Excerpts from Jeju Forum 2017 Keynote Speech - European Union-East Asia Relationship in the New International Context

Anibal Cavaco Silva 제주평화연구원 2017 JPI Research Series Vol.40 No.-

Optimal cross-section and configuration design of cyclic loaded elastic-plastic structures

Valido, Anibal J.,Sousa, Luis G.,Cardoso, J. Barradas Techno-Press 1996 Structural Engineering and Mechanics, An Int'l Jou Vol.4 No.1

This paper describes a continuum variational formulation for design optimization of nonlinear structures in the elastic-plastic domain, where unloading and reloading of the structures are allowed to occur. The Total Lagrangian procedure is used for the description of the structural deformation. The direct differentiation approach is used to derive the sensitivities of the various structural response measures with respect to the design parameters. Since the material goes into the inelastic range and unloading and reloading of the structure are allowed to occur, the structural response is path dependent and an additional step is needed to integrate the constitutive equations. It can be shown, consequently, that design sensitivity analysis is also path-dependent. The theory has been discretized by the finite element technique and implemented in a structural analysis code. Mathematical programming approach is used for the optimization process. Numerical applications on trusses are performed, where cross-sectional areas and nodal point coordinates are treated as design variables. Optimal designs have been obtained and compared by using two different strategies: a two level strategy where the levels are defined accordingly the type of design variables, cross sectional areas or node coordinates, and optimizing simultaneously with respect to both types of design variables.

Implications of diphoton searches for a radion in the bulk-Higgs scenario

Cox, Peter,Medina, Anibal D.,Ray, Tirtha Sankar,Spray, Andrew World Scientific Publishing Company 2017 International Journal of Modern Physics A Vol.32 No.4

<P>In this work, we point out that the apparent diphoton excess initially presented by the ATLAS and CMS collaborations could have originated from a radion in the bulk Higgs scenario within a warped extra dimension. In this scenario, the couplings of the radion to massive gauge bosons are suppressed, allowing it to evade existing searches. In the presence of mixing with the Higgs, due to the strong constraints from diboson searches, only points near what we denominate the alignment region were able to explain the diphoton signal and evade other experimental constraints. In light of the new measurements presented at ICHEP 2016 by both LHC collaborations, which do not confirm the initial diphoton excess, we study the current and future collider constraints on a radion within the bulk-Higgs scenario. We find that searches in the diphoton channel provide the most powerful probe of this scenario and already exclude large regions of parameter space, particularly for smaller warp factors. The radion has a sizeable branching ratio into top pairs and this channel may also give competitive constraints in the future. Finally, di-Higgs searches can provide a complementary probe in the case of nonzero radion-Higgs mixing but strong alignment.</P>

Novel collider and dark matter phenomenology of a top-philic Z ′

Cox, Peter,Medina, Anibal D.,Ray, Tirtha Sankar,Spray, Andrew Institute of Physics Pub 2016 The journal of high energy physics Vol.2016 No.6

Setting Procedure of a Robust Torsional Compensation Scheme Using a Shaft Angle Control Loop

Ricardo Leon,Guillermo Ramirez,Anibal Valenzuela 제어로봇시스템학회 2008 제어로봇시스템학회 국제학술대회 논문집 Vol.2008 No.10

In a related paper the authors developed a robust dynamic compensation scheme for high performance servo drives based on a shaft angle control loop. First, this paper establishes the physical relationship between the state feedback of load and motor speed and position differences and the proportional and derivative actions of the proposed control loop. Based on this relationship and a sensitivity analysis on the Bode diagram, a setting procedure for the controller gains is developed. Evaluation is done in a 2-mass servo drive model that includes the delays and quantization due to digital implementation, and a full-order observer of the unavailable signals.

Effects of copper loading on NH3-SCR and NO oxidation over Cu impregnated CHA zeolite

Nusnin Akter,Xianyin Chen,John Parise,Jorge Anibal Boscoboinik,김태진 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.1

Cu/CHA catalysts with various Cu loadings (0.5 wt%-6.0 wt%) were synthesized via incipient wetness impregnation. The catalysts were applied to the selective catalytic reduction (SCR) of NO with NH3 and NO oxidation reaction. XRD and N2 adsorption-desorption data showed that CHA structure was maintained with the incorporation of Cu, while specific surface areas decreased with increasing Cu loading. At intermediate Cu loading, 4 wt%, the highest NH3-SCR activity was observed with ~98% N2 selectivity from 150 oC to 300 oC. Small amounts of water, 2%, slightly increased NO conversion in addition to the remarkable N2O and NO2 reduction at high temperature. Water effects are attributed to the improved Cu ion reducibility and mobility. NO oxidation results provided no relation between NO2 formation and SCR activity. Physicochemical properties, NO conversion, N2 selectivity, and activation energy data showed that impregnated samples’ molecular structure and catalytic activity are comparable to the conventional ion-exchanged (IE) samples’ ones.

Evaluation of female masculinization in Pomacea canaliculata (Caenogastropoda, Ampullariidae) induced by tributyltin, heavy metals, and uranium in culture water

Maximiliano Giraud-Billoud,Alejandra Daniela Campoy-Diaz,Emilio Mansilla Munoz,Israel Anibal Vega 환경독성보건학회 2022 환경독성보건학회지 Vol.37 No.3

All female Pomacea canaliculata develop a small, male-like copulatory apparatus a few days after birth, which growths slowly until sexual maturity, and even further in older age. Previous studies have found trace elements like mercury (Hg), arsenic (As) and uranium (U) in tap water used for snail culture, and that these elements were accumulated in snail tissues. Here, we test whether the presence of these metals at maximum allowed concentrations (Environmental Protection Agency - EPA) in aquarium water could affect the development of the copulatory apparatus in mature females. Females of different ages were used as controls, grown in reconstituted metal-free water with or without the addition of Hg, As and U, as well as tributyltin (TBT), a compound used as masculinizing agent. Six and seven months old females cultured in tap water showed a longer penis and penile sheath, and a greater overall development of the copulatory apparatus, measured by an index (DI), as compared with same-age females cultured in reconstituted water. Moreover, when females were exposed to Hg, As or U at the maximum contaminant levels for human consumption allowed by EPA regulations, there was no further development of the copulatory apparatus, while there was a clearly positive effect in TBT-exposed females. This study confirms the masculinizing effect of organotin compounds on female copulatory apparatus and discusses the usefulness of the development of these organs as a bioindicator of environmental pollution.

Prognostic importance of atypical endometriosis with architectural hyperplasia versus cytologic atypia in endometriosis-associated ovarian cancer

Isabel Ñiguez Sevilla,Francisco Machado Linde,Maria del Pilar Marín Sánchez,Julián Jesús Arense,Amparo Torroba,Anibal Nieto Díaz,Maria Luisa Sánchez Ferrer 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.4

Objective: Patients with endometriosis are at increased risk of ovarian cancer. It has been suggested that atypical endometriosis is a precursor lesion of endometriosis-associated ovarian cancer (EAOC). The aim of this study is to evaluate if cytologic (cellular) atypia and architectural atypia (hyperplasia), histologic findings described as atypical endometriosis, play a different role in patients with EAOC. Methods: A prospective study was conducted between January 2014 and April 2017 at our institution with patients undergoing surgery with a histologic diagnosis of endometriosis, ovarian cancer, or EAOC. The prevalence and immunohistologic study (Ki-67, BAF250a, COX-2) of cases of cellular and architectural atypia in endometriosis were analyzed. Results: Two hundred and sixty-six patients were included: the diagnosis was endometriosis alone in 159 cases, ovarian cancer in 81, and EAOC in 26. Atypical endometriosis was reported in 23 cases (12.43%), 39.13% of them found in patients with EAOC. Endometriosis with cellular atypia was found mainly in patients without neoplasm (71.4%), and endometriosis with architectural atypia was seen in patients with ovarian cancer (88.9%) (p=0.009). Ki-67 was significantly higher in endometriosis patients with architectural atypia than those with cellular atypia. Conclusion: The diagnosis of endometriosis with architectural atypia is important because it may be a precursor lesion of ovarian cancer; therefore, pathologists finding endometriosis should carefully examine the surgical specimen to identify any patients with hyperplasia-type endometriosis, as they may be at higher risk of developing EAOC.

Efficacy of instillation of MB49 cells and thermoreversible polymeric gel in urothelial bladder carcinoma immunization

Jhonne Pedro Pedott Santana,Priscyla Daniely Marcato,Tais Nader Chrysostomo Massaro,Naiane Lima Godoy,Fernanda de Freitas Anibal,Borra Ricardo Carneiro 한국실험동물학회 2022 Laboratory Animal Research Vol.38 No.2

Background: Activating the immune system for therapeutic benefit has long been a goal in immunology, especially in cancer treatment, but the low immunogenicity of antitumor vaccines remains a limiting factor in the fight against malignant neoplasms. The increase in the immunogenicity of weak antigens using biodegradable polymers, such as chitosan, has been observed in the field of cancer immunotherapy. However, the effects of the vaccine using a combination of tumor cells and a thermoreversible delivery system based on chitosan in bladder cancer models, mainly using the intravesical route to stimulate the antitumor immune response, are unknown. We propose to evaluate the efficacy of a polymeric gel matrix (TPG) formed by poloxamer 407 and chitosan, associated with MB49 cells, as an intravesical antitumor vaccine using a C57BL/6 murine model of bladder urothelial carcinoma. The effectiveness of immunization was analyzed with the formation of three experimental groups: Control, TPG and TPG + MB49. In the vaccination phase, the TPG + MB49 group underwent a traumatic injury to the bladder wall with immediate intravesical instillation of the vaccine compound containing MB49 cells embedded in TPG. The TPG group was subjected to the same procedures using the compound containing the gel diluted in medium, and the control group using only the medium. After 21 days, the animals were challenged with tumor induction. Results: In vitro tests showed loss of viability and inability to proliferate after exposure to TPG. In vivo tests showed that animals previously immunized with TPG + MB49 had higher cumulative survival, as well as significantly lower bladder weight and size in contrast to the other two groups that did not show a statistically different tumor evolution. In addition, the splenocytes of these animals also showed a higher rate of antitumor cytotoxicity in relation to the TPG and control groups. Conclusions: We can conclude that MB49 cells embedded in a polymeric thermoreversible gel matrix with chitosan used in the form of an intravesical vaccine are able to stimulate the immune response and affect the development of the bladder tumor in an orthotopic and syngeneic C57BL/6 murine model.

Vitis vinifera L. Grape Skin Extract Prevents Development of Hypertension and Altered Lipid Profile in Spontaneously Hypertensive Rats: Role of Oxidative Stress.

Giselle Franca da Costa,Dayane Teixeira Ognibene,Cristiane Aguiar da Costa,Michelle Teixeira Teixeira,Viviane da Silva Cristino Cord,Graziele Freitas de Bem,Anibal Sanchez Moura,Angela de Castro Resen 한국식품영양과학회 2020 Preventive Nutrition and Food Science Vol.25 No.1

This study investigated the protective effect of a Vitis vinifera L. grape skin extract (ACH09) on blood pressure, lipid profile, and oxidative status in spontaneously hypertensive rats (SHR). Systolic blood pressure (SBP), total cholesterol, triglyceride, and glucose levels, as well as oxidative damage and antioxidant activity in the plasma and kidney, were evaluated in four experimental groups: control Wistar rats (W-C) and SHR-C that received water, and Wistar rats and SHR treated with ACH09 (200 mg/kg/d) in drinking water for 12 weeks (W-ACH09 and SHR-ACH09, respectively). SBP increased in the SHR group compared with the W groups and the treatment with ACH09 prevented the development of hypertension. Plasma triglyceride and total cholesterol levels increased in SHR compared with W-C rats; these changes prevented by treatment with ACH09. Glucose levels did not differ between the groups. The SHR group had increased oxidative damage in plasma, as expressed by 2-thiobarbituric acid reactive substances (TBARS) levels, and this prevented by ACH09. Levels of TBARS in the kidneys were lower in the SHR-ACH09 group than in the SHR-C group. Further, ACH09 increased the superoxide dismutase activity in both the plasma and kidneys of both SHR and Wistar rats. These results suggest that ACH09 is protective against disruption of blood pressures, oxidant status, and lipid profile in SHR, and provide important evidence on the benefits of ACH09 on hypertension and associated cardiovascular complications.