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( Norzana Abd Ghafar ),( Ropilah Abd Rahman ),( Jemaima Che Hamzah ),( Chua Kien Hui ),( Fauziah Othman ),( Aminuddin Bs3 ),( Ruszymah Bhi ) 한국조직공학·재생의학회 2007 조직공학과 재생의학 Vol.4 No.4
This study was designed to investigate the feasibility of using a serum-free and feeder layer-free culture system on serial expansion of rabbit limbal and corneal epithelial cells by evaluating the cell morphology, growth kinetics and gene expression pattern. Isolated epithelial cells(EC) from limbal and corneal regions of the rabbit corneoscleral tissues were culture expanded until three passages following initial culture in serum-free medium(SFM) supplemented with human corneal growth supplement(HCGS). EC morphology was examined daily with cell count and viability recorded at each passage by trypan blue exclusion test. Growth rate, number of cell doublings and total cell yield were measured and compared in each passage. The expression of Integrin β1; putative epidermal stem cell marker; Cytokeratin 12 and Connexin 43; differentiation markers for corneal epithelium; were detected by semiquantitative reverse transcriptase-polymerase chain reaction(RT-PCR). Limbal EC was able to retain compact and small cells morphology throughout the culture period. Corneal EC demonstrated a varying morphology with abundance of large, squamous cells and showed senescence earlier in culture. Limbal EC exhibited a greater proliferative activity demonstrated by higher growth rate, cumulative cell doublings and total cell yield compared to corneal EC. Integrin β1 expression was detected in freshly isolated and cultured limbal EC in all passages with relatively strong expression noted at the initial passage (P0). Corneal EC showed a very weak expression of Integrin β1 throughout the culture period. Cytokeratin 12 and connexin 43 were expressed in both freshly isolated limbal and corneal EC. Both corneal differentiation markers were expressed in cultured limbal and corneal EC in serial passages. These results suggested that corneal epithelium can be serially expanded in serum-free and feeder layer-free culture system with limbal EC showing a greater proliferative capacity while retaining its stemness via putative epidermal stem cell marker; Integrin β1 expression.
김경임 BS,김승희 BS,박지은 BS,채한정 Ph.D,최지선 MS,신완균 Pharm.D. Ph.D,손인자 Ph.D.,오정미 Pharm.D 한국임상약학회 2006 한국임상약학회지 Vol.16 No.2
Great inter-variability in drug response and adverse drug reactions is related to inter-variability of drug bioavailability, drug interaction and patient's disease and physyological state that cause change in absorption, distribution, metabolism and excretion of drugs. However, these alone do not sufficiently predict and explain inter-variability in drug response. In recent studies, it is reported that inter-variability in drug response and adverse drug reactions may largely resulted from genetically determined differences in drug absoption, distribution, metabolism and drug target proteins. Especially, the major human drug-metabolizing enzymes such as CYP450, N-acetyl tranferase, thiopurine S-methyl transferase, glutathione S-transferase are identified as the major gene variants that cause inter-individual variability in drug's response and adverse drug reactions. These variations may have most significant implications for those drugs that have narrow therapeutic index and serious adverse drug reactions. Therefore, the genetic variation such as polymorphisms in drug metabolizing enzymes can affect the response of individuals to drugs that are used in the treatment of depression, psychosis, cancer, cardiovascular disorders, ulcer and gastrointestinal disorders, pain and epilepsy, among others. This review describes the pharmacogenomics of the drug metabolizing enzymes associated with the drug response and its clinical applications.
구본술(BS Koo) 대한산부인과학회 1963 Obstetrics & Gynecology Science Vol.6 No.4
산과에서 대상으로 하는 임신, 분만, 산욕, 수유각기에 임신의 안부에 나타나는 질환은 순환장애,물질대사이상,내분비작용의 변화등이 주로 기인되며, 분만과 동시에 끝이는 병변도 있고, 종생이 남기는 것도 있다. 비교적 흔히 볼 수 있는 것으로 검피색소층식, 맥립종, 프리크텐성 결막염, 또는 분만시 노책으로 검,결막,망막,안와등의 소출혈을 볼 수 있으며 산욕열시에 전이성안염,패혈성망막염등이 나올 수 있으나 근래에는 거의 볼 수 없게 된 감이 있다. 그중에도 중요한 것은 임신중독(Toxemia of pregnancy), 임신구토(Hyperemesis gravidarum), 수유(Lactation)또는 신산아분만외상(Birth injury)등이라 하겠고 여기에 대하여 간단히 기술키로 하였다.
구병삼(BS Koo) 대한산부인과학회 1971 Obstetrics & Gynecology Science Vol.14 No.9
여성성기조직의 수분 및 전해질 함량에 관한 연구를 통해 자궁체부의 magnesium함량을 경부, 난관 및 난소에서 비교관찰하면 폐경기에서는 난소에서 magnesium량이 적었고 성성숙기경산부에서는 증식기 및 분비기에서 다같이 경부,난관,난소에서 적었다. The author attempted to observe the quantitative alterations of various tissue electrolytes in the human female genital organs. Chemical quantitative analyses for warter, chloride, sodium, potassium, calcium, and magnesium in the surgical specimens of 60 cases of the corporeal myometrium, 40 cases of the endometrium, 60 cases of the cervical myometrium, 60 cases of the Fallopian tube and 60 cases of the ovary were carried out. There was no evidence of gross or microscopic abnormalities in the tissues selected above. Flame-photometry was used for determination of sodium and potassium levels, Schales and Schales method for chloried content, and Kovacs and Tarrnoky`s method for calcium and magnesium contents. Comparison of the contents of water and various electrolytes in the human female genital organs was made between, before and after menopause. The results obtained are summerized as follows: 1. the contents of water and various electrolytes in the uterine corporeal myometrium before and after menopause were observed. The level of water was increased, Cl, Na and Mg were markedly decreased, and K not changed in the proliferative phase in reproductive women. In the sercetory phase, the water and K were increased. Cl, Na and Ca levels were markedly decreased in premenopausal women in comparison with those in post menopausal. The water, Cl, and K contents were markedly increased, however, Na and Mg were slightly increased in the secretory phase in the menstrual cycle. 2. The contents of water and various electrolytes in the cervical myometrium of women before menopause were compared to those of women after menopause. The water and Ca contents were markedly increased, and Na and Mg were decreased in the proliferative phase of premenopausal women. The contents of water, K and Ca were markeldy increased, and mg was decreased in the secretory phase of the premenopausal. In the menstrual cycle period, the Na, K and Mg contents in the secretory phase were increased. However, the water, cl and Mg contents were not changed.
Natural History of Chronic Hepatitis C and Type C Cirrhosis from Korea
Kim,BS,Byun,BH,Bae,SH,Yoon,SK,Choi,JY,Park,YM 가톨릭중앙의료원 가톨릭암센터 1998 암심포지움 Vol.- No.2
HCV 감염 후 간경변증, 간암 발생시까지 평균기간은 각각 73 및 113개월이었고, 간경변이나 간암으로 진행과 관련성이 있는 인자는 진단시 연령, ALT, α-FP, 혈소판이었다.
구병삼(BS Koo),차종욱(CU Cha),김선행(SH Kim),신재승(JS Shin),이규진(KJ Lee),정진각(JK Jung),김주환(CH Kim) 대한산부인과학회 1977 Obstetrics & Gynecology Science Vol.20 No.4
저자들은 자궁내의 변위임신으로서 자궁경부임신이 죄측자궁각임신과 공존되어 있으며 좌측난소종양이 동반되었던 1예를 경험하였기에 보고하며 간단한 문헌 고찰을 하였다. A case of intrauterine multiple ectopic pregnancies were coincidently occurred in the cervical canal and left angular portion of the uterus with association of left ovarian cyst in a 38-years multiparous wiman, is presented with a brief review of literatures.