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Bacopa monnieri in Patients with Parkinson's Disease: A Pilot Study
Andreia Fuentes dos Santos,Marília Moraes Queiroz Souza,Eduarda Carolina Amaral,Edilson Rodrigues Albuquerque,Durcelina Schiavoni Bortoloti,Arquimedes Gasparotto Junior,Emerson Luiz Botelho Lourenço,E 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.2
Bacopa monnieri (L.) Wettst. could be of interest in the control of symptoms of Parkinson's disease, but clinical evidence of its efficacy is lacking. This clinical trial assessed the effects of an extract of B. monnieri on parameters that are related to Parkinson's diseases. Twenty volunteers with Parkinson's disease were recruited for a primary, interventional, controlled, parallel, double-blind clinical study. The volunteers were assigned to treatment with either a commercial B. monnieri extract (225 or 450 mg/day) or placebo. The Parkinson's Disease Quality-of-Life (PDQL) questionnaire was applied, and motor activity was assessed before treatment and 30, 60, and 90 days after treatment with the B. monnieri extract or placebo. Characteristics such as age, body weight, and height were also collected. No differences in parkinsonian and systemic symptoms, emotional function, or social function were observed between. The delta percent (Δ%) showed time-dependent improvements in emotional function with B. monnieri treatment at the daily dose of 450 mg. A strong correlation was found between quality of life and motor outcomes at baseline and 30 days of treatment with B. monnieri, and a moderate correlation for 60 and 90 days of treatment with B. monnieri when compared with baseline time. A moderate correlation was found between motor outcomes and Hoehn and Yahr stages at baseline. Our results suggest that B. monnieri extract can improve emotional function in Parkinson's disease patients, but further clinical trials are needed to confirm this possibility.
Andreia Volpato,Dilmar Baretta,Talyta Zortéa,Gabriela Campigotto,Patricia Glombowsky,Roberto C.V. Santos,Priscilla M. Quatrin,Aline F. Ourique,Matheus D. Baldissera,Lenita M. Stefani,Aleksandro S. Da 한국응용곤충학회 2016 Journal of Asia-Pacific Entomology Vol.19 No.4
The aim of this study was to evaluate the in vitro susceptibility of larva and adult forms of Alphitobius diaperinus treated with cinnamon (Cinnamomum zeylanicum) essential oil on its free form, nanoemulsion (NE), and nanocapsule (NC), aswell as the effect of these treatments on the edaphic fauna using springtails of Folsomia candida (ISO) as a model. The tests with larvae and adults were performed using 1, 5, and 10% of the cinnamon essential oil, and 0.5, 1, and 5% of NE and NC containing 5% of cinnamon essential oil. To validate the test, three controlswere used: only oil diluent (Triton), blank nanoemulsion (without oil) and blank nanocapsule (without oil). Cinnamon essential oil at 5 and 10% caused mortality in larva and adult forms of A. diaperinus. The NE (1%) and NC (5%) causedmortality in both phases of A. diaperinus life cycle. After these promising findings,more studieswere conducted to verify the ecotoxicological effect of the cinnamon oil. For this, a Tropical Artificial Soil (TAS) was usedwith different doses of cinnamon oil, NE and NC, using springtails of F. candida. The use of cinnamon oil, even in very low concentrations (25 mg kg−1), on its original form significantly affected springtails survival and reproduction.However, the nanostructuring process seemed to minimize this toxic effectwithout affecting its insecticidal action. In summary, the pure oil and NE containing cinnamon oil showed effect against A. diaperinus, and may be considered an alternative to control this infestation.
Evaluation of Women with Myofascial Abdominal Syndrome Based on Traditional Chinese Medicine
Mitidieri, Andreia,Gurian, Maria Beatriz,Silva, Ana Paula,Tawasha, Kalil,Poli-Neto, Omero,Nogueira, Antonio,Reis, Francisco,Rosa-e-Silva, Julio KOREAN PHARMACOPUNCTURE INSTITUTE 2015 Journal of pharmacopuncture Vol.18 No.4
Objectives: This study used semiology based on traditional Chinese medicine (TCM) to investigate vital energy (Qi) behavior in women with abdominal myofascial pain syndrome (AMPS). Methods: Fifty women diagnosed with chronic pelvic pain (CPP) secondary to AMPS were evaluated by using a questionnaire based on the theories of "yin-yang," "zang-fu", and "five elements". We assessed the following aspects of the illness: symptomatology; specific location of myofascial trigger points (MTrPs); onset, cause, duration and frequency of symptoms; and patient and family history. The patients tongues, lips, skin colors, and tones of speech were examined. Patients were questioned on various aspects related to breathing, sweating, sleep quality, emotions, and preferences related to color, food, flavors, and weather or seasons. Thirst, gastrointestinal dysfunction, excreta (feces and urine), menstrual cycle, the five senses, and characteristic pain symptoms related to headache, musculoskeletal pain, abdomen, and chest were also investigated. Results: Patients were between 22 and 56 years old, and most were married (78%), possessed a elementary school (66%), and had one or two children (76%). The mean body mass index and body fat were 26.86 kg/cm2 (range: 17.7 - 39.0) and 32.4% (range: 10.7 - 45.7), respectively. A large majority of women (96%) exhibited alterations in the kidney meridian, and 98% had an altered gallbladder meridian. We observed major changes in the kidney and the gallbladder Qi meridians in 76% and 62% of patients, respectively. Five of the twelve meridians analyzed exhibited Qi patterns similar to pelvic innervation Qi and meridians, indicating that the paths of some of these meridians were directly related to innervation of the pelvic floor and abdominal region. Conclusion: The women in this study showed changes in the behavior of the energy meridians, and the paths of some of the meridians were directly related to innervation of the pelvic floor and abdominal region.
Gravena, Angela Andreia Franca,Brischiliari, Sheila Cristina Rocha,Gil, Lais Moraes,Lopes, Tiara Cristina Romeiro,Demitto, Marcela De Oliveira,Agnolo, Catia Millene Dell,Borghesan, Deise Helena Pellos Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Background: The purpose of the article was to analyze the years of potential life lost (YPLL) of women who died from breast and cervical cancer in the State of Paran$\acute{a}$, Southern Brazil. This was a temporal trend study (2000 to 2010) about the coefficients of mortality and the years of potential life lost in women aged 20 to 70 years. Materials and Methods: Data were obtained through the database of the Department of the Unified Health System (DATASUS) and the National Mortality Information System. Results: There was a loss of 125.075 YPLL due to breast cancer, with an average of 11.370 YPLL. Regarding cervical cancer, the figure obtained was 91.625 YPLL from 2000 to 2010, with an average of 8.329 YPLL. Increased risk of death from breast cancer was observed for women aged 50 to 59 years, with a significant increase among those in the age group from 40 to 49 years. There was an increased rate of cervical cancer among women 40 to 69 years. Conclusions: The risk of death grows with increasing age, being higher from 40 years. Prevention is paramount for both cancers. Thus, preventive measures are required and a reassessment of political strategies should be adopted.
Revisiting Covered Interest Parity in the European Union: the DCCA Approach
Paulo Ferreira,Andreia Dionisio 한국국제경제학회 2015 International Economic Journal Vol.29 No.4
This paper analyzes the evidence of financial integration, with covered interest parity (CIP), for a group of countries that have already adopted the euro and another group of countries that kept their currencies. We use detrended cross-correlation analysis, which allows analyzing the behavior of time series even when they are not stationary. The main results indicate that countries that adopted the euro do not show much evidence in favor of CIP, before joining the Eurozone, which could imply they will not benefit from all common currency advantages. In the group of countries that did not adopt the euro, Denmark, Sweden, the UK and the Czech Republic are the ones presenting better conditions for financial integration with the euro, while Bulgaria has also some evidence of this. Some possible explanations of CIP deviations are agents not considering all countries’ assets as similar and also the underdevelopment of markets and liquidity problems (more pronounced due to periods of turmoil).
Epidemiology of Abdominal Obesity among Adolescents from a Brazilian State Capital
Diego Augusto Santos Silva,Andreia Pelegrini,João Marcos Ferreira de Lima e Silva,Edio Luiz Petroski 대한의학회 2011 Journal of Korean medical science Vol.26 No.1
The objective of this study was to investigate the effects of socioeconomic, demographic and lifestyle factors on abdominal obesity in adolescents from a Brazilian state capital. In this cross-sectional study, 656 high school students (423 girls and 233 boys) from public schools, ranging in age from 14 to 19 yr, were evaluated. Abdominal obesity was identified based on waist circumference. Socioeconomic data (socioeconomic status,household head’s education, and school grade), demographic data (gender and age), and information regarding lifestyle (physical activity, eating habits, aerobic fitness, and nutritional status) were collected. Logistic regression was used for multivariate analysis. The prevalence of abdominal obesity was 6.6% (95% confidence interval [CI]: 4.6-8.4). Being in the second (odds ratio [OR] = 0.41; 95% CI: 0.19-0.88) or third year (OR = 0.18;95% CI: 0.06-0.59) of high school was a protective factor against abdominal obesity. In addition, students presenting low aerobic fitness (OR = 4.10; 95% CI: 1.62-10.4) and those with excess weight (OR = 208.6; 95% CI: 47.7-911.7) had a higher probability of abdominal obesity. In conclusion, demographic factors such as school grade, lifestyle habits, low aerobic fitness and excess weight are associated with central obesity.
Mammographic Screening of Women Attending a Reference Service Center in Southern Brazil
Lopes, Tiara Cristina Romeiro,Gravena, Angela Andreia Franca,de Oliveira Demitto, Marcela,Brischiliari, Sheila Cristina Rocha,Borghesan, Deise Helena Pelloso,Agnolo, Catia Millene Dell,de Barros Carva Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
Background: To investigate the prevalence of and factors associated with performance of annual mammography by women above 40 years of age. Materials and Methods: This cross-sectional retrospective study was conducted at an oncology reference service in Southern Brazil from October 2013 to October 2014 with 525 women aged 40 years or older. Results: The prevalence of annual mammography was 54.1%; annual mammographic screening was performed for women without private medical insurance, who were under hormone replacement therapy and who had used contraception in the past. An association was found between non-performance of breast clinical and self-examination and non-performance of mammographic screening. Conclusions: Use of mammography for breast cancer screening in the public health care setting proved to be accessible; nevertheless, the proportion of screened women was low, and they exhibited poor adherence to the basic measures of care recommended for breast assessment. Thus, control of breast cancer requires implementing actions targeting the population most vulnerable to non-adherence to screening in addition to continuously monitoring and assessing that population to reduce the prevalence of this disease.