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Constituents of the Edible Leaves of <i>Melicope pteleifolia</i> with Potential Analgesic Activity
Lee, Ba-Wool,Park, Jung-Geun,Ha, Thi Kim Quy,Pham, Ha Thanh Tung,An, Jin-Pyo,Noh, Jung-Ran,Lee, Chul-Ho,Oh, Won-Keun American Chemical Society and American Society of 2019 Journal of natural products Vol.82 No.8
<P><I>Melicope pteleifolia</I> has long been consumed as a popular vegetable and tea in Southeast Asian countries, including Malaysia and southern mainland China, and is effective in the treatment of colds and inflammation. In the search for active metabolites that can explain its traditional use as an antipyretic, six new phloroacetophenone derivatives (<B>3</B>-<B>8</B>) along with seven known compounds (<B>1</B>, <B>2</B>, and <B>9</B>-<B>13</B>) were isolated from the leaves of <I>M. pteleifolia</I>. Their chemical structures were confirmed by extensive spectroscopic analysis including NMR, IR, ECD, and HRMS. All compounds isolated from the leaves of <I>M. pteleifolia</I> (<B>1</B>-<B>13</B>) have a phloroacetophenone skeleton. Notably, the new compound <B>8</B> contains an additional cyclobutane moiety in its structure. The bioactivities of the isolated compounds were evaluated, and compounds <B>1</B>, <B>6</B>, and <B>7</B> inhibited tumor necrosis factor-α-induced prostaglandin E<SUB>2</SUB>. Moreover, the major constituent, 3,5-di-<I>C</I>-β-<SMALL>D</SMALL>-glucopyranosyl phloroacetophenone (<B>1</B>), was found to be responsible for the antipyretic activity of <I>M. pteleifolia</I> based on in vivo experiments.</P> [FIG OMISSION]</BR>
전치부 반대교합과 치간공극 및 하악 좌측 제1대구치 결손을 동반한 골격성 III급 부정교합 환자의 절충 치료 치험례
이바울(Ba-Wool Lee) 대한치과교정학회 2022 대한치과교정학회 임상저널 Vol.12 No.2
Nonsurgical camouflage orthodontic treatment can be effective in carefully selected patients with mild to moderate Class III malocclusion. After growth is complete, the only way to camouflage the skeletal Class III malocclusion is through dentoalveolar compensation. And in this borderline case, the use of micro-implant is a viable option. This clinical case report presents the use of micro-implant to correct a skeletal Class III malocclusion with anterior crossbite and spaced dentition. Careful biomechanical consideration was used to close the missing mandibular left first molar space by protracting the second molar. After 28 months of treatment, adequate overbite and overjet relationship were obtained. Occlusion and smile esthetics were significantly improved.
깊은 수직피개와 큰 수평피개를 동반한 I급 부정교합 환자의 마이크로 임플랜트를 이용한 비발치 교정치료
이바울(Ba-Wool Lee) 대한치과교정학회 2024 대한치과교정학회 임상저널 Vol.14 No.1
Deep bite is known as one of the most common malocclusions, and its treatment and retention are often challenging. Especially, in patients with an excess overjet and proclined maxillary incisors, a deep bite is associated with overeruption of the mandibular incisors. The use of microimplant has been suggested as an ideal method for the intrusion of incisors in deep bite patients. Careful biomechanical consideration and monitoring are required to design an appropriate force system. This clinical case report presents the skeletal I malocclusion with deep overbite and large overjet by distalization of the whole maxillary dentition and intrusion of the anterior teeth using microimplant. (Clin J Korean Assoc Orthod 2024;14(1):33-45)
Pham, Ha Thanh Tung,Ha, Thi Kim Quy,Cho, Hyo Moon,Lee, Ba Wool,An, Jin Pyo,Tran, Van On,Oh, Won Keun American Chemical Society and American Society of 2018 Journal of natural products Vol.81 No.11
<P>As part of ongoing research to find new antidiabetic agents from medicinal plants, the chemical composition of <I>Gynostemma longipes</I>, an ethnomedicinal plant used to treat type 2 diabetes mellitus by local communities in Vietnam, was investigated. Ten new dammarane triterpenes, including two 3,4-<I>seco</I>-dammarane analogues, secolongipegenins S1 and S2 (<B>1</B> and <B>2</B>), a 3,4-<I>seco-</I>hexanordammarane, secolongipegenin S3 (<B>3</B>), two hexanordammarane glycosides, longipenosides ND1 and ND2 (<B>4</B> and <B>5</B>), and five other dammarane glycosides, longipenosides GL1-GL5 (<B>6</B>-<B>10</B>), were isolated from a 70% EtOH extract of the whole <I>G. longipes</I> plant. The structures of the new compounds were elucidated using diverse spectroscopic methods. All of the isolates were evaluated for their stimulatory activities on glucose uptake in differentiated 3T3-L1 adipocyte cells using 2-[<I>N</I>-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-<SMALL>D</SMALL>-glucose as a fluorescent-tagged glucose probe. The stimulant activities on glucose uptake by the test compounds were mediated via the activation of the AMPK pathway using differentiated mouse C2C12 skeletal myoblasts. Consequently, compounds <B>1</B>, <B>2</B>, and <B>4</B> enhanced glucose uptake and GLUT4 translocation significantly by regulating the AMPK signaling pathway.</P> [FIG OMISSION]</BR>