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( Azis Arruda Chagury ),( Luiz Ubirajara Sennes ),( Julio Miranda Gil ),( Jorge Kalil ),( Helcio Rodrigues ),( Claudia B. Rosales ),( Ivan Dieb Miziara ) 대한피부과학회 2018 Annals of Dermatology Vol.30 No.1
Background: Bullous pemphigoid (BP) is an autoimmune disease with bullous vesicles and an incidence of 0.2 to 1.4 per 100,000 inhabitants. Many studies have been published demonstrating the association of pemphigoid with HLA class II system alleles in different populations, however there are no data on the BP, one of the most heterogeneous in the world. Objective: To typify HLA alleles in Brazilians with Bullous pemphigoid. Methods: The study group included 17 Brazilian patients with a confirmed diagnosis of BP from a hospital in Sao Paulo city, southeast Brazil. DNA was extracted from peripheral blood using Qiagen kits and HLA A, B, C, DR and DQ typing was performed using polymerase chain reaction. The control group was composed of a database of 297 deceased donors from the city of Sao Paulo. The statistical significance level was adjusted using the Bonferroni correction depending on the phenotypic frequencies evaluated for HLA class I (A, B and C) and class II (DRB1, DQB1 and DQA1). Results: Our findings show that alleles HLA C*17, DQB1*03:01, DQA1*01:03 and DQA1*05:05 are associated with the onset of the disease in the Brazilian pop- lation, with relative risks of 8.31 (2.46 to 28.16), 3.76 (1.81 to 7.79), 3.57 (1.53 to 8.33), and 4.02 (1.87 to 8.64), respectively (p<0.005). Conclusion: Our data indicate that Brazilian patients with BP present the same genetic predisposition linked to HLA-DQB1*03:01 previously reported in Caucasian and Iranian individuals and our study introduces three new alleles (C*17, DQA1*01:03 and DQA1*05:05) involved in the pathophysiology of BP. (Ann Dermatol 30(1) 8∼12, 2018)
Andréa Arruda Martins Shimojo,Sofia Elisa Moraga Galdames,Amanda Gomes Marcelino Perez,Thiago Heiji Ito,Ângela Cristina Malheiros Luzo,Maria Helena Andrade Santana 한국조직공학과 재생의학회 2016 조직공학과 재생의학 Vol.13 No.1
This study aimed to evaluate the in vitro biological effectiveness of chitosan microparticles crosslinked with sodium tripolyphosphate (TPP) in combination with activated pure platelet-rich plasma (aP-PRP) as an injectable composite scaffold for growth factors release, cell proliferation and osteogenic differentiation. Two main novelties were addressed in the field of scaffolds in regenerative medicine: the first is the approach including simultaneously the three vertices of the proliferation triangle formed by the capabilities genic progenitor cells, conductive scaffolds and inductive growth factors, which are provided by platelet rich plasma (PRP); secondly, the approach of an injectable composite scaffolds formed by the fibrin network from aP-PRP and the chitosan microparticles crosslinked with TPP. The microparticles were prepared by vortexing the chitosan and TPP solutions. The ionic crosslinking of chitosan with TPP was made at mass ratios of 2:1, 5:1, and 10:1 at pH 4.0. P-PRP was obtained via the controlled centrifugation of whole blood. The composite scaffolds were prepared by adding the microparticles to immediately activated P-PRP. The results showed that the microparticles had adequate physicochemical and mechanical properties for injection. Furthermore, the microparticles controlled the release of growth factors from P-PRP. The proliferation of human adipose-derived mesenchymal stem cells was lower than in aP-PRP alone but significant at a 2:1 chitosan-TPP mass ratio. Osteogenic differentiation was stimulated at all studied mass ratios, as indicated by the alkaline phosphatase activity. These results offer perspectives for optimizing the composite scaffold, and to prove its potential as an injectable scaffold in regenerative medicine.
Francisco José Arruda Mont`Alverne,Fabricio Oliveira Lima,Felipe de Araújo Rocha,Diego de Almeida Bandeira,Adson Freitas de Lucena,Henrique Coelho Silva,이진수,Raul Gomes Nogueira 대한뇌졸중학회 2020 Journal of stroke Vol.22 No.2
The benefit of mechanical thrombectomy (MT) in acute ischemic stroke (AIS) due to large vessel intracranial occlusions is directly related to the technical success of the procedures in achieving fast and complete reperfusion. While a precise definition of refractoriness is lacking in the literature, it may be considered when there is reperfusion failure, long procedural times, or high number of passes with the MT devices. Detailed knowledge about the causes for refractory MT in AIS is limited; however, it is most likely a multifaceted problem including factors related to the vascular anatomy and the underlying nature of the occlusive lesion amongst other factors. We aim to review the impact of several key unfavorable anatomical factors that may be encountered during endovascular AIS treatment and discuss potential bail-out strategies to these challenging situations.
Priscila Vaz de Arruda,Júlio César dos Santos,Rita de Cássia Lacerda Brambilla Rodrigues,Débora Danielle Virgínio da Silva,Celina Kiyomi Yamakawa,George Jackson de Moraes Rocha,Jonas Nolasco Júnior,Jo 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.47 No.-
In this study, volumetric oxygen mass transfer coefficient (kLa) was selected as a criterion for facilitatingthe scale up of xylitol production by Candida guilliermondii at the bench and pilot-scale level. A kLa valueof 16 h 1 was applied in reactors with volumetric capacity of 2.4 L, 18 L and 125 L. Fermentation wassuccessfully scaled-up from the bench to pilot-scale level with all experiments demonstrating aminimum of 60% xylose to xylitol conversion efficiency. Under all evaluated conditions glycerol andethanol were also produced as by-products of xylose metabolism. Only minor differences were observedin the fermentation profile when reactor volumes ranging from 2.4 L to 125 L were used forexperimentation purposes, reaching, at pilot scale, yield and volumetric productivity of 0.55 g g 1and 0.31 g L 1 h 1, respectively, with maximum specific growth rate of 0.26 h 1. This demonstrates andreinforces the feasibility of using kLa as scale up criterion. The use of this parameter allowed precisereproduction of results obtained at bench bioreactor level to a larger scale; this is extremely crucial andimportant information considering that the aim of the proposed biotechnological process is to reach thelevel required for the industrial viability.
Jacaranda cuspidifolia Mart. (Bignoniaceae) as an Antibacterial Agent
Ana Lu´cia A. Arruda,Carla J.B. Vieira,Daniella G. Sousa,Regilene F. Oliveira,Rachel O. Castilho 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.12
This study evaluated, in vitro, the antimicrobial activity of the hexane extract (JCHE), methanol extract (JCME),and chloroform fraction (JCCF) of bark from Jacaranda cuspidifolia Mart. (Family Bignoniaceae), a Brazilian medicinal plant,traditionally used as anti-syphilis and anti-gonorrhea treatment. The antimicrobial activity was evaluated using the disc diffusion method followed by the determination of minimum inhibitory concentration (MIC) values. JCHE was not active against the bacteria evaluated. JCME presented antibacterial activity against Streptococcus pyogenes, Staphylococcus aureus, and Neisseria gonorrhoeae with MIC values of 16.3mg/mL, 9.1mg/mL, and 25.2mg/mL, respectively. JCCF was active against Staphylococcus epidermidis, S. aureus, Proteus mirabilis, Serratia marcescens, S. pyogenes, Enterobacter aerogenes, and N. gonorrhoeae with MIC values of 18.3mg/mL, 9.3mg/mL, 6.3mg/mL, 6.1mg/mL, 9.2mg/mL, 6.2mg/mL, and 25.2mg/mL,respectively. Phytochemical analysis of JCME and JCCF gave positive results for saponins, coumarins, flavonoids, tannins,quinones, alkaloids, triterpenes, and steroids. Verbascoside was isolated and identified as a major peak in JCME and JCCF highperformance liquid chromatography fingerprints and might contribute to the observed antimicrobial activity.
Camila Saran da Silva,Camila Ribeiro de Arruda Monteiro,Guilherme Henrique Fagundes da Silva,Roseli Oselka Sacardo Sarni,Fabiola Isabel Suano Souza,David Feder,Marcia Cristina Fernandes Messias,Patrıc 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.3
Childhood obesity is a medical condition of major public health concern. Chia seeds are used to treat certain noncommunicable diseases, and they are rich in omega-3 fatty acids, which contribute to the absorption of vitamins. A randomized double-blind clinical trial of 30 obese children was performed. The sample was composed of prepubertal 5- to 10-year-old children of both sexes with body mass indexes equal to or above the 95th percentile who were recruited through the Pediatric Department of the Faculdade de Medicina do ABC. Blood samples were drawn, the children were weighed and measured, and a 24-h dietary recall was obtained before and after the treatment. Not only were significant differences observed for fibrinogen (P = .011) but a correlation between the changes in markers and the presence of fibers was also observed for two inflammatory parameters: tumor necrosis factor-α (P = .027) and nuclear factor-κβ (P = .059). These results indicate that chia seeds may have anti-inflammatory effects related to their fiber content in the context of childhood obesity.
Aguilar, M.,Ali Cavasonza, L.,Ambrosi, G.,Arruda, L.,Attig, N.,Aupetit, S.,Azzarello, P.,Bachlechner, A.,Barao, F.,Barrau, A.,Barrin, L.,Bartoloni, A.,Basara, L.,Baş,eğ,mez-du Pree, S.,Batta American Physical Society 2018 Physical Review Letters Vol.120 No.2
<P>We report on the observation of new properties of secondary cosmic rays Li, Be, and B measured in the rigidity (momentum per unit charge) range 1.9 GV to 3.3 TV with a total of 5.4 x 10(6) nuclei collected by AMS during the first five years of operation aboard the International Space Station. The Li and B fluxes have an identical rigidity dependence above 7 GV and all three fluxes have an identical rigidity dependence above 30 GV with the Li/Be flux ratio of 2.0 +/- 0.1. The three fluxes deviate from a single power law above 200 GV in an identical way. This behavior of secondary cosmic rays has also been observed in the AMS measurement of primary cosmic rays He, C, and O but the rigidity dependences of primary cosmic rays and of secondary cosmic rays are distinctly different. In particular, above 200 GV, the secondary cosmic rays harden more than the primary cosmic rays.</P>
On the use of the wave finite element method for passive vibration control of periodic structures
Silva, Priscilla B.,Mencik, Jean-Mathieu,Arruda, Jose R.F. Techno-Press 2016 Advances in aircraft and spacecraft science Vol.3 No.3
In this work, a strategy for passive vibration control of periodic structures is proposed which involves adding a periodic array of simple resonant devices for creating band gaps. It is shown that such band gaps can be generated at low frequencies as opposed to the well known Bragg scattering effects when the wavelengths have to meet the length of the elementary cell of a periodic structure. For computational purposes, the wave finite element (WFE) method is investigated, which provides a straightforward and fast numerical means for identifying band gaps through the analysis of dispersion curves. Also, the WFE method constitutes an efficient and fast numerical means for analyzing the impact of band gaps in the attenuation of the frequency response functions of periodic structures. In order to highlight the relevance of the proposed approach, numerical experiments are carried out on a 1D academic rod and a 3D aircraft fuselage-like structure.
Aguilar, M.,Ali Cavasonza, L.,Ambrosi, G.,Arruda, L.,Attig, N.,Aupetit, S.,Azzarello, P.,Bachlechner, A.,Barao, F.,Barrau, A.,Barrin, L.,Bartoloni, A.,Basara, L.,Baş,eğ,mez-du Pree, S.,Batta American Physical Society 2016 Physical review letters Vol.117 No.23
<P>Knowledge of the rigidity dependence of the boron to carbon flux ratio (B/C) is important in understanding the propagation of cosmic rays. The precise measurement of the B/C ratio from 1.9 GV to 2.6 TV, based on 2.3 million boron and 8.3 million carbon nuclei collected by AMS during the first 5 years of operation, is presented. The detailed variation with rigidity of the B/C spectral index is reported for the first time. The B/C ratio does not show any significant structures in contrast to many cosmic ray models that require such structures at high rigidities. Remarkably, above 65 GV, the B/C ratio is well described by a single power law R. with index. Delta = -0.333 +/- 0.014(fit) +/- 0.005(syst), in good agreement with the Kolmogorov theory of turbulence which predicts. Delta = -1/3 asymptotically.</P>