Aorta-Right Atrial Tunnel: An Interesting Type of a Congenital Coronary Artery Anomaly

Atila Iyisoy,Turgay Celik,Murat Celik,Cemal Sag 대한심장학회 2014 Korean Circulation Journal Vol.44 No.3

An 18-year-old girl with an aortico-right atrial tunnel originating from the left sinus of Valsalva, in which the left anterior descending andcircumflex coronary arteries arose independently from the different parts of the tunnel, was reported. In the differential diagnosis of continuousmurmur, this type of tunnel should be taken into consideration. Surgical approach should be offered.

Effect of Anchor Bars on Seismic Behavior of Infilled Walled Frames

Atila Kumbasaroglu 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.10

User-defined plastic hinge properties obtained experimentally are used to examine the structural behavior of bare, infilled walled frames with and without anchor bars in reinforced concrete (RC) buildings. Experimentally obtained moment-curvature relationships of structural members (i.e., beams and columns) are used to determine the plastic hinge properties of each section. Three building frames are modeled and examined for time-history analysis using 20 ground-motion records. Seismic performance levels of three buildings are analyzed to determine the effects of anchor bars. Limit states at each performance level are defined, and the multi-record incremental dynamic analysis curves are obtained; 16%, 50%, and 84% fractal curves are obtained for each case. Cumulative distribution functions are constructed to summarize the varieties in the roof-drift ratios of three RC buildings with different frame types for design-based and maximum-considered earthquake hazards. It is found that, with an increased spectral acceleration of ground motions, the probability of exceeding the performance levels of infilled walled frames in reinforced buildings is reduced with the help of anchor bars. The increased stiffness of RC buildings with infilled wall frames exhibiting lower ductility is re-gained by the absorption energy of the anchor bars.

Effect of Longitudinal Circular Hollows on the Flexural Strength of Reinforced Concrete Beams

Atila Kumbasaroglu,Emre Korkmaz 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.1

In this study, the effect of hollows passing through reinforced concrete (RC) beams in the longitudinal direction on flexural strength was examined. 4 RC beams were designed to satisfy the conditions for implementation. One of the beams was fabricated as a reference specimen and 3 of the remaining beams were fabricated with total of 5 pipes in the tension, neutral axis and compression regions. All experimental beam specimens were subjected to 4-point axial flexural tests with the request for constant flexural moments at the limits of loading. Experimental beams with pipes in the compression region, tensile region and neutral axis regions were confronted with the reference beam in terms of initial stiffness, ductility, load-bearing capacity and energy absorption capacity. It was verified that to provide that both the sufficient stiffness and sufficient ductility conditions for the reinforced concrete beams, do not establish any structural discontinuity, the longitudinal orbicular cross-section hollows created by pipes should be passed through the neutral axis region as much as possible. The results of the present study not only align with those of previous research (e.g., the correlative results) but also extend the current state of research (e.g., the revealed differences) and provide starting points for future research. Conclusions are drawn from these results at the end of the paper.

Simultaneous biosynthesis of reduced graphene oxide-Ag-Cu2O nanostructures by lichen extract for catalytic reduction of textile dyes

Zafer Çıplak,Bengü Getiren,Ceren Gökalp,Ceren Atila Dinçer,Atila Yıldız,Nuray Yıldız 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.12

Metal/metal oxide nanostructures based reduced graphene oxide (LrGO-Ag, LrGO-Cu2O, LrGO-Ag-Cu2O) nanocomposites were obtained via green method using Cetraria islandica (L.) Ach. lichen extract. Fourier transform infrared (FTIR) spectroscopy, transmission electron microscopy (TEM), scanning electron microscope energy-dispersive X-ray spectroscopy (SEM–EDX), ultraviolet-visible (UV-Vis) spectroscopy, X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) were performed to analyze the prepared nanostructures. The results indicated that the nanocomposites were synthesized effectively and Ag-Cu2O nanoparticles with the mean diameter of 27nm were well dispersed on the LrGO. The conversion of methylene blue (MB) to Leuco Methylene Blue (LMB) and 4-Nitrophenol (4- NP) to 4-Aminophenol (4-AP) was performed by biosynthesized catalysts in the presence of NaBH4. The reaction rate of LrGO-Ag-Cu2O nanocomposite during 4-NP and MB reduction was found as 0.0026 s1 and 0.0497 s1, respectively. The LrGO-Ag-Cu2O nanocomposite showed superior catalytic performance for the reduction of both textile dyes.

Coronary-Subclavian Steal Syndrome Presenting with Ventricular Tachycardia

Hurkan Kursaklioglu,Sedat Kose,Atila Iyisoy,Basri Amasyali,Turgay Celik,Kudret Aytemir,Ersoy Isik 연세대학교의과대학 2009 Yonsei medical journal Vol.50 No.6

Coronary-subclavian steal through the left internal mammary graft is a rare cause of myocardial ischemia in patients who have had a coronary bypass surgery. We report a 70-year-old man who presented with sustained monomorphic ventricular tachycardia 5 years after the surgical creation of a left internal mammary to the left anterior descending artery. Cardiac catheterization illustrated that the left subclavian artery was occluded proximally and that the distal course was visualized by retrograde filling through the left internal mammary graft. Clinical ventricular tachycardia was reproducibly induced with a single ventricular extrastimulus, and antitachycardia pacing terminated the tachycardia. Restoration of blood flow by way of a Dacron graft placed between the descending aorta and the subclavian artery resulted in the total relief of symptoms. Ventricular tachycardia could not be induced during the control electrophysiologic study after surgical revascularization. Coronary-subclavian steal through the left internal mammary graft is a rare cause of myocardial ischemia in patients who have had a coronary bypass surgery. We report a 70-year-old man who presented with sustained monomorphic ventricular tachycardia 5 years after the surgical creation of a left internal mammary to the left anterior descending artery. Cardiac catheterization illustrated that the left subclavian artery was occluded proximally and that the distal course was visualized by retrograde filling through the left internal mammary graft. Clinical ventricular tachycardia was reproducibly induced with a single ventricular extrastimulus, and antitachycardia pacing terminated the tachycardia. Restoration of blood flow by way of a Dacron graft placed between the descending aorta and the subclavian artery resulted in the total relief of symptoms. Ventricular tachycardia could not be induced during the control electrophysiologic study after surgical revascularization.

Meropenem Versus Piperacillin-Tazobactam as Empiric Therapy for Febrile Neutropenia in Pediatric Oncology Patients

Sezgin, Gulay,Acipayam, Can,Ozkan, Ayse,Bayram, Ibrahim,Tanyeli, Atila Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11

Background: Infection is a serious cause of mortality in febrile neutropenia of pediatric cancer patients. Recently, monotherapy has replaced the combination therapy in empirical treatment of febrile neutropenia. Since there has been no reported trial comparing the efficacy of meropenem and piperacillin-tazobactam (PIP/TAZ) monotherapies, the present retrospective study was conducted to compare safety and efficacy in febrile neutropenic children with cancer. Materials and Methods: Charts of febrile, neutropenic children hospitalized at our center between March 2008 and April 2011 for hemato-oncological malignancies were reviewed. Patients received PIP/TAZ 360 mg/kg/day or meropenem 60 mg/kg/day intravenously in three divided doses. Duration of fever and neutropenia, absolute neutrophil count, modification, and success rate were compared between the two groups. Resolution of fever without antibiotic change was defined as success and resolution of fever with antibiotic change or death of a patient was defined as failure. Modification was defined as changing the empirical antimicrobial agent during a febrile episode. Results: Two hundred eighty four febrile neutropenic episodes were documented in 136 patients with a median age of 5 years. In 198 episodes meropenem and in 86 episodes PIP/TAZ were used. Duration of fever and neutropenia, neutrophil count, sex, and primary disease were not different between two groups. Success rates and modification rate between two groups showed no significant differences (p>0.05). Overall success rate in the meropenem and PIP/TAZ groups were 92.4% and 91.9% respectively. No serious adverse effects occurred in either of the groups. Conclusions: Meropenem and PIP/TAZ monotherapy are equally safe and effective in the initial treatment of febrile neutropenia in children with cancer.

Chromosome Imbalances and Alterations of AURKA and MYCN Genes in Children with Neuroblastoma

Inandiklioglu, Nihal,Yilmaz, Sema,Demirhan, Osman,Erdogan, seyda,Tanyeli, Atila Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

Background: Neuroblastoma (NB), like most human cancers, is characterized by genomic instability, manifested at the chromosomal level as allelic gain, loss or rearrangement. Genetics methods, as well as conventional and molecular cytogenetics may provide valuable clues for the identification of target loci and successful search for major genes in neuroblastoma. We aimed to investigate AURKA and MYCN gene rearrangements and the chromosomal aberrations (CAs) to determine the prognosis of neuroblastoma. Methods: We performed cytogenetic analysis by G-banding in 25 cases [11 girls (44%) and 14 boys (66%)] and in 25 controls. Fluorescence in situ hybridization (FISH) with AURKA and MYCN gene probes was also used on interphase nuclei to screen for alterations. Results: Some 18.4% of patient cells exhibited CAs., with a significant difference between patient and control groups in the frequencies (P<0.0001). Some 72% of the cells had structural aberrations, and only 28% had numerical chnages in patients. Structural aberrations consisted of deletions, translocations, breaks and fragility in various chromosomes, 84% and 52% of the patients having deletions and translocations, respectively. Among these expressed CAs, there was a higher frequency at 1q21, 1q32, 2q21, 2q31, 2p24, 4q31, 9q11, 9q22, 13q14, 14q11.2, 14q24, and 15q22 in patients. 32% of the patients had chromosome breaks, most frequently in chromosomes 1, 2, 3, 4, 5, 8, 9, 11, 12, 19 and X. The number of cells with breaks and the genomic damage frequencies were higher in patients (p<0.001). Aneuploidies in chromosomes X, 22, 3, 17 and 18 were most frequently observed. Numerical chromosome abnormalities were distinctive in 10.7% of sex chromosomes. Fragile sites were observed in 16% of our patients. Conclusion: Our data confirmed that there is a close correlation between amplification of the two genes, amplification of MYCN possibly contributing significantly to the oncogenic properties of AURKA. The high frequencies of chromosomal aberrations and amplifications of AURKA and MYCN genes indicate prognostic value in children with neuroblastomas and may point to contributing factors in their development.

Replacing Actinomycin-D with Carboplatin for Newly Diagnosed Rhabdomyosarcoma

Sezgin, Gulay,Acipayam, Can,Bayram, Ibrahim,Ozkan, Ayse,Kupeli, Serhan,Tanyeli, Atila Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8

Background: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in the pediatric age group. All patients with RMS regardless of their initial stage or group receive combination chemotherapy as 'standard therapy' consisting of vincristine, actinomycin-D and cyclophosphamide. Actinomycin-D was not readily available in Turkey at one time. Carboplatin was used instead in order to prevent delays in treatment. The aim of this report is to present the results of patients with rhabdomyosarcoma receiving carboplatin or actinomycin-D therapy. Materials and Methods: Twenty four patients with rhabdomyosarcoma treated between December 2000 and June 2011 were included in this retrospective study. The patients were treated according to International Rhabdomyosarcoma Study Group guidelines. Eleven patients were treated with actinomycin-D and 13 with carboplatin ($250mg/m^2/dose$ for 2 days). The two groups were then compared in terms of 2- and 5-year overall survival (OS) and hematological and non-hematological toxicities. Results: Age, sex, stage and the mean duration of follow-up were similar in both groups (p>0.05). Two- and five-year OS levels were 68.2% in the carboplatin group and 78.0% and 40.0%, respectively, in the actinomycin-D group. There was no statistical difference in the number of febrile episodes (p=0.86) and no other hematological and non-hematological adverse effects were recorded in both groups. Conclusions: The findings show that carboplatin can be used as an alternative drug in the primary treatment of rhabdomyosarcoma in the event that actinomycin-D is unavailable or not tolerated.

Syntheses of MgCO₃ and Na₂Mg(CO₃)₂ through solid-gas reactions mediated by alkali nitrates

Oh, Kyung-Ryul,Kim, Kang-Yeong,Kwak, Jin-Su,Atila, Gulbahar,Kwon, Young-Uk Elsevier 2018 Journal of solid state chemistry Vol.263 No.-

<P><B>Abstract</B></P> <P>In this work, we devised a set of molten salt-mediated reactions that can make use of gaseous reagents in forming solid products. In order for gaseous molecules to be reacted, its solubility in the molten salt medium needs to be high, which condition, in turn, requires the molten salt material to have a low melting point. We used alkali nitrate (ANO<SUB>3</SUB>, A = Li, Na, K, Rb, and Cs) as the reaction medium, for their low melting points, for the reactions of CO<SUB>2</SUB>(g) with various Mg-reagents. Reactions between 4MgCO<SUB>3</SUB>·Mg(OH)<SUB>2</SUB>·4H<SUB>2</SUB>O or Mg(OH)<SUB>2</SUB> with CO<SUB>2</SUB> in the presence of an ANO<SUB>3</SUB> above a certain quantity (30 wt% with respect to the MgO content in the Mg-reagent) produced single phase MgCO<SUB>3</SUB>, after washing the ANO<SUB>3</SUB> with water. On the contrary, the same reactions without ANO<SUB>3</SUB> did not show any sign of incorporating gaseous CO<SUB>2</SUB> in the final products. Similarly, the reaction of a mixture between Na<SUB>2</SUB>CO<SUB>3</SUB> and 4MgCO<SUB>3</SUB>·Mg(OH)<SUB>2</SUB>·4H<SUB>2</SUB>O or Mg(OH)<SUB>2</SUB> with CO<SUB>2</SUB> in an ANO<SUB>3</SUB> medium produced Na<SUB>2</SUB>Mg(CO<SUB>3</SUB>)<SUB>2</SUB>, a double carbonate of MgCO<SUB>3</SUB> with Na<SUB>2</SUB>CO<SUB>3</SUB>. The X-ray diffraction patterns and the thermogravimetry data under a CO<SUB>2</SUB> flow of MgCO<SUB>3</SUB> and Na<SUB>2</SUB>Mg(CO<SUB>3</SUB>)<SUB>2</SUB> indicate their high phase purity. The effects of various synthesis parameters such as the nature of ANO<SUB>3</SUB> and the amounts on the products were systematically investigated.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We performed solid-gas reactions in molten salt medium to provide solid products. </LI> <LI> We prepared anhydrous MgCO<SUB>3</SUB>, and Na<SUB>2</SUB>Mg(CO<SUB>3</SUB>)<SUB>2</SUB> in pure phase. </LI> <LI> Small amount of alkali nitrate can be used to prepare carbonate species. </LI> <LI> The kind of alkali nitrate affects the morphology of products. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Solid-gas reactions are performed through molten salt route to produce pure anhydrous MgCO<SUB>3</SUB> and Na<SUB>2</SUB>Mg(CO<SUB>3</SUB>)<SUB>2</SUB>.</P> <P>[DISPLAY OMISSION]</P>

Formation and crystal structure of a new double carbonate phase between Na and Cd

Kim, Kang-Yeong,Kwak, Jin-Su,Oh, Kyung-Ryul,Atila, Gulbahar,Kwon, Young-Uk Elsevier 2018 Journal of solid state chemistry Vol.267 No.-

<P><B>Abstract</B></P> <P>We report on the formation of a new phase Na<SUB>2</SUB>Cd(CO<SUB>3</SUB>)<SUB>2</SUB> (<B>1</B>) and its crystal structure. <B>1</B> belongs to the rare examples of double carbonates composed of d-block element metal elements. It is formed in a narrow window of temperature from 230 °C to slightly higher than 350 °C, because of which synthesis of <B>1</B> as a pure phase is practically impossible. We attempted to elucidate the crystal structure of <B>1</B> based on a powder X-ray diffraction pattern on a mixture between <B>1</B> and CdO as the major phase. Comparing with known structures of double carbonates of alkaline earth metal elements and introducing structural distortions to them, we identified the mother structure of <B>1</B> to be an orthorhombic variant of the Fairchildite structure reported for K<SUB>2</SUB>Ca(CO<SUB>3</SUB>)<SUB>2.</SUB> Rietveld refinements with a model in which the two symmetry-independent carbonate ions are disordered resulted in a good agreement with the observed data, which leads to the composition of <B>1</B> to be Na<SUB>2</SUB>Cd(CO<SUB>3</SUB>)<SUB>2</SUB>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Solid-solid-gas reaction was performed to produce solid product. </LI> <LI> New double carbonate phase was formed between Na and Cd. </LI> <LI> Crystal structure of the product is determined to be a derivative of fairchildite structure. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>New double carbonate phase was observed between Na and Cd by solid-solid-gas reaction at 300 °C whose structure is analyzed as a fairchildite derivative.</P> <P>[DISPLAY OMISSION]</P>