OVARIAN TUMORS-PAST AND PRESENT

Barber, Hugh R.K 中央醫學社 1991 中央醫學 Vol.56 No.1

The ovarly is an organ of complexity and variety and steroidogenesis. All vertebrate species have ovaries and, therefore, exhibit complex reproductive phenomena. The phylogenetic development of the ovary will be quickly reviewed as will the comparative anatomy. In comparative anatomy, in birds the left ovary and oviduct develop to maturity and organs on the right side atrophy. It is interesting that if they live long enough they develop an ovarian cancer similar to the common epithelial ovarian cancer seen in humans. Embryology The ovaries and testes have very similar developments until about the fourth month of embryonic life in humans. The gonadal ridge, primitive germs cells, indifferent gonads, for both the ovary and testis will be reviewed. This will give an opprotunity to identify where tumors arise. In addition, it will provide an opportunity to show that the testis and the ovary develop the same type of germ cells and gonadal stromal tumors. Since the testis has a tunica albuginea, the epithelium on the surface disappears and, therefore, there are no common epithelial ovarian cancers in the testis. Early History A quick review will be given of the past history of the ovary and the time that deGraaf identified the ovary and ovum as separate entities from the testis. Ephraim McDowell The Current Management of Ovarian Cancer The aggressive surgical management will be reviewed and the adjuvant therapy will be discussed. Tumor Markers Tumor markers will be discussed in detail as well as the new work on receptor mechanisms. In addition, the HER-2/neu oncoprotein has been identified as a gene among those that develop ovarian cancer and will be discussed. Alpha-L-Fucosidase, which is often elevated in the sera of patients with a family history of ovarian cancer, will be reviewed and its significance discussed. New Approaches in the Management of Ovarian Cancer The use of the Cusa and the laser will be reviewed. A slide will be presented on some of the new chemotherapeutic agents, such as, Ifosfamide and Mesnex as well as Taxol. The mechanisms multidrug resistance will be presented. Tumor cells often become refractory to diverse drugs with different mechanisms of cytotoxic action. It has been shown that a glycoprotein which is P glycoprotein has been associated with multidrug resistance of cells and its mechanism will be discussed. Research is being conducted to determine if P glycoprotein may serve as a prognostic indicator for response to chemotherapy. Summary The highlights of the past, present and potential for management of ovarian cancer will be highlighted.

A Fluid Solution to Preventing Varnish Formation in Hydraulic Systems

Allan Barber,Brian Filippini,Robert Profilet,Nelson Tam 한국트라이볼로지학회 2008 Lubricants SYMPOSIUM Vol.2008 No.10

Head to head study comparing the efficacy and safety of ixekizumab to guselkumab in patients with moderate-to-severe plaque psoriasis

( Kirk Barber ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Laboratory and In-Situ Study of the Effect of Additives on the Compaction Strength of Snow

M. Barber(엠. 바버),R. L. Brown(알. 엘. 브라운),S. M. Lee(李成默) 한국해양공학회 1988 韓國海洋工學會誌 Vol.2 No.1

적설의 다짐강도에 대한 부가물의 효과를 고찰하기 위한 연구가 수행되었다. 본 연구의 목적은 본 연구에서 얻은 결과를 토대로 적설의 압착과정을 촉진시키고 나아가서 남극의 설상로나 설상활주로 등의 다짐강도를 증진시키는 데 있다. 실험실에서의 실험결과에 의하면 처리된 눈에 소량의 톱밥을 섞었을 때 더 큰 강도를 얻을 수 있다는 것을 알 수 있었으며, 이 방법은 남극과 McMurdo 설상로에 있는 시험도에서 실제 적용되었다. 현지 설험에서 얻은 자료를 분석한 결과 적설의 고결은 일반적으로 예측되는 극한 환경에서 보다 빨리 진행되었으며, 궁극적으로 큰 지장없이 육중한 운승장비를 지지할 수 있는 충분한 다짐강도를 얻을 수 있다는 것을 알 수 있었다.

The combination of intravenous bevacizumab and metronomic oral cyclophosphamide is an effective regimen for platinum-resistant recurrent ovarian cancer

Emma L. Barber,Emese Zsiros,John R. Lurain,Alfred Rademaker,Julian C. Schink,Nikki L. Neubauer 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.3

Objective: To determine the efficacy, progression-free survival (PFS) and overall survival (OS) for the combination of intravenous bevacizumab and oral cyclophosphamide in heavily pretreated patients with recurrent ovarian carcinoma. Methods: A retrospective review was performed for all patients with recurrent ovarian carcinoma treated with intravenous bevacizumab 10 mg/kg every 14 days and oral cyclophosphamide 50 mg daily between January 2006 and December 2010. Response to treatment was determined by Response Evaluation Criteria in Solid Tumors criteria and/or CA-125 levels. Results: Sixty-six eligible patients were identified. Median age was 53 years. Fifty-five patients (83%) had undergone optimal cytoreduction. All patients were primarily or secondarily platinum resistant at the time of administration of bevacizumab and cyclophosphamide. The median number of prior chemotherapy treatments was 6.5 (range, 3 to 16). Eight patients (12.1%) had side effects which required discontinuation of bevacizumab and cyclophosphamide. There was one bowel perforation (1.5%). Overall response rate was 42.4%, including, complete response in 7 patients (10.6%), and partial response in 21 patients (31.8%), while 15 patients (22.7%) had stable disease and 23 patients (34.8%) had disease progression. Median PFS for responders was 5 months (range, 2 to 14 months). Median OS from initiation of bevacizumab and cyclophosphamide was 20 months (range, 2 to 56 months) for responders and 9 months (range, 2 to 51 months) for non-responders (p=0.004). Conclusion: Bevacizumab and cyclophosphamide is an effective, well-tolerated chemotherapy regimen in heavily pretreated patients with recurrent ovarian carcinoma. This combination significantly improved PFS and OS in responders. Response rates were similar and favorable to the rates reported for similar patients receiving other commonly used second-line chemotherapeutic agents.

Ovarian Tumors - Past and Present

(Hugh R . K . Barber) 대한산부인과학회 1990 춘계학술대회 Vol.- No.-

Ovarian Tumors - Past and Present

( Hugh R. K. Barber ) 대한산부인과학회 1990 대한산부인과학회 학술대회 Vol.65 No.-

FRICTION CHARACTERISTICS OF A PAPER-BASED FRICTION MATERIAL

Gao, H.,Barber, G.-C.,Chu, H. The Korean Society of Automotive Engineers 2002 International journal of automotive technology Vol.3 No.4

A bench test set-up is employed to simulate the friction characteristics of a paper-based friction material operating against a steel plate. Dry friction tests are run as well as tests with transmission fluids. Glazed friction material produces a negative coefficient of friction versus sliding velocity (f-v) curve for both dry friction and lubrication with transmission fluids. At low sliding speeds, the coefficient of friction when operating in transmission fluids for glazed friction materials is greater than that under dry friction. An appreciable negative f-v slope occurs at low sliding speeds for glazed friction materials when running with the transmission fluid. The friction material after running in produces a constant f-v curve under dry friction and a negative slope when lubricated with transmission fluid. At low sliding speeds, the coefficient of friction of the run-in friction material is lower than that of the glazed wet material. On the other hand, the run-in friction material has a larger friction coefficient than does the glazed friction material at higher sliding speeds.

The Inhibitory Effect of Rosiglitazone on Agonist-Induced or Spontaneous Regulation of Contractility

Park, Sun-Young,Barber, Amy L.,Sohn, Uy-Dong,Je, Hyun-Dong 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.4

The present study was undertaker to determine whether rosiglitazone treatment influences on the agonist-induced or spontaneous regulation of vascular smooth muscle contraction and, if so, to investigate the related mechanism. Stimulants were directly added without any preanesthetic stress or spontaneous vasoconstriction was induced by preanesthetic Physical stress where rat aortic ring preparations isolated from rat exposed to preanesthetic stress such as pinch or prick for 30 min were mounted in organ baths and then exposed to contractile agents. Previously and subchronically ingested rosiglitazone decreased Rho-kinase activating agonist-induced contraction but not depolarization- or ${\alpha}$ adrenergic agonist-induced contraction. Moreover, preanesthetic stress induced the stress-induced spontaneous contraction and previously and subchronically ingested rosiglitazone abolished the stress-induced spontaneous contraction. In conclusion, this study provides the evidence and possible related mechanism concerning the vasorelaxing effect go an antidiabetic rosiglitazone as an antihypertensive on the agonist-induced contraction or stress-induced spontaneous vasoconstriction in rat aortic rings regardless of endothelial function.

STING signaling and host defense against microbial infection

Jeonghyun Ahn,Glen N. Barber 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-

The first line of host defense against infectious agents involves activation of innate immune signaling pathways that recognize specific pathogen-associated molecular patterns (PAMPs). Key triggers of innate immune signaling are now known to include microbial-specific nucleic acid, which is rapidly detected in the cytosol of the cell. For example, RIG-Ilike receptors (RLRs) have evolved to detect viral RNA species and to activate the production of host defense molecules and cytokines that stimulate adaptive immune responses. In addition, host defense countermeasures, including the production of type I interferons (IFNs), can also be triggered by microbial DNA from bacteria, viruses and perhaps parasites and are regulated by the cytosolic sensor, stimulator of interferon genes (STING). STING-dependent signaling is initiated by cyclic dinucleotides (CDNs) generated by intracellular bacteria following infection. CDNs can also be synthesized by a cellular synthase, cGAS, following interaction with invasive cytosolic self-DNA or microbial DNA species. The importance of STING signaling in host defense is evident since numerous pathogens have developed strategies to prevent STING function. Here, we review the relevance of STING-controlled innate immune signaling in host defense against pathogen invasion, including microbial endeavors to subvert this critical process.