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      • Effect of bio-mediated route synthesized silver nanoparticles for modification of polyethersulfone membranes

        Ananth, A.,Arthanareeswaran, G.,Ismail, A.,Mok, Y.S.,Matsuura, T. Elsevier 2014 Colloids and surfaces. A, Physicochemical and engi Vol.451 No.-

        This article reports the modification of polyethersulfone (PES) membrane using silver nanoparticles (n-Ag), their characterizations and protein separation performances. As a bio-mediated synthesis route, gram-positive Bacillus subtilis bacterial supernatants were employed for preparing n-Ag. The resulting n-Ag exhibited uniform and well defined spherical morphology with size less than 50nm. The effect of the incorporation of n-Ag on PES membrane in terms of cross sectional morphology, surface roughness, crystallinity and hydrophilicity were investigated systematically. XPS analysis showed that a significant portion of silver was in silver oxide form. Depth profiling by argon plasma etching and XPS showed the partition of Ag<SUB>2</SUB>O and Ag between the membrane surface and the bulk. A minor oxidation on the surface of the silver was observed whereas the internal structure of the membrane retained Ag in its metallic state. The potential of the nano composite membrane for the separation of BSA with varying feed concentration and transmembrane pressure were performed. At 1.5wt% loading of n-Ag in neat PES, enhancement in bovine serum albumin (BSA) flux and decrease in the rejection were observed. The results and performance of the PES/n-Ag nanocomposite membranes indicate that it would be a deserving candidate for future industrial separations. The experimental results confirm that the incorporation of Ag nanoparticles in PES UF membrane can increase hydrophilicity and reduce the fouling.

      • Indians and Rural Displacement: Exclusion from Region Building in Malaysia

        Anantha Raman Govindasamy 서울대학교행정대학원 2010 Asian Journal of Political Science Vol.18 No.1

        Building regions often creates socio-economic imbalances that exclude low-incomeearners from the benefits of development. In Malaysia, an example of this is theterritorial and cultural displacement of Indian plantation workers by rapid economicgrowth and urbanisation. Since 1980, nearly 300,000 Indians have been forced to movefrom the long-term relative security of their plantation estate communities, and haverelocated into urban squatter settlements, when plantation land has been subdivided forhousing and industrial estates. This article examines the loss of income, social role andcultural identity which accompanied the loss of physical place. Using a case study fromKamiri Estate in Perak, it also outlines the Indian community’s attempts to politicallyengage and negotiate a level of regional belonging.

      • SCISCIESCOPUS

        Nanostructuring of poly(diphenylamine) inside the galleries of montmorillonite organo clay through self-assembly approach.

        Gopalan, Anantha Iyengar,Lee, Kwang-Pill,Hong, Mung-Hwa,Santhosh, Padmanabhan,Manesh, Kalayil Manian,Kim, Sang-Ho American Scientific Publishers 2006 Journal of nanoscience and nanotechnology Vol.6 No.6

        <P>Hollow spheres of poly(diphenylamine) (PDPA) was prepared by confining PDPA in the galleries of montmorillonite organo clay modified with organoammonium cations (MMT). At first instant, diphenylamine (DPA) was loaded into the galleries of MMT and subjected to subsequent oxidative polymerization to form PDPA. beta-naphthalene sulfonic acid (NSA) was used as medium to influence self-assembly of DPA inside the galleries of MMT. Polymerization of self assembled structure resulted hollow spheres of PDPA inside galleries of MMT. X-ray diffraction analysis (XRD), field emission transmission electron microscopy (FETEM), Fourier transform infra-red spectroscopy (FT-IR) and thermogravimetric analysis (TGA) were used to characterize the composites. Transmission emission microscopy of the composite shows the hollow spherical morphology of PDPA. FT-IR, UV-Visible spectroscopy, conductivity measurement and X-ray photoelectron spectroscopy were used to characterize the PDPA extracted from MMT galleries. PDPA extracted from MMT galleries was found to have difference in electronic property than PDPA formed by the conventional method, due to the confinement effect.</P>

      • Reducing Faulty Node Detection Delay in Industrial Internet of Things

        Alifia Putri Anantha,Sanjay Bhardwaj,Jae-Min Lee,Dong-Seong Kim 한국통신학회 2019 한국통신학회 학술대회논문집 Vol.2019 No.6

        In industrial internet of things (IIoT), some data obtained may experience problems during the communication process between nodes that cause high latency and network congestion. Therefore, detection of faulty nodes is necessary. Various methods for detecting faulty nodes in IIoT and overviews of their systems are discussed in this paper. However, the previous solutions experienced long delays in identifying and isolating nodes that produced incorrect data. Artificial intelligence (AI) is a good solution to this problem because of its ability to accelerate time, thereby reducing computing time and delays. The principal purpose of this paper is to serve a framework for researchers about how faulty nodes in IIoT can be detected, point out the weaknesses of each system related to the problem of delay, and propose a mechanism which allows each node to identify whether it produces faulty data rapidly.

      • SCIESCOPUS

        Current and emerging applications of nanostructured metal–organic frameworks in cancer-targeted theranostics

        Lakshmi, Buddolla Anantha,Kim, Sanghyo Elsevier 2019 Materials Science and Engineering C Vol. No.

        <P><B>Abstract</B></P> <P>Nanostructured metal-organic frameworks (N-MOFs) are crystalline coordination nanopolymers in which metals are conjugated with organic and inorganic linker molecules. At present, N-MOFs have attracted significant interest owing to their intrinsically high porosity and ultrahigh surface areas, which allow them to be loaded with a broad array of materials, including drug molecules. In addition, N-MOFs possess other unique properties, such as good mobility, high reactivity, outstanding stability, real-time intracellular pH sensitivity, photosensitization, and penetration ability, which make them suitable candidates as drug delivery carriers for cancer and other targeted therapies. The opportunity for using a diverse array of chemical building components in N-MOFs facilitates the formation of structures with preferred properties for targeted therapy. In this review, we focus on the synthesis, characterization and other potential applications of N-MOFs in targeted theranostic nanodrug for cancer therapy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Cancer encountering significant lethal effects in human beings from the many decades </LI> <LI> Nanostructured metal-organic frameworks (N-MOFs) have potential role in the development of cancer targeted therapy. </LI> <LI> Various synthesis and characterization techniques of NMOFs have been reported. </LI> <LI> Recent advancements of N-MOFs in the cancer targeted therapy were discussed. </LI> <LI> Some of the challenges existing in the cancer targeted therapy were discussed using N-MOFs. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

      • Network Intrusion Detection System for IIoT Using GRU and Denoising Autoencoder

        Alifia Putri Anantha,Da Hye Kim(김다혜),Jae Min Lee(이재민),Dong-Seong Kim(김동성) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.2

        This work presents a denoising autoencoder-based anomaly detection model using GRU for intelligent network intrusion detection system. The main aim is to secure an IIoT system because its technologies are shadowed by privacy trade-offs and miserable security concerns. The dataset used is NSL-KDD dataset but it suffers from several inefficiencies, one of them is class imbalance issue. This fact made it difficult for classifiers to detect some underrepresented attack types resulting in poor accuracy. By combining denoising autoencoder with GRU and testing the method through a simulation, our proposed system is able to outperforms some methods in the existing literature with the highest accuracy.

      • KCI등재

        DNA barcoding in authentication of herbal raw materials, extracts and dietary supplements: a perspective

        D. B. Anantha Narayana,Sudhakar T. Johnson 한국식물생명공학회 2019 Plant biotechnology reports Vol.13 No.3

        Cultivation, supply, and availability of unadulterated plant raw material in botanical or herbal industry are a challenging task. Plant species that are either in short supply or in high demand are prone to adulteration and substitution. Such unscrupulous activity results in availability of substandard products with declining quality standards ultimately posing safety concerns and health of consumers. Raw materials which are in the form of dried, fragmented or powdered forms are major victims of adulteration. We present here DNA-based marker approach to authenticate botanicals. Recent research advances such as 2D-electrophoresis, microarray, next generation sequencing, high-resolution melting analysis, and PCR-based methods have been reviewed and their role in authentication of raw material, botanicals in herbal extracts, finished formulations, and ingredients in dietary supplements has been presented. Due to extraction processes such as steaming, extraction at extreme conditions and presence of secondary metabolites original DNA integrity are not preserved which lead to interference with DNA extraction and PCR amplification, thus making DNA unsuitable for further molecular analysis. There is a scope to develop and validate DNA mini-barcodes for finished formulations. DNA barcode along with chromatographic methods, metabolomics, proteomics, and genomics has to be used to resolve substitution and quantity of raw material in ambiguity. Emerging regulatory scenario on DNA barcode in various Pharmacopoeia is presented. Though several advanced methods of botanical authentication are available, an industry always expects simple, cost efficient, and quick method to resolve authentication issues.

      • Facile design and spectroscopic characterization of novel bio-inspired Quercetin-conjugated tetrakis (dimethylsulfoxide)dichlororuthenium(II) complex for enhanced anticancer properties

        Lakshmi, Buddolla Anantha,Bae, Jin-Young,An, Jeong Ho,Kim, Sanghyo Elsevier 2019 Inorganica chimica acta Vol.495 No.-

        <P><B>Abstract</B></P> <P>A facile reflux approach was employed in the design of novel complexes using ruthenium(II) and quercetin for enhanced anticancer applications. The designed metal-based flavonoid complex was thoroughly characterized by employing powder XRD, <SUP>1</SUP>H, <SUP>13</SUP>C NMR, elemental analysis (C, H, N, S, O), FT-IR, XPS, and UV–Vis spectroscopy techniques. The cell toxicity and cell proliferation properties of the Quercetin-Ru(II) complex were investigated on the non-small cell lung cancer cell lines (A549) along with the lung normal cells (WI-38) and human dermal fibroblast (HDFa) cells. Significant cytotoxicity was observed with the newly designed complex on A549 cells at minimum concentrations of (10–30 µM). Interestingly, no remarkable cytotoxicity was observed in the WI-38 and HDFa cells. The same was confirmed by assessing cellular damage and nuclear damage via Atomic force microscopy (Bio-AFM) and Hoechst staining assay. Moreover, the results of intracellular reactive oxygen species (ROS) generation are also interesting to confirm the abilities of designed novel Quercetin-Ru(II) complex for anticancer applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Novel Quercetin-Ru(II) complexes were designed using facile reflux reaction. </LI> <LI> The Mechanism for the formation of Quercetin-Ru(II) complex was described. </LI> <LI> Cellular damage studies were evaluated using atomic force microscopy. </LI> <LI> Intracellular reactive oxygen species & nuclear damage studies were investigated. </LI> <LI> Cytotoxicity studies were studied in WI-38, HDFa and A549 cells, respectively. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>We designed novel Quercetin-conjugated Tetrakis (dimethylsulfoxide)dichlororuthenium(II) complex and characterized thoroughly via spectroscopic and optical techniques, which exhibited enhanced anti-cancer effects with induced ROS generation. The cellular and nuclear damage studies in A549 cells were studied by employing Atomic force microscopy (Bio-AFM) and Hoechst staining assay.</P> <P>[DISPLAY OMISSION]</P>

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