안구적출에 따른 위둔덕의 칼슘결합단백질의 재구축 및 상호 연관성

안병수,고길석,안명수,김경주,권안성,정명섭,박춘매,조병옥,김진우,Samudra Acharya,Parmeshwar Narayan Amatya,장인엽 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1

Background: Superior colliculus is a part of midbrain, and participates in the visual reflexes, It receives afferent fibers from optic nerve, visual cortex, and spinotectal tract. After optic deprivation, the microscopic structure of the superior colliculus changed. Calcium-binding proteins (CBPs) Play an important role in the neuronal protection, differentiation and reorganization of the central nervous system, Objectives and Methods: The effects of neonatal retinal deafferentation on a CBPs, calbindm D-28k (CB), Parvalbumin (PB) and calretimn (CR), and the existence of colocalization between the CBPs were examined immunohistochemically in the rat superior colliculus. Results: On the experimental (contralateral to enucleation) side of superior colliculus, the number of CB-immunoreactive (IR) cells was reduced (77.4% compared to control), but not fibers. The number of PB-IR neurons and fibers was also reduced on the experimental side (88.5% compared to control), In the other hand, the CR-IR cells were dramatically increased (642% compared to control), but CR-IR fibers were markedly decreased on the experimental side. The colocalization between CB-CR and PV-CR was rarely observed in the superior colliculus Conclusion: These results suggest that the changes of retinotectal projection may alter the expressional pattern of CBPs in different manners; relatively stable in CB- and PV-IR neurons and plastic in CR-IR neurons.

VLBI NETWORK SIMULATOR: AN INTEGRATED SIMULATION TOOL FOR RADIO ASTRONOMERS

ZHEN ZHAO,Tao An,BAOQIANG LAO 한국천문학회 2019 Journal of The Korean Astronomical Society Vol.52 No.5

In this paper we introduce a software package, the Very long baseline interferometry Network SIMulator (VNSIM), which provides an integrated platform assisting radio astronomers to design Very Long Baseline Interferometry (VLBI) experiments and evaluate the network performance, with a user-friendly interface. Though VNSIM is primarily motivated by the East Asia VLBI Network, it can also be used for other VLBI networks and generic interferometers. The software package not only integrates the functionality of plotting (u; v) coverage, scheduling the observation, and displaying the dirty and CLEAN images, but also adds new features including sensitivity calculations for a given VLBI network. VNSIM provides flexible interactions on both command line and graphical user interface and offers friendly support for log reports and database management. Multi-processing acceleration is also supported, enabling users to handle large survey data. To facilitate future developments and updates, all simulation functions are encapsulated in separate Python modules, allowing independent invoking and testing. In order to verify the performance of VNSIM, we performed simulations and compared the results with other simulation tools, showing good agreement.

Imaging Features of Soft-Tissue Calcifications and Related Diseases: A Systematic Approach

Zhen-An Hwang,서경진,Dillon Chen,Wing P. Chan,Jim S. Wu 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.6

Soft-tissue calcification refers to a broad category of lesions. Calcifications are frequently identified by radiologists in daily practice. Using a simple algorithm based on the distribution pattern of the lesions and detailed clinical information, these calcified lesions can be systematically evaluated. The distribution pattern of the calcific deposits enables initial division into calcinosis circumscripta and calcinosis universalis. Using laboratory test results (serum calcium and phosphate levels) and clinical history, calcinosis circumscripta can be further categorized into four subtypes: dystrophic, iatrogenic, metastatic, and idiopathic calcification. This pictorial essay presents a systematic approach to the imaging features of softtissue calcifications and related diseases.

A Cooperative Guidance Approach Based on the Finite-Time Control Theory for Hypersonic Vehicles

Kai An,Zhen-yun Guo,Wei Huang,Xiao-ping Xu 한국항공우주학회 2022 International Journal of Aeronautical and Space Sc Vol.23 No.1

A distributed time cooperative guidance method based on the finite-time control theory is proposed to solve the salvo attack problem of multi-hypersonic vehicles in the three-dimensional space. Firstly, the second-order system is defined with the relative distance and the total leading angle as the state variables, and the finite-time controller is designed based on the multi-agent cooperative control theory for achieving the consistency of system. Novelty, taking the influence of parameters on the cooperative guidance results into account, an adaptive weight function is designed to replace the traditional constant coefficient to optimize guidance results. Then, the motion of vehicle in three-dimensional space is divided into two planes, the proportional navigation guidance (PNG) is applied in longitudinal and the lateral acceleration can be obtained via the finite-time controller and longitudinal acceleration. It is significant to establish the lateral leading angle finite-time convergence guidance law to compensate the lateral acceleration to accelerate the convergence speed. Furthermore, the biased term of terminal impact angle control is applied in PNG to achieve the terminal attack in arbitrary angle. Finally, the feasibility and robustness are verified by numerical simulations.

The Retention Behavior of Ginsenosides in HPLC and Its Application to Quality Assessment of Radix Ginseng

Ping Hu,Guo-An Luo,Zhong-Zhen Zhao,Wan Wang,Qing Wang,Zhi-Hong Jiang 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.10

This study systematically investigated the retention behavior of seven neutral ginsenosides Rg₁, Re, Rf, Rb₁, Rb₂, Rc, Rd, and an acidic ginsenoside R0, the major pharmacologically active components of Radix Ginseng with RP-HPLC. The effects of solvent, pH value, ionic strength of the mobile phase, and column temperature were investigated using an octadecylsiloxane-bonded silica gel column. Based on the ginsenosides’ retention characteristics, the concentration of acetonitrile and the gradient of the mobile phase needed to maintain the baseline separation of the major neutral ginsenosides in Radix Ginseng were theoretically predicted. Furthermore, the ionic strength of mobile-phase necessary to achieve good resolution of the neutral ginsenosides and acidic ginsenosides was carefully investigated. According to the results of the quantitative analysis of ginsenosides in eight batches of ginseng samples from different sources, the developed HPLC technique may be a valuable tool for the quality assessment of Radix Ginseng.

Nitrogen, phosphorus and potassium fertilization promotes Zanthoxylum armatum ‘Hanyuan Putao Qingjiao’ fl ower bud diff erentiation in Sichuan, China

Chaobin Zhou,Yu Cai,Zhen’an Yang,Hongmin Wang,Fang Deng,Zeping Bai,Wei Gong,Jingyan Wang 한국원예학회 2020 Horticulture, Environment, and Biotechnology Vol.61 No.4

Chinese prickly ash is an ecologically and economically important tree species. In southwestern China, its yield is low dueto severe fruit and fl ower drop related to the relatively low nutrient status of shoots and/or fl owers caused by a lack of nutrientsupply. Therefore, studies on fl ower bud diff erentiation are of great importance to improve the yield of Chinese pricklyash. An orthogonal experimental design was used to study the eff ects of N (urea, 97.8, 195.7 and 391.3 g/individual), P(superphosphate, 150, 300 and 600 g/individual) and K (potassium sulphate, 83.3, 166.7 and 333.3 g/individual) treatmentson fl ower bud diff erentiation in 3-year-old Zanthoxylum armatum ‘Hanyuan Putao Qingjiao’ trees. The results showed thatN, P and K fertilizer application signifi cantly increased the fl ower bud diff erentiation rate, branch diameter and number, thesoluble sugar content, the soluble protein content, the C/N ratio, the ABA content and the ABA/IAA ratio but decreasedthe GA content and IAA content in Chinese prickly ash. The fl ower bud diff erentiation rate was positively related to thesoluble sugar content, soluble protein content, C/N ratio and ABA/IAA ratio ( p < 0.05) but negatively related to GA andIAA ( p < 0.05). A higher P content increased the accumulation of nutrients and ABA in the buds, thereby promoting thefl ower bud diff erentiation in Z. armatum ‘Hanyuan Putao Qingjiao’. From these results, the fl ower bud diff erentiation in Z. armatum ‘Hanyuan Putao Qingjiao’ requires appropriate N, P and K fertilizer ratios and amounts. Treatment 12 (N 2 P 3 K 1 )signifi cantly improved the absorption of nutrients in the buds and promoted the diff erentiation of fl ower buds.

Time-varying Formation Tracking for Second-order Multi-agent Systems Subjected to Switching Topology and Input Saturation

Jing Liu,Jian-an Fang,Zhen Li,Guang He 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.4

This paper addresses the problem of time-varying formation tracking for a kind of second-order multiagent systems with a switching topology, in which the dynamics of agents are modeled by double integrators and harmonic oscillators respectively. The control input of each agent is subject to saturation. First, depending on the low-gain state feedback technique, an algorithm is designed to solve semi-global time-varying formation tracking problem, where feasibility condition of formation tracking is introduced. Then, by utilizing the Lyapunov function and low-gain feedback theory, it is proved that second-order multi-agent system with a switching topology achieves the specified semi-global time-varying formation tracking if some sufficient conditions hold. Further, as an extension, jointly connected switching topology is considered, and the corresponding formation tracking problem is also explored. Subsequently, several simulation examples is worked out for illustration.

The Retention Behavior of Ginsenosides in HPLC and Its Application to Quality Assessment of Radix Ginseng

Hu, Ping,Luo, Guo-An,Wang, Qing,Zhao, Zhong-Zhen,Wang, Wan,Jiang, Zhi-Hong 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.10

This study systematically investigated the retention behavior of seven neutral ginsenosides $Rg_1$, Re, Rf, $Rb_1$, $Rb_2$, Rc, Rd, and an acidic ginsenoside $R_0$, the major pharmacologically active components of Radix Ginseng with RP-HPLC. The effects of solvent, pH value, ionic strength of the mobile phase, and column temperature were investigated using an octadecylsiloxane-bonded silica gel column. Based on the ginsenosides' retention characteristics, the concentration of acetonitrile and the gradient of the mobile phase needed to maintain the baseline separation of the major neutral ginsenosides in Radix Ginseng were theoretically predicted. Furthermore, the ionic strength of mobile-phase necessary to achieve good resolution of the neutral ginsenosides and acidic ginsenosides was carefully investigated. According to the results of the quantitative analysis of ginsenosides in eight batches of ginseng samples from different sources, the developed HPLC technique may be a valuable tool for the quality assessment of Radix Ginseng.

The SH2 domain is crucial for function of Fyn in neuronal migration and cortical lamination

( Xi Lu ),( Xin De Hu ),( Ling Zhen Song ),( Lei An ),( Ming Hui Duan ),( Shu Lin Chen ),( Shan Ting Zhao ) 생화학분자생물학회(구 한국생화학분자생물학회) 2015 BMB Reports Vol.48 No.2

Neurons in the developing brain form the cortical plate (CP) in an inside-out manner, in which the late-born neurons are located more superficially than the early-born neurons. Fyn, a member of the Src family kinases, plays an important role in neuronal migration by binding to many substrates. However, the role of the Src-homology 2 (SH2) domain in function of Fyn in neuronal migration remains poorly understood. Here, we demonstrate that the SH2 domain is essential for the action of Fyn in neuronal migration and cortical lamination. A point mutation in the Fyn SH2 domain (FynR176A) impaired neuronal migration and their final location in the cerebral cortex, by inducing neuronal aggregation and branching. Thus, we provide the first evidence of the Fyn SH2 domain contributing to neuronal migration and neuronal morphogenesis. [BMB Reports 2015; 48(2): 97-102]

Evaluation fo Field Performance and Approval criteria in Herbicide Registration in China

Zhen Li,Xuehua An,Xueping Zhao 한국잡초학회 2011 한국잡초학회 별책(학술대회 초록집) Vol.31 No.2