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        • Prognostic Factors in Oligodendrogliomas: a Clinical Study of Twenty-Five Consecutive Patients

          Atalay,,Tugay,Ak,,Hakan,Celik,,Bahattin,Gulsen,,Ismail,Seckin,,Hakan,Tanik,,Nermin,Albayrak,,Sedat,Baki,Bavbek,,Murad Asian Pacific Organization for Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.13

          Background: The purpose of this study was to evaluate the prognostic significance of Ki-67 and subjective microvascular density (SMVD) indexes together with other factors in patients with oligodendroglioma. Materials and Methods: In this retrospective study, oligodendroglioma specimens obtained from twenty-five consecutive patients were evaluated for Ki-67 and SMVD indices to help determine histological grading and investigate the fidelity of these markers in clinical prognosis. Other potentially prognostic factors were Karnofsky performance scale, tumor histological grade, and adjuvant radiotherapy. Results: The Ki-67 proliferation index appeared to have a strong correlation with the grade of the tumor and the survival. Age, gender, adjuvant radiotherapy, surgical resection type (complete versus incomplete) did not have any influence on recurrence. The SMVD index correlated significantly with the 3 to 5-year survival. Conclusions: Ki-67 and MVD indexes are important and useful markers in estimating the prognosis of oligodendrogliomas.

        • KCI등재SCOPUS

          Diagnostic Utility of Osteocalcin, Undercarboxylated Osteocalcin, and Alkaline Phosphatase for Osteoporosis in Premenopausal and Postmenopausal Women

          Sacide,Atalay,Abdullah,Elci,Huseyin,Kayadibi,Can,B,Onder,Nurettin,Aka 대한진단검사의학회 2012 Annals of Laboratory Medicine Vol.32 No.1

          Background: We aimed to investigate the diagnostic utility of osteocalcin (OC), undercarboxylated osteocalcin (ucOC), and alkaline phosphatase (ALP) in pre- and postmenopausal women for femoral neck, L1-4, and L2-4 bone mineral density (BMD) values by taking into consideration their age, body mass index (BMI), and menopausal status. Methods: Premenopausal (N=40) and postmenopausal cases (N=42) were classified as 25-34 or 35-45 yr of age and within the first 5 yr or 5 yr or more after the onset of menopause, respectively. Results: Among the groups, statistical differences were found for age, BMI, OC, ucOC, ALP, femoral neck BMD, L1-4 BMD, and L2-4 BMD. The highest serum OC, ucOC, and ALP levels were observed in cases within the first 5 yr after the onset of menopause, probably due to a more rapid bone turnover rate. The best predictors for the femoral neck osteoporosis were ALP, OC, and calcium (areas under the ROC curve [AUC]=0.882, 0.829, and 0.761, respectively), and those for L1-4 and L2-4 osteoporosis were OC, ALP, and ucOC (AUC=0.949, 0.873, and 0.845; and 0.866, 0.819, and 0.814, respectively). Multiple logistic regression analysis revealed that the most discriminative parameter for osteoporosis was OC. Conclusions: These results indicate that serum OC levels, with or without ucOC and ALP, may be useful to monitor follow-up changes that currently cannot be assessed with BMD and to diagnose femoral neck, L1-4 spine, and L2-4 spine osteoporosis. Background: We aimed to investigate the diagnostic utility of osteocalcin (OC), undercarboxylated osteocalcin (ucOC), and alkaline phosphatase (ALP) in pre- and postmenopausal women for femoral neck, L1-4, and L2-4 bone mineral density (BMD) values by taking into consideration their age, body mass index (BMI), and menopausal status. Methods: Premenopausal (N=40) and postmenopausal cases (N=42) were classified as 25-34 or 35-45 yr of age and within the first 5 yr or 5 yr or more after the onset of menopause, respectively. Results: Among the groups, statistical differences were found for age, BMI, OC, ucOC, ALP, femoral neck BMD, L1-4 BMD, and L2-4 BMD. The highest serum OC, ucOC, and ALP levels were observed in cases within the first 5 yr after the onset of menopause, probably due to a more rapid bone turnover rate. The best predictors for the femoral neck osteoporosis were ALP, OC, and calcium (areas under the ROC curve [AUC]=0.882, 0.829, and 0.761, respectively), and those for L1-4 and L2-4 osteoporosis were OC, ALP, and ucOC (AUC=0.949, 0.873, and 0.845; and 0.866, 0.819, and 0.814, respectively). Multiple logistic regression analysis revealed that the most discriminative parameter for osteoporosis was OC. Conclusions: These results indicate that serum OC levels, with or without ucOC and ALP, may be useful to monitor follow-up changes that currently cannot be assessed with BMD and to diagnose femoral neck, L1-4 spine, and L2-4 spine osteoporosis.

        • KCI등재SCOPUS

          Evaluation of Energy Efficiency of Thermoelectric Generator with Two-Phase Thermo-Syphon Heat Pipes and Nano-Particle Fluids

          Tahsin,Atalay,Yavuz,Köysal,Ali,Ekber,Özdemir,Engin,Özbaş 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.5 No.1

          This paper investigates the effects of heat pipes filled with water and nanoparticles (MgO) on electricity generation. The experimental setup comprises of two-phase thermo-syphon heat pipes filled with water or MgO nanoparticle-water suspension, thermoelectric generator (TEG) modules and heat sinks that use passive and active cooling systems. Concentrated solar radiation with heat pipes was used as a heat source for heating. Specially constructed heat sinks with coolant tunnels were used for cooling. Heating and cooling processes are needed to create a temperature difference to generate electrical energy. The constructed model represents the influence of basic parameters such as the tilt angle of heat pipes, working fluids, cooling process, etc. on the maximum power generated. Systems in the constructed setup were arranged with a specific angle to the incident angle of solar radiation. The experiment was carried out on August 5th, 2015, in the northern coast of Turkey, city of Samsun with latitude of 41o14' N. The results obtained show that the presented experimental setup can be used to evaluate thermoelectric energy potential of local areas or to investigate optimum cooling or heating processes.

        • KCI등재SCOPUS

          Detection of progressive and regressive phase and LINE-1 retrotransposon in transfected dogs with transmissible venereal tumor during chemotherapy

          Sevil,Atalay,Vural,Rifki,Haziroglu,Mehmet,R.,Vural,Ibrahim,M.,Polat,Arda,S.,Tunc 대한수의학회 2018 JOURNAL OF VETERINARY SCIENCE Vol.19 No.5

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          Canine transmissible venereal tumor (CTVT) is a tumor that commonly occurs in genital and extragenital sites of both genders. Long interspersed nuclear elements (LINE-1) retrotransposon has a pivotal role in allogenic transfection among uncontrolled dog populations. This study aimed to perform pathomorphological, immunohistochemical, and in situ polymerase chain reaction (PCR) evaluation of CTVT (n = 18) in transfected dogs during chemotherapy. Immunohistochemically, tumor phases were investigated by using specific markers (CD3, CD4, CD8, CD79, and transforming growth factor beta [TGF-]), and investigated an amplified specific sequence of TVT LINE-1 retrotransposon by in situ PCR. Polyhedral-shaped neoplastic cells that had large, round, hypo/hyperchromatic nuclei and eosinophilic cytoplasm were detected. All marker results were positive, especially in the early weeks of recovery. CD4 and TGF- markers were conspicuously positive at the initial stage. In situ PCR LINE-1 sequence was initially positive in only four cases. It is believed that the CD and TGF- markers provide phase identification at tumor initiation and during chemotherapy. It is thought that presence of T and B lymphocytes, which have roles in cellular and humoral immunity, is needed so that regression of the tumor is possible.

        • KCI등재

          The effects of flavanoid on the treatment of hepatopulmonary syndrome

          Talha,Atalay,Murat,Cakir,Ahmet,Tekin,Tevfik,Kucukkartallar,Suleyman,Kargin,Adil,Kartal,Adnan,Kaynak 대한외과학회 2013 Annals of Surgical Treatment and Research Vol.85 No.5

          Purpose: Hepatopulmonary syndrome is an arterial oxygenation disorder brought about by advanced liver failure and pulmonary vascular dilatations. The reason why hypoxia develops in hepatopulmonary syndrome depends on the broadening of perialveolar capillary veins. Our study aims to investigate the effects of Flavanoid on hepatopulmonary syndrome through its inhibition of nitric oxide. Methods: Three groups, each having 8 rats, were formed within the scope of our study. Group I (the control group) only received laparatomy, group II received choledoch ligation, and group III was administered Flavanoid (90% flavonoid diosmin, 10% flavonoid hesperidin) following choledoch ligation. The rats were administered Flavanoid at week two following choledoch ligation. The rats' livers and lungs were examined histopathologically following a five-week follow-up and the perialveolar vein diameters were measured. Arterial blood gases and biochemical parameters were evaluated. Results: It was seen that fibrosis and oxidative damage in the liver with obstructive jaundice as well as hypoxia with pulmonary perialveolar vein sizes were significantly lower than the other group with cirrhosis formed through the administration of Flavanoid. Conclusion: We have concluded that Flavanoid administration might be useful in the treatment of hypoxia in hepatopulmonary syndrome and the delay of cirrhosis contraction.

        • KCI등재

          The Use of Pistachio Pollen for the Production of Nanostructured Porous Nickel Oxide

          F.,E.,Atalay,E.,Yigit,Z.,S.,Biber,H.,Kaya 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.12

          Natural biotemplates — such as bacteria, fungi and viruses — are used in nanostructured metal oxide production. The pollen can be found abundantly in nature, and their microcapsules can be easily isolated from the pollen by chemical treatments. To date, pollen microcapsules are mostly used as drug carriers and catalytic agent templates. In the present study, nanoporous-structured nickel oxide is produced using Pistachio pollen microcapsules. The raw pollen, chemically treated pollen and metal-coated pollen were characterized using scanning electron microscopy, Brunauer–Emmett–Teller (BET) surface area analysis, thermogravimetric analysis (TGA), differential thermal analysis (DTA) and X-ray diffraction (XRD) techniques. The natural Pistachio pollen which were procured from Gaziantep, Turkey, are spherical, with a diameter of approximately 23 μm. The maximum surface area obtained for nickel oxide-coated microcapsules is 228.82m2/g. This result shows that Pistachio pollen are an excellent candidate for the production of porous nanostructured materials for supercapacitor electrodes.

        • KCI등재

          Are the functional movement analysis scores of handball players related to athletic parameters?

          Emre,Serdar,Atalay,Devrim,Tarakci,Candan,Algun 한국운동재활학회 2018 JER Vol.14 No.6

          Handball is a popular sport in many countries. There is lack of knowledge about handball athlete's functional movement capacity. The aim of this study is to investigate the Functional Movement Screen (FMS) scores, to evaluate the injury risks of handball athletes and to determine its relationship with athletic performance. A total of 51 professional handball players were included in this study. The sport-specific features and demographic data were recorded. The functional movement analysis was performed, agility and balance and force were evaluated. 37 were females and 14 were males. The mean age 21.00± 4.50 years (range, 16–35 years). The mean FMS scores of handball athletes were 12.86± 2.57. In addition, asymmetries were found between the left and right side FMS scores. There was a statistically significant poor correlation between the FMS and agility (r= 0.292, P= 0.038) and balance (right: r= 0.224, P= 0.024; left: r= 0.228, P= 0.022). Handball is a risky sport for injuries; therefore, athletes, coaches, and medical staff should recognize about the removal of functional deficiency before performance training. The FMS is a useful and cost-effective approach to identify these deficiencies. It is necessary not only to prevent injuries, but also to improve performance. These tests must be done before every season and, then, corrective, medical, or conservative approaches may be applied to athletes before performance training. (Clinical Trial ID: NCT03468569)

        • Risk Factors of Lymph Node Metastases with Endometrial Carcinoma

          Cetinkaya,,Kadir,Atalay,,Funda,Bacinoglu,,Ahmet Asian Pacific Organization for Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15

          Background: The purpose of this study was to investigate and evaluate risk factors for lymph node metastases (LNM) in cases of endometrial cancer (EC). Materials and Methods: A retrospective single institution analysis of patients surgically staged for EC at Ankara Oncology Education and Research Hospital from 1996 to 2010 was performed. Roles of prognostic factors, such as age, histological type, grade, depth of myometrial invasion, cervical involvement, peritoneal cytology, and tumor size, in the prediction of LNM were evaluated. Fisher's exact test and logistic regression analysis were used to assess the effects of various factors on LNM. Results: LNM was observed in 22 out of 247 patients (8.9%) and was significantly more common in the presence of tumors of higher grade, deep myometrial invasion (DMI), cervical involvement, size >2cm, and with positive peritoneal cytology. Logistic regression analysis revealed that DMI remained the only independent risk factor for LNM. NPV, PPV, sensitivity, and specificity for satisfying LNM risk were 98.0, 19.5, 86.3, and 65.3%, respectively for DMI. Conclusions: The incidence of LNM is influenced independently by DMI. If data support a conclusion of DMI, LND should be seriously considered.

        • KCI우수등재

          토양중 Light Hydrocarbon의 용매추출에 미치는 계면활성제의 영향

          Hwang.,Keon-Joong,Atalay.,Asmare 한국환경보건학회 1998 한국환경보건학회지 Vol.24 No.2

          '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

          본 실험은 light hydrocarbon에 오염된 토양을 용매 추출할 때 계면활성제의 영향을 평가하고자 6가지의 계면활성제 (Witbreak DPG-482, Witbreak DRA-22, Witcomul 4016, Witcolate SL-1, Adsee 799, Triton X-100)와 2가지 용매(물, 메타놀)를 대상으로 실험하였다. Light hydrocarbon으로는 benzene, toluene, ethyl bnzene, o-xylene, m-xylene, p-xylene, n-propyl benzene, 1,2,4-trimethyl benzene, 그리고 n-butyl benzene등 9가지를 대상으로 하였다. 계면활성제중 Adsee-799과 Witbreadk DRA-22가 토양중 light hydrocarbon의 물추출 효율을 다소 증가시키는 것으로 나타나고 있으며, 나머지 계면활성제는 효과가 없었다. 또한 물중의 계면활성제의 농도가 0.5%이하에서는 효과가 없는 것으로 나타나고 있으며, 계면활성제의 농도가 4%일때 평균 10.8%의 추출증가 효과가 있었다. 메타놀을 추출용매로 사용할 때에는 Witbread DPG-782와 Witbreak DRA-22가 약 10%의 추출증가 효과를 나타내고 있었다. This study was conducted to evaluate the surfactant solutions which influence solvent extraction from light hydrocarbon contaminated soils. Nine characteristic compounds were studied: benzene, toluene, ethylbenzene, o-xylene, mxylene, p-xylene, n-propylbenzene, 1,2,4-trimethylbenzene, and n-butylbenzene which were found in gasoline. Adsee-799 and Witbreak DRA-22 showed some extractive capacity for light hydrocarbons from soil. There was no added advantage obtained by using other surfactants in this study. No removal of contaminants from soil was observed when the surfactant concentration was 0.5 percent or below. When the surfactant concentration was 4 percent, the average recovery for some hydrocarbons was 10.8 percent, which was the best obtained at these levels. There was 10 percent surfactant contribution for methanol extraction from soil with the Witbreak DPG-482 and Witbreak DRA-22. This study provided a useful screening technique for procedures that can be used to remediate soils contaminated with light hydrocarbons.

        • KCI우수등재

          Effect of Surfactant on Solvent Extraction for Light Hydrocarbon from Soils

          Hwang,,Keon-Joong,Atalay,,Asmare Korean Society of Environmental Health 1998 한국환경보건학회지 Vol.34 No.1

          본 실험은 light hydrocarbon에 오염된 토양을 용매 추출할 때 계면활성제의 영향을 평가하고자 6가지의 계면활성제 (Witbreak DPG-482, Witbreak DRA-22, Witcomul 4016, Witcolate SL-1, Adsee 799, Triton X-100)와 2가지 용매(물, 메타놀)를 대상으로 실험하였다. Light hydrocarbon으로는 benzene, toluene, ethyl bnzene, o-xylene, m-xylene, p-xylene, n-propyl benzene, 1,2,4-trimethyl benzene, 그리고 n-butyl benzene등 9가지를 대상으로 하였다. 계면활성제중 Adsee-799과 Witbreadk DRA-22가 토양중 light hydrocarbon의 물추출 효율을 다소 증가시키는 것으로 나타나고 있으며, 나머지 계면활성제는 효과가 없었다. 또한 물중의 계면활성제의 농도가 0.5%이하에서는 효과가 없는 것으로 나타나고 있으며, 계면활성제의 농도가 4%일때 평균 10.8%의 추출증가 효과가 있었다. 메타놀을 추출용매로 사용할 때에는 Witbread DPG-782와 Witbreak DRA-22가 약 10%의 추출증가 효과를 나타내고 있었다. This study was conducted to evaluate the surfactant solutions which influence solvent extraction from light hydrocarbon contaminated soils. Nine characteristic compounds were studied: benzene, toluene, ethylbenzene, o-xylene, mxylene, p-xylene, n-propylbenzene, 1,2,4-trimethylbenzene, and n-butylbenzene which were found in gasoline. Adsee-799 and Witbreak DRA-22 showed some extractive capacity for light hydrocarbons from soil. There was no added advantage obtained by using other surfactants in this study. No removal of contaminants from soil was observed when the surfactant concentration was 0.5 percent or below. When the surfactant concentration was 4 percent, the average recovery for some hydrocarbons was 10.8 percent, which was the best obtained at these levels. There was 10 percent surfactant contribution for methanol extraction from soil with the Witbreak DPG-482 and Witbreak DRA-22. This study provided a useful screening technique for procedures that can be used to remediate soils contaminated with light hydrocarbons.

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