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Impact and challenges of the COVID-19 pandemic on patients requiring botulinum toxin A treatment
Azalea Tenerife Pajo,Adrian Isidoro Espiritu,Roland Dominic Go Jamora 대한파킨슨병및이상운동질환학회 2021 Journal Of Movement Disorders Vol.14 No.1
In late December 2019, an initial outbreak of a mysterious pneumonia characterized by fever, dry cough, fatigue, and occasional gastrointestinal symptoms was reported in a seafood wholesale wet market in Wuhan involving approximately 66% of the staff.1 Over the next few months, the outbreak resulted in the spread to 213 countries, affecting 11.5 million people with an estimated mortality rate of 3.4%.2 It is the largest and most severe pandemic since the 1918 influenza pandemic.3 The first case was reported in the Philippines on January 30th, with its first local transmission documented on March 7.4
TRAIL and Bortezomib: Killing Cancer with Two Stones
Qureshi, Muhammad Zahid,Romero, Mirna Azalea,Attar, Rukset,Javed, Zeeshan,Farooqi, Ammad Ahmad Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.4
Cancer genomics and proteomics have undergone considerable broadening in the past decades and increasingly it is being realized that solid/liquid phase microarrays and high-throughput resequencing have provided platforms to improve our existing knowledge of determinants of cancer development, progression and survival. Loss of apoptosis is a widely and deeply studied process and different approaches are being used to restore apoptosis in resistant cancer phenotype. Modulating the balance between pro-apoptotic and anti-apoptotic proteins is essential to induce apoptosis. It is becoming more understood that pharmacological inhibition of the proteasome might prove to be an effective option in improving TRAIL induced apoptosis in cancer cells. Keeping in view rapidly accumulating evidence of carcinogenesis, metastasis, resistance against wide ranging therapeutics and loss of apoptosis, better knowledge regarding tumor suppressors, oncogenes, pro-apoptotic and anti-apotptic proteins will be helpful in translating the findings from benchtop to bedside.
Recently Emerging Signaling Landscape of Ataxia-Telangiectasia Mutated (ATM) Kinase
Farooqi, Ammad Ahmad,Attar, Rukset,Arslan, Belkis Atasever,Romero, Mirna Azalea,ul Haq, Muhammad Fahim,Qadir, Muhammad Imran Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16
Research over the years has progressively and sequentially provided near complete resolution of regulators of the DNA repair pathways which are so important for cancer prevention. Ataxia-telangiectasia mutated kinase (ATM), a high-molecular-weight PI3K-family kinase has emerged as a master regulator of DNA damage signaling and extensive cross-talk between ATM and downstream proteins forms an interlaced signaling network. There is rapidly growing scientific evidence emphasizing newly emerging paradigms in ATM biology. In this review, we provide latest information regarding how oxidative stress induced activation of ATM can be utilized as a therapeutic target in different cancer cell lines and in xenografted mice. Moreover, crosstalk between autophagy and ATM is also discussed with focus on how autophagy inhibition induces apoptosis in cancer cells.