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Aulakh, Amritpal Singh,Randhawa, Puneet Kaur,Singh, Nirmal,Jaggi, Amteshwar Singh The Korean Society of Pharmacology 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.2
Remote ischemic preconditioning (RIPC) is an intrinsic phenomenon whereby 3~4 consecutive ischemia-reperfusion cycles to a remote tissue (non-cardiac) increases the tolerance of the myocardium to sustained ischemia-reperfusion induced injury. Remote ischemic preconditioning induces the local release of chemical mediators which activate the sensory nerve endings to convey signals to the brain. The latter consequently stimulates the efferent nerve endings innervating the myocardium to induce cardioprotection. Indeed, RIPC-induced cardioprotective effects are reliant on the presence of intact neuronal pathways, which has been confirmed using nerve resection of nerves including femoral nerve, vagus nerve, and sciatic nerve. The involvement of neurogenic signaling has been further substantiated using various pharmacological modulators including hexamethonium and trimetaphan. The present review focuses on the potential involvement of neurogenic pathways in mediating remote ischemic preconditioning-induced cardioprotection.
Manpreet Kaur Aulakh,Bonamali Pal 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.80 No.-
Mono-dispersed and smaller sized TiO2 nanospheres (~8 nm and ~20 nm) exhibited superior photo-reductive efficiency for few aromatic aldehydes under UV light. It has been found that pnitrobenzaldehydeand benzaldehyde are efficiently reduced to p-aminobenzyl alcohol (80% and 61%)and benzyl alcohol (59% and 38%) by 8 nm and 20 nm particles respectively, relative to negligiblereduction by TiO2 (P25) under same experimental conditions. However, the successful photo-reductionof p-nitrotoluene (97%) was observed with P25 whose reduction potential ( 0.5 eV) lies below theconduction band (CB,0.85 eV vs NHE) of the catalyst. Thesefindings can be explained on the basis ofunsuitable and mismatched CB of P25 with respect to the lowest unoccupied molecular orbital ofCHOgroup to access its photo-activity. However, this hydrogenation occurred by synthesized smaller sizedTiO2 particles (~8 nm and~20 nm) due to their favorable band gap (3.85 eV and 3.62 eV) and conductionband edge ( 0.61 eV and0.50 eV). Moreover, the other physio-chemical characteristics of 8 nm and20 nm sized particles such as surface area (323 m2 g 1 and 297 m2 g 1), higher charge carrier relaxationtime (61 ms and 40 ms) are also co-related for ease of photo-activity relative to TiO2 (P25).
Amritpal Singh Aulakh,Puneet Kaur Randhawa,Nirmal Singh,Amteshwar Singh Jaggi 대한약리학회 2017 The Korean Journal of Physiology & Pharmacology Vol.21 No.2
Remote ischemic preconditioning (RIPC) is an intrinsic phenomenon whereby 3~4 consecutive ischemia-reperfusion cycles to a remote tissue (noncardiac) increases the tolerance of the myocardium to sustained ischemiareperfusion induced injury. Remote ischemic preconditioning induces the local release of chemical mediators which activate the sensory nerve endings to convey signals to the brain. The latter consequently stimulates the efferent nerve endings innervating the myocardium to induce cardioprotection. Indeed, RIPC-induced cardioprotective effects are reliant on the presence of intact neuronal pathways, which has been confirmed using nerve resection of nerves including femoral nerve, vagus nerve, and sciatic nerve. The involvement of neurogenic signaling has been further substantiated using various pharmacological modulators including hexamethonium and trimetaphan. The present review focuses on the potential involvement of neurogenic pathways in mediating remote ischemic preconditioninginduced cardioprotection.
Preparation and Characterization of Oxadiazole Based Electron Transporting Thin Films
Aman Mahajan,Ramanpreet Kaur Aulakh,R. K. Bedi 대한금속·재료학회 2012 ELECTRONIC MATERIALS LETTERS Vol.8 No.4
To study the effect of aggregation of the 2-(4-biphenylyl)-5-phenyl-1,3,4-oxadiazole (PBD) molecule in solid state, thin films of PBD have been prepared by the thermal evaporation technique onto glass and quartz substrates under different experimental conditions. These films have been studied for their structural, optical and electrical properties. AFM investigations of the films revealed that the films were smooth, dense and crack free with RMS roughness of 11-14 nm. XRD measurements indicate that films deposited on quartz are more crystalline than films deposited on glass substrate. Both absorption and reflectance spectra over the wavelength range 200 -800 nm have been recorded to find optical parameters, namely, absorption, extinction coefficient, refractive index and dielectric constants. The inter-band transition energies are found to lie within the range 3.45-3.49 eV. Optical studies of the films indicate that PBD molecules preferred J-aggregation. A prominent single emission peak in the range of 370-390 nm has been observed which confirms that the fluorescent property of this molecule is not quenched in the thin film state. The electrical conductivity results for the evaporated films exhibited semiconductor behaviour within the investigated field and temperature range. The nature of the substrate is found to be a useful tool to modify the film morphology and for enhancing the charge transport within the films.
Berhanu, Asnake Lealem,Sharma, Neha,Mohiuddin, Irshad,Malik, Ashok Kumar,Aulakh, Jatinder Singh,Lee, Jechan,Kim, Ki-Hyun Elsevier 2020 Journal of molecular structure Vol.1200 No.-
<P><B>Abstract</B></P> <P>In this study, a quantum chemical model was developed to better account for the properties of a Schiff base, (<I>Z</I>)-1-(thiophen-2-yl-methyleneamino) propane-2-ol, which is derived from thiophene-2-carboxy aldehyde and 1-amino-2-propanol. To predict its molecular structure, the assignment of the vibrational wavelength (for FT-IR) and chemical shift (for <SUP>1</SUP>HNMR) of (<I>Z</I>)-1-(thiophen-2-yl-methyleneamino) propane-2-ol was performed experimentally and theoretically. All of the theoretical calculations were performed using the Gaussian 09 program package. The theoretically and experimentally obtained results were in good agreement (R<SUP>2</SUP> ≥ 0.99). The energies of the highest occupied and lowest unoccupied molecular orbitals were estimated using B3LYP (Becke three-parameter hybrid functional combined with Lee–Yang–Parr correlation functional)/6-311++G (d, p). Optimization of the structure of (<I>Z</I>)-1-(thiophen-2-yl-methyleneamino) propane-2-ol provided information concerning the stable form of the geometry of the molecule, stoichiometry of the complexes, and thermodynamic parameters (e.g., energy and entropy). The results indicate that the Schiff base formed stable complexes with Ni<SUP>2+</SUP>. The energy of the complex was much lower than that of the free Schiff base. The charge distribution values of each atom in the Schiff base were in agreement with the Pauling scale for electronegativity and vibrational wavelength.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Experimental and Theoretical study of (Z)-1-(thiophen-2-yl-methyleneamino) propane-2-ol was investigated. </LI> <LI> The vibrational FTIR wavelength and chemical shift (for <SUP>1</SUP>HNMR) were studied with DFT studies. </LI> <LI> (Z)-1-(thiophen-2-yl-methyleneamino) propane-2-ol formed a more stable complex with Ni<SUP>2+</SUP>. </LI> <LI> Bond lengths and bond angles were calculated to characterize its strength. </LI> <LI> HOMO -LUMO energy gap of the Schiff base was calculated. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>