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Ayodele Jacob Akinyemi,Adedayo Oluwaseun Ademiluyi,Ganiyu Oboh 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.3
Angiotensin-1-converting enzyme (ACE) inhibitors are widely used in the treatment of cardiovascular diseases. This study sought to investigate the inhibitory effect of two varieties of ginger (Zingiber officinale) commonly consumed in Nigeria on ACE activity in rats fed a high cholesterol diet. The inhibition of ACE activity of two varieties of ginger (Z. officinale) was investigated in a high cholesterol (2%) diet fed to rats for 3 days. Feeding high cholesterol diets to rats caused a significant (P < .05) increase in the ACE activity. However, there was a significant (P < .05) inhibition of ACE activity as a result of supplementation with the ginger varieties. Rats that were fed 4% white ginger had the greatest inhibitory effect as compared with a control diet. Furthermore, there was a significant (P < .05) increase in the plasma lipid profile with a concomitant increase in malondialdehyde (MDA) content in rat liver and heart tissues. However, supplementing the diet with red and white ginger (either 2% or 4%) caused a significant (P < .05) decrease in the plasma total cholesterol, triglyceride, very low density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol levels, and in MDA content in the tissues. Conversely, supplementation caused a significant (P < .05) increase in plasma high-density lipoprotein-cholesterol level when compared with the control diet. Nevertheless, rats fed 4% red ginger had the greatest reduction as compared with control diet. In conclusion, both ginger varieties exhibited anti-hypercholesterolemic properties in a high cholesterol diet fed to rats. This activity of the gingers may be attributed to its ACE inhibitory activity. However, white ginger inhibited ACE better in a high cholesterol diet fed to rats than red ginger. Therefore, both gingers could serve as good functional foods/nutraceuticals in the management/treatment of hypertension and other cardiovascular diseases.
Ayodele J. Akinyemi,,Adedayo O. Ademiluyi,Ganiyu Oboh 한국식품영양과학회 2013 Journal of medicinal food Vol.16 No.7
Ginger has reportedly been used in folk medicine for the management and prevention of hypertension and other cardiovascular diseases. Therefore, this study sought to investigate the inhibitory effect of aqueous extracts of two varieties of ginger on a key enzyme linked to hypertension (angiotensin I.converting enzyme [ACE]), and on pro-oxidants [Fe2 + and sodium nitroprusside (SNP)] which have been shown to induce lipid peroxidation in the rat’s isolated heart in vitro. Aqueous extracts (0.05 mg/mL) of red ginger (Zingiber officinale var. Rubra) and white ginger (Zingiber officinale Roscoe) were prepared and the ability of the extracts to inhibit ACE along with Fe2 + - and SNP-induced lipid peroxidation was determined in rat’s heart in vitro. Results revealed that both extracts inhibited ACE in a dose-dependent manner (25.125 lg/ mL). However, red ginger extract (EC50 = 27.5 lg/mL) had a significantly (P < .05) higher inhibitory effect on ACE than white ginger extract (EC50 = 87.0 lg/mL). Furthermore, incubation of the rat’s heart in the presence of Fe2 + and SNP caused a significant increase (P < .05) in the malondialdehyde (MDA) content of the heart homogenates, while the introduction of the ginger extracts (78.313 lg/mL) caused a dose-dependent decrease in the MDA content of the stressed heart homogenates. This suggests that the possible mechanism through which ginger exerts its antihypertensive properties may be through inhibition of ACE activity and prevention of lipid peroxidation in the heart. Furthermore, red ginger showed stronger inhibition of ACE than white ginger. Additionally, it should be noted that these protective properties of the ginger varieties could be attributed to their polyphenol contents.
Effect of Two Ginger Varieties on Arginase Activity in Hypercholesterolemic Rats
Ayodele Jacob Akinyemi,Ganiyu Oboh,Adedayo Oluwaseun Ademiluyi,Aline Augusti Boligon,Margareth Linde Athayde 사단법인약침학회 2016 Journal of Acupuncture & Meridian Studies Vol.9 No.2
Recently, ginger has been used in traditional Chinese medicine as an herbal therapy for treating several cardiovascular diseases, however, information on its mechanism of action is limited. The present study assessed the effect of two ginger varieties (Zingiber officinale and Curcuma longa) on the arginase activity, atherogenic index, levels of liver thiobarbituric acid reactive substances (TBARSs), and plasma lipids in rats fed with a high-cholesterol (2%) diet for 14 days. Following the treatment period, it was found that feeding a high-cholesterol diet to rats caused significant (p < 0.05) increases in arginase activity, atherogenic index, levels of TBARS, total cholesterol (TC), triglycerides (TGs), and low-density lipoprotein cholesterol (LDL-C) with a concomitant decrease in highdensity lipoprotein cholesterol (HDL-C). However, both ginger and turmeric (2% and 4%) caused significant (p < 0.05) decreases in arginase activity and the atherogenic index, and prevented hypercholesterolemia by decreasing the TC, TGs, and LDL-C while increasing the HDL-C when compared with the controls. In conclusion, dietary supplementation with both types of rhizomes (ginger and turmeric) inhibited arginase activity and prevented hypercholesterolemia in rats that received a high-cholesterol diet. Therefore, these activities of ginger and turmeric represent possible mechanisms underlying its use in herbal medicine to treat several cardiovascular diseases.
Moses Ayodele Ojo 한국식품영양과학회 2022 Preventive Nutrition and Food Science Vol.27 No.1
Tannins, water-soluble phenolic compounds, have been reported to have the ability to form complexes with nutritionally important nutrients such as protein and mineral elements thereby making them unavailable for absorption and utilization. Toxicity of tannin has been demonstrated in experimental animals although no deleterious effect of ingestion of legume tannin on human physiology has been reported. This report highlights the processing effects of soaking and hydrothermal techniques on some underutilised hard-to-cook legume crops and the importance of tannin in legume nutrition. Soaking and hydrothermal processing reduce the tannin content of processed legume seeds and hence improve the availability of protein and mineral elements. In view of the recent findings of the health benefits, classification of tannin which is traditionally regarded as an antinutrient should be reconsidered. Provision of these information will enhance knowledge of legume nutrition and economic utility. Increasing consumption of underutilized nutritionally important legume seeds, it is hoped, will alleviate the problem of protein energy malnutrition in many developing nations.
Differential Response of Maize Inbreeding Depression to (Optimal and Stressed) Environments
Sunday Ayodele Ige,Bashir Omolaran Bello,Jimoh Mahamood,Michael Afolabi,Aremu Charity,Stephen Abolusoro,Abosede Victoria Adeniyi 한국육종학회 2023 Plant Breeding and Biotechnology Vol.11 No.4
Inbred lines generated from 10 maize population developed between 1979 and 2008 were used to investigate theinbreeding depression of tropical maize varieties developed at different breeding eras and evaluated in (optimal and stressed) condition. Across all the environments used for this study, estimates of inbred depression (I) for grain yield which ranged from 15.63% foroptimum environment to 35.85 under stem borer infestation, showed differences in the severity of the effects of practicing inbreedingin each of the populations and the different environments. The highest values of inbreeding depression for grain yield were recordedunder stem borer infestation. The effect of inbreeding was the most severe for var. DMR-LSR-W under borer infestation and least forDMR-LSR-Y in stress free environment. This is an indication that the responses of the maize populations to inbreeding as well as therate of attaining homozygosity differed with environments. Across the four different environments under which the genotypes wereevaluated, average inbreeding depression for grain yield were greater relative to other traits considered which should be expected sincegrain yield is a quantitatively inherited trait, governed by many genes each with minor effects.