Original Article : Red Cell Distribution Width: A Novel Marker of Activity in Infl ammatory Bowel Disease

( Atakan Yesil ),( Ebubekir Senates ),( Ibrahim Vedat Bayoglu ),( Emrullah Duzgun Erdem ),( Refi K Demirtunc ),( Ayse Oya Kurdas Ovunc ) 대한간학회 2011 Gut and Liver Vol.5 No.4

Background/Aims: Studies concerning red cell distribution width (RDW) for use in the assessment of infl ammatory bowel disease (IBD) activity are limited. We investigated whether RDW is a marker of active disease in patients with IBD. Methods: In total, 61 patients with ulcerative colitis (UC) and 56 patients with Crohn`s disease (CD) were enrolled in the study group, and 44 age- and-sex-matched healthy volunteers were included as the control group. A CD activity index >150 in patients with CD indicated active disease. Patients with moderate and severe disease based on the Truelove-Witts criteria were considered to have active UC. In addition to RDW, serum C-reactive protein levels, erythrocyte sedimentation rates, and platelet counts were measured. Results: Twenty-nine (51.7%) patients with CD and 35 (57.4%) patients with UC had active disease. The RDW was significantly higher in patients with CD and UC than in controls (p<0.001 and p<0.001, respectively). A subgroup analysis indicated that for a RDW cut-off of 14%, the sensitivity for detecting active CD was 79%, and the specicity was 93% (area under curve [AUC], 0.935; p<0.001). RDW was the most sensitive and specifi c marker for active CD. However, it was not valid for UC, as the ESR at a cutoff of 15.5 mm/hr showed a sensitivity of 83% and a specicity of 76% (AUC, 0.817; p<0.001), whereas the RDW at a cutoff of 14% showed 17% sensitivity and 84% specicity for detecting active UC. Conclusions: RDW was elevated in IBD in comparison with healthy controls and increased markedly in active disease. RDW may be a sensitive and specifi c marker for determining active CD, whereas ESR is an important marker of active UC. (Gut Liver 2011;5:460-467)

Estimating the Optimal Dexketoprofen Pharmaceutical Formulation with Machine Learning Methods and Statistical Approaches

Atakan Başkor,Yağmur Pirinçci Tok,Burcu Mesut,Yıldız Özsoy,Tamer Uçar 대한의료정보학회 2021 Healthcare Informatics Research Vol.27 No.4

Objectives: Orally disintegrating tablets (ODTs) can be utilized without any drinking water; this feature makes ODTs easy touse and suitable for specific groups of patients. Oral administration of drugs is the most commonly used route, and tabletsconstitute the most preferable pharmaceutical dosage form. However, the preparation of ODTs is costly and requires longtrials, which creates obstacles for dosage trials. The aim of this study was to identify the most appropriate formulation usingmachine learning (ML) models of ODT dexketoprofen formulations, with the goal of providing a cost-effective and timereducingsolution. Methods: This research utilized nonlinear regression models, including the k-nearest neighborhood (k-NN), support vector regression (SVR), classification and regression tree (CART), bootstrap aggregating (bagging), randomforest (RF), gradient boosting machine (GBM), and extreme gradient boosting (XGBoost) methods, as well as the t-test, topredict the quantity of various components in the dexketoprofen formulation within fixed criteria. Results: All the modelswere developed with Python libraries. The performance of the ML models was evaluated with R2 values and the root meansquare error. Hardness values of 0.99 and 2.88, friability values of 0.92 and 0.02, and disintegration time values of 0.97 and10.09 using the GBM algorithm gave the best results. Conclusions: In this study, we developed a computational approach toestimate the optimal pharmaceutical formulation of dexketoprofen. The results were evaluated by an expert, and it was foundthat they complied with Food and Drug Administration criteria.

Synthesis of microporous hollow spherical polystyrene carbons for the highly efficient CO2 adsorption and selectivity

Atakan Toprak,Baki Hazer 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.127 No.-

Carbon materials with economic and high adsorption capacity attract much attention to reducing fossilfuel and industrial CO2 emissions. For this purpose, porous hollow spheres with high surface area andmicropore volume, morphologically resembling fullerene or soccer balls, were first produced from thesynthesized polystyrene by hydrothermal and conventional activation. The highest micropore volumeand BET surface area were found in PS-hydroHCl with 0.61 cm3/g and 1481 m2/g, respectively. TheCO2 adsorption capacities of PS-hydroHCl at 0 and 25 C were relatively high and were obtained as6.25 and 3.62 mmol/g, respectively. It was determined that all microporous spheres were influential inthe isosteric heat of adsorption range of 17–26 kJ/mol, that is, typical CO2 physical adsorption. It has beenfound that hydrothermally synthesized PS-hydro and PS-hydroHCl contain higher amounts of oxygenthan PS and PSHCl produced according to the conventional method. In addition, CO2/N2 selectivity at25 C, PS-hydroHCl, was three times more effective than PSHCl. As a result, it can be said that the synthesisof porous hollow microspheres is simple, and the starting material (polystyrene) is cheap and abundant;high CO2 adsorption and effective CO2/N2 selectivity will be promising for industrial applications.

Red Cell Distribution Width: A Novel Marker of Activity in Infl ammatory Bowel Disease

Atakan Yeşil,Ebubekir Şenateş,İbrahim Vedat Bayoğlu,Emrullah Düzgün Erdem,Refi k Demirtunç,Ayşe Oya Kurdaş Övünç 거트앤리버 소화기연관학회협의회 2011 Gut and Liver Vol.5 No.4

Background/Aims: Studies concerning red cell distribution width (RDW) for use in the assessment of infl ammatory bowel disease (IBD) activity are limited. We investigated whether RDW is a marker of active disease in patients with IBD. Methods: In total, 61 patients with ulcerative colitis (UC)and 56 patients with Crohn’s disease (CD) were enrolled in the study group, and 44 age- and-sex-matched healthy volunteers were included as the control group. A CD activity index >150 in patients with CD indicated active disease. Patients with moderate and severe disease based on the Truelove-Witts criteria were considered to have active UC. In addition to RDW, serum C-reactive protein levels, erythrocyte sedimentation rates, and platelet counts were measured. Results: Twenty-nine (51.7%) patients with CD and 35 (57.4%)patients with UC had active disease. The RDW was significantly higher in patients with CD and UC than in controls (p<0.001 and p<0.001, respectively). A subgroup analysis indicated that for a RDW cut-off of 14%, the sensitivity for detecting active CD was 79%, and the specicity was 93% (area under curve [AUC], 0.935; p<0.001). RDW was the most sensitive and specifi c marker for active CD. However, it was not valid for UC, as the ESR at a cutoff of 15.5 mm/hr showed a sensitivity of 83% and a specicity of 76% (AUC, 0.817;p<0.001), whereas the RDW at a cutoff of 14% showed 17%sensitivity and 84% specicity for detecting active UC. Conclusions:RDW was elevated in IBD in comparison with healthy controls and increased markedly in active disease. RDW may be a sensitive and specifi c marker for determining active CD,whereas ESR is an important marker of active UC.

Magnetocaloric properties in a FeNiGaMnSi high entropy alloy

Kagan Sarlar,Atakan Tekgül,Ilker Kucuk 한국물리학회 2020 Current Applied Physics Vol.20 No.1

We investigated a new Fe26.7Ni26.7Ga15.6Mn20Si11 high entropy alloy (HEA) without the rare earth element. The structural, magnetic and magnetocaloric properties of the resulting materials are presented. The HEAs successfully is produced by the arc melting with suction casting method. The crystal structures are characterised through multiphase Rietveld refinement of X-ray diffraction data. The structure of the HEAs was found to be the body centred cubic (bcc). In the magnetic measurements, the ferromagnetic to paramagnetic transition was obtained in the range of 300–400 K. With the employed suction casting method; the Fe26.7Ni26.7Ga15.6Mn20Si11 HEA shows the best magnetocaloric properties as 1.59 Jkg−1K−1 maximum magnetic entropy change (0–2 T) and 75.68 Jkg-1 refrigeration capacity after the annealing process.

A work on inextensible flows of space curves with respect to a new orthogonal frame in E^3

Alperen Kızılay,Atakan Tuğkan Yakut 호남수학회 2023 호남수학학술지 Vol.45 No.4

In this study, we bring forth a new general formula for inextensible flows of Euclidean curves as regards modified orthogonal frame (MOF) in E^3. For an inextensible curve flow, we provide the necessary and sufficient conditions, which are denoted by a partial differential equality containing the curvatures and torsion.

Hydrogen sorption characteristics of Zonguldak region coal activated by physical and chemical methods

Turkan Kopac,Atakan Toprak 한국화학공학회 2009 Korean Journal of Chemical Engineering Vol.26 No.6

Hydrogen sorption characteristics of activated carbons (ACs) produced by physical and chemical activations from two coal mines (Kilimli and Armutcuk) in the Zonguldak region, Turkey were investigated by a volumetric technique at 77 K. H2 adsorption isotherms were obtained on the samples exposed to pyrolytic thermal treatments in a temperature range of 600-900℃ under N2 flow and chemical activation using different chemical agents such as KOH, NH4Cl, ZnCl2 from the two mines. Experimental hydrogen adsorption isotherm data at 77 K were used for the evaluation of the adsorption isotherm constants of the Brunauer-Emmett-Teller (BET) and the Langmuir models, and also the amount of hydrogen adsorbed on the various samples was evaluated by using the adsorption isotherm data. Higher hydrogen adsorption capacity values were obtained for all the heat and the chemically treated activated carbon samples from the Kilimli coal samples than Armutcuk. The amount of H2 adsorbed on the original Kilimli coal samples was 0.020 wt%, and it was increased to 0.89 wt% on the samples pyrolyzed at 800℃. The highest value of hydrogen adsorption obtained was 1.2 wt% for the samples treated with KOH+NH4Cl mixture at 750℃ followed by oxidation with ZnCl2. It was shown that chemical activations were much more effective than physical activations in increasing the surface area, pore volume and the hydrogen sorption capacities of the samples.

Cabot ring-like faggot cells in acute promyelocytic leukemia

Irfan Yavasoglu,Atakan Turgutkaya,Ali Zahit Bolaman 대한혈액학회 2022 Blood Research Vol.57 No.3

A shelf-life study of silica- and carbon-based mesoporous materials

Emma M. Björk,Aylin Atakan,Pei-Hsuan Wu,Alessandra Bari,Carlotta Pontremoli,Kai Zheng,Dimitra Giasafaki,Giorgio Iviglia,Elisa Torre,Clara Cassinelli,Marco Morra,Theodore Steriotis,Georgia Charalambopo 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.101 No.-

Mesoporous silica- and carbon-based materials, including bioactive glasses, have proven potential ascomponents of medical devices and as drug carriers. From an application perspective, knowledge aboutthe shelf-life stability of these materials under various conditions is vital. Here, mesoporous bioactiveglasses (MBGs) synthesized by aerosol-assisted spray-drying and by a batch sol–gel method, mesoporoussilicas of SBA-15 type, and mesoporous carbons CMK-1 and CMK-3 have been stored under varying conditions,e.g. at different temperature and relative humidity (RH), and in different storage vessels. Theresults show that the silica-based materials stored in Eppendorfs are sensitive to humidity. Spray driedMBGs decompose within 1 month at a RH >5%, whilst sol–gel MBGs are more stable up to a RH >60%. Changing the storage vessel to sealed glass flasks increases the MBGs lifetime significantly, with nodegradation during 2 months of storage at a RH = 75%. SBA-15 stored in Eppendorfs are more stable comparedto MBGs, and addition of F- ions added during the synthesis affects the material degradation rate. Mesoporous carbons are stable under all conditions for all time points. This systematic study clearlydemonstrates the importance of storage conditions for mesoporous materials which is crucial knowledgefor commercialization of these materials.

Silica Aerogel Application to Polyester Fabric for Outdoor Clothing

Pelin Altay,Raziye Atakan,Gülay Özcan 한국섬유공학회 2021 Fibers and polymers Vol.22 No.4

Most producers want to have a cheap, one-step system that will successfully apply multi-finishing operationswithout affecting any of the desired textile properties. Silica aerogel, used for isolation purposes in different areas such asconstruction, has been used in textile finishing in this study. 100 % polyester fabrics, which are widely used in outerwear,were impregnated with silica aerogel paste and binder at lower temperature and time than that applied for conventionalcoating method, providing decreased energy consumption. The samples were tested for wettability, soil release andhydrophobicity both before and after repeated laundering. Burst strength tests were also performed to investigate strengthproperties of the fabrics. The presence of silica groups on the treated fabrics was confirmed by FTIR spectra and thermalcharacteristics of the samples were evaluated by using differential scanning calorimeter (DSC). The results showed thataerogel impregnated fabrics provide superhydrophobic properties with a contact angle of around 170 o and improved soilrelease properties even at very low add-ons. It was also found that the silica aerogel treatment has no adverse effect on thefabric appearance or strength properties.