Evaluation of the crack formation of feldspathic ceramic reinforced with bor chemicals

Mustafa Hayati Atala,Esma Başak Gül Aygün,Arife Doğan 한양대학교 세라믹연구소 2020 Journal of Ceramic Processing Research Vol.21 No.4

The purpose of the current study was to improve the mechanical strength and reduce the micro-cracks on the microstructureof the dentin ceramic through addition of various boron compounds (borax, boric acid). Following addition of borax and boricacid (1, 2, 3% of the weight percent) to the traditional feldspathic porcelain; crack lengths, flexural strength and fracturetoughness were analyzed. The data analyses were performed by using one-way ANOVA (p<0.05). Differences between groupswere determined by Tukey HSD. The results of the present study suggested that the crack lengths were decreased and thefracture toughness were increased in all boric acid added groups (p<0.05). The group containing 1% boric acid hadsignificantly decreased the biaxial flexural strength value compared to the control group (p<0.05). The Vicker’s hardness valueof the group containing 1% borax was found to be significantly lower (p<0.05). The present study demonstrated that variousproportions of borax and boric acid addition in dentin ceramic had reduced the formation of cracks. The current study couldbe a good starting point on reinforcement of dental ceramics with a possible outcome that will reduce the failures of dentalrestorations.

Stem Cells Translational Medicine: The Journal of Tomorrow Is a Reality Today

unknown 2013 Stem cells translational medicine Vol.2 No.1

Re: Cancer Cells Promote Survival Through Depletion of the von Hippel-Lindau Tumor Suppressor by Protein Crosslinking

Williams and Wilkins Co 2012 The Journal of urology Vol.187 No.6

기능성이 강화된 고분자 지지체를 이용한 인사이투 조직재생

고인갑,유지,이상진,Atala Anthony 한국고분자학회 2011 고분자 과학과 기술 Vol.22 No.1

Cell-based therapy for kidney disease

정현철,고인갑,Anthony Atala,James J. Yoo 대한비뇨의학회 2015 Investigative and Clinical Urology Vol.56 No.6

The prevalence of renal disease continues to increase worldwide. When normal kidney is injured, the damaged renal tissue undergoes pathological and physiological events that lead to acute and chronic kidney diseases, which frequently progress to end stage renal failure. Current treatment of these renal pathologies includes dialysis, which is incapable of restoring full renal function. To address this issue, cell-based therapy has become a potential therapeutic option to treat renal pathologies. Recent development in cell therapy has demonstrated promising therapeutic outcomes, in terms of restoration of renal structure and function impaired by renal disease. This review focuses on the cell therapy approaches for the treatment of kidney diseases, including various cell sources used, as well recent advances made in preclinical and clinical studies.

Tissue Engineering: Current Strategies and Future Directions

Jennifer L. Olson,Anthony Atala,James J. Yoo 전남대학교 의과학연구소 2011 전남의대학술지 Vol.47 No.1

Novel therapies resulting from regenerative medicine and tissue engineering technology may offer new hope for patients with injuries, end-stage organ failure, or other clinical issues. Currently, patients with diseased and injured organs are often treated with transplanted organs. However, there is a shortage of donor organs that is worsening yearly as the population ages and as the number of new cases of organ failure increases. Scientists in the field of regenerative medicine and tissue engineering are now applying the principles of cell transplantation, material science, and bioengineering to construct biological substitutes that can restore and maintain normal function in diseased and injured tissues. In addition, the stem cell field is a rapidly advancing part of regenerative medicine, and new discoveries in this field create new options for this type of therapy. For example, new types of stem cells, such as amniotic fluid and placental stem cells that can circumvent the ethical issues associated with embryonic stem cells,have been discovered. The process of therapeutic cloning and the creation of induced pluripotent cells provide still other potential sources of stem cells for cell-based tissue engineering applications. Although stem cells are still in the research phase, some therapies arising from tissue engineering endeavors that make use of autologous, adult cells have already entered the clinical setting, indicating that regenerative medicine holds much promise for the future.

Cell-derived Secretome for the Treatment of Renal Disease

Kim, Michael W.,Ko, In Kap,Atala, Anthony,Yoo, James J. Korean Society of Pediatric Nephrology 2019 Childhood kidney diseases Vol.23 No.2

Kidney disease is a major global health issue. Hemodialysis and kidney transplantation have been used in the clinic to treat renal failure. However, the dialysis is not an effective long-term option, as it is unable to replace complete renal functions. Kidney transplantation is the only permanent treatment for end-stage renal disease (ESRD), but a shortage of implantable kidney tissues limits the therapeutic availability. As such, there is a dire need to come up with a solution that provides renal functions as an alternative to the current standards. Recent advances in cell-based therapy have offered new therapeutic options for the treatment of damaged kidney tissues. Particularly, cell secretome therapy utilizing bioactive compounds released from therapeutic cells holds significant beneficial effects on the kidneys. This review will describe the reno-therapeutic effects of secretome components derived from various types of cells and discuss the development of efficient delivery methods to improve the therapeutic outcomes.

Regenerative Medicine Strategies for Treating Neurogenic Bladder

James J. Yoo,Jennifer Olson,Anthony Atala,김법완 대한배뇨장애요실금학회 2011 International Neurourology Journal Vol.15 No.3

Neurogenic bladder is a general term encompassing various neurologic dysfunctions of the bladder and the external urethral sphincter. These can be caused by damage or disease. Therapeutic management options can be conservative, minimally invasive, or surgical. The current standard for surgical management is bladder augmentation using intestinal segments. However, because intestinal tissue possesses different functional characteristics than bladder tissue, numerous complications can ensue, including excess mucus production, urinary stone formation, and malignancy. As a result, investigators have sought after alternative solutions. Tissue engineering is a scientific field that uses combinations of cells and biomaterials to encourage regeneration of new, healthy tissue and offers an alternative approach for the replacement of lost or deficient organs, including the bladder. Promising results using tissue-engineered bladder have already been obtained in children with neurogenic bladder caused by myelomeningocele. Human clinical trials, governed by the Food and Drug Administration, are ongoing in the United States in both children and adults to further evaluate the safety and efficacy of this technology. This review will introduce the principles of tissue engineering and discuss how it can be used to treat refractory cases of neurogenic bladder.

Cell-derived Secretome for the Treatment of Renal Disease

Michael W. Kim,In Kap Ko,Anthony Atala,James J. Yoo 대한소아신장학회 2019 Childhood kidney diseases Vol.23 No.2

Kidney disease is a major global health issue. Hemodialysis and kidney transplantation have been used in the clinic to treat renal failure. However, the dialysis is not an effective long-term option, as it is unable to replace complete renal functions. Kidney transplantation is the only permanent treatment for end-stage renal disease (ESRD), but a shortage of implantable kidney tissues limits the therapeutic availability. As such, there is a dire need to come up with a solution that provides renal functions as an alternative to the current standards. Recent advances in cellbased therapy have offered new therapeutic options for the treatment of damaged kidney tissues. Particularly, cell secretome therapy utilizing bioactive compounds released from therapeutic cells holds significant beneficial effects on the kidneys. This review will describe the reno-therapeutic effects of secretome components derived from various types of cells and discuss the development of efficient delivery methods to improve the therapeutic outcomes.

In situ tissue regeneration through host stem cell recruitment

In Kap Ko,Sang Jin Lee,Anthony Atala,James J. Yoo 생화학분자생물학회 2013 Experimental and molecular medicine Vol.45 No.s

The field of tissue engineering has made steady progress in translating various tissue applications. Although the classical tissue engineering strategy, which involves the use of culture-expanded cells and scaffolds to produce a tissue construct for implantation, has been validated, this approach involves extensive cell expansion steps, requiring a lot of time and laborious effort before implantation. To bypass this ex vivo process, a new approach has been introduced. In situ tissue regeneration utilizes the body’s own regenerating capacity by mobilizing host endogenous stem cells or tissue-specific progenitor cells to the site of injury. This approach relies on development of a target-specific biomaterial scaffolding system that can effectively control the host microenvironment and mobilize host stem/progenitor cells to target tissues. An appropriate microenvironment provided by implanted scaffolds would facilitate recruitment of host cells that can be guided to regenerating structural and functional tissues.