Clinical Effectiveness of REGN-COV2 in Patients with COVID-19 in Japan: A Retrospective Cohort Study with a Bayesian Inference

Amano Norihiko,Iwata Kentaro,Iwata Sachiyo 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.4

Background: Neutralizing antibody cocktail therapy, REGN-COV2, is promising in preventing a severe form of coronavirus disease 2019 (COVID-19), but its effectiveness in Japan has not been fully investigated. Materials and Methods: To evaluate the effectiveness of REGN-COV2, clinical data of 20 patients with COVID-19 who received REGN-COV2 was compared with the control by matching age and sex. The primary outcome was the time from the onset to defervescence, the duration of hospitalization, and oxygen requirement. A sensitivity analysis using Bayesian analysis was also conducted. Results: The time to defervescence was significantly shorter in the treatment group (5.25 vs. 7.95 days, P = 0.02), and so was the duration of hospitalization (7.115 vs. 11.45, P = 0.0009). However, the oxygen therapy requirement did not differ between the two groups (15% vs. 35%, P = 0.27). For Bayesian analysis, the median posterior probability of the time to defervescence since the symptom onset on the REGN-COV2 group was 5.28 days [95% credible interval (CrI): 4.28 - 6.31 days], compared with the control of 7.99 days (95% CrI: 6.81 - 9.24 days). The posterior probability of the duration of the hospitalization on the REGN-COV2 group was 7.17 days (95% CrI: 5.99 - 8.24 days), compared with the control of 11.54 days (95% CrI: 10.28 - 13.14 days). The posterior probability of the oxygen requirement on the REGN-COV2 group was 18% (95% CrI: 3 - 33%), compared with the control of 36% (95% CrI: 16 - 54%). Conclusion: REGN-COV2 may be effective in early defervescence and shorter hospitalization. Its effectiveness for preventing a severe form of infection needs to be evaluated by further studies.

「学問」の果たす役割

Amano Katsushige(天野勝重) 일본어문학회 2017 일본어문학 Vol.77 No.-

二葉亭四迷(1887)『浮雲』は、内海文三と園田お勢、そして本田昇の三角関係を扱いながら、最終的には文三の近代人としての自我の芽生えや苦悩を描いた日本近代文学の嚆矢として誰もが知っている作品であるが、実はこの作品の中で、「学問」は非常に重要な意味を持っている。 主人公の内海文三は優秀な成績で学校を卒業したにも関わらず、うまく就職ができない。やっと就職することができた下級官吏の職も免職されてしまう。特に上司は海外留学までした高学歴の人物でありながら、文三では無く、学歴の不明な本田昇に目を掛けている。その理由を、論者はこの時期に「立身出世」をするために必要だった「学問」の価値に変化が起こったと考える。 本稿では、それを一つの立脚点として、文三が本田に勝てない設定になっている理由を考察する。そして当時の「学問」「学歴」の社会的意味を踏まえた結果、文三の思い描いている「学問」の優位さと、課長や本田が「学問」に見出す価値観に大きな断絶があることがわかった。 At Tsubouchi Shoyo “Tosei Shosei Katagi”(1885), the students are depicted very optimistic. But the future is different between Tokyo University graduates and private school graduates. In Futabatei Shimei “Ukigumo”(1887), “scholarship” has a very important meaning. Although the main character, Utsumi Bunzo, graduated from the private school with excellent results, he was unable to get a job well. He was dismissed from the position of a low-level official that led him to hard times. Especially his boss is a highly educated person who went to study abroad, but he is paying attention to Honda Noboru, who has unknown educational background. It seems that a change has occurred in the value of “academic” that was necessary to make “success” during this period. In this article, we examine why Bunzo cannot win Honda in “Ukigumo,” and reveal that there is a big discontinuity between “academics” envisioned by Bunzo and the values of “scholarship” recognized by his boss and Honda. Bunzo was unable to notice that the meaning of “scholarship” changed.

Observation of Seasonal Changes of Rivers in Tropical Forests from JERS-1 SAR Images

Amano, Takako Sakurai,Takagi, Mikio 대한원격탐사학회 2001 International Symposium on Remote Sensing Vol.17 No.1

In our previous studies, our new method using strong isolated scatterers visualizes narrow rivers in Amazon forests from JERS-1 SAR images and applied this method to multi-temporal 4 look JERS-1 SAR images of various tropical forests and detected seasonal changes of water levels qualitatively. In this paper, we summarized the results of the Amazon Basin, New Guinea, and Congo Basin and showed that the results are correlated with the regional precipitation patterns with some delay periods. Such delay probably shows the retention period of the water in the forested areas.

AUTOMATIC DETECTION OF NARROW OPEN WATER STREAMS IN AMAZON FORESTS FROM JERS-1 SAR IMAGERY

Amano, Takako Sakurai,Ilsaka, Joji,Kamiyama, Masataka,Takagi, Mikio 대한원격탐사학회 1999 International Symposium on Remote Sensing Vol.15 No.1

We extracted narrow open water streams From JERS-1 SAR images of the Amazon rain forest. The extracted range of these streams were almost comparable to a high level extraction of the same streams from near-IR images of JERS-1 VNIR data notwithstanding that these features in SAR images show the strong dependence of the observation angle. Large water bodies are relatively easy to extract from JERS-1 SAR images, as they tend to appear as very dark areas; but streams whose width is nearly equal to ar less than the spatial resolution no longer appear as very dark features. By using strong scatterers distributed sparsely along the radar facing sides of the streams, we can successfully estimate approximate ranges of waterways and then extract relatively dark line-like features within these ranges.

Prediction of Packing Density of Milled Powder Based on Packing Simulation and Particle Shape Analysis

Amano Yuto,Itoh Takashi,Terao Hoshiaki,Kanetake Naoyuki 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1

For precise property control of sintered products, it is important to understand accurately the packing density of the powder. We developed a packing simulation program that could make a packed bed of spherical particles having particle size distribution. In addition, the influence of the particle shape of the actual powder on the packing density was quantitatively analyzed. The predicted packing densities corresponded well to the actual data.

Extraction of Linear Features from an AVNIR data of a Suburban City

Amano, Takako Sakurai,Naito, Takahiro,Iisaka, Joji,Takagi, Mikio 대한원격탐사학회 1997 International Symposium on Remote Sensing Vol.13 No.1

Various linear geographic features were extracted from an ADEOS AVNII2 multispectral image of a small suburban city. Spectral data were transformed and normalized into three images representing the proportions of vegetated, inorganic, and dark surfaces, and binarized at multiple threshold levels. Each pixel in each binary image was evaluated for line-likeness at the local level. Values of line-likeness were summed over all threshold levels. The main components of linear features were extracted by applying simple image algebra, morphological operations, and size operations to the resulting images. Additionally, higher spatial operations needed to extract finer details were explored.

A Feature Mixing Model for AVHRR Data

Amano, Takako Sakurai,Iisaka, Joji,Takagi, Mikio 대한원격탐사학회 1996 International Symposium on Remote Sensing Vol.12 No.1

Since the spatial and spectral resolution of AVHRR data is coarse, each resolution cell usually contains many terrain features, not all of which are spectrally distinguishable. Therefore spectral differences between resolution cells often result from the differences in the ratio of the terrain features, rather than differences in the terrain features themselves. The Feature Mixing model assumes that each pixel in a scene consists of a mixture of a very small number of basic spectral features of the landscape, such as vegetation, soil or inorganic materials, and dark objects. The model was tested using AVHRR data to examine the feasibility of using it as a more general measure of monitoring global environmental changes. The results of the preliminary study were positive, although there are still many tasks to be done.

Extraction of Common GCPs from JERS-1 SAR Imagery

Amano, Takako Sakurai,Takagi, Mikio,Mitsui, Hiroe,Kobayashi, Shigeki,Fujii, Naoyuki,Okubo, Shuhei 대한원격탐사학회 1998 International Symposium on Remote Sensing Vol.14 No.1

「實業家」と「笑い」·「品性」の關係 - 夏目漱石の小說を一視点として-

天野勝重 ( Amano Katsushige ) 한국일본근대학회 2017 일본근대학연구 Vol.0 No.56

明治になって靑年たちが目指すものは當初は政治家であり官僚になるという「立身出世」であったが、明治20年代には制度が固定化され、そのようなことは現實的ではなくなった。 そのかわりに新しく登場したのが「實業家」である。「財閥」をつくり、敍?されるほどの社會的地位も獲得できるようになった彼等を目指す靑年たちが現われてくる。 ここで、それまで氣品や品性を重視してこなかった實業家像が大きな變化を起こし、實業家に品格を要請するようになる。そしてその品格を擔保するのがウィットやユ一 した時に、前者に登場する實業家は極めて人間性が低く、モアといった「笑い」の要素なのである。 文學作品においてもそのことを讀み取れる。例えば夏目漱石の『吾輩は猫である』と『彼岸過訖』を比較 「笑われる」對象であったのに對し、後者はウィットやユ一モアを解する人間として描かれている。 本稿ではこの實業家像の變化と笑いの關係について論じる。 In the Meiji era the aims of young people were initially politicians and became bureaucrats “Career advancement”, but in the Meiji 20s the system was fixed, such things became not realistic. Instead, it was “a businessman” that appeared newly. Young people aiming at becoming able to acquire the social status to be decorated and making “zaibatsu” appear. Here, the image of the businessmen who did not emphasize elegance and characterism so far caused a big change, so that business people will be asked for dignity. And it needs an element of “laugh” such as wit and humor to secure that dignity. You can read about it in literary works as well. For example, when Natsume Soseki`s “I am a cat” is compared with “Higan sugimade”, business people who appear in the former are extremely low in humanity, while the latter is a human who understands wit and humor It is drawn. In this paper we discuss the relationship between this change in businessman image and laughter.

Long-term Embryogenic Callus Cultures as a Source of Tetraploid Plants in the Liliaceous Ornamental Tricyrtis hirta

Junji Amano,Toshikazu Nomizu,Keiko Mizunashi,Mami Suzuki,Shiro Mori,Sachiko Kuwayama,Megumi Hayashi,Hiroto Umehara,Eriko Oka,Hiroyuki Kobayashi,Megumi Asano,Shintaro Sugawara,Hiroki Takagi,Yoshihiro H 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-