Doxycycline-Induced Esophagitis

Amendola, Marco A.,Spera, Thomas D. MediMedia Korea 1986 JAMA-Korea Vol.1 No.4

Cosmology and fundamental physics with the Euclid satellite

Amendola, Luca,Appleby, Stephen,Avgoustidis, Anastasios,Bacon, David,Baker, Tessa,Baldi, Marco,Bartolo, Nicola,Blanchard, Alain,Bonvin, Camille,Borgani, Stefano,Branchini, Enzo,Burrage, Clare,Camera, Springer International Publishing 2018 Living reviews in relativity Vol.21 No.1

<P>Euclid is a European Space Agency medium-class mission selected for launch in 2020 within the cosmic vision 2015–2025 program. The main goal of Euclid is to understand the origin of the accelerated expansion of the universe. Euclid will explore the expansion history of the universe and the evolution of cosmic structures by measuring shapes and red-shifts of galaxies as well as the distribution of clusters of galaxies over a large fraction of the sky. Although the main driver for Euclid is the nature of dark energy, Euclid science covers a vast range of topics, from cosmology to galaxy evolution to planetary research. In this review we focus on cosmology and fundamental physics, with a strong emphasis on science beyond the current standard models. We discuss five broad topics: dark energy and modified gravity, dark matter, initial conditions, basic assumptions and questions of methodology in the data analysis. This review has been planned and carried out within Euclid’s Theory Working Group and is meant to provide a guide to the scientific themes that will underlie the activity of the group during the preparation of the Euclid mission.</P>

Quetiapine Treatment for Post-traumatic Stress Disorder: A Systematic Review of the Literature

Calogero Crapanzano(Calogero Crapanzano ),Stefano Damiani(Stefano Damiani ),Ilaria Casolaro(Ilaria Casolaro ),Chiara Amendola(Chiara Amendola ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

Paroxetine and Sertraline are the only medications approved in posttraumatic stress disorder (PTSD). However, about 60% of traumatized patients fail to show an adequate clinical response. Second generation antipsychotics are recommended as second-line monotherapy or third-line augmentation strategies and quetiapine appears as one of the most used and promising agents. Up to date, no reviews assessed the efficacy of quetiapine in the treatment of PTSD. We aimed to assess the effectiveness and general safety of quetiapine on PTSD. A systematic review was conducted following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) and Cochrane guidelines, selecting studies that evaluated the efficacy of quetiapine on global or specific PTSD symptomatology. Ten studies (n = 894) were considered eligible for qualitative synthesis: one case report, one case series, one prospective cohort study, 3 open-label trials, 3 retrospective studies, one randomized controlled trial. Quetiapine was effective on global PTSD symptomatology assessed in 6 studies as well as on re-experiencing (4/4 studies), avoidance (4/3 studies) and hyperarousal (4/4 studies), flashbacks (2/2 studies), depressive (4/4 studies), anxiety (1/1 studies), psychotic (3/3 studies), insomnia (4/5 studies), nightmares (3/3 studies) specific symptoms and PTSD domains. Sedation was among the most frequently observed adverse effects and the main cause of drug discontinuation. Preliminary findings support the efficacy of quetiapine in ameliorating symptoms relative to PTSD and its overall safety. However, quetiapine use in PTSD cannot be recommended yet as studies mainly rely on open-label, retrospective studies or case series.

Efficacy of Olanzapine in Anxiety Dimension of Schizophrenia: A Systematic Review of Randomized Controlled Trials

Calogero Crapanzano(Calogero Crapanzano ),Ilaria Casolaro(Ilaria Casolaro ),Stefano Damiani(Stefano Damiani ),Chiara Amendola(Chiara Amendola ) 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.4

Anxiety symptoms and anxiety disorders are frequent in patients with schizophrenia and are associated with greater severity of both positive and negative symptoms, cognitive impairment, poorer functioning and quality of life. Accumulating evidence suggests that atypical antipsychotics may have a role in treating comorbid anxiety symptoms. A systematic review was conducted following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) and Cochrane guidelines, selecting randomized control trials (RCTs) that evaluated efficacy of olanzapine on anxiety symptoms in patients diagnosed with schizophrenia and included anxiety evaluation scales. We searched PubMed and Web of Science databases for articles in English language available until September 2021. We selected 7 studies (3 with primary data analysis, 4 with secondary data analysis) regarding the use of olanzapine in patients with schizophrenia. In fours studies olanzapine was superior to haloperidol in improving anxiety symptoms. Four studies compared olanzapine versus risperidone: in two of them risperidone was superior to olanzapine, although one study was limited by a relatively small sample size. In the other two there were no significant differences between olanzapine and risperidone-treated patients. One study found that olanzapine and clozapine were comparable in terms of efficacy. Although olanzapine was superior to haloperidol in treating anxiety, this symptom was a secondary outcome measure in most of the considered studies. Future RCTs comparing different antipsychotics and larger sample sizes may allow to develop more solid treatment strategies.

Validation of a smart structural concept for wing-flap camber morphing

Pecora, Rosario,Amoroso, Francesco,Amendola, Gianluca,Concilio, Antonio Techno-Press 2014 Smart Structures and Systems, An International Jou Vol.14 No.4

The study is aimed at investigating the feasibility of a high TRL solution for a wing flap segment characterized by morphable camber airfoil and properly tailored to be implemented on a real-scale regional transportation aircraft. On the base of specific aerodynamic requirements in terms of target airfoil shapes and related external loads, the structural layout of the device was preliminarily defined. Advanced FE analyses were then carried out in order to properly size the load-carrying structure and the embedded actuation system. A full scale limited span prototype was finally manufactured and tested to: ${\bullet}$ demonstrate the morphing capability of the conceived structural layout; ${\bullet}$ demonstrate the capability of the morphing structure to withstand static loads representative of the limit aerodynamic pressures expected in service; ${\bullet}$ characterize the dynamic behavior of the morphing structure through the identification of the most significant normal modes. Obtained results showed high correlation levels with respect to numerical expectations thus proving the compliance of the device with the design requirements as well as the goodness of modeling approaches implemented during the design phase.

Intraoperative near-infrared spectroscopy for pedicled perforator flaps: a possible tool for the early detection of vascular issues

Marchesi, Andrea,Garieri, Pietro,Amendola, Francesco,Marcelli, Stefano,Vaienti, Luca Korean Society of Plastic and Reconstructive Surge 2021 Archives of Plastic Surgery Vol.48 No.4

Background Pedicled perforator flaps can present postoperative complications similar to those encountered in free flap surgery. Beyond a clinical evaluation, there is still no reliable technical aid for the early prediction of vascular issues. The aim of this study was to assess the support of near-infrared spectroscopy technology as an intraoperative tool to anticipate postsurgical flap ischemia. Methods We prospectively enrolled 13 consecutive patients who were referred to our hospital from March 2017 to July 2018 and required a reconstructive procedure with a pedicled fasciocutaneous perforator flap. We measured flap peripheral capillary oxygen saturation (SpO₂) in each patient with a Somanetics INVOS 5100C Cerebral/Somatic Oximeter (Medtronic), both before and after transposition. Patient demographics, operative data, and complications were then recorded during the following 6 months. We analyzed the data using the Wilcoxon signed-rank test and linear regression. Results The mean flap SpO₂ before and after transposition was 92%±3% and 78%±19%, respectively. The mean change in SpO₂ was 14%±17%, with a range of 0% to 55%. The change in saturation and mean saturation ratio were significantly different between patients with and without postoperative flap necrosis. Conclusions An immediate quantitative analysis of flap peripheral capillary SpO₂ after transposition has never before been described. In our experience, an intraoperative drop in SpO₂ equal to or greater than 15%-20% predicted vascular complications in pedicled perforator flaps. Conversely, flap size and rotation angle were not correlated with the risk of flap necrosis.

Restoring blood flow to the lateral plantar artery after elevation of an instep flap or medialis pedis flap

Jonathan Velazquez-Mujica,Francesco Amendola,Davide Spadoni,Hung-Chi Chen 대한성형외과학회 2022 Archives of Plastic Surgery Vol.49 No.1

The instep flap and medialis pedis flap are both originate based on the medial plantar artery. The medialis pedis flap is based from the deep branch and the instep flap is based from the superficial branch. To increase the axial rotation, it is acceptable to ligate the lateral plantar artery. However, this can partially affect the blood supply of the plantar metatarsal arch. We restored the blood flow with a vein graft between the posterior tibial artery and the ligated stump. From 2012 to 2020, 12 cases of heel reconstruction, including seven instep flaps and five medialis pedis flaps, were performed with ligation of the lateral plantar artery. The stump of the lateral plantar artery was restored with a vein graft and between the posterior tibial artery and the ligated stump. Patients were followed for 18 months. Long-term results showed the vascular restoration of the lateral plantar artery remained patent demonstrated by doppler ultrasonography. Restoring blood flow to the lateral plantar artery maintains good blood supply to the toes. If the patient in the future develops a chronic degenerative disease, with microvascular complications, bypass surgery can still be performed because of the patency of both branches.

Lithium and Valproate in Bipolar Disorder: From International Evidence-based Guidelines to Clinical Predictors

Calogero Crapanzano,Ilaria Casolaro,Chiara Amendola,Stefano Damiani 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.3

Since decades, lithium and valproate remain the pharmacological cornerstone to treat bipolar disorder. Different response patterns occur according to the phases of illness. At same time, individual pretreatment variables may concur to determine a specific drug-response. Our narrative review focuses on these two key clinical aspects to summarize the state of art. Information from i) clinical trials and ii) the most relevant international guidelines is collected to assess the clinical and preclinical factors that may guide the use of lithium rather than valproate. Lithium may be effective in treating acute mania, and lithium efficacy is maximized when used to prevent both manic and depressive episodes. Lithium may be a better treatment choice in patients with: positive family history for bipolar disorder, mania-depression-interval pattern, few previous affective episodes/hospitalizations, high risk for suicide, no comorbidities. Valproate may be more effective as antimanic rather than prophylactic agent. Valproate might be a better choice in patients with many previous affective episodes/hospitalizations and psychiatric comorbidities. Finally, neither lithium nor valproate are suggested for the treatment of acute mixed states or bipolar depression. To consider clinical and preclinical factors may thus be useful to select the best treatment strategy.

Treatment of Ednometrial Carcinoma Stage II

Han I.,Kanellitsas C.,Kumar N.,Amendola B.,Morley G. The Korean Society for Radiation Oncology 1984 Radiation Oncology Journal Vol.2 No.2

Between January 1971 and December 1580 fifteen patients diagnosed of adenocarcinoma of the endometrium, stage II seen and treated at the University of Michigan Hospitals. are reviewed. Ten patients were treated with radiation therapy alone. five received hysterectomy after radiation. The five year survival of the patients receiving radiation and surgery was $100\%$ although one of them died after 62 month aster treatment. Of those receiving radiotherapy alone two died at i and 24months after therapy. All of the patients died of distant metastasis. Radiation cystitis was observed among surgically treated patients. while proctitis was observed in 3 cases receiving radiation alone. Though the number of cases reported is small due to rarity of the disease. it appears that radiation alone could provide reasonable tumor control. Also it appears that preoperative irradiation might lead to a longer survival. One patient who survived 62 months had para-aortic node involvement.

Validation of a smart structural concept for wing-flap camber morphing

Rosario Pecora,Francesco Amoroso,Gianluca Amendola,Antonio Concilio 국제구조공학회 2014 Smart Structures and Systems, An International Jou Vol.14 No.4

The study is aimed at investigating the feasibility of a high TRL solution for a wing flap segment characterized by morphable camber airfoil and properly tailored to be implemented on a real-scale regional transportation aircraft. On the base of specific aerodynamic requirements in terms of target airfoil shapes and related external loads, the structural layout of the device was preliminarily defined. Advanced FE analyses were then carried out in order to properly size the load-carrying structure and the embedded actuation system. A full scale limited span prototype was finally manufactured and tested to: • demonstrate the morphing capability of the conceived structural layout; • demonstrate the capability of the morphing structure to withstand static loads representative of the limit aerodynamic pressures expected in service; • characterize the dynamic behavior of the morphing structure through the identification of the most significant normal modes. Obtained results showed high correlation levels with respect to numerical expectations thus proving the compliance of the device with the design requirements as well as the goodness of modeling approaches implemented during the design phase.