Highly Porous Poly(o-Phenylenediamine) Loaded Magnetic Carboxymethyl Cellulose Hybrid Beads for Removal of Two Model Textile Dyes

Tugce A. Arica,Fadime Mert Balci,Sinan Balci,Mehmet Yakup Arica 한국섬유공학회 2022 Fibers and polymers Vol.23 No.10

Ensuring the removal of complex dyes from wastewater is a topic of great interest as it is vital for the environment. The present study reports a facile preparation method for poly(o-phenylenediamine) [p(o-PDA)] micro-particles loaded tomagnetic carboxymethyl cellulose (CMC) hydrogel beads as adsorbents. The prepared products were characterized by FTIR,TGA, VSM, SEM, BET, and zeta sizer. The Fe3O4@p(o-PDA)@CMC beads were used for the removal of Reactive Blue 4(RB-4) and Congo Red (CR) textile dyes from an aqueous medium. Different factors, such as adsorbent dose, initial pH, ionicstrength, contact time, temperatures, and initial RB-4 and CR concentrations were examined. The maximum adsorptioncapacities of the RB-4 dye and CR at optimum pH 5 reached 398.7 and 524.6 mg/g in 120 min, respectively. The adsorptionof RB-4 and CR on the hybrid magnetic beads can be due to the electrostatic, hydrogen bonding, and π-π interactions. Moreover, the magnetic hybrid beads showed easy regeneration ability and good reusability. The adsorbent can be a verygood candidate for the efficient removal of micro-pollutant from wastewater.

Adsorption of Congo Red dye by native amine and carboxyl modified biomass of Funalia trogii: Isotherms, kinetics and thermodynamics mechanisms

Gulay Bayramoglu,Mehmet Yakup Arica 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.6

Native, iminodiacetic acid and triethylenetetraamine modified biomasses of Funalia trogii were used for removal of Congo Red dye (CRD) from aqueous medium. The native and modified fungal biomasses were characterized using ATR-FTIR, Zeta potential, contact angle studies and analytical methods. FTIR studies of the native and chemically modified adsorbent preparations show that amine, carboxyl and hydroxyl groups are involved in the adsorption of the model dye (i.e., Congo Red). The maximum adsorption of the CRD on the native, carboxyl and amine groups modified fungal biomasses was obtained at pH 5.0. The amount of adsorbed dye on the adsorbent samples increased as the initial concentration of CRD in the solution increased to 200mg/L. The adsorption capacities of native, carboxyl groups and amine modified fungal preparations were 90.4, 153.6 and 193.7mg/g dry adsorbents, respectively. The data was fitted well with the Langmuir isotherm model, and followed the pseudo-second-order equations. Thermodynamic parameters (Go, Ho and So) were also calculated. The results showed that triethylenetetraamine (TETA) modified biomass of F. trogii presented an excellent dye removal performance and can be used in various environmental applications such as various micro-pollutants removal from aqueous medium.

Effectiveness of Stimulant Medications on Disruptive Behavior and Mood Problems in Young Children

Ian Parsley,Zhuo Zhang,Mark Hausmann,Arica Lerdahl,Brigette Vaughan,Ryan Edwards,Soonjo Hwang 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.3

Objective: There are very few studies on the effectiveness of stimulant medications for the treatment of disruptive mood and behavior problems in young children (less than 7 years) with Disruptive Behavior Disorders (DBD). The current study aims to determine whether young children (ages 4−7) in a long-term, intensive outpatient behavioral treatment program who are receiving stimulant medications show greater improvement in mood and behavior problems compared to peers who did not. Methods: A retrospective chart review was conducted for 97 participants diagnosed with DBD, aged 4−7 years old who were enrolled in an intensive outpatient behavioral intervention program. Pre- and post-intervention Child Behavior Checklist (CBCL) scores for disruptive behavior and mood problems were compared between the children who received stimulant medications and those who did not. Results: Paired t tests showed a statistically significant improvement in CBCL outcomes between pre- and post-intervention scores of disruptive behavior and mood problems. ANCOVA analysis, however, showed no clear further improvement in those same CBCL scores in the participants who received stimulant medications compared to the participants who did not. CBCL scores for Conduct Disorder were marginally significant for less improvement for the participants who received stimulant medications. Conclusion: This retrospective review suggests a possibility that stimulant medications may not provide additional benefit for the long-term treatment of disruptive behavior and mood problems in young children under age 7. Future study is warranted to evaluate the efficacy/effectiveness of stimulant medications in the treatment of disruptive behavior and mood problems in this population.

Cyclic-carbonate functionalized polymer brushes on polymeric microspheres: Immobilized laccase for degradation of endocrine disturbing compounds

Gulay Bayramoglu,Bunyamin Karagoz,M. Yakup Arica 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.60 No.-

A novel support material containing cyclic carbonate group for facile enzyme immobilization was synthesized from [poly(styrene-co-divinylbenzene)-graft-poly(glycidyl methacrylate)] “[PS-co-DVB-g-P(GMA)]” microsphere under carbon dioxide atmosphere. It was named as (poly(styrene-co-divinylbenzene)-graft-poly(cyclic-carbonate methacrylate)] “[PS-co-DVB-g-P(CCMA)]” microsphere. Laccase was covalently immobilized using the microspheres carrying cyclic epoxy and cyclic carbonate groups. The amount of enzyme loading on the cyclic carbonate groups of the microspheres was 47.8 mg/g. The immobilized enzyme was used for degradation of Bisphenol A, and Congo Red dye in packed bed reactor. The immobilized laccase preserved its initial activity about 67.5% and 93.0% for degradation of Bisphenol A and Conge Red, respectively.

A Case of Frontotemporal Dementia with Amyotrophic Lateral Sclerosis Presenting with Pathological Gambling

Ozel-Kizil ET,Sakarya AL,Arica B,Haran S 대한신경과학회 2013 Journal of Clinical Neurology Vol.9 No.2

Background Pathological gambling (PG), which is characterized by consistent, repetitive gambling and unsuccessful quitting attempts, is classified as an impulse control disorder. PG has also been reported in patients with Parkinson’s disease, frontotemporal dementia, and amyotrophic lateral sclerosis. Case Report A 53-year-old male visited the outpatient clinic due to excessive gambling and personality changes. Based on electrophysiological findings and neuropsychiatric assessment,he was diagnosed as frontotemporal dementia-amyotrophic lateral sclerosis. Conclusions This case report underlines that PG can also be seen in patients with neurological disorders involving the orbitofrontal cortex.

Signaling by a Conserved Quorum Sensing Pathway Contributes to Growth <i>Ex Vivo</i> and Oropharyngeal Colonization of Human Pathogen Group A Streptococcus

Makthal, Nishanth,Do, Hackwon,VanderWal, Arica R.,Olsen, Randall J.,Musser, James M.,Kumaraswami, Muthiah American Society for Microbiology 2018 Infection and immunity Vol.86 No.5

<P>Bacterial virulence factor production is a highly coordinated process. The temporal pattern of bacterial gene expression varies in different host anatomic sites to overcome niche-specific challenges. The human pathogen group A streptococcus (GAS) produces a potent secreted protease, SpeB, that is crucial for pathogenesis. Recently, we discovered that a quorum sensing pathway comprised of a leaderless short peptide, SpeB-inducing peptide (SIP), and a cytosolic global regulator, RopB, controls <I>speB</I> expression in concert with bacterial population density. The SIP signaling pathway is active <I>in vivo</I> and contributes significantly to GAS invasive infections. In the current study, we investigated the role of the SIP signaling pathway in GAS-host interactions during oropharyngeal colonization. The SIP signaling pathway is functional during growth <I>ex vivo</I> in human saliva. SIP-mediated <I>speB</I> expression plays a crucial role in GAS colonization of the mouse oropharynx. GAS employs a distinct pattern of SpeB production during growth <I>ex vivo</I> in saliva that includes a transient burst of <I>speB</I> expression during early stages of growth coupled with sustained levels of secreted SpeB protein. SpeB production aids GAS survival by degrading LL37, an abundant human antimicrobial peptide. We found that SIP signaling occurs during growth in human blood <I>ex viv</I>o. Moreover, the SIP signaling pathway is critical for GAS survival in blood. SIP-dependent <I>speB</I> regulation is functional in strains of diverse <I>emm</I> types, indicating that SIP signaling is a conserved virulence regulatory mechanism. Our discoveries have implications for future translational studies.</P>

Immobilization of Candida rugosa Lipase on Magnetic Biosilica Particles: Hydrolysis and Transesterification Studies

Ilkay Acıkgoz-Erkaya,Gulay Bayramoglu,Aydin Akbulut,Mehmet Yakup Arica 한국생물공학회 2021 Biotechnology and Bioprocess Engineering Vol.26 No.5

Biodiesel is a renewable fuel used mainly in diesel engines. At the present time, biodiesel is largely produced by acid or alkali transesterification reactions. A hot spring water algae isolate "Kamptonema formosum" was cultivated at three different temperatures, and the algae oil was extracted using chloroform and methanol (v/v, 1/1 ratio) as the solvent. The maximum amount of algal biomass (1.86 g/L) was obtained at 25°C, and the extracted oil was found to be 48.7% of the total dry biomass. Diatomic earth particles (Biosilica) were magnetized via thermal coprecipitation reaction, and then it was grafted with polydopamine (MBioSi@PDA). The lipase was covalently immobilized on the surface of the MBioSi@PDA via Schiff’s base reaction. The immobilization conditions were optimized and 3.0 mg/mL as the initial lipase concentration in the immobilization medium was found to be the most favorable. At this lipase concentration, the amount of the immobilized lipase on the MBioSi@PDA particles and immobilization yield were found to be 81.9 mg/g and 67.9%, respectively. The MBioSi@PDA@lipase particles were used for conversion of K. formosum oil into biodiesel, and the conversion yield was found as 91.2% under optimum conditions. The fatty acid methyl ester (FAME) compositions of the alga oil were identified using a gas chromatography-mass spectrometry (GC-MS). K. formosum oil mainly composed of the required fatty acids (i.e., 16 and 18 carbon long-saturated and unsaturated fatty acids) for biodiesel synthesis, and these were advantageous for synthesis of biodiesel from the algal oil.

Preparation and Characterization of Poly(hydroxyethyl methacrylate-co-poly(ethyl-eneglycol-methacrylate)/Hydroxypropyl-chitosan) Hydrogel Films:Adhesion of Rat Mesenchymal Stem Cells

Gulay Bayramoglu,K. Can Akcall,Sinan Gultekin,Erman Bengu,M. Yakup Arica 한국고분자학회 2011 Macromolecular Research Vol.19 No.4

This study examined the effects of the surface properties of the materials, such as the hydroxyl, methyl and amino groups, on rat bone marrow derived Mesenchymal Stem Cell (MSC) seeding. A series of hydrogels were prepared in film form using 2-hydroxyethyl methacrylate (pHEMA), poly(ethyleneglycol) methacrylate (PEG-MA),and/or hydroxypropyl-chitosan (HPC). The physicochemical properties of these hydrogel films, such as water content, functional groups, contact angle, surface energy and thermal properties were affected by the composition of the materials. The ability of the MSCs to form colonies, as well as their viability on these materials were also analyzed. The water content of the hydrogel films increased with increasing PEG-MA and HPC ratio in the hydrogel. Contact angle measurements of the surface of the hydrogel films demonstrated that all the materials gave rise to a significantly hydrophilic surface compared to pure pHEMA. The blood protein interactions and platelet adhesion were reduced significantly on the surface of the materials upon the incorporation of PEG-MA compared to the control pure pHEMA and vice versa for HPC. The ability of the MSCs to adhere and form colonies on these materials was also analyzed. The results showed that these materials are suitable candidates to isolate and expand MSCs.