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Mohammad Shojaie,Armin Abtahian,Armin Abtahian,Mohamed Amin Ghobadifar,Azadeh Esmail Pour,Armin Akbarzadeh 대한가정의학회 2015 Korean Journal of Family Medicine Vol.36 No.1
Ba ckground: This study aimed to evaluate some of the major risk factors of myocardial infarction including dehydroepiandrosterone sulfate in patients with premature myocardial infarction (age <50 years old) and myocardial infarction (age ≥50 years). Me thods: This is a parallel case-control study on 50 premature myocardial infarction patients and 50 myocardial infarction patients. We also recruited 50 matched participants for each of the two groups. Patients and their control groups were assessed for dehydroepiandrosterone sulfate serum level, diabetes mellitus, hyperlipidemia, hypertriglyceridemia, and hypertension. In addition, family history of cardiovascular disease and current smoking was recorded. Univariate and multivariate logistic regression analyses were performed to evaluate predictors of premature myocardial infarction and myocardial infarction. Re sults: No significant differences were observed between the demographic data of patients and their controls. The dehydroepiandrosterone sulfate serum level was significantly higher in patients with premature myocardial infarction compared with controls. Multivariate logistic regression analysis revealed only serum dehydroepiandrosterone sulfate dehydroepiandrosterone sulfate level to be significantly associated with premature myocardial infarction (odds ratio, 2.65; 95% confidence interval, 1.44 to 4.877; P = 0.002). Additionally, hypertension was found to be associated with myocardial infarction. Co nclusion: Higher levels of serum dehydroepiandrosterone sulfate level are associated with premature myocardial infarction but not with myocardial infarction, and this association is independent of the effects of other risk factors.
Gene Therapy and Cell Transplantation for Alzheimer's Disease and Spinal Cord Injury
Armin Blesch,Mark H. Tuszynski 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.SUP
The targeted delivery of genes and the transplantation of suitable cell types into the adult nervous system have received considerable interest over the last years. The development of improved vector systems for in vivo gene delivery and the discovery of neural stem cells in the adult nervous system have opened new venues for potential therapeutic intervention in progressive neurodegenerative disease and nervous system injury. Thus, strategies have evolved for the delivery of potentially neuroprotective molecules, such as neurotrophic factors, and the replacement of cells and tissue lost due to CNS injury and degeneration.
Armin Mirzapour-Kouhdasht,이철원,윤효숙,은종방 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.13
In this study, we investigated the multi-functionalityof bioactive peptides derived from fermentedskate (Raja kenojei) skin gelatin hydrolysates. Theextracted gelatin was hydrolyzed using a combination offood grade subtilisin and actinidin. The hydrolysates werethen fractionated via ultrafiltration, and the fractions withthe highest dipeptidyl peptidase-IV (DPP-IV) inhibitory,angiotensin-converting enzyme (ACE) inhibitory, andantibacterial proprieties were further purified via ionexchange, solid phase extraction, and reverse phase highperformance liquid chromatography. Analysis of theobtained extract revealed a direct relationship betweenhydrolysis time, degree of hydrolysis, and biologicalactivities. The peptides GRPGNRGE (P1) andAKDYEVDAT (P2), with a molecular weight of 841.42and 1010.46 Da, respectively, were identified throughtandem mass spectrometry. P1 had a lower ACE and DPPIVinhibitory activity, with a half maximal inhibitoryconcentration [IC50] of 0.74 and 0.69 mg.mL-1, respectively,than P2 (0.52 and 0.58 mg.mL-1, respectively). Antibacterial analysis showed similar results, with a minimuminhibitory concentration of 0.52 and 0.46 mg.mL-1against Staphylococcus aureus (highest activity) and 1.75and 1.44 mg.mL-1 against Klebsiella pneumonia (lowestactivity) for P1 and P2, respectively. Overall, this studyrevealed two fish gelatin-derived multifunctional peptides,exhibiting ACE inhibitory, DPP-IV inhibitory, andantibacterial activities, as natural nutraceuticals.
Armin Azad,Hojat Karami,Saeed Farzin,Amir Saeedian,Hamed Kashi,Fatemeh Sayyahi 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.7
Water quality management and control has high importance in planning and developing of water resources. This study investigatedapplication of Genetic Algorithm (GA), Ant Colony Optimization for Continuous Domains (ACOR) and Differential Evolution (DE)in improving the performance of adaptive neuro-fuzzy inference system (ANFIS), for evaluating the quality parameters ofGorganroud River water, such as Electrical Conductivity (EC), Sodium Absorption Ratio (SAR) and Total Hardness (TH). Accordingly, initially most suitable inputs were estimated for every model using sensitivity analysis and then all of the qualityparameters were predicted using mentioned models. Investigations showed that for predicting EC and TH in test stage, ANFIS-DEwith R2 values of 0.98 and 0.97, respectively and RMSE values of 73.03 and 49.55 and also MAPE values of 5.16 and 9.55,respectively were the most appropriate models. Also, ANFIS-DE and ANFIS-GA models had the best performance in prediction ofSAR (R2 = 0.95, 0.91; RMSE = 0.43, 0.37 and MAPE = 13.43, 13.72) in test stage. It is noteworthy that ANFIS showed the bestperformance in prediction of all mentioned water quality parameters in training stage. The results indicated the ability of mentionedalgorithms in improving the accuracy of ANFIS for predicting the quality parameters of river water.
Increased shelf life of Oncorhynchus mykiss (Rainbow trout) through Cu-Clay nanocomposites
Armin Azar,Hamed Ahari,Amir Ali Anvar 한국식품과학회 2022 Food Science and Biotechnology Vol.31 No.3
Microbial growth is widely responsible for shortened shelf life of cold water-living fish products. So, it seems that current chemical-based food packaging has no acceptable efficacy, and food industrialists tend to the usage of more novel approaches like active food packag- ing. Among them, there is a great research interest in nanotechnology-emerging approaches. This study aimed to investigate the anti-microbial efficacies of Polyethylene/ CuNP/nanoclay nanocomposites to enhance the shelf life and physiochemical features of rainbow trout. Three main nanocomposites with various concentrations of Cu and clay nanoparticles were examined. SEM, XRD, and EDX (as physiochemical analysis), disk diffusion (as antimicrobial assays), total volatile nitrogen (TVB-N), and peroxide value (PV) (as biochemical parameters) were measured. Based on the results, nanocomposites could reduce the microorganism growth rate by reducing the number of colonies (33.3%), inhibitory activities against both gram- positive (8 mm) and gram-negative bacteria (10 mm), maintenance of TVB-N (42% reduction), and PV (44% reduction) below the standard range. To sum up, these new nanocomposites can be a good candidate to enhance the shelf life of Rainbow Trout.
A review on fire resistance of steel-concrete composite slim-floor beams
Armin Memarzadeh,Amir Ali Shahmansouri,Mahdi Nematzadeh,Aliakbar Gholampour 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.40 No.1
The use of steel-concrete composites (SCCs) is growing rapidly in the construction industry because of their improved constructability, decreased labor cost, improved bond to reinforcing steel, improved structural integrity and accelerated project schedules compared to conventional composites. Fire is a constant danger to these structural composites. Therefore, the effect of fire on the behavior of SCCs must be evaluated and included in design provisions. Slim-floor beams (SFBs) are cost-effective systems which permit a major decrease in the thickness of industrial and commercial buildings floors. The present study reviews the recent advancements and history of SCCs together with recent studies investigating the fire performance of SFBs. First, the evolution of SCC systems is briefly discussed. Then, the fire resistance and specific thermal definitions of the main structural members are presented. Finally, analytical and numerical methods for predicting fire resistance, as well as the relevant experimental results are presented. The main focus of this study is on analyzing the performance of SFBs as a flooring system under fire. It is found that further investigation is required to improve Eurocode 4 provisions for enabling the rapidly growing construction industry to benefit from the advantages provided by composite construction methods with safety considerations. Numerous studies have so far been conducted in terms of enhancing the design quality of these systems, among which some will be discussed in this study.