Chemical Composition of Endemic Scorzonera sandrasica and Studies on the Antimicrobial Activity Against Multiresistant Bacteria

Aysel Ugur,Nurdan Sarac,Ozgur Ceylan,M. Emin Duru,Yavuz Beyatli 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.3

The present study describes the antimicrobial activity and chemical composition of Scorzonera sandrasica Hartvig et Strid (Family Asteraceae), endemic to Turkey. The antimicrobial activity of the hexane, chloroform, ethyl acetate, and ethanol extracts of the aerial parts of S. sandrasica was evaluated against microorganisms, including multiresistant bacteria, using a paper disc diffusion method. The chemical composition of the chloroform extract of the plant was determined by gas chromatography and gas chromatography-mass spectrometry. The major compounds of the chloroform extract of the plant were caryophyllene oxide (19.7%), manoyl oxide (16.5%), and manool (11.3%), respectively. The extracts had antibacterial activity; however, no antifungal activity was observed against the two fungi. In particular, the ethanol and chloroform extracts exhibited significant activity against multiresistant strains of Stenotrophomonas maltophilia.

Congenital Anomalies of the Aortic Arch: Evaluation with the Use of Multidetector Computed Tomography

Aysel Turkvatan,Fatma Gul Buyukbayraktar,Tulay Olçer,Turhan Cumhur 대한영상의학회 2009 Korean Journal of Radiology Vol.10 No.2

Congenital anomalies of the aortic arch have clinical importance, as the anomalies may be associated with vascular rings or other congenital cardiovascular diseases. Multidetector computed tomography (MDCT) angiography enables one to display the detailed anatomy of vascular structures and the spatial relationships with adjacent organs; this ability is the greatest advantage of the use of MDCT angiography in comparison to other imaging modalities in the evaluation of the congenital anomalies of the aortic arch. In this review article, we illustrate 16-slice MDCT angiography appearances of congenital anomalies of the aortic arch.

The Effect of Grape Seed Extracts on Serum Paraoxonase Activities in Streptozotocin-Induced Diabetic Rats

Aysel Kıyıcı,Nilsel Okudan,Hakkı Gokbel,Muaz Belviranlı 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.3

Procyanidins, a group of flavonoids, are oligomeric forms of catechins that are abundant in red wine, grapes, cocoa, and apples. Paraoxonase acts as an antioxidant enzyme and protects low-density lipoprotein-cholesterol against oxidation. In our study we aimed to evaluate the effects of grape seed extract (GSE) on paraoxonase activities in streptozotocin-induced diabetic rats. Our study included four groups of rats: Group I (n=8), control; Group II (n=10), GSE-supplemented; Group III (n=6), streptozotocin-induced diabetic; and Group IV (n=7), GSE-supplemented diabetic rats. Serum paraoxonase activities were determined with a spectrophotometric method. Paraoxonase activities in Group III were significantly lower than in the other three groups (P<.001, P<.001, and P=.005 for Groups I, II, and IV, respectively), and Group IV showed increased paraoxonase activities compared to Group III (P=.005). This is the first study to show an association between paraoxonase status and GSE supplementation and demonstrated that GSE increased paraoxonase activities. This beneficial effect of GSE was more obvious in the diabetic group, which was more prone to atherosclerotic events compared to the healthy population.

Immunological mechanism of postherpetic neuralgia and effect of pregabalin treatment on the mechanism: a prospective single-arm observational study

( Aysel Mercan ),( Sema Tuncer Uzun ),( Sevgi Keles ),( Gulcin Hacibeyoglu ),( Resul Yilmaz ),( Ruhiye Reisli ) 대한통증학회 2021 The Korean Journal of Pain Vol.34 No.4

Background: Although neuropathic pain is a severe and common pain, its pathophysiology has not been elucidated yet. Studies in recent years have focused on the immune system’s role in the pathogenesis of neuropathic pain. The aim of this study was to investigate the role of immunological mechanisms in neuropathic pain and the effect of pregabalin by measuring immunological marker levels in peripheral blood before and after pregabalin treatment in postherpetic neuralgia (PHN) patients with neuropathic pain. Methods: Forty patients diagnosed with PHN were included in the study. CD4, T follicular cells (Tfh: CD4⁺CXCR5⁺PD1⁺), Th17 (CD4⁺CCR6⁺ and CD4⁺IL17A⁺), regulatory T cells (Treg: CD4⁺ CD25⁺foxp3⁺), Th1 (CD4⁺ CXCR3⁺ and CD4⁺ IFN-γ⁺) and Th2 (CD4⁺ IL-4⁺) cell ratios were measured in peripheral blood samples before treatment and after 3 months of treatment. Results: When immunological marker and inflammation parameter levels were compared before and after treatment, the helper T cell ratio (CD3⁺, CD4⁺) was 30.28 ± 12.27% before treatment and 34.93 ± 11.70% after treatment, so there was a statistically significant increase (P = 0.028). Th17 was 4.75 ± 5.02% before treatment and 5.80 ± 3.13% after treatment, and there was a statistically significant increase (P = 0.036). Conclusions: Immunological mechanisms play an essential role in the pathogenesis of neuropathic pain, immunologically based treatment approach will be the critical point of treatment.

An In Vitro Study on Antimicrobial Activity of Propolis from Mugla Province of Turkey

Aysel Ugur,Tulin Arslan 한국식품영양과학회 2004 Journal of medicinal food Vol.7 No.1

Antibacterial and antifungal activities of acetone and dimethyl sulfoxide (DMSO) extracts of 45 different propo-lis samples from the Mugla province of Turkey were investigated. Antimicrobial activity of propolis varied depending onpropolis sample, dosage of propolis, and the extraction solvents for all test microorganisms. Antimicrobial activity of all propo-lis samples increased with increasing dosage without reaching a plateau at the highest dosage tested. Except for Brucellamelitensis,the DMSO extracts of all propolis samples were more active than the acetone extracts of the same samples. ForB. melitensis, the acetone extracts of all propolis samples showed greater activity. The most sensitive microorganism to propo-lis was Shigella sonnei in the gram-negative group and Streptococcus mutans in the gram-positive group. The least sensitivemicroorganism was Candida albicans.A control test run with standard antibiotics revealed that propolis samples from theMugla province of Turkey has a similar or greater inhibitory effect on S. mutans, Salmonella typhi, Pseudomonas aeruginosa,S. sonei, and C. albicans growth.

Psychosocial Problems and Coping Strategies among Turkish Women with Infertility

Aysel Karaca,Gul Unsal 한국간호과학회 2015 Asian Nursing Research Vol.9 No.3

Purpose: The aim of our study was to determine the factors affecting the psychosocial problems of infertile Turkish women and to identify their coping strategies. Methods: This study employed a descriptive qualitative approach. We conducted in-depth interviews to examine the psychosocial problems faced by infertile Turkish women. The participants were selected in two stages. In the first stage, 118 women diagnosed with primary infertility completed a personal information form and the Fertility Problem Inventory (FPI). In the second stage, in-depth interviews (lasting 45e90 minutes) were conducted with 24 (age 20 to 41 years) infertile women randomly selected from the groups formed according to their FPI global stress levels determined in Stage 1. Content analysis was used to examine the qualitative data. Results: The results comprised nine main themes regarding the psychosocial problems encountered by women and the methods used to overcome these problems. These included the meaning attributed to being childless, negative self-concept, perceived social pressure, perceived social support, psychological symptoms, social withdrawal and isolation, spiritual coping, cherishing hope/restructuring life, and adopting traditional methods. Social pressure and stigma were common. Infertility was found to negatively affect the participants' self-perception and view of life. The women used spiritual methods for overcoming stress and avoiding society, as well as traditional fertility remedies. Conclusions: Infertile women suffer from various psychosocial problems because of infertility and they adopt emotion-focused coping methods.

Congenital Variants and Anomalies of the Pancreas and Pancreatic Duct: Imaging by Magnetic Resonance Cholangiopancreaticography and Multidetector Computed Tomography

Aysel Türkvatan,Ays¸e Erden,Mehmet Akif Türkog˘lu,Özlem Yener 대한영상의학회 2013 Korean Journal of Radiology Vol.14 No.6

Though congenital anomalies of the pancreas and pancreatic duct are relatively uncommon and they are often discovered as an incidental finding in asymptomatic patients, some of these anomalies may lead to various clinical symptoms such as recurrent abdominal pain, nausea and vomiting. Recognition of these anomalies is important because these anomalies may be a surgically correctable cause of recurrent pancreatitis or the cause of gastric outlet obstruction. An awareness of these anomalies may help in surgical planning and prevent inadvertent ductal injury. The purpose of this article is to review normal pancreatic embryology, the appearance of ductal anatomic variants and developmental anomalies of the pancreas,with emphasis on magnetic resonance cholangiopancreaticography and multidetector computed tomography.

Knowledge Level of Working and Student Nurses on Cervical Cancer and Human Papilloma Virus Vaccines

Topan, Aysel,Ozturk, Ozlem,Eroglu, Hulya,Bahadir, Ozgur,Harma, Muge,Harma, Mehmet Ibrahim Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

Purpose: To determine knowledge levels of working and student nurses about cervical cancer and prophylactic cancer vaccines. Materials and Methods: This study was performed on 259 nursing students in the Department of Nursing and 137 nurses working in Health Research and Practice Center, approved to participate in the study between April-June 2012. The study was performed universally without selecting a sample. A questionnaire that was prepared for evaluating participants' knowledge and attitudes about human papilloma virus (HPV) vaccine was distributed to the nurses and data obtained from the forms were transferred to SPSS 15.00 program and statistically analyzed. Results: It was found that 54.8% of the student nurses were between 21-24 years old and 13.1% of working students were between 25-28 years old. When student nurses and working nurses were compared in terms of their knowledge about the causes of cervical cancer, their ideas about prevention from cervical cancer with HPV vaccine, their ideas about possible risks of HPV vaccine and conservation ratios of HPV vaccine, it was observed that there were no statistically significant differences (p>0.05). When student nurses and working nurses were compared in terms of the information-source about HPV, ways of HPV contamination, awareness about people who are susceptible to HPV contamination and age of HPV vaccination, it was determined that there was a statistically significant difference (p<0.05). Conclusions: It was found that all nurses had some knowledge about cervical cancer and HPV vaccine, but this was not sufficient. Therefore; it is recommended to use verbal, written and visual communication tools intensively in order to have topics on cervical cancer, early diagnosis and prevention in bachelor and master programs for nurses, to inform society about cervical cancer and HPV vaccine for public health and to teach precautions for its prevention.

Clinical Manifestations of Behcet's Disease : An Analysis of 2147 Patients

Gurler, Aysel,Boyvat, Ay?e,Tursen, ?mit Yonsei University, College of Medicine 1997 Yonsei medical journal Vol.38 No.6

Chemical composition and anti-biofilm activity of Thymus sipyleus BOISS. subsp. sipyleus BOISS. var. davisianus RONNIGER essential oil

Ozgur Ceylan,Aysel Ugur 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.6

In this study, antimicrobial and antibiofilmactivities and the chemical composition of Thymus sipyleusBOISS. subsp. sipyleus BOISS. var. davisianus RONNIGERessential oil was evaluated. The essential oil wasobtained by hydro-distillation and analyzed by gas chromatography-mass spectrometry. Fourteen compounds werecharacterized, having as major components thymol(38.31 %) and carvacrol (37.95 %). Minimum inhibitoryconcentrations (MICs) of oil and the major componentswere calculated by serial dilution method, and anti-biofilmeffects by microplate biofilm assay against five Grampositive (Staphylococcus aureus MU 38, MU 40, MU 46,MU 47, Stahylococcus epidermidis MU 30) and five Gramnegative (Pseudomonas aeruginosa MU 187, MU 188, MU189, Pseudomonas fluorescens MU 180, MU 181) bacteria. It was found that MICs for essential oil, thymol and carvacrolwere between 5 and 50 ll/ml, 0.125–0.5 lg/ml and0.125–05 ll/ml, respectively. The results showed thatdoses of MIC produced a greater anti-biofilm influencethan 0.5, 0.25 and 0.125 MIC. In the presence of essentialoil (MIC), the mean biofilm formation value was equal to67 ± 5.5 % for P. aeruginosa MU 188, and essential oil(MIC) inhibition exceeds 60 % for P. aeruginosa biofilms. The results also showed that carvacrol (MIC) was able toinduce an inhibition 72.9 ± 4.1 % for S.aureus (MU 40)biofilm. In addition, thymol (MIC) showed 68.6 ± 5.3 %reduction in biofilm formation of P. fluorescens MU 181. This study demonstrated the antimicrobial and antibiofilmactivity of T. sipyleus BOISS. subsp. sipyleus BOISS. var. davisianus RONNIGER essential oil and points out theexceptional efficiency of thymol and carvacrol, whichcould represent candidates in the treatment of Pseudomonasand Staphylococcus biofilms.