134 women between 40-61 years of age. The instruments used for this study were The Menopausal symptom scale by Neugartom and Depression scale by Zung. The results of the study were as follows. 1. Mean score of menopausal symptoms was 1.59. Mean score orders of experienced symptoms were $quot;Back pain and joint pain$quot;(2.02), $quot;General weakness$quot; (1.98), $quot;Nervousness$quot; (1.96). The most serious menopausal symptom was psychosomatic symptom.(1.88). Total score orders of experienced symptoms was 27.9 and over 90.3% of women complained menopausal symptom. 2 Mean score orders of depression was 39.13. It was normal range of depression. 85.1% of the women were normal range of depression and 14.2% of women mild depression. 3. The relationship between menopausal symptoms and depression was statistically significant(r=0.5307, P=0.000). When the relationship among three dimensions of menopausal symptoms were explored the psychosomatic symptom(r=0.4090, P=0.000), Physical symptom(r=0.319, P=0.000) were statistically significant. 4. General characteristic variables were significantly related to the level of menopausal symptoms as follows ; environment of living (F=2.89, p=0.038), religion (F=4.18, P=0.007), times of birth (F=2.66, p=0.043). The analysis of this study have implication for management of middle aged women's health, to solve the nursing problems, and to prevent and relieve climacteric symptoms.
Peng, Li-qun,Li, Ping,Zhang, Qiu-li,Hong, Lan,Liu, Li-ping,Cui, Xun,Cui, Bai-ri The Korean Society of Pharmacology 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1
Adenosine 3',5'-cyclic monophosphate (cAMP) participates in the regulation of numerous cellular functions, including the $Na^+-K^+$-ATPase (sodium pump). Ouabain, used in the treatment of several heart diseases, is known to increase cAMP levels but its effects on the atrium are not understood. The aim of the present study was to examine the effect of ouabain on the regulation of atrial cAMP production and its roles in atrial endothelin-1 (ET-1) secretion in isolated perfused beating rabbit atria. Our results showed that ouabain ($3.0{\mu}mol/L$) significantly increased atrial dynamics and cAMP levels during recovery period. The ouabain-increased atrial dynamics was blocked by KB-R7943 ($3.0{\mu}mol/L$), an inhibitor for reverse mode of $Na^+-Ca^{2+}$ exchangers (NCX), but did not by L-type $Ca^{2+}$ channel blocker nifedipine ($1.0{\mu}mol/L$) or protein kinase A (PKA) selective inhibitor H-89 ($3.0{\mu}mol/L$). Ouabain also enhanced atrial intracellular cAMP production in response to forskolin and theophyline ($100.0{\mu}mol/L$), an inhibitor of phosphodiesterase, potentiated the ouabain-induced increase in cAMP. Ouabain and 8-Bromo-cAMP ($0.5{\mu}mol/L$) markedly increased atrial ET-1 secretion, which was blocked by H-89 and by PD98059 ($30{\mu}mol/L$), an inhibitor of extracellular-signal-regulated kinase (ERK) without changing ouabain-induced atrial dynamics. Our results demonstrated that ouabain increases atrial cAMP levels and promotes atrial ET-1 secretion via the mitogen-activated protein kinase (MAPK)/ERK signaling pathway. These findings may explain the development of cardiac hypertrophy in response to digitalis-like compounds.
Chen, Shu-Dong,Song, Mao-Min,Zhong, Zhi-Qiang,Li, Na,Wang, Pi-Lin,Cheng, Shi,Bai, Ri-Xing,Yuan, Hui-Sheng Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3
Radixin, encoded by a gene on chromosome 11, plays important roles in cell motility, invasion and tumor progression. However, its function in pancreatic cancer remains elusive. In this study, radixin gene expression was suppressed with a lentivirus-mediated short-hairpin RNA (shRNA) method. We found that radixin shRNA caused down-regulation of radixin in PANC-1 cells, associated with inhibition of pancreatic cancer cell proliferation, survival, adhesion and invasive potential in vitro. When radixin-silenced cells were implanted in nude mice, tumor growth and microvessel density were significantly inhibited as compared to blank control cells or nonsense shRNA control cells. Thrombospondin-1 (TSP-1) and E-cadherin were up-regulated in radixin-silenced PANC-1 cells. Our results suggest that radixin might play a critical role in pancreatic cancer progression, possibly through invvolvement of down-regulation of TSP-1 and E-cadherin expression.
Li-qun Peng,Ping Li,Qiu-li Zhang,Lan Hong,Li-ping Liu,Xun Cui,Bai-ri Cui 대한생리학회-대한약리학회 2016 The Korean Journal of Physiology & Pharmacology Vol.20 No.1
Adenosine 3 ,5 -cyclic monophosphate (cAMP) participates in the regulation of numerous cellular functions, including the Na<sup>+</sup>-K<sup>+</sup>-ATPase (sodium pump). Ouabain, used in the treatment of several heart diseases, is known to increase cAMP levels but its effects on the atrium are not understood. The aim of the present study was to examine the effect of ouabain on the regulation of atrial cAMP production and its roles in atrial endothelin-1 (ET-1) secretion in isolated perfused beating rabbit atria. Our results showed that ouabain (3.0 μmol/L) significantly increased atrial dynamics and cAMP levels during recovery period. The ouabainincreased atrial dynamics was blocked by KB-R7943 (3.0 μmol/L), an inhibitor for reverse mode of Na<sup>+</sup>-Ca<sup>2+</sup> exchangers (NCX), but did not by L-type Ca<sup>2+</sup> channel blocker nifedipine (1.0 μmol/L) or protein kinase A (PKA) selective inhibitor H-89 (3.0 μmol/L). Ouabain also enhanced atrial intracellular cAMP production in response to forskolin and theophyline (100.0 μmol/L), an inhibitor of phosphodiesterase, potentiated the ouabain-induced increase in cAMP. Ouabain and 8-Bromo-cAMP (0.5 μmol/L) markedly increased atrial ET-1 secretion, which was blocked by H-89 and by PD98059 (30 μmol/L), an inhibitor of extracellular-signal-regulated kinase (ERK) without changing ouabain-induced atrial dynamics. Our results demonstrated that ouabain increases atrial cAMP levels and promotes atrial ET-1 secretion via the mitogen-activated protein kinase (MAPK)/ERK signaling pathway. These findings may explain the development of cardiac hypertrophy in response to digitalis-like compounds.