The Role of Genetic Polymorphisms in Nrf2 and P73 in Egyptian Women with Breast Cancer

Azhary, Nevin M Al,Kamel, Mahmoud M,Ismail, Yahia M,Mahmoud, Amal A,Radwan, Enas M Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.11

Background: Breast cancer is the commonest cancer in Egyptian females. Nrf2 is involved in oxidative stress while P73 functions in response to DNA damage. This study aimed to assess the role of Nrf2 promoter and P73 G4C14 to A4T14 SNPs in breast cancer in Egypt. Patients: Eighty-five female patients with breast tumours (41 malignant, 44 benign) were included. Nrf2 (rs6721961) and p73 (G4A) SNPs were determined by PCR- CTPP assay. Results: Genotype frequencies of the Nrf2 promoter SNP were 34.2% and 37.9% for AA in benign and malignant groups respectively, and 43.9% and 40.5% for CC and, 21.9 % and 21.6% for CA. Genotype frequencies for the P73 G4A SNP were 52.9% and 44.7% for GA in benign and malignant groups respectively, and 47.1% and 55.3% for GG. Discussion: Nrf2 genotypes in pre - and post-menopausal patients, showed significantly different distributions in the 2 patient groups, the AA genotype being significantly more common in pre-menopausal patients. The P73 G4A SNP showed no relation to age of disease onset. Conclusion: The Nrf2 (rs6721961) AA genotype might be related to early breast cancer onset. In contrast the P73 G4A polymorphism showed no relation to either disease risk or age at presentation.

The Bullet Launcher with A Pneumatic System to Detect Objects by Unique Markers

Jasmine Aulia,Zahrah Radila,Zaenal Afif Azhary,Aulia M. T. Nasution,Detak Yan Pratama,Katherin Indriawati,Iyon Titok Sugiarto,Wildan Panji Tresna 한국정보통신학회 2023 Journal of information and communication convergen Vol.21 No.3

A bullet launcher can be developed as a smart instrument, especially for use in the military section, that can track, identify,detect, mark, lock, and shoot a target by implementing an image-processing system. In this research, the application of objectrecognition system, laser encoding as a unique marker, 2-dimensional movement, and pneumatic as a shooter has been studiedintensively. The results showed that object recognition system could detect various colors, patterns, sizes, and laser blinking.Measuring the average error value of the object distance by using the camera is ±4, ±5, and ±6% for circle, square and triangleform respectively. Meanwhile, the average accuracy of shots on objects is 95.24% and 85.71% in indoor and outdoor conditionsrespectively. Here, the average prototype response time is 1.11 s. Moreover, the highest accuracy rate of shooting results at 50cm was obtained 98.32%.

No Association of Cytochrome P450-1B1 Gene Polymorphisms with Risk of Breast Cancer: an Egyptian Study

Ibrahim, Mona H,Rashed, Reham A,Hassan, Naglaa M,Al-azhary, Nevin M,Salama, Asmaa I,Mostafa, Marwa N Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6

It is thought that population characteristics of breast cancer may be due to a variation in the frequency of different alleles of genes such as CYP1B1. We aimed to determine the association of CYP1B1 polymorphisms in 200 breast cancer cases and 40 controls by PCR-RFLP. Frequencies were assessed with clinical and risk factors in Egyptian patients. The genotype LV and the Leu allele frequencies for patients and controls were 42.9% and 50%, and 52.9% and 53.3%, respectively), with no significant differences observed (P values = 0.8 and 0.6, respectively). There was also no significant association between genotypes and any risk factors for cases (P>0.05) except laterality and metastasis of the tumor (P values=0.006 and 0.06, respectively). The CYP1B1 polymorphism Val432Leu was not associated with breast cancer in Egypt, but may provide clues for future studies into early detection of the disease.

Monitoring bridge scour using dissolved oxygen probes

Azhari, Faezeh,Scheel, Peter J.,Loh, Kenneth J. Techno-Press 2015 Structural monitoring and maintenance Vol.2 No.2

Bridge scour is the predominant cause of overwater bridge failures in North America and around the world. Several sensing systems have been developed over the years to detect the extent of scour so that preventative actions can be performed in a timely manner. These sensing systems have drawbacks, such as signal inaccuracy and discontinuity, installation difficulty, and high cost. Therefore, attempts to develop more efficient monitoring schemes continue. In this study, the viability of using optical dissolved oxygen (DO) probes for monitoring scour depths was explored. DO levels are very low in streambed sediments, as compared to the standard level of oxygen in flowing water. Therefore, scour depths can be determined by installing sensors to monitor DO levels at various depths along the buried length of a bridge pier or abutment. The measured DO is negligible when a sensor is buried but would increase significantly once scour occurs and exposes the sensor to flowing water. A set of experiments was conducted in which four dissolved oxygen probes were embedded at different soil depths in the vicinity of a mock bridge pier inside a laboratory flume simulating scour conditions. The results confirmed that DO levels jumped drastically when sensors became exposed during scour hole evolution, thereby providing discrete measurements of the maximum scour depth. Moreover, the DO probes could detect any subsequent refilling of the scour hole through the deposition of sediments. The effect of soil permeability on the sensing response time was also investigated.

Organochlorine Insecticides Residues in Sudanese Soil of Intensive Pesticide Use and in Surface Soil of Qurashi Pesticide Store

Azhari O. Abdelbagi,Mohamed A. Elmahi,Dirdiri G. Osman 한국농약과학회 2003 한국농약과학회 학술발표대회 논문집 Vol.- No.-

Physicochemical and Functional Properties of Flour and Protein Isolates Extracted from Seinat (Cucumis melo var. tibish) Seeds

Azhari Siddeeg,Yanshun-Xu,Qixing-Jiang,Wenshui-Xia 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.2

The physicochemical and functional propertiesof seinat seed flour (SSF), defatted seinat flour (DSSF),and protein isolates were studied. Protein was extractedfrom DSSF using an alkali solution with isoelectricprecipitation and freeze drying. Freeze dried seinat seedprotein isolates (FSSPI), SSF, and DSSF were evaluatedfor their physicochemical and functional properties. SSFcontained high levels of crude fat and fiber (31.13% and24.75%, respectively). FSSPI contained 91.83% proteinversus 28.58% for SSF. The amounts of potassium, themineral with the highest content, were 9,548.33, 6,439.03,and 1,029 mg/100 g in SSF, DSSF, and FSSPI, respectively. The functional properties were variable among samples. The protein solubility of FSSPI was significantly higher(p<0.05) than for DSSF and SSF. FSSPI has a significantlybetter (p<0.05) foaming capacity, water/fat absorptioncapacity, and bulk density than SSF and DSSF. FSSPI alsoshowed an emulsifying capacity comparable to commercialsoy protein isolates.

PART Ⅲ. ECONOMIC DEVELOPMENT AND CHALLENGES ; CHAPTER 7. PROSPECTS OF INDONESIA'S OIL AND GAS SECTOR

Azhari Warga Dalem 경남대학교 극동문제연구소 1984 KOREA AND INDONESIA IN THE YEAR 2000 Vol.- No.-

A parametric study on buckling loads and tension field stress patterns of steel plate shear walls concerning buckling modes

M. Azhari,P. Memarzadeh,M.M. Saadatpour 국제구조공학회 2006 Steel and Composite Structures, An International J Vol.6 No.1

A Steel Plate Shear Wall (SPSW) is a lateral load resisting system consisting of an infill plate located within a frame. When buckling occurs in the infill plate of a SPSW, a diagonal tension field is formed through the plate. The study of the tension field behavior regarding the distribution and orientation patterns of principal stresses can be useful, for instance to modify the basic strip model to predict the behavior of SPSW more accurately. This paper investigates the influence of torsional and out-of-plane flexural rigidities of boundary members (i.e. beams and columns) on the buckling coefficient as well as on the distribution and orientation patterns of principal stresses associated with the buckling modes. The linear buckling equations in the sense of von-Karman have been solved in conjunction with various boundary conditions, by using the Ritz method. Also, in this research the effects of symmetric and anti-symmetric buckling modes and complete anchoring of the tension field due to lacking of in-plane bending of the beams as well as the aspect ratio of plate on the behavior of tension field and buckling coefficient have been studied.

Air Quality Modelling and Sustainable Urban Traffic Management Strategies for Kuala Lumpur

Azliyana Azhari,Kadaruddin Aiyub,Mohd Talib Latif 한국대기환경학회 2021 한국대기환경학회 학술대회논문집 Vol.2021 No.10

This study predicts concentration and dispersion pattern of primary pollutants in Kuala Lumpur city centre. The forecast was carried out under different traffic scenarios; business as usual (BAU) and 30% traffic reduction to see the impact of traffic reduction for a sustainable city management. The Danish OML-Highway model was utilized to calculate hourly time series of particulate matter concentration and distribution caused by traffic emission under different scenario. The average concentration of PM2.5 are 37.6±24.3 μg/m³ and 35.3±23.9 μg/m³ for BAU and 30% traffic reduction scenario respectively, while average concentration of PM10 are 54.5±27.8 μg/m³ and 50.8±26.4 μg/m³ for BAU and 30% traffic reduction scenario respectively. The spatial concentration distribution of annual mean for all primary pollutants in Kuala Lumpur City Centre clearly indicated that the concentration of particulate matter decreases with reduction of traffic volume in the city. The average mean concetration for CO during the BAU runs are ranging at 861-1439 μg/m³ compared to during 30% traffic reduction run at 834-1294 μg/m³. The average mean concentration for NO₂ during the BAU runs are ranging at 31.9-95.8 μg/m³ compared to during 30% traffic reduction run at 28.6-83.9 μg/m³. Average mean concentration for PM2.5 and PM10 during BAU runs are ranging at 30.4-43.7 μg/m³ and 41.4-65.9 μg/m³ respectively compared to during 30% traffic reduction run at 29.9-40.3 μg/m³ and 40.5-59.5 μg/m³ respectively. The average mean concentration for O₃ during the BAU runs are ranging at 3.81-28.6 μg/m³ compared to during 30% traffic reduction run at 5.05-30.7 μg/m³. This research demonstrates that traffic emission in urban area originates from vehicle emission and reduction of traffic volume in the city contributes to reduce the concentration of particulate matter pollution that is harmful to the environment and human health.

Decision-Making Process in Patients with Thoracolumbar and Lumbar Burst Fractures with Thoracolumbar Injury Severity and Classification Score Less than Four

Shirzad Azhari,Parisa Azimi,Sohrab Shahzadi,Hassan Reza Mohammadi,Hamid Reza Khayat Kashani 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.1

Study Design: Cross-sectional. Purpose: To develop a strategy to determine a sound method for decision-making based on postoperative clinical outcome satisfaction. Overview of Literature: The ideal management of thoracolumbar and lumbar burst fractures (TLBF) without neurological compromise remains controversial. Methods: This was a prospective study. Patients with thoracolumbar injury severity and classification score (TLICS) <4 were treated nonoperatively, with bed rest and bracing until the pain decreased sufficiently to allow mobilization. Surgery was undertaken in patients with intractable pain despite an appropriate nonoperative treatment (surgery group). The Oswestry disability index (ODI) measure was observed at baseline and at the last follow-up. Clinically success was defined at least a 30% improvement from the baseline ODI scores in both the conservative and surgery groups. All case records were assessed for gender, age, residual canal and angulations at the site of the fracture in order to determine which patients benefited from surgery or conservative treatment and which did not. Results: In all 113 patients with T11–L5, TLBFs were treated. The patients’ mean age was 49.2 years. Patients successfully completed either nonoperative (n=99) or surgical (n=14) treatment based on ODI. Clinical examinations revealed that all of the patients had intact neurology. The mean follow-up period was 29.5 months. There was a significant difference between the two groups based on age and residual canal. The mean ODI score significantly improved for both groups (p <0.01). According to the findings, a decision matrix was proposed. Conclusions: The findings confirm that TLICS <4, age, and residual canal can be used to guide the treatment of TLBF in conservative decision-making.