The Combination of Amygdalin with Some Anticancer, Antiparasitic, and Antigout Drugs Against MG63, Saos2, SW1353, and FL Cells In Vitro

Davut Aydın,Korhan Özkan,Ali Aydın 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.11

Osteosarcoma has a poor prognosis and survival rate due to inadequate chemotherapy, high recurrence ability, high metastasis potential, and almost no radiotherapy being applied. One of the strategies to solve these problems is to develop the pharmacologically active plant metabolite, amygdalin, in combination therapeutic systems. In this project, the antiproliferative effects of amygdalin alone and in binary or ternary combinations with some anticancer drugs (cisplatin, 5-fluorouracil, oxaliplatin, and camptothecin), antiparasitic drugs (metronidazole and miltefosine), and an antigout drug (colchicine) were examined using human bone osteosarcoma cell lines (MG-63 and Saos2), the chondrosarcoma cell line (SW1353), and the normal human cell line (FL). Known half-maximal inhibitory concentration values of the drugs were taken into consideration, and the recommended combination ratios were used in the Chou–Talalay method. The strong synergistic effect commonly seen in the combination of amygdalin with miltefosine, metronidazole, camptothecin, colchicine, oxaliplatin, 5-fluorouracil, and cisplatin dual drug indicates that these combinations can be used in cancer treatment. The synergistic effect caused by amygdalin decreases toxicity by increasing drug yield. However, amygdalin antagonism seen in several combinations may prevent these pairs from being used together. In combination with antagonistic effects, it may be preferable to use amygdalin alone as it generally causes strong antiproliferative effects. Besides, there is a more potent synergism between amygdalin and triple drug combinations. Overall, these results emphasize that amygdalin combinations in treatment of bone cancer are significant.

Predictor factors of 1-rooted mandibular second molars on complicated root and canal anatomies of other mandibular teeth

Aydın Hakan,Harorlı Hatice 대한치과보존학회 2024 Restorative Dentistry & Endodontics Vol.49 No.1

Objectives This study aimed to determine the effects of 1-rooted mandibular second molar (MnSM) teeth on root canal anatomy complexities of the mandibular central incisor (MnCI), mandibular lateral incisor (MnLI), mandibular canine (MnCn), mandibular first premolar (MnFP), mandibular second premolar (MnSP), and mandibular first molar (MnFM) teeth. Materials and Methods Cone-beam computed tomography images of 600 patients with full lower dentition were examined. Individuals with 1-rooted MnSMs were determined, and the complexity of root canal anatomy of other teeth was compared with individuals without 1-rooted MnSMs (Group-1; subjects with at least one 1-rooted MnSM, Group-2; subjects with more than a single root in both MnSMs). A second canal in MnCIs, MnLIs, MnCns, MnFPs, and MnSPs indicated a complicated root canal. The presence of a third root in MnFMs was recorded as complicated. Results The prevalence of 1-rooted MnSMs was 12.2%, with the C-shaped root type being the most prevalent (9%). There were fewer complicated root canals in MnCIs (p = 0.02), MnLIs (p < 0.001), and MnFPs (p < 0.001) in Group 1. The other teeth showed no difference between the groups (p > 0.05). According to logistic regression analysis, 1-rooted right MnSMs had a negative effect on having complex canal systems of MnLIs and MnFPs. Left MnSMs were explanatory variables on left MnLIs and both MnFPs. Conclusions In individuals with single-rooted MnSMs, a less complicated root canal system was observed in all teeth except the MnFMs. Objectives This study aimed to determine the effects of 1-rooted mandibular second molar (MnSM) teeth on root canal anatomy complexities of the mandibular central incisor (MnCI), mandibular lateral incisor (MnLI), mandibular canine (MnCn), mandibular first premolar (MnFP), mandibular second premolar (MnSP), and mandibular first molar (MnFM) teeth. Materials and Methods Cone-beam computed tomography images of 600 patients with full lower dentition were examined. Individuals with 1-rooted MnSMs were determined, and the complexity of root canal anatomy of other teeth was compared with individuals without 1-rooted MnSMs (Group-1; subjects with at least one 1-rooted MnSM, Group-2; subjects with more than a single root in both MnSMs). A second canal in MnCIs, MnLIs, MnCns, MnFPs, and MnSPs indicated a complicated root canal. The presence of a third root in MnFMs was recorded as complicated. Results The prevalence of 1-rooted MnSMs was 12.2%, with the C-shaped root type being the most prevalent (9%). There were fewer complicated root canals in MnCIs (p = 0.02), MnLIs (p < 0.001), and MnFPs (p < 0.001) in Group 1. The other teeth showed no difference between the groups (p > 0.05). According to logistic regression analysis, 1-rooted right MnSMs had a negative effect on having complex canal systems of MnLIs and MnFPs. Left MnSMs were explanatory variables on left MnLIs and both MnFPs. Conclusions In individuals with single-rooted MnSMs, a less complicated root canal system was observed in all teeth except the MnFMs.

The effect of different neural mobilization exercises on hamstring flexibility and functional flexibility in wrestlers

Aydın Balcı,Ezgi Ünüvar,Tuğba Kocahan 한국운동재활학회 2020 JER Vol.16 No.6

Sociological Observations on ‘Strangerhood’ : Attributions in European History

Aydın, Yasar 이화여자대학교 이화인문과학원 2010 탈경계인문학 Vol.2 No.-

This article deals with two questions: How are individuals or groups categorised as ‘strangers’ Which socio-political mechanisms (structural aspects) or governmental policies (political aspects) play a role in this categorisation? ‘Stranger’ is understood as a person who is perceived and categorised as stranger, and became target of resentments and stigmatisation. The thesis supported in this article is as follows: The both semantics (ideas, concepts, notions, explanations etc.) of strangerhood as well as the socio-political situation and status of strangers vary in the European history and correlate with societal structure.

The relationships between isometric muscle strength and respiratory functions of the Turkish National Paralympic Goalball Team

Aydın Balcı,Bihter Akınoğlu,Tuğba Kocahan,Adnan Hasanoğlu 한국운동재활학회 2021 JER Vol.17 No.1

Maximal Exercise-Corrected QT as a Predictor of Coronary Artery Disease: Comparison of Simpler Heart Rate Corrections

Aydın Akyuz,Seref Alpsoy,Dursun Cayan Akkoyun,Hasan Degirmenci,Niyazi Guler 대한심장학회 2013 Korean Circulation Journal Vol.43 No.10

Background and Objectives: The relationship between QT prolongation and myocardial ischemia is widely known. Due to the limited value of ST depression, we aimed to evaluate, by using four simpler heart rate corrections (Bazett, Framingham, Fridericia and Hodges), the value of maximal exercise-QTc prolongation in the diagnosis of coronary artery disease (CAD) presence and severity. Subjects and Methods: We enrolled 234 subjects (mean age 57.3±9 years, 143 men) who had undergone exercise testing and coronary angiography due to a suspicion of CAD in the study. Evaluating CAD severity with Gensini scoring, the CAD group (n=122) and controls with non-CAD were compared in terms of corrected QT duration at maximal exercise. Results: Age, gender, hypertension, dyslipidemia, smoking, exercise duration, resting, and peak heart rate were similar between the two groups (all p>0.05). The CAD group had higher raw QT values than the controls {268 (169-438) vs. 240 (168-348), p<0.001}. Although Fra-mingham QTc of ≥350 ms and Fridericia QTc of ≥340 ms were seen to be useful for the diagnosis of CAD, there was no additive diagnostic value of exercise QTc in addition to ST depression. Maximal exercise-QTc Bazett (r=0.163, p=0.01), Framingham (r=0.239, p=0.001), and Fri-dericia (r=0.206, p=0.001) equations were weakly positively correlated with Gensini scoring. Conclusion: The patients with CAD have longer QTc intervals at peak heart rates during exercise. This finding provides insufficient evid-ence to support routine incorporation of QTc at peak heart rates into exercise test interpretation.

Spontaneous Coronary Artery Dissection and Woven Coronary Artery: Three Cases and a Review of the Literature

Aydın Akyuz,Seref Alpsoy,Dursun Cayan Akkoyun 대한심장학회 2013 Korean Circulation Journal Vol.43 No.6

Spontaneous coronary artery dissection (SCAD) and woven coronary artery anomaly (WCAA) are relatively rare. A few of the previously reported woven coronary artery cases have involved in a single coronary artery. We present an unusual woven case involving all coronary arteries and two patient with SCAD. We have also reviewed the literature related to these disease, as they resemble one another.

Optimization of gold recovery from copper anode slime by acidic ionic liquid

Aydın Rüşen,Mehmet Ali Topçu 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.11

Hydrometallurgical gold recovery from primary or secondary sources is mainly based on a cyanide process, which is very dangerous for the environment due to the high toxicity levels. In view of the environmental effect, the present study proposes a new green solvent called 1-ethyl-3-methyl-imidazolium hydrogen sulfate (EmimHSO4) ionic liquid (IL) to recover gold from copper anode slime (CAS). The optimum leaching conditions for maximizing gold recovery were determined by orthogonal array (OA) of Taguchi’s experimental design method. OA L16 (44) including four parameters with four levels each, was used to examine the effects of IL concentration (20%, 40%, 60%, 80% v/v), temperature (25, 50, 75, 95 oC), time (½, 1, 2, 4 h) and solid/liquid ratio (1/10, 1/15, 1/20, 1/25 g/mL) on leaching efficiency of the gold recovery. Statistical analysis of variance (ANOVA) was used to determine the relevance between experimental conditions and gold recovery. The selective leaching tests results showed that gold recovery up to 89.07% was attained on laboratory scale under the optimum leach conditions: 80% IL concentration, 75 oC, 4 h and 1/25 g/mL solid/liquid ratio. According to these results, EmimHSO4 IL provides a very good ambiance for the oxidative leaching of gold and can be offered as an alternative leaching agent instead of harmful cyanide-based solvents.

Maxillary Ameloblastoma Case of a Dog

Aydın Gurel,Gulbin .ennazli,Kur.at Ozer,Ahmet Gulcubuk 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.1

In this report, an ameloblastoma case, which hasbeen occurred on the left maxilla of a 10 year-old,male,German shepherd,was described on the clinicaland morphological features. The mass with thedimensions of 5×2.5 cm was removed totally bymaxillectomy and examined by radiography, magneticresonance (MR) and biopsy. The tumor was histopa-thologically classified ameloblastoma of follicular typeand in some fields showed acanthotic form. Theinvasiveness of the tumor was also observed to behigh. This report is the first case of maxillaryameloblastoma in dogs in Turkey.

Experimental Study on the Flexural Behaviour of a Novel Concrete Filled Hybrid Beams Reinforced with GFRP and Steel Bars

Ferhat Aydın 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.11

This study presents the flexural performances of hybrid beams where glass fibre reinforced plastic (GFRP) box profile, concrete, steel or GFRP bars were used together. By conducting flexural tests on beams of varying properties produced for this purpose, the minimum reinforcement effects in GFRP profile-concrete beams were experimentally presented. Beam series of two sizes, as 74−74−500 mm small beams and 100−100−1,500 mm large beams, and varying combinations were produced. In addition, some properties of GFRP box profiles were improved. Following the tests conducted on small beams, the number of large beam samples was reduced and while steel bars were used in some beams, GFRP bars were used in others. The hybrid beams were compared with reinforced concrete beams have the same dimensions in large beams. On the basis of the results obtained from the tests it was determined that the flexural performances of steel reinforced hybrid beams increased at a higher level. Flexural strength of the improved hybrid beams increased by about two times compared to the classical reinforced concrete beams. Fracture toughness of the hybrid beams improved 53%.