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      • KCI등재후보

        Metastatic Squamous Cell Carcinoma of the Lower Lip: Analysis of the 5-Year Survival Rate

        Tommaso Agostini,Giuseppe Spinelli,Francesco Arcuri,Raffaella Perello 대한두개안면성형외과학회 2017 Archives of Craniofacial Surgery Vol.18 No.2

        Background: The author analyse the impact of extracapsular lymph node spread and bone engagement in the ipsilateral neck of patients suffering squamous cell carcinoma (SCC) of the lower lip. Methods: The data of 56 neck dissections performed in patients suffering SCC of the lower lip between January 2000 and December 2008 were retrospectively analysed. Statistical analysis was performed with the Kaplan-Meier life table method, and the survival rate was investigated with the log rank statistic and significance test. The values were considered statistically significant at p<0.05. Results: Nine patients took advantage from simultaneous treatment of tumor and prophylactic neck dissection (level I–III), reaching 100% survival rate. Patients suffering metastasized disease, who received radical neck dissection at the time of tumor treatment, presented 83.3% survival rate. Patients who underwent previous surgery and radiotherapy presented worse prognosis although radical neck dissection in case of extra-capsular spread only (24.7%) and osseous engagement (22.2%). Conclusion: Prophylactic neck dissection (level I–III) is recommended in T3–T4 N0 SCC. Simultaneous treatment of tumor and cervical lymph nodes provides a better prognosis as respect to delayed nodal management. Extra-capsular spread with or without bone engagement represents independent risk factor responsible for high mortality rate of SCC of the lower lip.

      • KCI등재

        Production of Fungal Lipases Using Wheat Bran and Soybean Bran and Incorporation of Sugarcane Bagasse as a Co-substrate in Solid-state Fermentation

        Luciana Francisco Fleuri,Mariana Cassani de Oliveira,Mariana de Lara Campos Arcuri,Bruna Luiza Capoville,Milene Stefani Pereira,Clarissa Hamaio Okino Delgado,Paula Kern Novelli 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.4

        Fungal strains were screened for lipase producingactivities and 10 strains were classified as good producers. Aspergillus sp., Fusarium sp., and Penicillium sp. exhibitedthe highest activities when fermented in wheat bran (WB)and soybean bran (SB). No fungal growth was observedusing sugarcane bagasse (CB). An experimental designwas applied to incorporate CB into the fermentation processfor lipase production by Aspergillus sp. and Penicilliumsp., and to evaluate the best moisture content for thesubstrate. Strains studied achieved maximum lipase activitieswith 25% CB combined with 75% WB or SB at 40%moisture content. The highest lipase activities were observedfor WB and SB, and for SB combined with CB usingAspergillus sp. Fermentation of 96 h was the optimumperiod for enzyme production.

      • SCIESCOPUSKCI등재

        Effect of Lipid Sources with Different Fatty Acid Profiles on Intake, Nutrient Digestion and Ruminal Fermentation of Feedlot Nellore Steers

        Fiorentini, Giovani,Carvalho, Isabela P.C.,Messana, Juliana D.,Canesin, Roberta C.,Castagnino, Pablo S.,Lage, Josiane F.,Arcuri, Pedro B.,Berchielli, Telma T. Asian Australasian Association of Animal Productio 2015 Animal Bioscience Vol.28 No.11

        The present study was conducted to determine the effect of lipid sources with different fatty acid profiles on nutrient digestion and ruminal fermentation. Ten rumen and duodenal fistulated Nellore steers (268 body weight${\pm}27kg$) were distributed in a duplicated $5{\times}5$ Latin square. Dietary treatments were as follows: without fat (WF), palm oil (PO), linseed oil (LO), protected fat (PF; Lactoplus), and whole soybeans (WS). The roughage feed was corn silage (600 g/kg on a dry matter [DM] basis) plus concentrate (400 g/kg on a DM basis). The higher intake of DM and organic matter (OM) (p<0.001) was found in animals on the diet with PF and WF (around 4.38 and 4.20 kg/d, respectively). Treatments with PO and LO decreased by around 10% the total digestibility of DM and OM (p<0.05). The addition of LO decreased by around 22.3% the neutral detergent fiber digestibility (p = 0.047) compared with other diets. The higher microbial protein synthesis was found in animals on the diet with LO and WS (33 g N/kg OM apparently digested in the rumen; p = 0.040). The highest C18:0 and linolenic acid intakes occurred in animals fed LO (p<0.001), and the highest intake of oleic (p = 0.002) and C16 acids (p = 0.022) occurred with the diets with LO and PF. Diet with PF decreased biohydrogenation extent (p = 0.05) of C18:1 n9,c, C18:2 n6,c, and total unsaturated fatty acids (UFA; around 20%, 7%, and 13%, respectively). The diet with PF and WF increased the concentration of $NH_3-N$ (p<0.001); however, the diet did not change volatile fatty acids (p>0.05), such as the molar percentage of acetate, propionate, butyrate and the acetate:propionate ratio. Treatments PO, LO and with WS decreased by around 50% the concentration of protozoa (p<0.001). Diets with some type of protection (PF and WS) decreased the effects of lipid on ruminal fermentation and presented similar outflow of benefit UFA as LO.

      • KCI등재

        Effect of Lipid Sources with Different Fatty Acid Profiles on Intake, Nutrient Digestion and Ruminal Fermentation of Feedlot Nellore Steers

        Giovani Fiorentini,Isabela P.C. Carvalho,Juliana D. Messana,Roberta C. Canesin,Pablo S. Castagnino,Josiane F. Lage,Pedro B. Arcuri,Telma T. Berchielli 아세아·태평양축산학회 2015 Animal Bioscience Vol.28 No.11

        The present study was conducted to determine the effect of lipid sources with different fatty acid profiles on nutrient digestion and ruminal fermentation. Ten rumen and duodenal fistulated Nellore steers (268 body weight±27 kg) were distributed in a duplicated 5×5 Latin square. Dietary treatments were as follows: without fat (WF), palm oil (PO), linseed oil (LO), protected fat (PF; Lactoplus), and whole soybeans (WS). The roughage feed was corn silage (600 g/kg on a dry matter [DM] basis) plus concentrate (400 g/kg on a DM basis). The higher intake of DM and organic matter (OM) (p<0.001) was found in animals on the diet with PF and WF (around 4.38 and 4.20 kg/d, respectively). Treatments with PO and LO decreased by around 10% the total digestibility of DM and OM (p<0.05). The addition of LO decreased by around 22.3% the neutral detergent fiber digestibility (p = 0.047) compared with other diets. The higher microbial protein synthesis was found in animals on the diet with LO and WS (33 g N/kg OM apparently digested in the rumen; p = 0.040). The highest C18:0 and linolenic acid intakes occurred in animals fed LO (p<0.001), and the highest intake of oleic (p = 0.002) and C16 acids (p = 0.022) occurred with the diets with LO and PF. Diet with PF decreased biohydrogenation extent (p = 0.05) of C18:1 n9,c, C18:2 n6,c, and total unsaturated fatty acids (UFA; around 20%, 7%, and 13%, respectively). The diet with PF and WF increased the concentration of NH3-N (p<0.001); however, the diet did not change volatile fatty acids (p>0.05), such as the molar percentage of acetate, propionate, butyrate and the acetate:propionate ratio. Treatments PO, LO and with WS decreased by around 50% the concentration of protozoa (p<0.001). Diets with some type of protection (PF and WS) decreased the effects of lipid on ruminal fermentation and presented similar outflow of benefit UFA as LO.

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