Effectiveness of Preemptive Analgesia Using a Frequency Rhythmic Electrical Modulation System in Patients Having Instrumented Fusion for Lumbar Stenosis

Serhat Aydoğan,Uygur Er,Onur Özlü 대한척추외과학회 2014 Asian Spine Journal Vol.8 No.2

Study Design: A randomized prospective study. Purpose: To assess postoperative analgesic requirements after Phyback therapy preemptively in patients undergoing lumbar stabilization. Overview of Literature: Frequency Rhythmic Electrical Modulation System is the latest method of preemptive analgesia. Methods: Forty patients were divided into two groups. Patients who were to receive tramadol were allocated to “group A” and those who were to receive Phyback therapy were allocated to “group B.” In patients with a visual analog scale score of >4 or a verbal rating scale score of >2, 75 mg of diclofenac IM was administered. The amount of analgesic consumption, the bolus demand dosage, and the number of bolus doses administered were recorded. Patient satisfaction was evaluated using the visual analog patient satisfaction scale. Results: There were statistically significant differences in the visual analog scale and verbal rating scale scores in the fourth, sixth, 12th, and 24th hours. The number of bolus infusions was significantly lower in group B. The amount of analgesic consumption was higher in group A. There was a significant difference between the two groups in the number of bolus infusions and the total amount of analgesic consumption, and this comparison showed better results for group B. Conclusions: Application of Phyback therapy reduced postoperative opioid consumption and analgesic demand, and it contributed to reducing patients’ level of pain and increased patient satisfaction. Moreover, the application of preemptive Phyback therapy contributed to reducing preoperative pain which may have reduced patient anxiety.

Male Breast Cancer: 37-Year Data Study at a Single Experience Center in Turkey

Fatih Selcukbiricik,Fatih Aydoğan,Nuran Beşe,Evin Büyükünal,Süheyla Serdengeçti,Deniz Tural 한국유방암학회 2013 Journal of breast cancer Vol.16 No.1

Purpose: The aim of this study is to evaluate the effects of prognostic factors on the overall survival (OS) and locoregional control (LC) among male breast cancer (MBC) patients treated at Cerrahpasa Medical School Hospital, along with a review of the related literature. Methods: The data of 86 patients treated for MBC from 1973 to 2010 are retrospectively reviewed. Patient demographics and clinical information, including the date of diagnosis, treatment, clinical course, and the date and causes of death are routinely recorded. Results: Median follow-up was 66 months. Isolated local-regional recurrence and distant metastases were observed in 15 (17.4%) and 24 (34.1%) of the cases, respectively. The 5-year OS rate was 65.8%; the disease-free survival rate was 72.4%, and the LC rate was 89.7%. The prognostic factors influencing local relapse were the T stage (p=0.002) and the chest wall muscular invasion (p=0.027) in the univariate analysis. The prognostic factors influencing OS were the presence of a positive axillary lymph node (p=0.001) and the T stage (p=0.001) in the univariate analysis. The T stage (p=0.008) and node (N) stage (p=0.038) were significant prognostic factors for OS in the multivariate analyses. Also, the T stage (p=0.034) was found to be significant for LC. Conclusion: We found that only the tumor size and lymph node status were independent prognostic factors for survival. In addition, only the tumor size was an independent prognostic factor for locoregional relapse. Modified radical mastectomy and conservative surgical procedures had similar outcomes for LC.

Are Systemic Voriconazole and Caspofungin Ototoxic? An Experimental Study with Rats

Emine Aydın,Filiz Aydoğan,,Eren Taştan,,Ayşe İriz,Gökhan Karaca,İlknur Haberal Can 대한이비인후과학회 2012 Clinical and Experimental Otorhinolaryngology Vol.5 No.3

Objectives. To determine whether systemic administration of voriconazole and caspofungin causes ototoxicity. Methods. This study was conducted on 32 healthy male Wistar albino rats. The baseline auditory brainstem response (ABR)thresholds of all animals were obtained under general anesthesia. Then, the rats were randomly divided into 4 groups (groups I-IV), each group consisting of 8 rats. Rats in group I were injected intraperitoneally with voriconazole 10 mg/kg/day for 7 days, and the rats in the group II were injected intraperitoneally with caspofungin 5 mg/kg/day for 7 days. Group III received 120 mg/kg/day gentamicin for 7 days. Group IV received saline for 7 days. The animals were then observed for 7 days, and on 14th day of the trial, posttreatment ABRs of both ears were recorded. Results. We did not find any significant differences between pretreatment and posttreatment median ABR thresholds in the voriconazole, caspofungin, or saline groups. In the gentamicin group, there was a statistically significant difference between pretreatment and posttreatment ABR thresholds. Conclusion. Caspofungin and voriconazole did not change ABR thresholds in speech frequencies after a 7-day-period of their administration. We believe that further animal studies must be performed after administration of these agents for a longer time period, and these findings must be consolidated with histopathological investigations. Objectives. To determine whether systemic administration of voriconazole and caspofungin causes ototoxicity. Methods. This study was conducted on 32 healthy male Wistar albino rats. The baseline auditory brainstem response (ABR)thresholds of all animals were obtained under general anesthesia. Then, the rats were randomly divided into 4 groups (groups I-IV), each group consisting of 8 rats. Rats in group I were injected intraperitoneally with voriconazole 10 mg/kg/day for 7 days, and the rats in the group II were injected intraperitoneally with caspofungin 5 mg/kg/day for 7 days. Group III received 120 mg/kg/day gentamicin for 7 days. Group IV received saline for 7 days. The animals were then observed for 7 days, and on 14th day of the trial, posttreatment ABRs of both ears were recorded. Results. We did not find any significant differences between pretreatment and posttreatment median ABR thresholds in the voriconazole, caspofungin, or saline groups. In the gentamicin group, there was a statistically significant difference between pretreatment and posttreatment ABR thresholds. Conclusion. Caspofungin and voriconazole did not change ABR thresholds in speech frequencies after a 7-day-period of their administration. We believe that further animal studies must be performed after administration of these agents for a longer time period, and these findings must be consolidated with histopathological investigations.

A Retrospective Review of Radiographic and Clinical Findings from the M6 Cervical Prosthesis

İsmail Oltulu,Özgür Korkmaz,Ender Sarıoğlu,Mehmet Aydoğan 대한척추외과학회 2019 Asian Spine Journal Vol.13 No.6

Study Design: Retrospective clinical study. Purpose: To evaluate clinical results of the M6 cervical prosthesis. Overview of Literature: Cervical disk prostheses have been developed to preserve motion and reduce degeneration in adjacent seg-ments in degenerative disk diseases. Methods: A retrospective evaluation was performed on 43 patients who received the M6 cervical disk prosthesis between 2012 and 2016. Standard and dynamic radiographs, computed tomography, and magnetic resonance imaging were used to evaluate all the patients preoperatively and postoperatively. The Neck Disability Index (NDI) and Visual Analog Scale (VAS) scores were examined in evaluating the clinical and functional results of patients with collapsed disk herniation who had received the M6 cervical prosthesis and to evaluate whether the core structure of the prosthesis protects motion. Results: The mean follow-up period was 34.12±6.70 months. Radiologically, the preoperative cervical segment ROM was measured as a mean of 5.77°±2.19° preoperatively and 8.49°±2.37° at the inal postoperative follow-up examination. In the patients with a preoperative disk height of <4 mm, the segmental ROM increased from 4.53°±2.79° preoperatively to 7.2°±3.18° postoperatively. In the patients with a preoperative disk height of >4 mm, the cervical segment ROM increased from 6.4°±1.45° preoperatively to 8.6°±2.02° at the inal postoperative follow-up examination. The NDI scores reduced from 53.86±9.77 preoperatively to 22.69±7.26 postop-eratively and the VAS scores reduced from 8.74±0.58 to 1.88±1.14. During follow-up in any patient, no collapse of the levels at which surgery was performed was observed. No heterotopic ossiication or implant failure was recorded in any patient during the follow-up period. Conclusions: The M6 new-generation cervical disk prosthesis had few complications. No heterotopic ossiication was observed in any patient, and lexion-extension ROM was maintained in all the patients, indicating the M6 prosthesis as a promising alternative.

Concurrent Assay for Four Bacterial Species Including Alloiococcus Otitidis in Middle Ear, Nasopharynx and Tonsils of Children with Otitis Media with Effusion: A Preliminary Report

Emine Aydın,Eren Taştan,,Filiz Aydoğan,,Esra Karakoç,Yunus Kantekin,Münir Demirci,Mihriban Yücel,Necmi Arslan 대한이비인후과학회 2012 Clinical and Experimental Otorhinolaryngology Vol.5 No.2

Objectives. To detect the prevalences of Alloiococcus otitidis, as well as Haemophilus influenzae, Streptococcus pneumoniae,and Moraxella catarrhalis in children with chronic otitis media with effusion (OME) and to simultaneously investigate the colonization of these bacteria in the nasopharynx and palatine tonsils of these patients. Methods. The study included 34 pediatric patients with OME, and 15 controls without OME. In the study group, A. otitidis,H. influenzae, S. pneumoniae, and M. catarrhalis were investigated in the samples obtained from middle ear effusions (MEE), nasopharyngeal swabs (NPS) and tonsillar swabs (TS), using multiplex polymerase chain reaction (PCR) and conventional culture methods. Only the samples obtained from NPS and TS were studied with the same techniques in the control group. Results. A. otitidis was isolated only in MEE and only with multiplex PCR method. A. otitidis, S. pneumoniae, M. catarrhalis,H. influenzae were identified in 35%, 8.8%, 8.8%, and 2.9%, respectively, in 34 MEE. A. otitidis was not isolated in NPS or TS of the study and the control groups. Conclusion. The prevalence of A.otitidis is high in children with OME and A.otitidis doesn’t colonize in the nasopharynx or tonsil. Objectives. To detect the prevalences of Alloiococcus otitidis, as well as Haemophilus influenzae, Streptococcus pneumoniae,and Moraxella catarrhalis in children with chronic otitis media with effusion (OME) and to simultaneously investigate the colonization of these bacteria in the nasopharynx and palatine tonsils of these patients. Methods. The study included 34 pediatric patients with OME, and 15 controls without OME. In the study group, A. otitidis,H. influenzae, S. pneumoniae, and M. catarrhalis were investigated in the samples obtained from middle ear effusions (MEE), nasopharyngeal swabs (NPS) and tonsillar swabs (TS), using multiplex polymerase chain reaction (PCR) and conventional culture methods. Only the samples obtained from NPS and TS were studied with the same techniques in the control group. Results. A. otitidis was isolated only in MEE and only with multiplex PCR method. A. otitidis, S. pneumoniae, M. catarrhalis,H. influenzae were identified in 35%, 8.8%, 8.8%, and 2.9%, respectively, in 34 MEE. A. otitidis was not isolated in NPS or TS of the study and the control groups. Conclusion. The prevalence of A.otitidis is high in children with OME and A.otitidis doesn’t colonize in the nasopharynx or tonsil.

Subtype Is a Predictive Factor of Nonsentinel Lymph Node Involvement in Sentinel Node-Positive Breast Cancer Patients

Kaptan Gülben,Uğur Berberoğlu,Ogün Aydoğan,Volkan Kınaş 한국유방암학회 2014 Journal of breast cancer Vol.17 No.4

Purpose: This study aimed to identify the effect of breast cancersubtype on nonsentinel lymph node (NSLN) metastasis in patientswith a positive sentinel lymph node (SLN). Methods: Therecords of 104 early breast cancer patients with a positive SLNbetween April 2009 and September 2013 were retrospectivelyevaluated. All patients underwent axillary lymph node dissection. The effects of the tumor subtype (luminal A, luminal/HER2+, humanepidermal growth factor receptor 2 [HER2] overexpression,and triple-negative) and other clinicopathological factors onNSLN metastasis were examined by univariate and multivariatestatistical analyses. Results: Fifty of 104 patients (48%) exhibitedNSLN metastasis. Univariate and multivariate analyses revealedthat tumor size and the ratio of positive SLNs were significantrisk factors of NSLN metastasis in patients with a positive SLN. The rate of NSLN metastasis was higher in patients with luminal/HER2+ and HER2 overexpression subtypes than that in patientswith other subtypes in the univariate analysis (p<0.001). In themultivariate analysis, both patients with luminal/HER2+(p<0.006) and patients with HER2 overexpression (p<0.031)subtypes had a higher risk of NSLN metastasis than patientswith the luminal A subtype. Conclusion: Subtype classificationshould be considered as an independent factor when evaluatingthe risk of NSLN metastasis in patients with a positive SLN. Thisresult supports the development of new nomograms includingbreast cancer subtype to increase predictive accuracy.

Effects of PEDOT:PSS and crystal violet interface layers on current-voltage performance of Schottky barrier diodes as a function of temperature and variation of diode capacitance with frequency

Deniz A.R.,Taş A.İ.,Çaldıran Z.,İncekara Ü.,Biber M.,Aydoğan Ş.,Türüt A. 한국물리학회 2022 Current Applied Physics Vol.39 No.-

In this study, diode applications of Crystal Violet (CV) and PEDOT materials were studied. The Ni/p-Si/Al, Ni/CV/p-Si/Al and Ni/PEDOT:PSS/CV/p-Si/Al diodes were fabricated. The I–V (current-voltage) characteristics of all diodes were analyzed at room temperature, it was determined that the PEDOT:PSS and CV materials improved the basic diode parameters. Also, I–V characteristics of Ni/PEDOT:PSS/CV/p-Si/Al of diode were investigated for different temperature values. It has been determined that the basic diode parameters are strongly dependent on temperature. It was determined that while the barrier height (Φb) increased with increasing temperature, the ideality factor (n) and the series resistance (Rs) values decreased. Using temperature-dependent measurements, it was determined that the potential barrier and ideality factor values at the contact interface has a double Gaussian distribution. In addition, C–V (capacitance-voltage) measurements of these diodes were analyzed depending on the frequency. It was found that the diode capacitance decreased with increasing frequency.

Patients’ and parents’ concerns and decisions about orthodontic treatment

Fatih Kazancı,Cihan Aydo?an,Ozer Alkan 대한치과교정학회 2016 대한치과교정학회지 Vol.46 No.1

Objective: Patients’ and parents’ expectations are important in orthodontic treatment decision making. The literature generally demonstrates the perceived benefits of orthodontic treatment, but patients’ and their parents’ concerns about orthodontic treatment have not been investigated comprehensively. The aim of this study was to identify patients’ and parents’ concerns about orthodontic treatment and compare them according to sex, age, and treatment demand level. Methods: One hundred and eighty-nine children and their parents were interviewed about concerns related to orthodontic treatment. Patients and parents were asked about orthodontic treatment decisions. Answers were recorded as “yes,” “no,” or “don’t know.” Chi-squared and Fisher’s exact tests were used to compare concerns between age groups, sexes, and treatment demand levels. Kappa statistics were used to assess agreement between patients and their parents. Results: Concerns about orthodontic treatment were gathered under 10 items as follows: “feeling pain,” “the appearance of braces,” “being teased,” “avoiding smiling,” “speech problems,” “dietary changes,” “problems with transportation,” “economic problems,” “long treatment duration,” and “missing school.” There was no statistically significant difference in concerns between the sexes or age groups. Some concern items and treatment demand were inversely related in patients. Conclusions: The results of this study demonstrate patients’ and parents’ concerns about orthodontic treatment. Differences between the concerns of patients with different treatment demands imply that children might reject orthodontic treatment because of their concerns. Appropriate consultation of patients addressing their concerns may help reduce anxiety and improve the acceptance of treatment.

Double-bond depletion of soybean oil triglycerides with KMnO4/H2O in dense carbon dioxide

?ner Horta?su,Selen Aydo?an,Selim K?sefo?lu,U?ur Akman 한국화학공학회 2006 Korean Journal of Chemical Engineering Vol.23 No.5