Association of VAMP-2 and Syntaxin 1A Genes with Adult Attention Deficit Hyperactivity Disorder

Ay˚e Nur Inci Kenar,Özlem I˙zci Ay,Hasan Herken,Mehmet Emin Erdal 대한신경정신의학회 2014 PSYCHIATRY INVESTIGATION Vol.11 No.1

Objective The etiology of attention deficit hyperactivity disorder (ADHD) has not been entirely clarified yet. Structural and metabolicdifferences at the prefrontal striatal cerebellary system and the interaction of gene and environment are the main factors that thought toplay roles in the etiology. Genetic investigations are performed especially about the dopamine pathways and receptors. In this study; itwas aimed to investigate the association of the synaptobrevin-2 (VAMP-2) gene Ins/Del polymorphism and syntaxin 1A gene intron7 polymorphism, which take place in encoding presynaptic protein, with adult ADHD. Methods One hundred thirty-nine patients, having ADHD aging between 18 and 60 years and 106 healthy people as controls were includedinto the study. DNA samples were extracted from whole blood and genetic analysis were performed. ResultsaaA significant difference was determined between ADHD and VAMP-2 Ins/Del polymorphism and syntaxin 1A intron 7 polymorphismaccording to the control group. These polymorphisms were found not to be associated with subtypes of ADHD. Conclusion It is supposed that synaptic protein genes together with dopaminergic genes might have roles in the etiology of ADHD.

Antifungal Activity of the Honeybee Products Against Candida spp. and Trichosporon spp.

Ayşe Nedret Koç,Sibel Silici,Filiz Kasap,Hatice Tuna Hörmet-Öz,Hikmet Mavus-Buldu,Barış Derya Ercal 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.1

Honeybee products (honey, royal jelly, pollen, and propolis) were evaluated for their ability to inhibit the growth of 40 yeast strains of Candida albicans, Candida glabrata, Candida krusei, and Trichosporon spp. The broth microdilution method was used to assess the antifungal activity of honeybee products against yeasts. Fluconazole was selected as the antifungal control agent. Using the broth microdilution method, minimal inhibitory concentration ranges with regard to all isolates were 5–80% (vol/vol), 0.06–1μg/mL, 0.002–0.25μg/mL, 0.006–0.1μg/mL, and 0.02–96μg/mL for honey, royal jelly, pollen, propolis, and fluconazole, respectively. The antifungal activities of each product decreased in the following order: propolis >pollen>royal jelly>>honey. This study demonstrated that honeybee products, particularly propolis and pollen, can help to control some fluconazole-resistant fungal strains.

A Case Report of Pathergy-Like Reaction in a Patient with Behçet’s Disease Triggered by Wax Epilation

( Ayşe Boyvat ),( Merve Aygun ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.4

ON THE GEOMETRY OF RATIONAL BÉZIER CURVES

( Ayşe Yilmaz Ceylan ),( Tunahan Turhan ),( Gözde Özkan Tükel ) 호남수학회 2021 호남수학학술지 Vol.43 No.1

The purpose of this paper is to assign a movable frame to an arbitrary point of a rational Bézier curve on the 2-sphere S² in Euclidean 3-space R³ to provide a better understanding of the geometry of the curve. Especially, we obtain the formula of geodesic curvature for a quadratic rational Bézier curve that allows a curve to be characterized on the surface. Moreover, we give some important results and relations for the Darboux frame and geodesic curvature of a such curve. Then, in specific case, given characterizations for the quadratic rational Bézier curve are illustrated on a unit 2-sphere.

Remarkable effects of deep eutectic solvents on the esterification of lactic acid with ethanol over Amberlyst-15

Ayşe Ezgi Ünlü,Azime Arıkaya,Aybike Altundağ,Serpil Takaç 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.1

Deep eutectic solvents (DESs) are widely used in numerous reactions both as a solvent and a catalyst. In this study, different types of DESs were investigated as a supplementary component for Amberlyst-15 to enhance its catalytic activity in the esterification reaction of lactic acid with ethanol. The effects of the following parameters such as DES type, choline chloride : glycerol (ChCl-Gly) (1 : 2) amount, molar ratio of reactants, temperature and agitation rate on the initial rate of reaction and yield of ethyl lactate were investigated. According to the results, DESs alone did not have any catalytic effect on the esterification; however, DESs together with Amberlyst-15 provided a significant increase in the initial rate of reaction and yield. The activation energy of the reaction decreased significantly with the combined use of Amberlyst-15 and ChCl-Gly (1 : 2). Internal and external mass transfer limitations were found to be negligible under optimum reaction conditions.

The effect of local application of thymoquinone, Nigella sativa’s bioactive component, on bone healing in experimental bone defects infected with Porphyromonas gingivalis

Ayşe Yılmaz Baştuğ,Ceyda Özçakır Tomruk,Elif Güzel,İlkay Özdemir,Gonca Duygu,Esma Kütan,Gül Merve Yalçın Ülker,Fatma Özen Arıcı 대한치주과학회 2022 Journal of Periodontal & Implant Science Vol.52 No.3

Purpose: This study was performed to evaluate the influence of local application of thymoquinone (TQ) on bone healing in experimental bone defects infected with Porphyromonas gingivalis (PG). Methods: Forty-two female rats were randomly divided into 6 groups. A bone defect was created on the right tibia of all animals. The PG, PG/collagen membrane (COL) and PG/ TQ/COL groups were infected with PG. In the COL and PG/COL groups, the defects were covered with a COL; in the TQ/COL and PG/TQ/COL groups, the defects were covered with a TQ-containing COL. After 28 days, all animals were sacrificed. Quantitative measurements of new bone formation and osteoblast lining, as well as semiquantitative measurements of capillary density and tissue response, were analyzed. Furthermore, the presence of bacterial infections in defect areas was evaluated. Results: The new bone formation, osteoblast number, and capillary density were significantly higher in the TQ groups than in the control groups (P<0.001, P<0.001, and P<0.01, respectively). In a comparison between the TQ/COL group, with a TQ-containing COL (TQ/COL), and the PG–infected TQ-containing COL (PG/TQ/COL) group, the newly formed bone and capillary density were higher in the TQ/COL group (P<0.01). When the control group was compared to the PG, PG/COL, and PG/TQ/COL groups in terms of tissue response, the differences were statistically significant (P<0.001, P=0.02, and P=0.041, respectively). The intensity of the inflammatory cell reaction was higher in the PG, PG/COL, and PG/TQ/COL groups (P<0.05). Conclusions: Within the limitations of this study, the local application of a TQ-containing COL positively affected bone healing even if the bone defects were infected. The results suggest that TQ increased angiogenesis and showed promise for accelerating bone defect healing. Further research is warranted to support these findings and reach more definitive conclusions.

Mergers and Acquisitions by Emerging Country Multinational Companies

Ayş,e Yü,ce 한국유통과학회 2016 KODISA ICBE (International Conference on Business Vol.2016 No.-

This paper investigates the mergers and acquisitions by the emerging country multinational companies. We examine whether or not emerging country multinationals earn positive abnormal returns as a result of merger and acquisitions. This paper examines the emerging country multinational companies'merger and acquisition decisions. We examine whether or not abnormal returns are created after the acquisitions by the emerging market multinational companies. The paper is organized as follows: Section I shows the previous studies, Section II presents the data and the methodology and finally Section III displays the results.

Emotional reactions of people who stutter in difficult communication situations: a preliminary study

Ayşe Nur Koçak,M. Emrah Cangi 한국언어재활사협회 2022 Clinical Archives of Communication Disorders Vol.7 No.3

Purpose: Few studies have examined the emotional responses of adults who stutter (AWS) in specific situations. The aim of this study is to determine the emotions of AWS in different communication situations at various times in communication. Methods: The study included 38 AWS. The first stage of the study determined the difficulties related to stuttering in communication situations by requiring the participants to complete a questionnaire consisting of open-ended questions. The four SLTs scored these situations from various aspects (e.g., common experience of difficulty for AWS) and the final version of the 19-item list of situations in the “Determining Emotions Regarding Communication Situations in Stuttering Questionnaire (DERCSQ)” has been reached. The DERCSQ also provided a list of 90 emotions related to communication situations and stuttering. The participants completed the DERCSQ by indicating their feelings in three communication situations (before, during, and after communication). Results: The results indicated that AWS frequently experience negative emotions in different communication situations. The participants indicated that they experience the following emotions in pre-communication: excited (194), anxious (143), restless (142), tense (128), and concerned (118). During the communication, the participants experience the following emotions: uneasy (90), excited (88), uncomfortable (81), insufficient (78), and restless (75). During the after-communication period, the participants indicated that they experience the following emotions: anxiety (38), uneasy (34), uncomfortable (34), insufficient (33), and self-rage (32). Conclusions: The emotions obtained are compatible with the stuttering and psychology literature, it is remarkable that emotions such as anxiety and uneasy after stuttering were prominent.

The effect of thermo-mechanical fatigue on the retentive force and dimensional changes in polyetheretherketone clasps with different thickness and undercut

Ayşegül Güleryüz,Cumhur Korkmaz,Ayşe Şener,Mehmet Ozan Taş 대한치과보철학회 2021 The Journal of Advanced Prosthodontics Vol.13 No.5

PURPOSE. Esthetic expectations have increased the use of polyetheretherketone (PEEK) clasps as alternatives to Cr-Co in removable partial dentures (RPDs). The objective of this study was to evaluate the retentive force and dimensional change of clasps with different thickness and undercut made from PEEK by the thermo-mechanical fatigue. MATERIALS AND METHODS. PEEK clasps (N = 48) with thicknesses of 1 or 1.50 mm and 48 premolar monolithic zirconia crowns with undercuts of 0.25 mm or 0.50 mm were fabricated. Samples are divided into four groups (C1-C4) and were subjected to 7200 thermal aging cycles (at 5 – 55°C). The changes in the retentive force and dimensions of the clasps were measured by micro-stress testing and micro-CT devices from five measurement points (M1 - M5). One-way ANOVA, paired t-test, two-way repeated ANOVA, and post-hoc tests were used to analyze the data (P < .05). RESULTS. The retentive forces of C1, C2, C3, and C4 groups in initial and final test were found to be 4.389-3.388 N, 4.67 - 3.396 N, 5.161 - 4.096 N, 5.459 - 4.141 N, respectively. The effects of retentive force of all PEEK clasps groups were significant decreased. Thermo-mechanical cycles caused significant dimensional changes at points with M2, M4, and M5, and abraded the clasp corners and increased the distance between the ends of the clasp, resulting in reduced retentive forces (P * = .016, P * = .042, P < .001, respectively). CONCLUSION. Thermo-mechanical aging decreases the retentive forces in PEEK clasps. Increasing the thickness and undercut amount of clasps decreases the amount of dimensional change. The values measured after aging are within the clinically acceptable limits.

The Effects of Baby Massage on Attachment between Mother and their Infants

Ayşe Gürol,Sevinç Polat 한국간호과학회 2012 Asian Nursing Research Vol.6 No.1

Purpose: This study was conducted to examine the effect of baby massage on attachment between mothers and their newborns. Methods: This study was carried out from June 2008 to February 2010 in a quasi-experimental design (57in the experimental group, 60 in the control group). Between the dates of the study, all healthy primipara mothers and their healthy babies were included. Data were collected regarding their demographic characteristics and by using the Maternal Attachment Inventory (MAI). All mothers were assessed on the first and the last days of the 38-day study period. In the experimental group, the babies received a 15-minute massage therapy session everyday during the 38 days. Results: There was no significant difference found in the pretest mean value baseline of the MAI score in both groups. The posttest mean values of the MAI of the experimental group mothers (90.87 ± 10.76)were significantly higher than those of control group (85.10 ± 15.50). There was a significant difference between groups (p < .05). Conclusion: The results of the study have shown that baby massage is effective in increasing the mothere infant attachment. Purpose: This study was conducted to examine the effect of baby massage on attachment between mothers and their newborns. Methods: This study was carried out from June 2008 to February 2010 in a quasi-experimental design (57in the experimental group, 60 in the control group). Between the dates of the study, all healthy primipara mothers and their healthy babies were included. Data were collected regarding their demographic characteristics and by using the Maternal Attachment Inventory (MAI). All mothers were assessed on the first and the last days of the 38-day study period. In the experimental group, the babies received a 15-minute massage therapy session everyday during the 38 days. Results: There was no significant difference found in the pretest mean value baseline of the MAI score in both groups. The posttest mean values of the MAI of the experimental group mothers (90.87 ± 10.76)were significantly higher than those of control group (85.10 ± 15.50). There was a significant difference between groups (p < .05). Conclusion: The results of the study have shown that baby massage is effective in increasing the mothere infant attachment.